MICROCHEMICAL JOURNAL
·
2026
·
IF 5.1
Zhenzhen Du,Weiting Zhong,Weifang Deng,Lei Sun,Xu Zhang,Yanbao Zhao
In this paper, Ag + doped CdS quantum dots (Ag:CdS QDs) nanoprobes for obtaining near-infrared (NIR) nanoprobes for antibiotic detection and biological imaging were synthesized via an aqueous phase method based on CdS QDs. The emission wavelength of doped QDs was redshifted from visible region to NIR. Ag:CdS QDs nanoprobes have the characteristics of water solubility, uniform particle size, and fluorescence stability. When the nanoprobes are used to detect a certain concentration of Oxytetracycline (OTC), the fluorescence intensity will change accordingly. Ag:CdS QDs nanoprobes enabled rapid and sensitive detection to OTC within the range of 1.25 to 5.00 μM, the linear correlation equations were y = 29.9 x-18.541 (R 2 = 0.992), with a limit of detection (LOD) as low as 0.076 μM. The feasibility of this method was verified in fresh milk. At the same time, hyaluronic acid (HA) was coated on Ag:CdS QDs nanoprobes to improve the biocompatibility and obtained HA/Ag:CdS QDs nanoprobes that still retained good fluorescence properties and stability. Cell proliferation assay, red cell hemolysis assay, bioimaging experiment, and vivo imaging assay demonstrated that HA/Ag:CdS QDs nanoprobes possessed minimal cytotoxicity, excellent biocompatibility, and efficient cellular internalization via endocytosis, clearance capability, facilitating in vivo imaging. Therefore, Ag:CdS QDs nanoprobes can be used for detection OTC and HA/Ag:CdS QDs nanoprobes for bioimaging.
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ULTRASONICS SONOCHEMISTRY
·
2022
·
IF 9.336
Samira Haddadi,Alireza Khataee,Samira Arefi-Oskoui,Behrouz Vahid,Yasin Orooji,Yeojoon Yoon
In light of growing environmental concerns over emerging contaminants in aquatic environments, antibiotics in particular, have prompted the development of a new generation of effective sonocatalytic systems. In this study, a new type of nano-laminated material, Ti 2 SnC MAX phase, is prepared, characterized, and evaluated for the sonocatalytic degradation of oxytetracycline (OTC) antibiotic. A variety of identification analyses, including X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectrometry, Brunauer-Emmett-Teller, and diffuse reflectance spectroscopy, were conducted to determine the physicochemical properties of the synthesized catalyst. By optimizing the operating factors, total degradation of OTC occurs within 120 min with 1 g L -1 catalyst, 10 mg L -1 OTC, at natural pH of 7.1 and 150 W ultrasonic power. The scavenger studies conclude that the singlet oxygen and superoxide ions are the most active species during the sonocatalytic reaction. Based on the obtained data and GC–MS analysis, a possible sonocatalytic mechanism for the OTC degradation in the presence of Ti 2 SnC is proposed. The catalyst reusability within eight consecutive runs reveals the proper stability of Ti 2 SnC MAX phase. The results indicate the prospect for MAX phase-based materials to be developed as efficient sonocatalysts in the treatment of antibiotics, suggesting a bright future for the field.
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高影响因子
BIORESOURCE TECHNOLOGY
·
2022
·
IF 11.889
Hongkui Zhang,Xue Song,Jie Zhang,Yongde Liu,Hailiang Zhao,Junkai Hu,Jihong Zhao
In this study, sycamore flocs (SF), which caused environmental and health problems, were utilized to prepare biochar. SFB 2-900 obtained under the conditions of activation agent K 2 CO 3 , pyrolysis temperature 900℃ and m(K 2 CO 3 ):m(BC) 2 had the strongest adsorption capacity (730 mg/g) for oxytetracycline hydrochloride (OTC-HCl). The pseudo-second-order kinetic model and Langmuir model described the adsorption kinetics and isotherms best. SFB 2-900 exhibited high OTC-HCl adsorption capacity in both higher ionic strength and wide pH range. The theoretical simulation indicated that the closest interaction distance between OTC-HCl and SFB 2-900 was 2.44 Å via π-π stacking configuration. Pore filling, π-π electron donor acceptor (EDA) interaction, H-bonding and electrostatic interactions were also involved in the process of OTC-HCl removal. SFB 2-900 showed great removal efficiency for OTC-HCl in different water matrices and good regeneration ability . This study solved the problems caused by SF, realized waste biomass recycling, and achieved preparing high-efficient adsorbent for antibiotic.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2021
·
IF 4.291
Yunmei Wu,Sining Zheng,Yanying Ye,Hongyu Guo,Fafu Yang
This work reported the novel organic fluorescence sensor for oxytetracyline based on a novel AIE-macrocycle. By “1 + 1” condensation of diphenylacrylonitrile bearing OH groups and its derivative with terminal Cl groups, the crown-ether-bridging bis-diphenylacrylonitrile macrocycle ( CBP ) was prepared in quantitative yield of 38 %. CBP exhibited strong AIE fluorescence at 430−550 nm in aqueous media. It presented good selective sensing ability for oxytetracyline with dramatically fluorescence quenching among all kinds of ions and biomolecules. The detection limit was as low as 1.33 × 10 −7 M. The sensing mechanism was confirmed as 1:1 stoichiometric ratio. This detection ability was successfully applied on sensing oxytetracycline in test strip and biological samples. Moreover, CBP displayed good sensing ability for oxytetracycline in living cells based on its good living-cell fluorescence imaging property. This paper not only provided the novel organic fluorescence sensor for oxytetracyline, but also opened a new strategy based on AIE-macrocycle to construct the novel sensor for complex biomolecules.
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Journal of Oceanology and Limnology
·
2020
·Vol. 39
·期 1
·160-172
·
IF 0.617
Zhou Xudong,Jiang Xincheng,Gao Shan,Wan Zhenjia,Gao Pengcheng
The increasing use of pharmaceuticals has become a major environmental issue in China. The presence of antibiotics in water may have deleterious effects on non-target aquatic organisms such as microalgae. In this study, a cyanobacterium and an alga species in surface waters, Microcystis aeruginosa and Chlamydomonas microsphaera , were exposed to 0, 0.1, 0.5, 1.0, 2.0, 5.0, 10.0, and 20.0 mg/L of oxytetracycline dihydrate (OXY) and sulfamethoxazole (SMZ) for 96 h to determine the effects of these antibiotics on the growth and surface morphology. Moreover, the photosynthetic activity and the contents of superoxide dismutase (SOD), malondialdehyde (MDA), and protein were measured to examine the biochemical characteristics of M. aeruginosa and C. microsphaera under OXY and SMZ stress. The effects of both antibiotics on the growth of both species were concentration-dependent and characterized by low-dose stimulation and high-dose inhibition. C. microsphaera was more sensitive to both antibiotics than M. aeruginosa was. The algal cell membranes of both species disintegrated after exposure to a high concentration of OXY. All of the physiological parameters measured in this study were relatively stable at low concentrations of OXY and SMZ. After exposure to high concentrations of OXY and SMZ, photosynthetic activity decreased significantly, whereas lipid peroxidation and the abundance of SOD, MDA, and protein increased significantly. Thus, low-dose antibiotics may increase algal blooms in eutrophic waters.
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BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
·
2020
·Vol. 107
·期 2
·269-275
·
IF 1.657
Feng Lirong,Yuan Guodong,Xiao Liang,Wei Jing,Bi Dongxue
Biochar has limited capacity to adsorb oxytetracycline (OTC). Here we have used bamboo willow biochar (BC) as a carrier to produce nMnO 2 -loaded biochars (MBC) by a co-precipitation method. Their chemical compositions, morphological features, specific surface area, and surface functional groups were observed or determined. Batch experiments were conducted to assess the effects of reaction time, initial OTC concentrations, pH, salt concentrations, and natural organic matter (NOM) on OTC removal. Kinetics and isotherms indicated that OTC was mainly adsorbed via chemical interactions, and mono- and multi-layer adsorption occurred on the surface. MBC removed 19–25 times more OTC than BC, and the removal was highest at near-neutral pH, not influenced by NaCl (2, 10 mM), slighted reduced by NOM (0–20 mg L −1 ), and enhanced by NaHCO 3 (2, 10 mM). Besides being an adsorbent, MBC acted as an oxidant and degraded 58.5% of OTC at 24 h.
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Environmental Science-Processes & Impacts
·
2022
·Vol. 24
·期 12
·2368-2377
·
IF 5.334
Yinhan Jin,Mengya Liu,Qiang Zhang,Usman Farooq,Weifeng Chen,Taotao Lu,Zhichong Qi
The current state of knowledge on the transport behaviors of oxytetracycline (OTC, a typical tetracycline antibiotic) in porous media with heterogeneous chemical surfaces is inadequate. In this work, the mobility properties of OTC through saturated porous media with different chemical heterogeneities (i.e., quartz sand, montmorillonite (MMT)-, humic acid (HA)-, and goethite (Goe)-coated sands) were investigated. In comparison with the mobility of OTC in the quartz sand, HA and goethite coatings inhibited the mobility of OTC, whereas montmorillonite coating enhanced OTC mobility. HA coating inhibited the transport of OTC that stemmed from the strong interactions between HA and OTC via complexation, π–π stacking, hydrogen bonding, and hydrophobic interaction. The positively charged iron oxide coating on Goe-coated sand provided favorable sites for OTC deposition through complexation and electrostatic attraction. The enhanced transport of OTC through MMT-coated sand was mainly due to the strong electrostatic repulsion between the anionic OTC species (i.e., OTC−) and negatively charged porous media. Solution pH (5.0–9.0) posed a negligible effect on the trend of OTC mobility in different porous media. Furthermore, Ca2+ inhibited the transport of OTC mobility through various porous media via cation-bridging. The findings of this work contribute significantly to our understanding of the influence of aquifer surface chemical heterogeneities on OTC mobility behaviors in the subsurface environment.
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CHEMOSPHERE
·
2023
·
IF 8.8
Wenqiang Jia,Jiaying Song,Jian Wang,Jinying Li,Xue Li,Qianwen Wang,Xiang Chen,Guocheng Liu,Qinghua Yan,Chengzhi Zhou,Shuaishuai Xin,Yanjun Xin
The pharmaceutical factories of oxytetracycline (OTC) massively produce OTC fermentation residues (OFRs). The high content of residual OTC and antibiotic resistance genes in OFRs must to be considered and controlled at an acceptable level. This study therefore investigated the applicability of Fenton oxidation in OTC degradation and resistant gene inactivation of OFRs. The results revealed that Fe 2+ as catalyzer could very rapidly activate H 2 O 2 to produce HO • , leading to instantaneous degradation of OTC. The optimum conditions for OTC removal were 60 mM H 2 O 2 and 140 mg/L Fe 2+ under pH 7. After Fenton oxidation treatment, the release of water-soluble polysaccharides , NO 3 –N, and PO 4 –P was enhanced, whereas for proteins and NH 3 –N were reduced. Three soluble fluorescence components (humic, tryptophan-like, and humic acid-like substances) were identified through fluorescence spectra with parallel factor analysis, and their reduction exceeded 50% after Fenton oxidation. There were twelve intermediates and three degradation pathways of OTC in OFRs during Fenton process. According to toxicity prediction, the comprehensive toxicity of OTC in OFRs was alleviated via Fenton oxidation treatment. In addition, Fenton oxidation showed the ability to reduce antibiotic resistance genes and mobile genetic elements, and even tetO , tetG , intI1 , and intI2 were eliminated completely. These results suggested that Fenton oxidation treatment could be an efficient strategy for removing OTC and resistance genes in OFRs.
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Journal of Environmental Sciences
·
2017
·
IF 2.865
Yuwei Wu,Qinyan Yue,Yuan Gao,Zhongfei Ren,Baoyu Gao
In this study, bimetallic nanoscale zero-valent iron particles (nZVI), including copper/nanoscale zero-valent iron particles (Cu/nZVI) and nickel/nanoscale zero-valent iron particles (Ni/nZVI), were synthesized by one-step liquid-phase reduction and applied for oxytetracycline (OTC) removal. The effects of contact time and initial pH on the removal efficiency were studied. The as-prepared nanoscale particles were characterized by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD). Finally, the degradation mechanisms of OTC utilizing the as-prepared nanoparticles were investigated by using X-ray photoelectron spectroscopy (XPS) and mass spectrometry (MS). Cu/nZVI presented remarkable ability for OTC degradation and removed 71.44% of OTC (100 mg/L) in 4 hr, while only 62.34% and 31.05% of OTC was degraded by Ni/nZVI and nZVI respectively. XPS and MS analysis suggested that OTC was broken down to form small molecules by ·OH radicals generated from the corrosion of Fe 0 . Cu/nZVI and Ni/nZVI have been proved to have potential as materials for application in OTC removal because of their significant degradation ability toward OTC.
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高影响因子
ANALYTICAL LETTERS
·
2016
·
IF 1.088
Fang Yuan,Huimin Zhao,Xiaodan Wang,Xie Quan
A colorimetric aptamer sensor for the determination of oxytetracycline was developed based on the controllable peroxidase-like catalysis of a graphene/gold nanoparticle hybrid and the high affinity between oxytetracycline aptamers and oxytetracycline. The oxytetracycline aptamer was a single-stranded DNA sequence that was adsorbed on the interface of the hybrid, resulting in inhibition of the catalysis. The aptamer–oxytetracycline complex formed spontaneously following the addition of oxytetracycline, escaped from the hybrid, and recovered the catalytic ability that was inhibited by the aptamer. In the presence of hydrogen peroxide, the recovered hybrid oxidized a colorimetric reagent, causing a concomitant change in color. The whole process did not involve labeling and the color change was readily observed. This method provided a linear dynamic range for oxytetracycline from 0.17 to 0.50 µM with a detection limit of 91 nM and a quantification limit of 0.17 µM. In addition, the selectivity of the sensor was confirmed in the presence of high concentrations of potential interferents. This work is expected to encourage the development of additional simple and visible sensors for the determination of other pollutants.
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MOLECULES
·
2025
·Vol. 30
·期 15
·3289
·
IF 4.6
Jingfei Luan,Tiannan Zhao
In this study, a Z-scheme Ho2InSbO7/Ag3PO4(HAO) heterojunction photocatalyst was successfully fabricated for the first time by ultrasound-assisted solvothermal method. The structural features, compositional components and morphological characteristics of the synthesized materials were thoroughly characterized by a series of techniques, including X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectrum, X-ray photoelectron spectroscopy, transmission electron microscopy, scanning electron microscopy and energy-dispersive X-ray spectroscopy. A comprehensive array of analytical techniques, including ultraviolet-visible diffuse reflectance absorption spectra, photoluminescence spectroscopy, time-resolved photoluminescence spectroscopy, photocurrent testing, electrochemical impedance spectroscopy, electron paramagnetic resonance, and ultraviolet photoelectron spectroscopy, was employed to systematically investigate the optical, chemical, and photoelectronic properties of the materials. Using oxytetracycline (OTC), a representative tetracycline antibiotic, as the target substrate, the photocatalytic activity of the HAO composite was assessed under visible light irradiation. Comparative analyses demonstrated that the photocatalytic degradation capability of the HAO composite surpassed those of its individual components. Notably, during the degradation process, the application of the HAO composite resulted in an impressive removal efficiency of 99.89% for OTC within a span of 95 min, along with a total organic carbon mineralization rate of 98.35%. This outstanding photocatalytic performance could be ascribed to the efficient Z-scheme electron-hole separation system occurring between Ho2InSbO7and Ag3PO4. Moreover, the adaptability and stability of the HAO heterojunction were thoroughly validated. Through experiments involving the capture of reactive species and electron paramagnetic resonance analysis, the active species generated by HAO were identified as hydroxyl radicals (•OH), superoxide anions (•O2−), and holes (h+). This identification provides valuable insights into the mechanisms and pathways associated with the photodegradation of OTC. In conclusion, this research not only elucidates the potential of HAO as an efficient Z-scheme heterojunction photocatalyst but also marks a significant contribution to the advancement of sustainable remediation strategies for OTC contamination.
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高影响因子
Nanoscience and Nanotechnology Letters
·
2018
·Vol. 10
·期 8
·1095-1100
·
IF 2.917
Du Jingjing,Song Ya,Xie Shaowen,Feng Yahui,Jiang Jianbing,Xu Lijian
A facile and sensitive electrochemical sensor based on hierarchical nanoporous Pd-HSiO1.5/Ni–Co composite electrode for detecting oxytetracycline (OTC) was prepared in this study through the composite electrodeposition method. Electrodeposition conditions and detecting
parameters, such as concentration of hierarchical nanoporous Pd-HSiO1.5 particles, detection temperature and scanning rate were also studied. Moreover, the repeatability, accuracy and anti-interference performance of electrochemical biosensor were investigated. Results showed that
the hierarchical nanoporous composite electrode had the optimum electrocatalytic activity for OTC when the concentration of hierarchical nanoporous Pd-HSiO1.5 particles was 2 g/L and detection temperature was 25 °C. In addition, the electrochemical biosensor showed good electrocatalytic
activity for OTC detection, with a linear relationship between oxidation peak current and concentration of OTC detection from 4.0 × 10–4 to 1.0 × 10–8 M. The limit of detection was as low as 1.0 × 10–8 M. Moreover, practical
operations showed that the biosensor had good reproducibility, accuracy, and good anti-interference performance for other antibiotics such as ampicillin sodium and rifampicin.
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