JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2020
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IF 2.734
Jiahong Dou,Fang Zhao,Wenting Fan,Zhonghang Chen,Xuhong Guo
An ideal anticancer drug release system is designed to release drugs over a prolonged period while minimizing the initial burst to significantly reduce the side effects and the number of medications. In this study, CaCO 3 particles (average diameter 800-1600 nm with PDI < 0.2) aiming at such controlled release system were successfully prepared via Flash Nano Precipitation technique. Hydroxypropyl methylcellulose and sodium dodecyl sulfate were both employed as additives for CaCO 3 crystallization to promote the formation of vaterite and convex-disc-shaped CaCO 3 , and at the same time as stabilizers for CaCO 3 particles to control particle growth and avoid particle agglomeration . By using the as-prepared vaterites, a satisfying drug loading capacity (~0.1 mg drug/mg particle) was realized, and prolonged drug release was achieved with a low initial release (< 10% within 1 day at pH = 6.0) and approximately zero-order release kinetics before 36 h ( R 2 > 0.97) or after 36 h ( R 2 > 0.99). Besides, by changing the particle size, different drug release kinetics could be achieved while the high drug loading capacity and low initial release were both maintained. The vaterite particles prepared in this work could be a potential candidate drug carrier for extended drug release with minimized initial burst and a constant drug releasing rate.
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DOI
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
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2026
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IF 8.9
Zhongyi Xin,Le Guo,Jianing He,Fengjuan Wang,Liguo Wang,Zhiyong Liu,Jinyang Jiang
Construction and demolition waste (CDW) generates a vast amount of calcium-rich cementitious powders, yet these materials are currently underutilized—largely relegated to low-value applications that fail to exploit their inherent chemical potential. To address this challenge, this study develops an innovative strategy for converting hardened cement paste powder (HCPP) into high-value-added vaterite-type CaCO 3 (vaterite), aiming to simultaneously achieve CO 2 sequestration and the high-value utilization of waste cement materials. The research systematically investigates the effects of parameters on Ca 2 + leaching efficiency, and thoroughly reveals the synergistic regulatory mechanisms of CO 2 flow rate, liquid-to-solid (L/S) ratio, and crystal modifier on the phase composition, morphology, and particle size of the carbonation products. Under optimized conditions, the vaterite content reaches up to 96.69%, yielding spherical particles with uniform morphology. Furthermore, applying the obtained vaterite in a low-carbon cementitious material reveals that its reactivity is significantly higher than that of calcite. It participates earlier in the hydration reaction, promoting the early formation of a substantial amount of C-(A)-S-H gel, hemicarboaluminate (Hc) and monocarboaluminate (Mc) in the cementitious material system, thereby refining optimizing the pore structure and accelerating strength development. This study successfully establishes a functional conversion pathway from waste cement-based materials to high-performance CaCO 3 , providing important theoretical foundations and technical support for the recycling of construction waste and the development of low-carbon cementitious materials.
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高影响因子
CARBON
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2024
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IF 10.5
Jin-Ling Zhang,Zhan-Zhan Wang,Ting-Yu Yang,Sobhan Chatterjee,Mao-Sheng Cao,Hong-Shang Peng
Mineralization of CO 2 to minerals like calcium carbonate (CaCO 3 ) has been considered as an effective approach to combat global warming. In this paper, Ca 2+ ions were firstly extracted from waste carbide slag, and then facilely transformed to vaterite CaCO 3 via disperse bubbling carbonization method assisted with an air stone. By optimizing the reaction conditions, highly mono-dispersed vaterite CaCO 3 microspheres (VCMs) were obtained. These microspheres consisted of aggregated CaCO 3 nanocrystals , bearing a mesoporous structure. As a proof-of-concept, these mesoporous microspheres were utilized for dye adsorption and electromagnetic (EM) microwave absorption. For the former, the VCMs were used to adsorb Congo red, yielding a fast adsorption time of 9 min and a high adsorption capacity of 138.77 mg/g. For the latter, EM microwave dielectric parameters were measured, and dye-adsorbed VCMs exhibited better microwave-absorption performance with a minimum reflection loss of −43.2 dB, about 3 times of pristine vaterite. To the best of our knowledge, this is the first report of solid-waste-derived VCMs as microwave absorbent and dye adsorbent. Considering the low-cost, eco-friendly and facile preparation and effective utilization of VCMs, our work provides a promising strategy for large-scale carbon capture, solid waste utilization, and treatment of microwave and wastewater pollution.
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高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
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2026
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IF 8.9
Xiaoqian Wu,Junfeng Gu,Weiwei Li,Zelin Liao,Hao Xie,Hao Wang,Weimin Wang,Hang Ping,Zhengyi Fu
Biominerals possess the capability to encapsulate organic macromolecules or inorganic nanoparticles within their matrix crystals during the growth process. The robust interfacial interactions between guest nanoparticles and the host crystals contribute to the exceptional mechanical properties of biominerals. Inspired by this natural encapsulation process, vaterite microspheres incorporating green fluorescence protein-modified Escherichia coli (GFP- E. coli @vaterite) are synthesized. The encapsulation process involves the initial adhesion of amorphous calcium carbonate precursor onto the surface of E. coli , followed by progressive mineralization with growing vaterite crystals, thereby achieving the encapsulation of 14.6 wt% bacteria within vaterite microspheres. Subsequently, dense composite bulks are fabricated through cold sintering of the GFP- E. coli @vaterite powder at 100 °C under a pressure of 1 GPa. The resulting composites achieved flexural strength and fracture toughness of 69.9 MPa and 0.75 MPa·m 1/2 , representing 1.4-fold and 2.2-fold improvements over pure vaterite bulk (48.4 MPa and 0.34 MPa·m 1/2 ), respectively. Notably, the GFP- E. coli @vaterite composite bulks maintained stable fluorescence for more than eighteen months, with minimal signal attenuation and a fluorescence lifetime exceeding 1.1 μs. Our work provides an efficient approach to fabricate integrated structural and functional composites under low temperature conditions. This work also establishes a new direction in fluorescent marking technologies and demonstrates promising potential for practical implementation.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Gangan Wang,Chaoyi Chen,Junqi Li,Xin Lin,Haonan Zheng
Calcium-silica slag (CSS) is a highly alkaline residue, rich in calcium, generated during the chemical pre-desilication process of medium- and low-grade bauxite. Mismanagement of CSS can result in detrimental environmental impacts. This study developed a novel method that combines CO 2 sequestration with CSS utilization, thereby achieving simultaneous dual-value enhancement of CSS and eliminating waste discharge. Under optimized Ca 2+ leaching and carbonation conditions, a remarkable Ca 2+ extraction efficiency of 96.93 % was attained, while the carbonation efficiency reached 99.37 %. Consequently, this process sequestered 301.7 kg of CO 2 per ton of CSS. The leaching process of Ca 2+ in NH 4 Ac solution was realized based on the unreacted shrinking core model, which accounts for internal diffusion and chemical reaction as factors influencing leaching. The resulting carbonated product exhibited outstanding characteristics: high-purity vaterite composed of 97.43 wt% CaCO 3 with a whiteness level of 95.2 %. By regulating the carbonation temperature, the crystal particulate size distribution of CaCO 3 was tailored to meet specific requirements for various applications. Furthermore, silicon content was enriched in the leaching residue, increasing the effective SiO 2 content from 25.2 wt% to 53.12 wt% and reducing the pH from 12.23 to 7.34, rendering it a suitable silica fertilizer for agricultural production.
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高影响因子
危险品化学品经营许可证（带存储）