Scientific Reports
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2024
·Vol. 14
·期 1
·1-11
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IF 3.8
Wei Zhengyu,Shen Zhisen,Deng Hongxia,Kuang Tairong,Wang Jinggang,Gu Zhipeng
Using three-dimensional (3D) printing technology to make the porous tantalum plate and modify its surface. The physicochemical properties, cytocompatibility, antioxidant capacity, and histocompatibility of the modified materials were evaluated to prepare for the repair of craniomaxillofacial bone defects. The porous tantalum plates were 3D printed by selective laser melting technology. Tantalum plates were surface modified with a metal polyphenol network. The surface-modified plates were analyzed for cytocompatibility using thiazolyl blue tetrazolium bromide and live/dead cell staining. The antioxidant capacity of the surface-modified plates was assessed by measuring the levels of intracellular reactive oxygen species, reduced glutathione, superoxide dismutase, and malondialdehyde. The histocompatibility of the plates was evaluated by animal experiments. The results obtained that the tantalum plates with uniform small pores exhibited a high mechanical strength. The surface-modified plates had much better hydrophilicity. In vitro cell experiments showed that the surface-modified plates had higher cytocompatibility and antioxidant capacity than blank tantalum plates. Through subcutaneous implantation in rabbits, the surface-modified plates demonstrated good histocompatibility. Hence, surface-modified tantalum plates had the potential to be used as an implant material for the treatment of craniomaxillofacial bone defects.
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Journal of Materials Chemistry B
·
2026
·
IF 6.2
Lian Wang,Junmei Song,Hao Wang,Tianyou Wang,Jiaqi Li,Ningrui Cao,Yiwen Li,Zhipeng Gu,Xian Jiang
Acne is an inflammatory dermatological disorder caused by Cutibacterium acnes (C. acnes), which primarily affects the face, neck, chest, and back, leading to skin impairment. This condition is often associated with post-inflammatory erythema, hyperpigmentation, scarring, as well as psychosocial and emotional distress. Based on the major pathological characteristics of acne with microbiome colonization, and multiple immune responses, we selected doxycycline, a clinically commonly used antibiotic and anti-inflammatory drug, and epigallocatechin gallate (EGCG), a polyphenol, to construct topical-applicable nanoparticles (NPs). The resulting doxycycline-EGCG (DE) NPs significantly reduced the proportion of dead cells in C. acnesinduced HaCaT cells and demonstrated excellent anti-inflammatory effects through inhibition of NF-κB and STAT3 pathways compared to doxycycline alone. Moreover, the DE NPs exhibited better enhanced antibacterial efficacy against C. acnes along with improved antioxidant capacity than doxycycline. In an acne-like mouse model, the DE NPs also effectively suppressed skin inflammation and reduced inflammatory cytokines expression. Overall, this work presents a co-assembly strategy driven by covalent and non-covalent interactions, affording polyphenol-based doxycycline NPs with potent antiinflammatory, antioxidant, antibacterial properties, and offering new opportunities for safe and effective acne local therapy.
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ACS Nano
·
2025
·
IF 16
Wei Xu,Xiyu Jia,Mingchuan Yang,Ziyi Peng,Hongping Chen,Xiangchun Zhang,Bing Wei
Fruit spoilage has led to significant food waste and economic losses and poses risks to human health. Currently, widely used plastic bag preservation techniques exhibit limited effectiveness, often leading to environmental pollution and potential health hazards. Moreover, many emerging nanopreservation materials lack comprehensive safety evaluations, raising concerns regarding their biological safety and stability. In this study, we developed a nanocomposite coating that utilizes plant-derived polyphenols as a structural framework for food preservation. This coating is synthesized through a one-step self-assembly process involving tea polyphenols and zinc ions (TPZn). The TPZn nanocomposite coating exhibits exceptional antibacterial, antioxidant, adhesion, and water retention properties. By inhibiting the formation of bacterial biofilms, it effectively prevents bacteria from colonizing the surfaces of fruits, resulting in long-lasting antibacterial effects and significantly extending the shelf life. Additionally, the application of TPZn on strawberries and bananas has led to a doubling of their shelf life while maintaining the freshness and nutrient content of the fruits. This polyphenol-based preservation material not only provides a shield coating against spoilage but also demonstrates excellent biological safety across various models including cells, zebrafish, nematodes, mice, and bean sprouts. This study presents insights into the rational design of biosafe preservation materials utilizing natural plant-derived components.
研究领域:
食品科学
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纳米技术
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材料科学
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食品保鲜
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微生物学
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农业科学
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-9
·
IF 16.6
Zhu Bin,He Shanshan,Yang Yan,Li Songwei,Lau Cher Hon,Liu Shaomin,Shao Lu
Advances in membrane technologies are significant for mitigating global climate change because of their low cost and easy operation. Although mixed-matrix membranes (MMMs) obtained via the combination of metal-organic frameworks (MOFs) and a polymer matrix are promising for energy-efficient gas separation, the achievement of a desirable match between polymers and MOFs for the development of advanced MMMs is challenging, especially when emerging highly permeable materials such as polymers of intrinsic microporosity (PIMs) are deployed. Here, we report a molecular soldering strategy featuring multifunctional polyphenols in tailored polymer chains, well-designed hollow MOF structures, and defect-free interfaces. The exceptional adhesion nature of polyphenols results in dense packing and visible stiffness of PIM-1 chains with strengthened selectivity. The architecture of the hollow MOFs leads to free mass transfer and substantially improves permeability. These structural advantages act synergistically to break the permeability-selectivity trade-off limit in MMMs and surpass the conventional upper bound. This polyphenol molecular soldering method has been validated for various polymers, providing a universal pathway to prepare advanced MMMs with desirable performance for diverse applications beyond carbon capture.
研究领域:
材料科学
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环境工程
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化学工程
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Nuoya Chen,Derong He,Xin Tan,Liqin Ge
Chitosan, as a natural polysaccharide, is widely used in the field of hemostasis. However, its inherent limitations such as poor mechanical strength and difficulty in dissolving under alkaline conditions restrict the broader application. This study designed a glycidyl methacrylate-modified carboxymethyl chitosan (M-CMCS) photo-crosslinked hydrogel, incorporating metal-polyphenol network (MPN) microcapsules. The integration of these microcapsules functionalized the hydrogel, enhancing its hemostatic and mechanical properties while imparting anti-inflammatory and antioxidant capabilities. The hydrogel demonstrated excellent biocompatibility and hemostatic efficacy, promoting the formation of stable blood clots, and had significant potential as a clinically relevant hemostatic material.
研究领域:
生物材料学
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医学工程
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组织工程
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Surface Topography-Metrology and Properties
·
2019
·Vol. 7
·期 2
·025010
·
IF 2.439
Jinpeng Yu,Han Yan,Mingsi Yang,Yuetao Ma,Xiaoqiang Fan,Minhao Zhu
Graphene as a physical barrier in organic coating exhibits good anticorrosion property, whereas its agglomeration would greatly debase such performance. Here, functionalized graphene was prepared via a green/facile method with tea polyphenol as reductant and graphene oxide (GO) as precursor. The anticorrosion performance of polyphenol-reduced graphene oxide (T-rGO) in waterborne epoxy coating was evaluated according to the electrochemical impedance spectroscopy, polarization curve, water absorption and salt spray test. Results indicate that the T-rGO/epoxy coating has the largest impedance modulus and corrosion potential, and the corrosion current density is an order of magnitude lower than that of pure epoxy coating. The T-rGO/epoxy coating displays excellent corrosion protection under continuous high salt spray environment, with pure epoxy coating as a comparison. T-rGO greatly enhances the corrosion resistance of waterborne epoxy coating, which is attributed to its good dispersibility and intrinsic characteristics.
研究领域:
材料科学
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腐蚀与防护
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Guan-Qi Zheng,Bo-Wen Liu,Ling Yuan,Lin Chen,Xiu-Li Wang,Hai-Bo Zhao,Yu-Zhong Wang
Multifunctional and high-performance polymers have long been the pursuit of materials scientists, but are seldom reported or require complex preparation. Herein, inspired by the multiple functions of natural polyphenols, we report a synthetic polymer called PIP (polyphenol-inspired polymer) with facile bulk preparation process aiming for multiple application scenarios. With tunable polyphenol content from 1 to 40 mol%, PIP exhibited adjustable performances. At low polyphenol content, PIP possesses excellent full-band ultraviolet shielding performance and 1.9-fold mechanical strength compared with a typical commercial competitor, due to the abundant hydrogen bonds. Based on the radical-scavenging and char-forming ability of polyphenols, PIP realizes high fire safety at high polyphenol content. Notably, PIP can be easily processed into films and fibers, enabling its wide potential application fields. In sight of these findings, this work provides a new strategy for the design and synthesis of high-performance and multifunctional polymers with broader applications.
研究领域:
材料科学
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高分子化学
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Frontiers in Chemistry
·
2023
·
IF 5.5
Xu Li,Luo Zhibing,Liu Qing,Wang Chuancui,Zhou Fei,Zhou Min
Chemotherapy combined with photothermal therapy (PTT) is a new way to improve the curative effect of cancer treatment. Here, we developed a multifunctional nanoparticle, namely PTX@mPDA@Fe-GA with the loading of a chemotherapeutic drug paclitaxel (PTX) for targeted and synergistic chemotherapy/photothermal therapy in lung cancer. Fe-gallic acid (Fe-GA) was coated on the surface of mesoporous polydopamine (mPDA) nanoparticles, and then the PTX was placed in the mesopores. The drug release of the loaded PTX exhibited pH- and thermal-dual responsive manner. Both mPDA and Fe-GA have high photothermal conversion ability and play a role in photothermal therapy. In addition, the results revealed that mPDA@Fe-GA had excellent biocompatibility and low hemolysis rate. The PTX-loaded mPDA@Fe-GA not only has excellent killing effect on lung cancer cells (A549) in vitro, but also can significantly suppress the growth of A549 subcutaneous tumor in nude mice. In a nutshell, the developed multifunctional nanoparticles integrate photothermal therapy and efficient chemotherapeutic drug delivery, providing new therapeutic ideas in the fight against lung cancer.
研究领域:
癌症治疗
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纳米技术
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药物递送系统
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生物医学工程
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高影响因子
Food Bioscience
·
2023
·
IF 5.2
Nan Deng,Xiaofang Bian,Shunjing Luo,Chengmei Liu,Xiuting Hu
Debranched rice starch and different polyphenols, including genistein , quercetin , naringin, gallic acid , ferulic acid and caffeic acid, formed the V-type inclusion complex, which was confirmed by diffraction peaks at 7.5°, 13.0° and 20.0° and the presence of the endothermic peak during DSC analysis. Moreover, the inhibitory effect of polyphenols on α-amylase was in the order of quercetin > genistein > gallic acid = ferulic acid > naringin = caffeic acid, and their inhibitory effect on amyloglucosidase was in the order of quercetin = naringin > gallic acid > caffeic acid = genistein > ferulic acid. The starch-genistein and starch-naringin complexes had the highest polyphenol content, followed by the starch-ferulic acid complex, the starch-caffeic acid complex, the starch-quercetin complex and the starch-gallic acid complex. The resistant starch content of starch-genistein, starch-quercetin, starch-naringin, starch-gallic acid, starch-ferulic acid and starch-caffeic acid complexes was 72.49%, 79.86%, 68.82%, 60.96%, 71.06% and 71.24%, respectively. These results suggested that these starch-polyphenol inclusion complexes were highly resistant to digestion. Particularly, the starch-quercetin complex was the most resistant, which might be due to that its highest crystallinity and the strongest inhibitory effect of quercetin on amylases .
研究领域:
食品科学
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营养学
·
化学
·
生物化学
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高影响因子
FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Wenyue Wang,Xuan Li,Zhongxiang Fang,Jinfeng Bi
Pectin structure plays a vital role in determining the quality of food systems. This study investigated the impact of pectin structural variations on polyphenol oxidase (PPO)-catalyzed catechin oxidation using a series of pectin fractions prepared through polygalacturonase (PG) treatment. PG progressively degraded homogalacturonan (HG) regions, reduced molecular weight, and increased the exposure of hydroxyl and carboxyl groups, thereby converting the pectin matrix from a compact to a disordered state. Among these fractions, pectin enriched in rhamnogalacturonan I (RG-I) with an extended conformation, characterized by longer RG-I chains and fewer branches, exhibited weaker interactions with PPO and catechin, resulting in disordered aggregation and the lowest catalytic efficiency. Integration with molecular docking further revealed that high-HG pectin formed compact hydrophobic networks that restricted substrate access, resulting in high Vmax but low affinity. Conversely, low-HG pectin promoted hydrogen bonding with PPO and catechin, as well as facilitated ordered aggregation. Despite a lower Vmax, it exhibited a markedly reduced Km, resulting in enhanced overall catalytic efficiency. These findings demonstrate that pectin modulates PPO-catalyzed oxidation through steric hindrance, affinity interactions, and aggregation behavior, providing new insights for controlling enzymatic browning in food systems through structural modulation of pectin.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Jun Zeng,Gang Du,Xue Shao,Ke-Na Feng,Ying Zeng
Theaflavins (TFs) have attracted much attention due to their various bioactivities in black tea. This paper describes the first trial for enzymatic production of TFs by recombinant polyphenol oxidases (PPOs). PPO genes were cloned from nine species and expressed in E. coli . Crude enzyme assays by LC-MS revealed that eight recombinant PPOs were active for TFs production from tea polyphenols as substrates. Much higher activities were observed for crude enzymes of Md2 from Malus domestica (apple), Pp4 from Pyrus pashia (pear), and Ej2 from Eriobotrya japonica (loquat). When immobilized on mesoporous silica, crude Md2 was most active. The purified Md2 was immobilized and showed almost twice activity as high as its free enzyme. While the maximum activity of free enzyme was found at pH 5 and 10–30 °C, the immobilized enzyme had broader range of pH 4–6 and 10–40 °C. The activity of immobilized enzyme was relatively constant during the pH and thermal stability test. When used at 0.2 mg/ml in the beginning, the immobilized enzyme retained approximately 40% of its initial activity after 8 cycles of operation.
研究领域:
生物技术
·
酶学
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食品科学
·
植物生化
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PubMed
高影响因子
Food Packaging and Shelf Life
·
2026
·
IF 10.8
Xin Hu,Zhen Zhang,Chen geng,Peijie Hou,Jun Wang,Yang Li,Lifang Zhang
Food spoilage driven by oxidative stress and microbial contamination remains a major challenge in minimally processed fruits, while the development of flexible biodegradable packaging systems with regulated and responsive bioactivity remains limited. In this study, a flexible bio-based active film was fabricated by incorporating gallic acid (GA) into a biodegradable poly( L -lactide)-b-poly(trimethylene carbonate) (PLLA-b-PTMC, PLT) matrix. Intermolecular hydrogen bonding between GA and PLT induced microstructural reorganization and altered chain mobility, enabling biphasic, diffusion-controlled GA release with pH-dependent behavior. The composite films exhibited reactive oxygen species scavenging activity, dose-dependent antibacterial performance against Escherichia coli and Staphylococcus aureus, and maintained cytocompatibility at effective GA loadings. Application in a fresh-fruit preservation model demonstrated delayed browning and moderated quality deterioration during storage. These findings indicate that regulating polymer–polyphenol interactions can align release behavior with storage-induced environmental changes, contributing to oxidative and microbial spoilage control in minimally processed fruits.
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