POLYMER SCIENCE SERIES B
·
2021
·Vol. 63
·期 3
·239-244
·
IF 1.049
Huanhuan Zhu,Niu Mingkang,Feng Zhongtai,Li Chengjie,Li Yonghao,Jiao Qingze,Wang Shanshan,Feng Caihong,Zhao Yun,Lv Yuzhen
Abstract To obtain aromatic polyamides with reduced dielectric constant, a series of aromatic polyamide copolymers derived from the reaction between m -phenylenediamine to trans -1,2-cyclohexanediamine and isophthaloyl chloride were synthesized using the low-temperature solution polymerization in the presence of 2-methylpyridine. The influence of the content of trans -1,2-cyclohexanediamine on the structure and properties of aromatic copolyamides was evaluated. With increasing the content of trans -1,2-cyclohexanediamine, the inherent viscosities of copolymers decrease from 1.95 to 1.14 dL/g. The copolymer with 25 mol % of trans -1,2-cyclohexanediamine has a reduced dielectric constant ε r of 4.61 at 1 MHz, which is 26% lower than homopolyamide. Meanwhile, as-synthesized aromatic polyamides and copolyamides show good thermal stability and mechanical properties.
研究领域:
材料科学
·
高分子化学
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EUROPEAN POLYMER JOURNAL
·
2025
·
IF 6.3
Hezhen Pang,Jian Wang,Penglei Guo,Jie Zhang,Weiwei Zhao,Na Wang,Xiaoqing Liu
2,2,4,4-Tetramethyl-1,3-cyclobutanediol (CBDO) modified co-polyesters are expected to replace bisphenol A polycarbonate applications in many fields, and the cis – trans isomerisation of CBDO directly affects the co-polyester properties. However, the separation of cis – trans CBDO isomers and the influence of cis–trans isomer ratio on the performance of co-polyester are poorly investigated at present. In this paper, an efficient method of separating cis – trans CBDO isomers was proposed, and CBDO modified PET co-polyesters (PEBT) with a total CBDO content of about 40 % and a cis -CBDO content of 20–100 % were synthesized by modulating the cis - content. The glass transition temperature (T g ) of the co-polyester with 100 % cis -CBDO was as high as 117.8 °C, and the increment in T g of the co-polyester with per mol of cis -CBDO introduced was calculated to be 0.92 °C, which was 2.7 times of the increment of trans -CBDO (0.34 °C). With the increase of cis -CBDO content from 20 % to 100 %, the tensile strength was correspondingly increased from 35.4 MPa to 40.2 MPa, and the elongation at break decreased from 74 % to 18 %, respectively. This paper provides a theoretical basis for the preparation of high-performance CBDO-modified co-polyesters.
研究领域:
高分子化学
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材料科学
·
聚合物物理
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功能材料
·
化学工程
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LANGMUIR
·
2026
·
IF 4.4
Huan Zheng,Haoran Wang,Yongsen Han,Xinyu Wang,Yujia Ju
To systematically compare the effects of different introduction methods on the direct-current (DC) electrical performance of polyethylene insulation, low-density polyethylene (LDPE) modified with an identical content of trans,trans-dibenzalacetone (TTD) was prepared via blending and grafting approaches. The DC breakdown strength, electrical conductivity, space charge behavior, surface potential decay, and trap distribution characteristics of the modified LDPE were comparatively investigated. The results indicate that both blending and grafting modification can effectively regulate the DC electrical behavior of LDPE and improve its insulation performance to varying extents. Compared with the blended system, the grafted samples exhibit a significantly higher DC breakdown strength, increasing from 353.20 kV/mm to 403.31 kV/mm, accompanied by a pronounced reduction in electrical conductivity and a markedly lower average volume charge density under a DC electric field of 40 kV/mm, indicating more effective suppression of space charge accumulation. Meanwhile, a slower surface potential decay process is observed in the grafted samples, revealing pronounced differences in charge trapping characteristics within the materials. Combined with quantum chemical calculations and trap formation analysis, it is suggested that the different introduction methods alter the existence state of functional molecules in the polymer matrix, thereby affecting the stability and effectiveness of charge trap structures. Chemical grafting is favorable for stably transforming the electron-capturing capability of TTD into intrinsic charge trapping structures within LDPE, enabling sustained and effective regulation of charge transport under DC electric fields. This study provides useful insights into the molecular design and optimization of polyethylene-based insulation materials for high voltage DC applications.
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Toxics
·
2026
·Vol. 14
·期 5
·388
·
IF 4.9
Xiaoli Wu,Xinyue Zhang,Zengliang Ruan
Trans , trans -2,4-decadienal ( tt -DDE), the primary aldehyde component found in cooking oil fumes, is a prevalent environmental pollutant. However, its potential adverse effects on ocular development remain largely unexplored. This study evaluated its toxicity on ocular development and angiogenesis in zebrafish larvae, as well as on human retinal vascular endothelial cells (HRECs). Zebrafish ( Danio rerio ) larvae at 48 h post-fertilization were microinjected intraocularly with various doses of tt -DDE (65.87–521.3 mM) for 24 h. We observed dose-dependent impairments in ocular development following tt -DDE exposure. It significantly reduced eye size and inhibited the intraocular vascular area at concentrations of 128.9 mM and above. Histopathological analysis revealed retinal structural disorganization, eye shrinkage, and a clear dose-dependent increase in acridine orange (AO) fluorescence intensity. Apoptosis assays confirmed a significant escalation in ocular cell death at higher exposure doses. Additionally, our results demonstrated that tt -DDE (5–100 μM) significantly reduced the viability of HRECs in vitro. These findings suggest that early-life exposure to tt -DDE impairs ocular development in zebrafish by inducing histopathological damage, inhibiting angiogenesis, and promoting apoptosis, and also exerts direct cytotoxicity to human retinal cells. This study underscores the potential risk of tt -DDE exposure as an environmental factor contributing to ocular developmental toxicity.
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JOURNAL OF RAMAN SPECTROSCOPY
·
2015
·Vol. 46
·期 11
·1067-1072
·
IF 2.671
Yanbin Su,Lei Chen,Yingkun Cheng,Fengrong Zhang,Yanwen Su,Zhengqiang Li
In this paper, the molecular mechanism of diallyl trisulfide (DATS) on trans-crotonaldehyde (TCA) was studied by UV–vis absorption and Raman spectroscopies combining with density functional theory calculations. Experimental results indicate that the introduction of DATS can not only make the maximum absorption peak of TCA shift 15 nm, but also obviously alter the Raman vibrational frequency of aldehyde (―CHO). In addition, the Raman intensity of TCA decreased significantly, especially in the presence of mitochondria. Our theoretical calculations reproduce fairly well the experimental data. Copyright © 2015 John Wiley & Sons, Ltd.
研究领域:
光谱学
·
理论化学
·
分子生物学
·
分析化学
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Marine Life Science & Technology
·
2025
·
IF 5.3
Wang Yan,Wang Zhen,Zhao Wen-Xiao,Yuan Xiao-Jie,Yu Yang,Wang Peng,Wang Min,McMinn Andrew,Zhang Yu-Zhong,Peng Ming,Fu Hui-Hui,Chen Xiu-Lan
Free trans -4-hydroxy-L-proline (T4LHyp), a non-proteinogenic amino acid, is mainly released from the degradation of collagen, hydroxyproline-rich glycoproteins, and some peptide antibiotics in nature. Although it has been known that some terrestrial bacteria utilize T4LHyp as carbon and nitrogen source via a T4LHyp gene cluster, which and how marine microorganisms catabolize T4LHyp still remains unclear. Here, five T4LHyp-utilizing marine bacterial strains, Halomonas sp. 5021, Salinicola sp. 4072, Alteromonas sp. 6022, Alteromonas sp. 5112 and Alteromonas sp. 30521, were isolated from hydrothermal vent sediment samples collected from the southwest Indian Ocean. While Halomonas sp. 5021 can utilize T4LHyp as both a nitrogen and carbon source, the other four strains can utilize T4LHyp as only a nitrogen source. Then, the T4LHyp catabolic mechanisms of Halomonas sp. 5021 and Salinicola sp. 4072, as a representative of the four strains, were further investigated by genomic, transcriptional, and biochemical analyses. Halomonas sp. 5021 adopts an intact T4LHyp gene cluster containing four enzymes to catabolize T4LHyp into NH 3 and α-ketoglutarate to provide nitrogen and carbon sources for its growth. Compared to Halomonas sp. 5021, Salinicola sp. 4072 lacks an α-KGSA dehydrogenase gene in the T4LHyp gene cluster and can only catabolize T4LHyp into NH 3 and α-ketoglutarate semialdehyde to provide a nitrogen source for its growth. Bioinformatic investigation showed that the 5021-like and 4072-like T4LHyp gene clusters are predominantly found in bacteria from Pseudomonadota , which are widely distributed in multiple marine habitats. Thus, Pseudomonadota bacteria are likely the dominant group to drive the recycling and mineralization of T4LHyp in the ocean.
研究领域:
海洋微生物学
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微生物生态学
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生物化学
·
基因组学
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Cell Communication and Signaling
·
2025
·Vol. 23
·期 1
·1-21
·
IF 8.9
Li Lei,Peng Ruilong,Wang Cong,Chen Xin,Gheyret Dilmurat,Guan Siyu,Chen Bo,Liu Yafan,Liu Xilei,Cao Yiyao,Han Cha,Xiong Jianhua,Li Fanjian,Lu Taoyuan,Jia Haoran,Li Kaiji,Wang Jinchao,Zhang Xu,Xu Jianye,Wang Yajuan,Xu Xin,Li Tuo,Zhang Jianning,Zhang Shu
Neutrophils are the first responders among peripheral immune cells to infiltrate the central nervous system following a traumatic brain injury (TBI), triggering neuroinflammation that can exacerbate secondary tissue damage. The precise molecular controls that dictate the inflammatory behavior of neutrophils post-TBI, however, remain largely elusive. Our comprehensive analysis of the molecular landscape surrounding the trauma in TBI mice has revealed a significant alteration in the abundance of β2 integrin (ITGB2), predominantly expressed by neutrophils and closely associated with immune responses. Using the fluid percussion injury (FPI) mouse model, we investigated the therapeutic efficacy of Rovelizumab, an agent that blocks ITGB2. The treatment has demonstrated significant improvements in neurologic function in TBI mice, attenuating blood–brain barrier permeability, mitigating oxidative stress and inflammatory mediator release, and enhancing cerebral perfusion. Moreover, ITGB2 blockade has effectively limited the adherence, migration, and infiltration of neutrophils, and has impeded the formation of neutrophil extracellular traps (NETs) upon their activation. Finally, it was demonstrated that ITGB2 mediates these effects mainly through its interaction with intercellular adhesion molecule-1 (ICAM 1) of endotheliocyte. These findings collectively illuminate ITGB2 as a crucial molecular switch that governs the adverse effects of neutrophils post-TBI and could be targeted to improve clinical outcome in patients.
研究领域:
神经科学
·
免疫学
·
创伤医学
·
药理学
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CELL
·
2025
·
IF 42.5
Yixiao Gao,Fengyuan Xin,Tao Wang,Chengjun Shao,Ying Hu,Zhuoya Chen,Yiwei Wang,Fenghua Xie,Tianyu Li,Sijie Li,Liqun Ren,Caiqin Li,Xian Yang,Zhongjun Yang,Meijie Li,KaMun Tan,Tao Bai,Changwei Wei,Hanchuan Peng,Kun Li,Yichang Jia,Kexin Yuan
Biological structures across scales integrate seamlessly to perform essential functions. While various histological methods have been developed to reveal these intricate structures, preserving the integrity of large-volume architectures while revealing microstructures with high resolution remains a major challenge. Here, we introduce vitreous ionic-liquid-solvent-based volumetric inspection of trans-scale biostructure (VIVIT), a 3D histological method leveraging the chemical properties of ionic liquids. VIVIT transforms biological tissue into an ionic glassy state, which enables optical clearing with minimal distortion and high transparency, preserves tissue from low-temperature crystal damage, and amplifies fluorescent signals from both genetically encoded and immunostained labels, thus yielding precise and reliable mapping of fluorescent signals within intact 3D architectures. Using VIVIT, we demonstrate the link between the modality of synaptic inputs to multisensory thalamic neurons and the targets of their brain-wide outputs and identified aspects of inhibitory control in the human cortex. VIVIT thus offers opportunities to elucidate the organizational principles underlying trans-scale biostructures.
研究领域:
组织学
·
神经科学
·
生物成像
·
组织工程
·
细胞生物学
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JOURNAL OF BIOLOGICAL CHEMISTRY
·
2023
·Vol. 299
·期 5
·
IF 4.8
Danxue He,Lei Tao,Binxiang Cai,Xiangjun Chen,Yan Wang,Shiying Li,Chunyan Liao,Yuling Chen,Jingmeng Chen,Zuguo Liu,Yalin Wu
Dry age-related macular degeneration (AMD) and recessive Stargardt’s disease (STGD1) lead to irreversible blindness in humans. The accumulation of all-trans-retinal (atRAL) induced by chaos in visual cycle is closely associated with retinal atrophy in dry AMD and STGD1 but its critical downstream signaling molecules remain ambiguous. Here, we reported that activation of eukaryotic translation initiation factor 2α (eIF2α) by atRAL promoted retinal degeneration and photoreceptor loss through activating c-Jun N-terminal kinase (JNK) signaling-dependent apoptosis and gasdermin E (GSDME)-mediated pyroptosis. We determined that eIF2α activation by atRAL in photoreceptor cells resulted from endoplasmic reticulum homeostasis disruption caused at least in part by reactive oxygen species production, and it activated JNK signaling independent of and dependent on activating transcription factor 4 and the activating transcription factor 4/transcription factor C/EBP homologous protein (CHOP) axis. CHOP overexpression induced apoptosis of atRAL-loaded photoreceptor cells through activating JNK signaling rather than inhibiting the expression of antiapoptotic gene Bcl2. JNK activation by eIF2α facilitated photoreceptor cell apoptosis caused by atRAL via caspase-3 activation and DNA damage. Additionally, we demonstrated that eIF2α was activated in neural retina of light-exposed Abca4−/−Rdh8−/− mice, a model that shows severe defects in atRAL clearance and displays primary features of human dry AMD and STGD1. Of note, inhibition of eIF2α activation by salubrinal effectively ameliorated retinal degeneration and photoreceptor apoptosis in Abca4−/−Rdh8−/− mice upon light exposure. The results of this study suggest that eIF2α is an important target to develop drug therapies for the treatment of dry AMD and STGD1.
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POLYMER SCIENCE SERIES B
·
2019
·Vol. 61
·期 5
·550-559
·
IF 0.907
Xin-Ru Dai,Geng Yue,Shao Guangqiang,Luo Zhang,Jiang Xiubo,Zhang Zhen-Xiu
Abstract Here triblock copolymer synthesis mediated by trans -1,4-polyisoprene is reported for the first time. Carbonyl telechelic trans -1,4-polyisoprene ( trans -structure >95%) was synthesized by the epoxidation of trans -1,4-polyisoprene followed by oxidative cleavage. Bromine terminated trans -1,4-polyisoprene was then synthesized by the reduction reaction of carbonyl groups of trans -1,4-polyisoprene to hydroxyl groups followed by end group transformation. Atom transfer radical polymerization of styrene was conducted then using bromine terminated trans -1,4-polyisoprene as macroinitiator. Triblock copolymers were characterized by 1 H-NMR, FTIR, GPC, DSC, and XRD.
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IUBMB LIFE
·
2019
·Vol. 71
·期 7
·1014-1020
·
IF 3.051
Yanbin Su,Chengyu Sun,Yan Chen,Shichang Liu,Ning Jing,Shuxin Li
The aim of this study was to explore how the toxic trans -crotonaldehyde (TCA) in mitochondria or aldehyde dehydrogenase (ALDH) at different pHs was intercepted by oxyresveratrol (Oxy-Res) contributing to anticancer. Ultraviolet–visible (UV–vis) spectroscopy and Raman spectroscopy were employed. UV–vis spectra showed that the Oxy-Res red shifted the peak of the toxic TCA from 316 nm to 325 nm, while the peaks of the Oxy-Res shifted from 329 nm with 290 nm and 300 nm to 325 nm with 303 nm. In the mitochondria, the Oxy-Res blue shifted the peaks of the toxic TCA from 325 nm with 303 nm to 321 nm with 301 nm. Raman spectra revealed that the Oxy-Res caused shifting of the CHO of the toxic TCA from 1,689 cm −1 to 1,671 cm −1 with band decline. The CC of the toxic TCA at 1641 cm −1 was split into 1,639 cm −1 and 1,642 cm −1 with band decline. The bands of the Oxy-Res at 1634 cm −1 , 1,617 cm −1 , and 1,595 cm −1 disappeared. In the mitochondria, the CC of the toxic TCA at 1641 cm −1 splitting disappeared. In ALDH, with the decrease of pH from 7.8 to 6.5, the CHO of the toxic TCA did not red shift from 1,689 cm −1 to 1,674 cm −1 up to pH 6.5. There was no change in the CC of the toxic TCA at 1640 cm −1 in ALDH at different pHs. The conclusion of the study was that the CHO of the toxic TCA was intercepted by the Oxy-Res under the action of ALDH in the mitochondria, particularly at pH 7.8. © 2019 IUBMB Life, 2019
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2017
·
IF 2.323
Xiaopo Wang,Yao Zhang,Dongbo Wang,Yanjun Sun
In recent years, trans-1,3,3,3-tetrafluoropropene (R1234ze(E)) was proposed as a possible replacement for hydrofluorocarbons. In this work, the vapor–liquid phase equilibrium of R1234ze(E) with three imidazolium ionic liquids (ILs) were measured from (283.15 to 343.15) K based on the isochoric method. The ILs include 1-ethyl-3-methylimidazolium tetrafluoroborate ([Emim][BF4]), 1-hexyl-3-methylimidazolium tetrafluoroborate ([Hmim][BF4]), and 1-octyl-3-methylimidazolium tetrafluoroborate ([Omim][BF4]). The experimental results were correlated using the nonrandom two-liquid activity coefficients model. The deviations between experimental data and calculated values for pressure were 1.77%, 2.07%, and 2.32% for R1234ze(E) + [Emim][BF4], + [Hmim][BF4], and + [Omim][BF4] systems, respectively.
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危险品化学品经营许可证（带存储）