JOURNAL OF NANOPARTICLE RESEARCH
·
2020
·Vol. 22
·期 11
·1-12
·
IF 2.132
Wang Linjuan,Zan Ling
MoS 2 -modified In 2 S 3 ( x wt.%MoS 2 -In 2 S 3 ) samples (0 ≤ x ≤ 20) were fabricated through a facile one-pot hydrothermal process. All In 2 S 3 samples modified by MoS 2 deliver an excellent Cr 6+ removal ability under visible-NIR-light-driven, and 5% MoS 2 -In 2 S 3 can reduce 20 mg/L Cr 6+ solution completely within 30 min with a trace photocatalyst concentration (0.27 mg/mL) which is 3.2-hold higher than that of single In 2 S 3 . Further investigations demonstrate that the loaded MoS 2 can not only enhance the absorption of light scope but also promote the interfacial electron transfer from In 2 S 3 to MoS 2 and then to Cr 6+ , thus greatly improving the Cr 6+ removal ability. ESR shows that the modifying of MoS 2 can accelerate the transformation of electrons from the In 2 S 3 to MoS 2 which results in that the intensity of O 2 − • significantly increased. PL, photocurrent, and EIS further identified that the modification of MoS 2 can greatly improve the charge carrier separation efficiency. The fabricated MoS 2 -In 2 S 3 samples also exhibit characteristic features such as stable and reducing Cr 6+ in the weak alkaline environment for the first time, which could always be a great challenge for wastewater purification in alkaline condition.
研究领域:
材料科学
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环境科学
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光催化技术
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Bijiang Geng,Hua Qin,Wenwen Shen,Ping Li,Fuling Fang,Xiaokai Li,Dengyu Pan,Longxiang Shen
Osteosarcoma as an aggressive malignant neoplasm is commonly treated by surgical resection, chemotherapy, and radiotherapy, but surgery induces bone defects and chemo/radiotherapy causes severe systemic toxicity. We have designed a novel low-toxic bifunctional 0D/2D heterojunction (HJ) that can be used to generate effective photothermal effects in the second NIR window (NIR-II, 1000–1350 nm) for simultaneous osteosarcoma treatment and bone regeneration. To construct this 0D/2D nanostructure, biocompatible, positively charged NIR-II-responsive carbon dots (CDs) were synthesized by an ultrafast microwave-assisted hydrothermal method, followed by electrostatically driven assembly on both sides of negatively charged WS 2 nanosheets. We found that the HJs exhibited enhanced NIR-II absorption and photothermal conversion efficiency. Due to the deep-tissue penetration ability of 1064 nm laser, complete osteosarcoma ablation was realized at a low power density even when being covered by a 10-mm-thick additional tissue. Furthermore, osteogenic differentiation was remarkably enhanced by mild photothermal effects of CD/WS 2 HJs, which significantly up-regulated bone-related gene expressions, particularly, heat shock protein expression. Designed CD/WS 2 HJs can be used in osteosarcoma treatment and bone-tissue engineering.
研究领域:
生物医学工程
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纳米技术
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癌症治疗
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组织工程
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Huixian Jia,Yujie Liu,Wei Tang,Chenghui Liu,Xinrui Duan
Multiplexed fluorescence imaging is mainly applied to cellular imaging. However, the application of an analogous technique to mammals remains challenging due to the presence of substantial scattering and autofluorescence in biological tissues in the visible (350–700 nm) and near-infrared I region (NIR-I, 700–900 nm). Herein, we report multiplexing excitation and single-channel detection in the near-infrared II region (NIR-II) with two fluorescent probes for dual-color imaging in vivo. The first one, FNIR-1090 was constructed on Pr-1099 derivative by attaching with 1-Ethylpiperazine through the SRN1 displacement reaction. The second one, IR-765 was synthesized by a one-step reaction between the Vilsmeier–Haack reagent with 2-(3,5,5-trimethylcyclohex-2-enylidene) malononitrile (TEMO). It is noteworthy that the absorption spectrum of FNIR-1090 is almost completely separated from that of IR-765, which facilitates dual-color in vivo imaging. The two dyes can be used for high-contrast dual-channel vivo imaging of different tissues. All these prominent performances show the great promise of FNIR-1090 and IR-765 in non-invasive, real-time, and dual-color NIR-II imaging (>900 nm) in vivo.
研究领域:
生物医学工程
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分子成像
·
光学成像
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产品关联
DOI
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-21
·
IF 14.7
Tang Dongsheng,Cui Minhui,Wang Bin,Liang Ganghao,Zhang Hanchen,Xiao Haihua
Cationic polymers have great potential for cancer therapy due to their unique interactions with cancer cells. However, their clinical application remains limited by their high toxicity. Here we show a cell membrane-targeting cationic polymer with antineoplastic activity (P mt ) and a second near-infrared (NIR-II) fluorescent biodegradable polymer with photosensitizer Bodipy units and reactive oxygen species (ROS) responsive thioketal bonds (P Bodipy ). Subsequently, these two polymers can self-assemble into antineoplastic nanoparticles (denoted mt-NP Bodipy ) which could further accumulate at the tumor and destroy cell membranes through electrostatic interactions, resulting in cell membrane destabilization. Meanwhile, the photosensitizer Bodipy produces ROS to induce damage to cell membranes, proteins, and DNAs to kill cancer cells concertedly, finally resulting in cell membrane lysis and cancer cell death. This work highlights the use of near-infrared light to spatially and temporarily control cationic polymers for photodynamic therapy, photo-immunotherapy, and NIR-II fluorescence for bio-imaging.
研究领域:
癌症治疗
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生物医学工程
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纳米技术
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光动力疗法
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生物成像
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光免疫治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2022
·
IF 6.556
Qi Dai,Zichun Qi,Zhenzhen Yan,Biao Yu,Jingqiu Li,Baosheng Ge,Hua He,Fang Huang,Xiaojuan Wang
A novel ratiometric fluorescent tyrosinase assay is developed based on hybrid nano-assembly of gold nanocluster and tyrosine-containing peptides. The AuNCs@YCY nano-probe ( AYNP ) is fabricated through the hydrophobic interactions and π-π stacking between the tyrosine residues of the Tyr-Cys-Tyr tripeptide (YCY) and the ligands on the surfaces of AuNCs under the near-isoelectric pH value. The resulted AYNP shows distinct fluorescence responses, spontaneous turn-on of the blue emission and turn-off of the near-infrared emission, with a single wavelength excitation. It is demonstrated that the enhancement and quenching are due to the production of pheomelanin and dopaquinone structures, respectively, induced by tyrosinase oxidation. The internal referencing system provides the tyrosinase assay with superior sensitivity and a detection limit as low as 6.3 U L −1 could be achieved. The experimental results also demonstrate the excellent selectivity, good photo-stability, and both in vitro and cellular applications of AYNP . This assay technique is low-cost, easy to prepare, and shows excellent potential as a novel melanoma clinical diagnostic platform and a tyrosinase inhibitor screening tool.
研究领域:
生物化学
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医学诊断
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药物筛选
✓ 已验证
DOI
PubMed
高影响因子
Advanced Science
·
2025
·
IF 14.1
Yueyang He,Jinyan Lin,Jingwen Bai,Xiao Shen,Kangliang Lou,Yuanyuan Zhu,Zishan Qiao,Weiling Chen,Yang Li,Xiaolong Liu,Guojun Zhang
Breast-conserving surgery (BCS) has become the standard care for early-stage breast cancer. The accurate assessment of tumor margins is urgently required for BCS because positive resection margins often lead to local recurrence. To address this clinical dilemma, a Hf(IV)-coordinated NIR-II fluorescence “turn-on” nanoprobe based on the clinically approved NIR-II fluorescent dye indocyanine green (ICG) for intraoperative tumor visualization is developed. Notably, the fluorescence of ICG can be efficiently quenched by Hf(IV) and subsequently recovered in vivo, showing a remarkable fluorescence “quenching-recovery-amplification” capacity. This nanoprobe can effectively accumulate in tumor sites, accurately identifying submillimeter-sized primary and residual tumors with high sensitivity. In addition, subcutaneous, muscle-infiltrating, and orthotopic breast cancer models are built to repeatedly prove that this ultrasensitive nanoprobe is feasible for precise imaging-guided surgery in breast cancer. Overall, this study constructs an activatable fluorescent nanoprobe for real-time intraoperative tumor margin visualization, holding promise for complete surgical resection and reduction of local recurrence.
研究领域:
肿瘤学
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生物医学工程
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分子影像学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Taihe Han,Shuai Mu,Qin Huang,Jiaxing Sun,Xin Lv,Yanxia Zhang,Xiaoyan Liu,Wei Guo,Haixia Zhang
The development of high fluorescence quantum yield molecular fluorophores for second-order near-infrared (NIR-II) imaging is highly desirable but remains challenging due to the lack of reliable design guidelines. We report a method to construct “J-aggregates” by combining the inhibition of twisted intramolecular charge transfer (TICT) and electron-withdrawing strategies. Introducing electron-withdrawing substituents at the middle position of the classic boron dipyrromethene (BODIPY) backbone promotes J-type slip stacking, enhancing NIR-II fluorescence through increased electrostatic repulsion and intermolecular hydrogen bonding. The 3,5-aryl position is modified with sulfone and quaternary piperazine groups. The negative inductive effect (–I effect) from strong electron-withdrawing action increases the ionization potential (IP) of the amino group, inhibiting the TICT process and improving the quantum yield to 9.03 % and 16.9 %, respectively. Notably, the fluorescence quantum yield of NBDP-SO 2 increased to 18.2 % after self-assembly with F127, successfully applied in bioimaging. This study provides a new method for constructing high fluorescence quantum yield NIR-II emission by manipulating molecular stacking and establishing the relationship between molecular structure, intermolecular interactions, and fluorescence properties.
研究领域:
生物医学工程
·
分子影像学
✓ 已验证
DOI
高影响因子
Nanoscale Research Letters
·
2021
·Vol. 16
·期 1
·1-11
·
IF 4.703
Zhao Shubi,Luo Yiqun,Chang Zong,Liu Chenchen,Li Tong,Gan Lu,Huang Yong,Sun Qinchao
The second near infrared window is considered to be the optimal optical window for medical imaging and therapy as its capability of deep tissue penetration. The preparation of the gold nanorods with long wavelength absorption and low cytotoxicity is still a challenge. A series gold nanorods with large aspect ratio have been synthesized. Strong plasma absorption in the second near infrared window from 1000 to 1300 nm could be observed. The biocompatibility of the synthesized gold nanorods is dramatically improved via coating by bovine serum albumin (BSA), while the optical properties of which remains. The breast cancer tumor-bearing mouse could be well treated by the prepared gold nanorods with the NIR-II light intensity as low as 0.75 W/cm2. In summary, these results demonstrate the feasibility of using low illumination dose to treat tumor in the NIR-II region via the large aspect ratio gould nanoparticles.
研究领域:
纳米技术
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生物医学工程
·
癌症治疗
·
光学成像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2024
·Vol. 11
·期 15
·4711-4720
·
IF 6.1
Zhexuan Gao,Yi Zhang,Yinyan Li,Shilong Zhao,Peng Zhang,Xiaolong Dong,Degang Deng,Shiqing Xu
The second near-infrared window (NIR-II, 1000–1700 nm) emitting phosphor is a key component for the phosphor-converted light-emitting diode (pc-LED), which has garnered significant attention. However, it remains a major challenge to discover efficient NIR-II broadband phosphors that can be excited by blue LEDs. Herein, Cr3+ and Ni2+ ions were co-doped into the Li2ZnSn3O8 (LZSO) host. LZSO:Cr3+,Ni2+ phosphor achieves a broadband NIR-II emission peak at 1465 nm with a large full width at half maximum (FWHM) of 300 nm and internal quantum efficiency (IQE) of 43.31% under excitation at 426 nm because of the efficient energy transfer (ET) from Cr3+ to Ni2+. In addition, a dual-emissive doped phosphor across the NIR-I (700–1000 nm) and NIR-II regions with a higher sensitivity at physiological temperatures was obtained. The relative sensitivity value (Sr) reaches 1.44% K−1 at 293 K, indicating that the LZSO:Cr3+,Ni2+ phosphor is a potential candidate for NIR optical thermometers in biotechnological applications. The manufactured NIR-II pc LED provides a radiative flux of 8.26 mW with a photoelectric conversion efficiency of 2.71% at a drive current of 100 mA and has promising potential in night vision, medical imaging, and spectral analysis applications.
研究领域:
材料科学
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生物医学工程
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光学
✓ 已验证
产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2024
·
IF 4.1
Yongjie Wang,Qingzhou Bu,Dongshuo Li,Shuai Yang,Li Li,Guotao Xiang,Sha Jiang,Ying Chang,Chuan Jing,Xianju Zhou,Lev-Ivan Bulyk,Andrzej Suchocki
Near-infrared phosphor-converted light-emitting diodes (NIR pc-LEDs) are compact light sources of great interest for NIR spectroscopy applications. Beyond typical Cr 3+ -activated NIR-emitting phosphors, there exists a strong demand for Cr 3+ -free alternatives with high efficiency and broadband emission to rich the landscape of NIR luminescent materials and extend their range of application fields. Here, we report a series of Fe 3+ -activated Ca 3 Ga 2 Sn 3 O 12 garnet-type phosphors exhibiting broadband NIR emission in the 650–1000 nm range attributed to 4 T 1 (G) → 6 A 1 (S) transition, with a maximum at 754 nm and a FWHM of 89 nm upon UV excitation. The spectroscopic results were analyzed according to the Tanabe-Sugano theory from which the crystal field parameter D q and Racah parameters B and C were obtained for the octahedrally coordinated Fe 3+ ion. Notably, the NIR persistent luminescence lasting over 1 h was detected following UV or X-ray irradiation. The possible mechanism involving electron traps was proposed to explain the observed persistent luminescence. Furthermore, a NIR pc-LED was fabricated by coating synthesized phosphor on a UV chip, and its performance was evaluated to assess its potential suitability as a NIR light source. Our discovery of novel type of nontoxic Fe 3+ -activated broadband NIR luminescence phosphors with efficient NIR persistent luminescence paves the way for discovering Cr 3+ -free multifunctional NIR luminescence materials, thereby expanding their application possibilities.
研究领域:
材料科学
·
光学
·
光电子学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2024
·
IF 3.3
Xiaoyu Wu,Yang Yu,Kejie Li,Mingqin Huang,Zuoling Fu
The near-infrared-II (NIR-II) fluorescence thermometer based on rare earth-doped double perovskite is rarely. Herein, Er 3+ -Ho 3+ and Yb 3+ co-doped lead-free double perovskite La 2 MgTiO 6 (LMTO) phosphors were synthesized by a conventional high temperature solid phase method. The phase purity and morphology of the samples were analyzed using XRD and FE-SEM. The NIR-II luminescence properties of LMTO: Er 3+ -Ho 3+ -Yb 3+ phosphors were systematically investigated under laser irradiation at 980 nm. A NIR-II fluorescence thermometer was also designed based on non-thermal coupled energy levels originated from the 4 I 13/2 energy level of Er 3+ and the 5 I 6 energy level of Ho 3+ . The maximum value of relative sensitivity (S r ) was 0.54 % at 513 K. Compared to visible thermometers (LMTO: Er 3+ -Yb 3+ and LMTO: Ho 3+ -Yb 3+ ), the NIR-II thermometers offer better temperature measurement capability and penetration depth. All the experimental results show that the NIR-II thermometer with a wider range and higher sensitivity has been realized, which puts forward a new idea for the design and optimization of NIR-II thermometers.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Huiping Dang,Youliang Tian,Quan Cheng,Changchang Teng,Kai Xie,Lifeng Yan
It is essential to develop novel multifunctional and easily synthesized stable NIR-II fluorescent probes to guide photothermal therapy for tumors. Here, we propose a new strategy to construct boron dipyrromethene (BODIPY) J-aggregates by intermolecular hydrogen bonding (H-bond) and π-π stacking interactions to achieve fluorescence emission in the second near-infrared window (NIR-II, 1000–1700 nm). A novel meso -benzamide galactose hexanoate-BODIPY (Gal-OH-BDP) amphiphilic small molecular dye was synthesized and it formed nanoparticles spontaneously in aqueous solution with a maximum emission wavelength near 1060 nm, which works as a smart nanomedicine for targeting NIR-II imaging-guided photothermal therapy (PTT) of hepatocellular carcinoma. Galactose not only provided hydrogen bonds to regulate the aggregation pattern of the molecules but also effectively targeted hepatocellular carcinoma cells and promoted the formation of well-dispersed nanoparticles of dye molecules due to their hydrophilicity . Moreover, due to high photothermal conversion efficiency (PCE = 55%), Gal-OH-BDP NPs achieve galactose-targeted NIR-II imaging and PTT, which is important for the precise diagnosis and treatment of tumors ( Scheme 1 ). In the present research work, H-bond was introduced for the first time into BODIPY for building J-aggregates to achieve the NIR-II fluorescence.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）