BIORESOURCE TECHNOLOGY
·
2015
·
IF 4.494
Yun Liu,Hua Zhou,Shihui Wang,Keqin Wang,Xiaojun Su
The effect of γ-irradiation pretreatment was compared with other pretreatment methods including ionic liquids (ILs), 1% HCl, 1% H 2 SO 4 , acidic aqueous Ils (AA-ILs), on the bioconversion efficiency of microcrystalline cellulose (MCC) for bioethanol production. The efficiency of MCC pretreatment followed with simultaneous saccharification and fermentation (SSF) was firstly evaluated according to the variations of the irradiation-derived compounds and structure of MCC, as well as yeast growth curve and bioethanol yield. Results showed that the appropriate irradiation dose (891 kGy used in our work) could eliminate the negative effect of toxic irradiation-derived compounds on SSF for ethanol bioconversion with the yield value of 67%. Analyses of SEM, FT-IR, reducing sugar and bioethanol yield showed that the efficiency of pretreatment on MCC was ILs ≈ irradiation pretreatment > AA-ILs pretreatment > 1% HCl pretreatment > 1% H 2 SO 4 pretreatment.
研究领域:
生物工程
·
可再生能源
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENZYME AND MICROBIAL TECHNOLOGY
·
2024
·
IF 3.4
Yuguang Wang,Mengjing Wu,Huifang Zheng,Dongmei Wu,Panpan Yao,Wenjing Li,Kexin Jin,Xinjun Yu
A strain high-performance of esterase producing bacteria was screened from soil, which could selectively hydrolyze D -homoserine lactone from its racemate to achieve the resolution of L - homoserine lactone with more than 99% e.e. in 48% yield. L -homoserine lactone building block was then converted to L -α-amino-γ-bromobutyronic acid chiral blocks, which reacted with various nucleophilic reagent modules could to be applied to prepare L -γ- substituted α-amino acids such as L -selenomethionine, L -methionine, L -glufosinate and L -selenocystine. Its advantages included high selectivity of biocatalytic resolution reactions, high optical purity of products, racemic recycle of D -substrates and modular reaction, which simplified the production process of these products and highlighted the power of biological manufacturing.
研究领域:
生物化学
·
生物制造
·
酶工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Yuting Yan,Yuhang Ge,Hanping Mao,Qirui Wang,Qinglin Li,Henan Li
The development of an innovative peroxidase mimic is crucial for achieving accurate and low-cost naked-eye detection for pesticide residues in agricultural products. Herein, a visual sensor for chlorpyrifos was engineered by employing γ-Fe 2 O 3 /thiophene-sulfur-doped graphene (γ-Fe 2 O 3 /t-SG) magnetic nanocomposite as an artificial nanozyme . The γ-Fe 2 O 3 /t-SG magnetic nanocomposite with single–crystalline structure was fabricated by a facile thermal-treatment strategy by controlling the annealing temperature between graphene oxide (GO) and ferric sulfate. Significantly, the resulting γ-Fe 2 O 3 /t-SG magnetic nanocomposite revealed the markable peroxidase-like activity toward 3,3,5,5-tetramethyl benzidine oxidation (TMB). A novel colorimetric method for the rapid detection of chlorpyrifos was developed based on the high enzyme-like activity of γ-Fe 2 O 3 /t-SG magnetic nanocomposite and the inhibition of acetylcholinesterase activity by chlorpyrifos. This colorimetric sensor demonstrated excellent performance in chlorpyrifos quantification, with a linear range from 0.5 to 1000 μg mL −1 and a detection limit of 0.17 μg mL −1 (S/N = 3). The stability, ease of separation, and high peroxidase-like catalytic activity of γ-Fe 2 O 3 /t-SG magnetic nanocomposite makes it as an ideal candidate for a wide range of potential applications as peroxidase mimetics.
研究领域:
分析化学
·
环境科学
·
农业科学
✓ 已验证
产品关联
DOI
高影响因子
TOXICOLOGY AND APPLIED PHARMACOLOGY
·
2013
·
IF 3.975
Zhaobin Zhang,Libei Sun,Ying Hu,Jian Jiao,Jianying Hu
Parabens are p -hydroxybenzoic acid esters that have been used extensively as preservatives in foods, cosmetics, drugs and toiletries. These intact esters are commonly detected in human breast cancer tissues and other human samples, thus arousing concern about the involvement of parabens in human breast cancer. In this study, an in vitro nuclear receptor coactivator recruiting assay was developed and used to evaluate the binding activities of parabens, salicylates and benzoates via antagonist competitive binding on the human oestrogen-related receptor γ (ERRγ), which is known as both a diagnostic biomarker and a treatment target of breast cancer. The results showed that all of the test parabens (methyl-, ethyl-, propyl-, butyl- and benzylparaben) possessed clear inverse antagonist activities on ERRγ, with a lowest observed effect level (LOEL) of 10 − 7 M and the 50% relative effective concentrations (REC50) varying from 3.09 × 10 − 7 to 5.88 × 10 − 7 M, whereas the salicylates possessed much lower activities and the benzoates showed no obvious activity. In silico molecular docking analyses showed that parabens fitted well into the active site of ERRγ, with hydrogen bonds forming between the p -hydroxyl group of parabens and the Glu275/Arg316 of ERRγ. As the paraben levels reported in breast cancer tissues are commonly higher than the LOELs observed in this study, parabens may play some role via ERRγ in the carcinogenesis of human breast cancer. In addition, parabens may have significant effects on breast cancer patients who are taking tamoxifen , as ERRγ is regarded as a treatment target for tamoxifen.
研究领域:
药理学
·
分子生物学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2013
·Vol. 15
·期 21
·8228-8236
·
IF 3.829
Shaofeng Zhang,Feng Ren,Wei Wu,Juan Zhou,Xiangheng Xiao,Lingling Sun,Ying Liu,Changzhong Jiang
Composite materials containing different components with well-defined structures may cooperatively enhance their performance and extend their applications. In this work, core–shell γ-Fe2O3@SnO2 hollow nanoparticles (NPs) were synthesized by a low-cost and environmentally friendly seed-mediated hydrothermal method. Firstly, the γ-Fe2O3 hollow NPs were synthesized by a template-free method. Then they were used as the cores for the growth of SnO2 shells. The thickness of the shell can be simply tailored by controlling the reaction time. Various techniques, including SEM, XRD, TEM and HRTEM, were employed to investigate the morphology, structure and formation process of the special core–shell hollow structures. The combination of magnetic semiconductor (γ-Fe2O3) and wide band-gap semiconductor (SnO2) endowed them with great potential to be used as recyclable photocatalysts. Experiments on photo-degradation of Rhodamin B (RhB) dye in the presence of the samples showed that the hybrid structures possessed higher photocatalytic activities than the monomer structures of SnO2 and γ-Fe2O3 materials indicating a strong coupling enhancement effect between the wide and narrow band-gap semiconductors. Moreover, the gas sensing tests of the γ-Fe2O3@SnO2 hollow NPs revealed that the samples exhibited fast response and recovery rates, which enable them to be promising materials for gas sensors.
研究领域:
材料科学
·
环境科学
·
纳米技术
✓ 已验证
DOI
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 2
·724-731
·
IF 2.936
Jun Luo,Ren Zheng Qiu,Zhi Sheng Yang,Yan Xiang Wang,Qi Feng Zhang
In this paper, γ-butyrolactone (GBL) solvent vapor post-annealing (SVPA) on CH3NH3PbI3 thin films is reported, aiming to improve the complete transformation of PbI2 and increase the grain size of the CH3NH3PbI3 crystal, thus boosting the performance of mesoporous CH3NH3PbI3 perovskite solar cells (PSCs). The influence of GBL SVPA on the microstructure of perovskite layers and performance of PSCs was studied. The short circuit current density (Jsc) of the devices significantly increased, yielding a high efficiency of 16.58%, which was 27.05% higher than that of thermally annealed films. A model was derived to explain the effect of GBL SVPA on PSCs. The perovskite films prepared by this method present several advantages such as complete transformation of PbI2 to CH3NH3PbI3, high crystallinity, large grain size, and fewer grain boundaries than those prepared without GBL SVPA. This improvement is beneficial for charge dissociation and transport in hybrid photovoltaic devices.
研究领域:
材料科学
·
能源技术
✓ 已验证
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Jia Liu,Boning Zhang,Haifeng Yang,Ye Ying
Due to the small molecular weight and low Raman activity of γ-Aminobutyric acid (GABA), a Schiff base reaction was introduced. 4-mercaptobenzaldehyde (4-MBA) was assembled onto AuNPs via Au-S bond to form functional nanoparticles (AuNPs@4-MBA). Then, under certain conditions, it reacts with GABA to form a Schiff base, which increases the Raman scattering cross section area and enhances the Raman signal of GABA. In addition, because 4-MBA was assembled on AuNPs in advance through Au-S bond, the characteristic peak at 1080 cm −1 was selected as the internal standard, and compared with the characteristic peak at 1560 cm −1 of the newly generated C=N double bond. A linear standard curve was drawn between the peak intensity ratio of I 1560 /I 1080 and the concentration of GABA. The proposed material has a good linear relationship between 1 × 10 −5 and 1 × 10 −9 mol/L, R 2 was 0.9942, and the detection limit was 3.2 × 10 −11 mol/L. SERS detection of GABA was realized, and it was successfully applied to the detection of GABA in human serum that has important application value for future practical.
研究领域:
分析化学
·
生物医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
·
2017
·Vol. 34
·期 3
·1600430
·
IF 4.474
Jie Wang,Jielin Rong,Zhong Fang,Mozhen Wang,Anila Asif,Qichao Wu,Xiao Zhou,Xuewu Ge
Biosafe nanoparticles with strong near-infrared (NIR) light photothermal conversion effect can bring effective hyperthermia as one of the promising approaches in cancer therapy. In this work, a new facile and green preparation method of polypyrrole (PPy) nanoparticles based on 60 Co γ-ray radiation on a simple air-saturated strong acidic aqueous solution of pyrrole (pH ≤ 1) is studied. According to the MCAP-FACSIMILE simulation on the concentrations of the radiolysis products of water at the presence of H + and O 2 , the main strong oxidative radiolysis products · OH and H 2 O 2 rapidly induce the polymerization of pyrrole. The size of the prepared PPy nanoparticles is about several tens of nanometers and can be controlled by the pH, the concentration of the stabilizer poly(vinyl alcohol), and the absorbed dose rate (the amount of energy absorbed per unit mass of the irradiated material within per unit of time). The PPy nanoparticles show rapid and remarkable NIR (808 nm) photothermal conversion efficiency up to 40.1% in water. Furthermore, the in vitro and in vivo experiments confirm that the prepared PPy nanoparticles exhibit enough strong NIR photothermal effect in tumor cells (4T1 and HeLa) and show a promising prospect as the NIR photothermal agent for the future cancer therapy.
研究领域:
材料科学
·
生物医学工程
·
肿瘤学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2014
·Vol. 5
·期 7
·5164-5172
·
IF 3.708
Yuhao Xiong,Fanggui Ye,Cong Zhang,Shufen Shen,Linjing Su,Shulin Zhao
A novel and inexpensive approach was adopted to develop magnetic porous γ-Fe2O3/C@HKUST-1 composites for the adsorption of dyes and heavy metal ions from aqueous solution. The γ-Fe2O3/C with unique functional groups present such as –OH and –NH2 was used as the support to directly grow HKUST-1 by a stepwise liquid-phase epitaxy process. The crystallographic, morphology, and magnetic properties as well as porosity of the as-synthesized γ-Fe2O3/C @HKUST-1 composites were carefully studied by XRD, SEM, TEM, XPS, TGA, and BET. The results indicated that the BET surface area, micropore volume, and saturation magnetization of the γ-Fe2O3/C @HKUST-1 are 993.4 m2 g−1, 0.69 cm3 g−1, and 12.6 emu g−1, respectively. In addition, a uniform distribution of ultrafine γ-Fe2O3 nanoparticles with an average diameter of 2–3 nm was observed in the γ-Fe2O3/C@HKUST-1 composites. Our results showed that methylene blue (MB) and Cr(VI) (used as a model for typical dye pollutants and heavy metal ions) are effectively removed from aqueous solutions by γ-Fe2O3/C@HKUST-1. The maximum adsorption capacities were 370.2 and 101.4 mg g−1 of adsorbent for MB and Cr(VI), respectively. Moreover, a removal efficiency of about 90% was retained after five cycles of consecutive adsorption–desorption. The adsorption kinetics data were well described by a pseudo-second-order model (R2 > 0.99), and equilibrium data were well fitted to the Langmuir isotherm model (R2 > 0.99). Finally, our results suggested that the γ-Fe2O3/C@HKUST-1 composites have a great potential to be employed for treatment of wastewater containing MB and Cr(VI).
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Guanying Shi,Wenyu Gao,Zuobing Xiao,Le Zhang,Pengfei Jiang,Lili Zhao,Zhaogai Wang,Zhimin Xu
γ-Glutamyl transpeptidase (GGT) in Toona sinensis shoot (TS) was extracted and purified through salt precipitation, ion-exchange column, and gel filtration chromatography methods. The GGT had two peptides with M.W. 35 and 50 kDa. Its function in the formation of TS sulfur-containing volatiles (SCVs) was evaluated. The highest GGT hydrolytic activity was at pH 7.0 and 50 °C. Its activity was enhanced by Ca2+, Mg2+, K+, Na+, and Ba2+ and reduced by Cu2+, Fe3+, Mn2+, and Zn2+. The SCVs reached the highest level at GGT to TS sulfur-containing precursors extract 1:20. The aroma produced by GGT from the extract was similar to that of raw TS, especially for the cooked onion-like/TS-like flavor. These results revealed the characteristics and function of GGT in TS on sulfurous aroma formation. It could be applied to retrieve the production of sulfur-containing aroma from thermally preserved TS or similar vegetables, which lost GGT activity irreversibly during heat drying.
研究领域:
植物生物化学
·
食品科学
·
酶学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small Methods
·
2019
·Vol. 3
·期 10
·1900187
·
IF 0
Aruuhan Bayaguud,Zhibo Zhang,Maoning Geng,Yanpeng Fu,Yan Yu,Changbao Zhu
The development of cathode materials with high Li storage capacity and fast Li-ion diffusion kinetics is considered to be a promising way to extend the energy and power densities of Li-ion batteries (LIBs). As potential high-capacity cathode materials for LIBs, polyoxometalates (POMs) suffer greatly from inherent drawbacks. Therefore, another possibility for the application of POMs in LIBs is shown, which is to transform POMs into relevant 3D porous Li-containing oxides. Here, a unique 3D porous γ-LiV 2 O 5 film is successfully prepared by combining the electrostatic spray deposition technique and the POM as a precursor. Outstanding high capacity with stable cycling performance and excellent rate capability is realized based on 3D porous nanostructure and thin-film morphology, which effectively facilitate the transport of both lithium ion and electron. Moreover, this work demonstrates the feasibility of achieving high-performance metal oxide cathode by the transformation of POMs and also shows the superiority of γ-phase over α-phase as a starting cathode material in LIBs as well.
研究领域:
材料科学
·
能源存储与转换
✓ 已验证
DOI
JOURNAL OF POWER SOURCES
·
2024
·
IF 8.1
Hongsheng Liu,Hengyue Li,Bin Huang,Yange Yang,Haibo Guo,Yan Xiao,Weiguang Yang
To enhance the proton conductivity and durability of Ce-based hybrid proton exchange membranes (PEMs), this study fabricates modified perfluorosulfonic acid (PFSA) hybrid membranes by incorporating the dual-function γ-AlOOH@Ti-supported CeO 2 composite oxide (γ-AlOOH@Ti/CeO 2 ). In addition to combining the inherent proton conductivity of γ-AlOOH with the excellent radical scavenging ability of CeO 2 , both the proton conductivity and durability of Ce-based PEMs are further improved by introducing Ti-dopant, which not only increases hydrogen vacancies on the surface of γ-AlOOH, which facilitate proton conduction, and induces electron transfer from γ-AlOOH@Ti to CeO 2 , which enhance free radical adsorption. As results shown, the proton conductivity and the fluoride release value of the resulting hybrid membrane are about 76 % higher and 35.25 % lower than those of the PFSA-CeO 2 membrane, respectively. Moreover, the performance of cells shows that, after accelerated degradation testing, the PFSA-γ-AlOOH@Ti/CeO 2 membrane exhibits the lowest peak power density decrease rate, the impedance increase rate and hydrogen crossover current density, with 11.79 %, 27.54 % and 3.04 mA cm −2 , respectively. These results suggest that compared to CeO 2 -hybrid PEMs, γ-AlOOH@Ti/CeO 2 -based hybrid PEMs exhibit higher proton conductivity and superior chemical stability, indicating the potential application of γ-AlOOH@Ti/CeO 2 -based hybrid PEMs in proton exchange membrane fuel cells.
研究领域:
材料科学
·
能源化学
·
电化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）