Journal of Pharmaceutical Innovation
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2026
·Vol. 21
·期 1
·101
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IF 2.7
Boudoukhani Meriem,Yahoum Madiha Melha,Toumi Selma,Lefnaoui Sonia,Bañobre-López Manuel,Moulai-Mostefa Nadji
A cationic derivative of xanthan gum (Ca-XG) was synthesized through grafting of quaternary amine groups, with a degree of substitution of 0.43 confirmed by ¹H-NMR analysis. The modified polymer displayed amphiphilic behavior, characterized by a critical aggregation concentration of 0.25% (w/v), and demonstrated efficient emulsifying properties. Ca-XG was incorporated into fusidic acid emulgels, where sixteen formulations were evaluated for their physicochemical and functional characteristics. All samples showed homogeneous appearance, with pH values ranging between 5.95± 0.297 to 6.83 ± 0.352, consistent with dermal compatibility. The formulations exhibited good spreadability (32.17–66.91 cm²) and stable drug content (1.96–1.99%). Among them, the optimized formulation provided sustained permeation of fusidic acid over 24 h, with a cumulative permeation of 16.67 mg/cm² and a steady-state flux of 0.724 mg/cm².h. Furthermore, diffusion coefficients (0.015–0.051 cm²/h) confirmed the ability of Ca-XG to control drug transport while ensuring hydration of the topical matrix. Overall, these results demonstrate that Ca-XG acts not only as a bio-based emulsifier but also as a multifunctional excipient, supporting controlled drug. Graphical
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ENERGY & FUELS
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2021
·
IF 3.605
Xiaosheng Fu,Feifei Qin,Tao Liu,Xiuxia Zhang
Xanthan gum (XG) is one of the widely used biopolymers in oil-field development. It has low cost and will not pollute the environment. However, its limited temperature and salt tolerance restricts its application in high temperature and high salt reservoirs. An environmentally friendly hydrophobic associative polymer was prepared by grafting long-chain alkyl groups onto xanthan gum through an etherification reaction for enhanced oil recovery (EOR). The hydrophobically modified xanthan gum (MXG) was characterized by Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (NMR), gel permeation chromatography (GPC), and thermogravimetric analysis (TGA). Due to the hydrophobic association, MXG had excellent thickening, rheological properties, antiaging, temperature, and salt resistance properties. In the 30 g/L NaCl solutions, the viscosity of MXG (335 mPa s) was about 3 times that of XG (115.3 mPa s) at 65 °C. Whether in a high-salt solution (20 g/L NaCl) or reservoir injection water (mineralization of water is 7542 mg/L), modified xanthan gum can show good antiaging properties. The polymer flooding experiments showed that EOR of MXG is 25%, 7% higher than that of XG. The macroscopic mechanism of MXG flooding was studied. In summary, MXG has a wide range of applications in EOR.
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Food Biophysics
·
2019
·Vol. 14
·期 2
·142-153
·
IF 2.411
Jiao Wenjuan,Li Lin,Fan Penghui,Zhao Di,Li Bing,Rong Hui,Zhang Xia
The effect of xanthan gum on the freeze-thaw stability of wheat gluten was evaluated during a 60-day storage period at −18 °C with thawing every 5 days for 4 h at 25 °C. The physicochemical and rheological properties of wheat gluten-xanthan gum mixtures with multiple scales were analyzed. In the control samples (wheat gluten without xanthan gum), the molecular weight by size-exclusion chromatography-multiple angle laser light scattering (SEC-MALLs), content of free SH groups measured by UV/VIS spectrophotometry, and the hole sizes in the wheat gluten network structure shown by SEM increased as the freeze-thaw storage time increased, while the surface hydrophobicity index (H 0 ) decreased. For the wheat gluten-xanthan gum mixtures, more disulfide bonds were preserved and numerous small pores in the wheat gluten structure were observed. Meanwhile, the sample with 0.225% xanthan gum (w/w) had the lowest content of free SH groups. The wheat gluten-xanthan gum mixtures had more α-helixes than the control samples with the same freeze-thaw storage time. Rheological analysis showed that the wheat gluten-xanthan gum mixtures had higher elasticity and viscosity than the control samples. Overall, the addition of xanthan gum improved the freeze-thaw stability of the wheat gluten network.
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REACTIVE & FUNCTIONAL POLYMERS
·
2019
·
IF 3.074
Q. Zhang,X.M. Hu,M.Y. Wu,M.M. Wang,Y.Y. Zhao,T.T. Li
Poly(vinyl alcohol) (PVA)-xanthan gum (XG) hydrogel, which possesses good reusable absorption properties, has been prepared by the freezing–thawing method. Hydrogels prepared with different ratios compositions are characterized using Fourier transform infrared spectroscopy (FTIR) and Scanning electron microscope (SEM), and examined in terms of their swelling behavior, mechanical, rheological and adsorption properties. The results show that a shift in the major signals of FTIR for OH absorption, and with varied intensities in the FTIR spectra andmore and more wrinkles observed in SEM indicated cross-linked interaction by the polymers. All the features of the PVA-XG hydrogel are closely related to its rheological properties. The presence of XG visibly improves the swelling ratio of PVA-XG and reduces the compression properties of PVA-XG due to the formation of hydrogen bonds between the PVA and XG. PVA-XG-4 had the best adsorption of methylene blue (MB) dye, such enhancement in adsorption can be attributed to strong electrostatic attraction between XG and MB. The adsorption conformed to the second-order kinetic model and the adsorption process conformed to the Langmuir isotherm model. In addition, PVA-XG-4 exhibits a promising cycling absorption performance. The 1st and 5th cycle of dye removal for PVA-XG-4 reached to 92 and 80%, respectively. Provides basis for application in water treatment.
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MATERIALS & DESIGN
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2016
·
IF 3.997
Shunli Liu,Fang Yao,Mengmeng Kang,Siqi Zhao,Qianqian Huang,Guodong Fu
Light-weight and high-performance nanocomposites that contain reinforcements with preferred orientation have attracted significant attention. Here, a hierarchical, lightweight, and nacre-like graphene oxide (GO) and xanthan gum (XG) nanocomposite film was fabricated via a simple, rapid, economic, and green method. Graphene oxide and xanthan gum were used in making of “bricks and mortar” and forced to self-assemble into GO/XG-Fe(III) hydrogel via ferric ions coordination. Oriented and hierarchical GO/XG-Fe(III) nanocomposite film was obtained by drying the hydrogel. Due to the well-defined hierarchical structure and coordination bond, the GO/XG-Fe(III) nanocomposite film exhibited high strength of 93.6 ± 3.82 MPa. Accompanied by the mechanical strength, specific thermal conductivity on the parallel and perpendicular direction was obtained due to the anisotropy of the GO nanosheets in the nanocomposite film. Furthermore, the stability of the GO/XG-Fe(III) nanocomposite film against various organic solvents and acidic solution was demonstrated. It may enable these materials to be used in aerospace, electronic devices, biological membranes and scaffolds.
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CARBOHYDRATE POLYMERS
·
2012
·
IF 3.628
Haiping Li,Renfu Chen,Xiaomei Lu,Wanguo Hou
Rheological properties of aqueous solution containing xanthan gum (XG) and cationic cellulose JR400 were investigated at different composition ratio, shear rate, pH and electrolyte concentrations. It was found that the mixing of XG and JR400 can induce a viscosity-increasing effect for the mixed solution. As the concentration fraction ( f JR ) of JR400 in the mixed solution increases from 0 to 0.40 with the total polymer concentration ( c t ) of 1%, the solution transforms from an elastic fluid into a viscoelastic one, while as f JR decreases from 1 to 0.78, the solution transforms from a viscous fluid into a viscoelastic one. At pH 5–10, both the viscosity and elasticity of XG/JR400 mixture ( f JR = 0.15) are independent of pH and the viscosity-increasing effect is obvious. Outside this pH range, the viscosity, elasticity and viscosity-increasing effect of the mixture decrease. The increase of added NaCl concentration and shear rate can induce the decrease of viscosity, elasticity and viscosity-increasing effect of the XG/JR400 mixture.
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PubMed
高影响因子
JOURNAL OF FOOD ENGINEERING
·
2025
·
IF 5.8
Yue Chen,Shengqi Li,Na Zhang,Ke Zhang,Xiaoqiang Chen
Oleogels have significant potential for delivering lipid-soluble bioactive compounds. We here prepared a tea polysaccharide conjugate (TPC)-Xanthan gum (XG) complex using the emulsion template method and investigated its curcumin (Cur) loading capacity and in vitro digestion mechanisms. Results unveiled that XG interacts non-covalently with TPC, primarily through electrostatic interactions and hydrogen bonding, enhancing emulsion template formation and stabilization. In addition, XG improved the oleogel’s oil-binding capacity, gel strength, hardness, apparent viscosity, and other gel properties. Meanwhile, the complex oleogel-loaded Cur exhibited a high Cur encapsulation efficiency (>80%), increased antioxidant activity, an augmented free fatty acid release rate, and improved Cur bioaccessibility (>50%) and digestive stability. These findings provide a novel approach to designing oleogels for the effective delivery of lipid-soluble bioactive compounds.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Minglu Xu,Rongfeng Ge,Wenyu Wang,Yunqi Peng,Zhenchun Li,Wenhua Liu,Lei Wang
Highly stretchable strain sensors based on conductive polymer hydrogels are rapidly becoming promising candidates for various wearable skin and smart monitoring devices. However, due to the inherent limitations of low adhesion and large hysteresis, existing strain sensors are not able to realize their full potential in applications. In this study, we harnessed the self-polymerization capability of polydopamine (PDA) to encapsulate silica (SiO 2 ) and load Fe 3+ onto the surface of PDA, resulting in the formation of SiO 2 @PDA-Fe nanoparticles. We incorporated polyacrylamide (PAM), SiO 2 @PDA-Fe nanoparticles, MXene, and xanthan gum (XG) into the system, thereby creating a multifunctional conductive hydrogel (SiO 2 @PDA-Fe/MXene/XG/PAM) characterized by excellent self-adhesion, impressive mechanical properties (1680 % strain), lack of cytotoxicity, anti-swelling, photothermal capabilities, and antimicrobial effects. Furthermore, the hydrogel strain sensor constructed from SiO 2 @PDA-Fe/MXene/XG/PAM exhibits outstanding sensing properties, including high sensitivity (GF = 3.14), durability, and stability over 2500 cycles. This sensor was employed for human motion detection, effectively adapting to the complex movements of various joints while delivering stable and reliable physiological signal data. It also serves as a wearable medical patch to monitor vital signs such as Electrocardiogram (ECG) and Electromyography (EMG). Additionally, we designed a pressure sensor capable of detecting whether piglets are pressed by sows, offering a reliable concept to enhance piglet survival rates, which holds significant potential for practical applications.
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高影响因子
FOOD CHEMISTRY
·
2018
·
IF 4.946
Meixia Zheng,Fengli Lian,Yao Xiong,Bo Liu,Yujing Zhu,Song Miao,Longtao Zhang,Baodong Zheng
To improve the thermal stability and adsorption performance, xanthan gum was modified with acrylamide and trimethylolpropane triglycidyl ether (TTE). The modified xanthan gum (XGTTE) was characterized by Fourier transform infrared (FT-IR) spectroscopy, X-ray diffractogram (XRD), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The characteristic peaks at 3449, 1655, 1611 and 1420 cm −1 in the FT-IR confirm the modification. The XGTTE crystal grew well upon addition of TTE. The XRD and DSC data revealed that the XGTTE enhanced its thermal stability. Analysis of SEM revealed that the grafting introduced major changes on the microstructure making it porous and resulting in the adsorption of crystal violet (CV) with flocculation. The CV adsorption capacity of the hydrogel with different dosages of TTE (XGTTE2, XGTTE3, XGTTE4, XGTTE5 and XGTTE6) were between 28.13 with 35.12 mg/g. In addition, the adsorption capacity, thermal stability, and swelling property of XGTTE4 were the best.
研究领域:
高分子科学
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环境工程
·
材料化学
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Gels
·
2021
·Vol. 7
·期 4
·179
·
IF 4.702
Youjie Sheng,Canbin Yan,Yang Li,Yunchuan Peng,Li Ma,Qiuhong Wang
The foams stabilized by nanoparticles (NPs), water-soluble polymers, and surfactants have potential application prospects in the development of new, environmentally friendly firefighting foams. In the present study, a gel foam containing a water-soluble polymer (xanthan gum, XG), hydrophilic silica NPs, hydrocarbon surfactant (SDS), and fluorocarbon surfactant (FS-50) were prepared. The surface activity, conductivity, viscosity, and foaming ability of foam dispersions were characterized. The gel foam stability under a radiation heat source and temperature distribution in the vertical foam layer were evaluated systematically. The results show that the addition of NPs and XG has a significant effect on the foaming ability, viscosity and foam thermal stability, but has a very subtle effect on the conductivity and surface activity. The foaming ability of the FS-50/SDS solution was enhanced by the addition of NPs, but decreased with increasing the XG concentration. The thermal stability of the foams stabilized by SDS/FS-50/NPs/XG increased with the addition of NPs and increasing XG concentration. Foam drainage and coarsening were significantly decelerated by the addition of NPs and XG. The slower foam drainage and coarsening are the main reason for the intensified foam thermal stability. The results obtained from this study can provide guidance for developing new firefighting foams.Keywords:foam;thermal stability;xanthan gum;nanoparticle;surfactant
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2017
·
IF 1.591
Hong Zhang,Yongjun Lu,Bo Fang,Xiaohui Qiu,Wen Zhai,Liwei Wang,Hao Jin,Kejing Li
The crosslinking process of xanthan gum was studied under static and shear conditions. Conventional rotational rheometer was adopted to study the shear crosslinking process, and the static crosslinking process was monitored using an optical microrheometer without physical contact between the instrument and the sample. Both experiment and numerical simulation were adopted to compare the two gelation processes at different temperatures. The results showed that the effects of temperature on static and shear crosslinking processes of xanthan gum have the same trend and the rheological curves of the two gelation processes are similar in shape. The same rheokinetics equations were established to describe the two gelation processes and the simulated values are in good agreement with the experimental data. The changes of the model parameters with respect to temperature are quite similar for both the gelation processes, which verifies the feasibility of the microrheology method for measuring the static crosslinking reaction.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
·
IF 5.4
Wenbo Fu,Lu Sun,Xiaoming Zhang,Hualong Xu,Meiwen Cao
The effects of sodium dodecyl sulfate (SDS) and sodium dodecyl benzene sulfonate (SDBS) on the corrosion inhibition of xanthan gum (XG) on Q235 carbon steel were investigated. The corrosion inhibition performance was characterized by weight loss, kinetic potential polarization, electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM), and ultraviolet-visible spectroscopy (UV–vis) measurements. XG significantly reduced the corrosion rate of Q235 steel in HCl solution, and the corrosion rate decreased with increasing XG concentration. XG acted as a mixed inhibitor to inhibit corrosion by forming a protective adsorption layer on the metal surface. At a fixed SDS concentration, the XG/SDS mixture showed enhanced corrosion inhibition with increasing XG concentration, indicating that SDS had a synergistic effect on the corrosion inhibition of XG. In contrary, SDBS showed different behaviors in affecting the corrosion inhibition of XG. SDBS showed a synergistic effect on the corrosion inhibition at low XG concentrations, whilst further increasing XG concentration would not lead to a decreased anticorrosion performance. Structural variation in the adsorbed film formed by the XG/surfactant mixture on the metal surface is responsible for the anticorrosion performance. The study probes into the synergistic effects of surfactant on the ability of xanthan gum for metal corrosion inhibition, which is helpful for the development of more efficient and sustainable polymer/surfactant mixed corrosion inhibitors.
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