BIOMACROMOLECULES
·
2014
·
IF 5.788
Feng Liu,Shudong Lin,Zuoquan Zhang,Jiwen Hu,Guojun Liu,Yuanyuan Tu,Yang Yang,Hailiang Zou,Yangmiao Mo,Lei Miao
Three ternary graft copolymers bearing polystyrene (PS), poly(ethylene glycol) methyl ether (MPEG), and poly(acrylic acid) (PAA) side chains were synthesized and characterized. At pH = 7.4, these copolymers stabilized doxorubicin (DOX)-containing benzyl benzoate (BBZ) nanoemulsion droplets in water and formed a compact polymer layer to inhibit DOX release. Upon lowering the solution pH to 5.0, the AA groups dissociated less and became less soluble. Moreover, the neutralized AA groups formed presumably H-bonded complexes with the EG units, reducing the solubility of the EG units. This dual action drastically shifted the hydrophilic and hydrophobic balance of the copolymer and caused the original stabilizing polymer layer to rupture and the nanoemulsion droplets to aggregate, releasing DOX. The rate and extent of DOX release could be increased by matching the numbers of PAA and MPEG chains per graft copolymer. In addition, these nanoemulsions were not toxic and entered human carcinoma cells, releasing DOX there. Thus, these nanoemulsions have potential as drug delivery vehicles.
研究领域:
药剂学
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聚合物化学
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药物递送系统
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Fansu Meng,Panpan Wang,Lina Yang,Junjie Yan,Anil K. Giri,Jaiwoo Lee,Kosuke Kusamori,Makiya Nishikawa,Shoko Itakura,Honghui Gu,Qi Li,Zhong Chen,Zhenjiang Yang,Detang Li,Yu Cai
Breast cancer (BC) stands as one of the primary malignancies threatening women's health. Baicalin (BA) exhibits anti - BC effects, yet it is plagued by issues such as low water solubility and poor bioavailability. To enhance the anti-BC efficacy of BA, this study developed a pH - responsive albumin nanoparticle loaded with BA (BA-AN-FA@mPEG). The optimized BA-AN-FA@mPEG features an average particle size of (185.8 ± 2.36) nm, a Zeta potential of (−32.70 ± 1.27) mV, an encapsulation efficiency of approximately 73.82 %, and a drug loading of about 5.68 %. The aqueous solution of BA-AN-FA@mPEG demonstrates excellent stability at 4 °C, with no significant drug leakage occurring within 12 weeks. BA-AN-FA@mPEG shows a certain sustained - release effect, and the drug release rate is faster under acidic conditions. The results of efficacy evaluation indicate that the half - maximal inhibitory concentration of BA-AN-FA@mPEG against MDA-MB-231 cells is 26.34 μg/mL. It can promote cellular uptake, effectively induce apoptosis, and cause cell cycle arrest. In summary, BA-AN-FA@mPEG is a promising tumor - targeted therapeutic formulation that can improve drug stability, tumor delivery efficiency, and therapeutic efficacy.
研究领域:
药剂学
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纳米技术
·
肿瘤学
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药物递送
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2019
·
IF 3.973
Bailong Tao,Yiman Deng,Liying Song,Wenwen Ma,Ying Qian,Chuanchuan Lin,Zhang Yuan,Lu Lu,Maowen Chen,Xin Yang,Kaiyong Cai
Bacterial infection and surface biointertness are two main causes for titanium (Ti)-based orthopedic implants failure. To improve the antibacterial ability and enhance poor osteogenic property of Ti substrates, in this work, we employed titania nanotubes (TNTs) as Bone Morphogenetic Protein 2 (BMP2) carrier, and a pH-responsive multilayer film composed of alginate dialdehyde-gentamicin (ADA-Gen) and chitosan (Chi) was constructed onto BMP2-loaded TNTs substrates through layer-by-layer (LBL) assembly technique, resulting in TNT-BMP2-LBLg samples. The release experiments revealed that acidic environment could trigger the release of Gen from the multilayer films and in turn accelerate the release of BMP2 from TNTs. Moreover, antibacterial assay against E. coli and S. aureus confirmed that the TNT-BMP2-LBLg had excellent antibacterial capacity both in early (6 h) and in long-term (72 h). Meanwhile, in vitro cellular tests demonstrated that TNT-BMP2-LBLg had good cytocompatibility toward osteoblasts even co-cultured with S. aureus . Importantly, the obtained TNT-BMP2-LBLg promoted differentiation of osteoblasts, including enhanced alkaline phosphatase activity, improved mineralization capability and stimulated osteogenic-relative gene expression. This study thus provides a promising strategy to develop pH-responsive antibacterial and enhance bone integrative Ti-based implants for potential orthopedic application.
研究领域:
生物医学工程
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材料科学
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骨科医学
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产品关联
DOI
PubMed
高影响因子
MINERALS ENGINEERING
·
2025
·
IF 5
Yunzhen Hu,Kangjing Wu,Shuai Wang,Zhanfang Cao,Xin Ma,Hong Zhong
The flotation separation of chalcopyrite (CuFeS 2 ) and molybdenite (MoS 2 ) is hindered by similar surface properties, typically requiring environmentally detrimental high-alkalinity conditions (pH > 10.0). Herein, we introduce 3,4,5-Trihydroxy-N,N-bis(2-hydroxyethyl)benzamide (TBHB), a gallic acid-derived surfactant, as an efficient selective depressant for chalcopyrite under near-neutral conditions (pH 6.0–8.0). Notably, chalcopyrite recovery is reactivatable via pH adjustment (pH > 9.0). Micro-flotation tests demonstrated TBHB's high selectivity, achieving 91.81% molybdenite recovery while suppressing chalcopyrite recovery to 12.61% at pH 8.0, outperforming conventional depressants (e.g., sodium thioglycolate). Artificial mixed minerals flotation further confirmed TBHB's efficacy, with a dosage of 75 mg/L achieving Mo recovery exceeding 80%, Cu recovery below 20%. Mechanistic investigations revealed TBHB chemisorbs on the chalcopyrite surface via phenolic hydroxyl-Fe coordination, supported by high adsorption capacity (> 1.6 mg/m 2 ), reduced hydrophobicity, and FTIR/XPS analyses, which showed Fe–O bond formation and red-shifted C=O/benzene ring vibrations. Zeta potential measurements affirmed pH-dependent adsorption/desorption. DFT calculations confirmed spontaneous adsorption ( ΔE = −1.8206 eV) and short O–Fe bond (1.99 Å), verifying Fe-site affinity. Conversely, TBHB showed negligible adsorption on the molybdenite surface, with values below 0.4 mg/m 2 and a contact angle of approximately 70°, preserving its floatability. This work establishes TBHB as a sustainable alternative for Cu-Mo separation, eliminating high-alkalinity requirements while advancing green reagent design through integrated experimental and computational insights.
研究领域:
矿物加工工程
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表面化学
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环境友好技术
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计算化学
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资源回收
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产品关联
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2021
·
IF 7.963
Song Ma,Yanzheng Ji,Yongjie Dong,Siqi Chen,Yingjie Wang,Shaoyu Lü
Stimulus-responsive pesticide or fertilizer systems have been emerged to improve the use efficiency of agrochemicals , reduce over-application and ensuing environmental problems. However, environmental-friendly synthesis of these systems still remain challenging. In this work, an environmental-friendly synthesis strategy has been developed to form a pesticide and fertilizer combination to achieve the integration of plant protection and nutrient supply. This pesticide-fertilizer combination system was fabricated using ammonium zinc phosphate (ZNP) and in-situ synthesized zeolitic imidazolate framework-8 (ZIF-8) as nutrients resources, and dinotefuran (DNF) as a pesticide. DNF was encapsulated in-situ (loading capacity of 12.32 ± 0.46%) during the ZIF-8 crystal synthesis process, rather than loaded by further adsorption, which improved its stability and prevented premature or rapid release. The hydrophobic ZIF-8 provided a pH-responsive slow-release behavior. The cumulative released DNF within seven days at pH 4.0, 7.0 and 10.0 was 66.30%, 40.41%, and 37.44%, respectively. The pesticide-fertilizer combination system showed significant effects on corn seed pre-cultivation, soil cultivation and pest control. This work provides a strategy for the integration of pesticide and fertilizer, which will reduce negative environmental effects caused by their over-applications and have great potential in modern sustainable agriculture.
研究领域:
农学
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环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 8
·1-9
·
IF 5.479
Gao Jian Bang,Sann Ei Ei,Wang Xin Yu,Ye Cui,Liu Rui,Gao Zhong Feng
A pH-responsive superwettable chip is described whose surface can switch between superhydrophobic and superhydrophilic. It can be used for the visual detection of the prostate specific antigen (PSA) based on contact angle readout. Magnetic beads were modified with primary antibody against PSA. After immunobinding, gold nanoparticles loaded with secondary antibody labeled with glucose oxidase is added. On addition of glucose, gluconic acid is formed which causes a drop in the local pH value. This results in a wettability switch of the pH-responsive superwettable chip from hydrophobic to hydrophilic. Under the optimized conditions, PSA can be quantified with a 3.2 pg mL −1 limit of detection by analyzing the contact angle and the related color that changes from blue via orange to red. The method is applicable to PSA detection in serum samples and for visual classification by cancer patients and healthy persons. It is also suitable for color-blind and color-weak individuals. Conceivably, this kind of assay can be transferred to the determination of various kinds of other bioanalytes including nucleotide, proteins, and even of ions and small organic molecules, and thus is has a wide scope.
Schematic presentation of a pH-responsive superwettable chip coated with silica nanoparticles for the visual detection of prostate specific antigen (PSA) by reading the contact angle. The superwettable chip achieves reliable clinical detection of serum PSA from prostate cancer patients.
研究领域:
生物医学工程
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分析化学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2025
·
IF 4
Aiguo Gu,Chengshuai He,Shuo Zhang,Hao Wu,Song Yang,Jie Zhou,Yunhao Gao
Nanocarrier-based controlled-release technologies significantly enhance the effective utilization rate of pesticides. Multimodal synergistic antimicrobial strategies that disrupt multiple pesticide resistance pathways are considered promising for plant disease management. In this study, a novel pH-responsive pesticide delivery system based on kasugamycin-intercalated Zn Fe hydrotalcites (KAS-Zn-Fe HTlc) was developed to achieve synergistic antibacterial effects. KAS-Zn-Fe HTlc was synthesized via a co-precipitation method. Its physicochemical properties were characterized using SEM, XRD, UV–vis, and FT-IR. The loading capacity, controlled release kinetics, thermal stability, photostability, antibacterial activity, and crop safety were evaluated. KAS-Zn-Fe HTlc exhibited rapid release of KAS and Zn 2+ under acidic conditions. KAS-Zn-Fe HTlc enhanced the thermal stability of KAS and significantly reduced its photodegradation during the initial phase. Bioactivity assays demonstrated that KAS-Zn-Fe HTlc exhibited 32-fold and 2-fold increased antibacterial activity against Clavibacter michiganensis subsp. michiganensis and Pseudomonas syringae pv. lachrymans , respectively, when compared to KAS. No phytotoxicity was observed in tomato seedlings treated with KAS-Zn-Fe HTlc. Therefore, KAS-Zn-Fe HTlc holds significant potential for synergistic antimicrobial functions and offers a sustainable approach to plant disease control.
研究领域:
纳米技术
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植物病理学
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农药科学
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材料科学
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农业生物技术
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 115
·114852-114858
·
IF 3.289
Kaili Lin,Na Zhang,Zhilan Yin,Yuhui Shen,Weibin Zhang
Silicon-containing hydroxyapatite (Si-HAp) nanoparticles with adjustable degradation rates were successfully synthesized via simple hydrothermal treatment of a precursor, calcium silicate hydrate powder, in trisodium phosphate aqueous solution. The degradation rate of the products could be facilely tailored by regulating the hydrothermal temperature, while the obtained Si-HAp nanoparticles exhibited high loading capacities toward doxorubicin (DOX) as well as sustained and pH-dependent drug release properties. HeLa cell culture results confirmed that the toxicity of DOX loaded in Si-HAp nanoparticles was more sustained than that of free DOX. Their biodegradability, good water dispersibility and drug-loading capacity, and sustained and pH-responsive drug release properties suggest that these synthetic Si-HAp nanoparticles have great potential applications as drug carriers.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
药剂学
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DOI
高影响因子
Small
·
2017
·Vol. 13
·期 29
·1700623
·
IF 8.643
Wei Cheng,Chaoyu Liang,Lv Xu,Gan Liu,Nansha Gao,Wei Tao,Lingyan Luo,Yixiong Zuo,Xusheng Wang,Xudong Zhang,Xiaowei Zeng,Lin Mei
A nanocarrier system of d -a-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized polydopamine-coated mesoporous silica nanoparticles (NPs) is developed for sustainable and pH-responsive delivery of doxorubicin (DOX) as a model drug for the treatment of drug-resistant nonsmall cell lung cancer. Such nanoparticles are of desired particle size, drug loading, and drug release profile. The surface morphology, surface charge, and surface chemical properties are also successfully characterized by a series of techniques such as transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Brunauer-Emmett-Teller (BET) method, thermal gravimetric analysis (TGA), dynamic light scattering (DLS), and Fourier transform infrared spectroscopy (FTIR). The normal A549 cells and drug-resistant A549 cells are employed to access the cytotoxicity and cellular uptake of the NPs. The therapeutic effects of TPGS-conjugated nanoparticles are evaluated in vitro and in vivo. Compared with free DOX and DOX-loaded NPs without TPGS ligand modification, MSNs-DOX@PDA-TPGS exhibits outstanding capacity to overcome multidrug resistance and shows better in vivo therapeutic efficacy. This splendid drug delivery platform can also be sued to deliver other hydrophilic and hydrophobic drugs.
研究领域:
纳米技术
·
药剂学
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癌症研究
·
材料科学
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Hengyang Mao,Shouyong Zhou,Meisheng Li,Rong Wang,Zhong Ma,Huifang Xiao,Ailian Xue,Yijiang Zhao,Wenbo Peng,Chenglung Chen
Membrane separation is an efficient strategy to disrupt the spread of pathogens in an aqueous solution and produce clean water, but its performance is seriously affected by fouling caused by bioadhesive. In this study, novel pH-response attapulgite (p-ATP) nanofibers were prepared and applied in the modification of poly(vinylidene fluoride) (PVDF) ultrafiltration membrane for bovine serum albumin (BSA) solution purification. Poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) was grafted onto the surface of attapulgite (ATP) to offer pH-response property and to improve compatibility with PVDF. p-ATP is a hydrophilic material, which can increase the anti-biofouling performance of PVDF, and its one-dimensional structure is beneficial for enhancing the inter-entanglement with organic chains in the membrane matrix. The resultant composite membrane loaded with 7% p-ATP presented 77.2% and 108.1% increase in stationary permeance and mechanical strength, respectively, than that of the pristine PVDF membrane. Furthermore, the PDMAEMA chains in p-ATP will be shrunken or swollen with the change of pH value, resulting in adsorbing or releasing water molecules. This process is effective to mitigate the adhesion between biofoulants and membrane and can break the already formed biofouling layer. So, the composite membranes are easily to be cleaned via a simple pH-change cleaning process. The molecular dynamic simulation was also conducted to analyze the high performance of the PVDF/p-ATP membrane to provide theoretical support.
研究领域:
环境科学与工程
·
材料科学与工程
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Shouyan Zhu,Huimin Wu,Rongrong Ma,Xiaoying Wang,Qin Wu
The good water solubility and film-forming properties of sodium carboxymethylcellulose (CMC–Na) render it an excellent matrix for a pH-responsive color indicator film, but its basic character inhibits its direct application. Natural acids can be used to solve this problem, but the buffering system formed in these processes may decrease the sensitivity and improve the heterogeneous compound distribution of the film. Previous studies have tried to address this problem by adjusting the species and amounts of the acids. However, the underlying mechanism has not been comprehensively clarified. Herein, a CMC–Na and CaCl2 mixture was used as the matrix for a pH-responsive color indicator film, alizarin (AZ) was used as the pH indicator, cinnamaldehyde (CMA) was used as an ultraviolet (UV) shielding agent, and natural acids were used as pH-controlling agents. Three protic acids with distinct numbers of acidic protons and pKa, acetic acid (monoacid), tartaric acid (diacid) and citric acid (triacid), were compared to elucidate the effect of these properties on the matrix pH, dye dispersion, and film response. The results showed that tartaric acid can be a good candidate in solving the problem on a basic CMC–Na matrix owing to its good performance in adjusting the film color and the sensitive color response of the resulting film at pH 6.0–7.0. The hydrogen bonds, hydrophobic interactions and chelation reactions formed among the compounds improve the mechanical property and oxygen barrier performance of the film, which are also beneficial to the homogeneous distribution of AZ and CMA, leading to a uniform color response and good UV-shielding performance. This film displays excellent color response quality in beef sub-freshness detections, suggesting its high sensitivity in “point-of-care” detections of real meat samples via naked eyes.
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产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-20
·
IF 12.6
Xie Hanbin,Wei Cong,Xiong Chang,Huang Ziyan,Chen Chaojin,Xiao Xue,Zhang Linan,Lin Zhenjia,Yao Weifeng,Zhao Tianyu,Hei Ziqing
Intestinal ischemia/reperfusion (I/R) injury is a common life-threatening condition. Inflammatory dysregulation plays a crucial role in the pathological progression of intestinal I/R injury, indicating that controlling excessive inflammatory responses can be an effective strategy for mitigating I/R injury. Herein, after establishing a correlation between cell-free DNA (cfDNA) levels and postoperative inflammatory factors in samples from patients with intestinal I/R, we tested a cfDNA-scavenging approach for the treatment of intestinal I/R injury. Poly-ε-caprolactone (PCL) microspheres (Micro DEA2k) functionalized with a pH-responsive cationic polymer (DEA2k) to efficiently scavenge cfDNA were synthesized and evaluated.These microspheres exhibited enhanced cfDNA adsorption under inflammation-induced acidic conditions, along with low toxicity, reduced non-specific protein binding, and extended peritoneal retention. In a mouse model of intestinal I/R injury, the intraperitoneal injection Micro DEA2k effectively bound cfDNA, regulated the mononuclear phagocytic system, decreased the number of M1 macrophages, suppressed inflammation, and significantly improved the survival rate of the mice. These findings suggest that cfDNA scavenging using cationic microspheres has considerable potential for alleviating intestinal I/R injury. Graphical
研究领域:
药理学
·
免疫学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）