Food & Function
·
2023
·
IF 6.1
Pengkui Xia,Mengge Zhao,Hong Jin,Tao Hou,Zhichang Deng,Mengting Zhang,Qiaoyun Zhou,Fuchao Zhan,Bin Li,Jing Li
Curcumin has been proved to be an effective strategy to reduce inflammatory responses. However, low bioavailability and instability at physiological pH have limited its anti-inflammation in ulcerative colitis patients. In the present study, the complex of curcumin and konjac glucomannan (KGM) could inhibit intestinal inflammation more effectively and this effect was associated with KGM degradation degrees. Results demonstrated that treatment with complex markedly mitigated colitis symptoms and decreased the inflammatory cytokines levels, especially in the complex treatment groups with K110 (KGM treated in 110 ℃) and konjac oligosaccharides (KOS). Furthermore, increasing KOS content in KOC (complex of curcumin and KOS) promoted the gene expressions of intestinal barrier and inhibited the gene expressions of inflammatory cytokines as well as improved gut microbiota dysregulation. Overall, our researches suggest that the complex of curcumin and KGM exerts more effective anti-inflammatory effects via regulating the intestinal immune response and modulating microbiota diversity and composition.
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高影响因子
FUEL
·
2023
·
IF 7.4
Shiqin Sun,Yanshun Li,Ruixiang Sun,Luzhen Jiao,Shiwei Liu,Shitao Yu
A novel Zn-based acidic functionalized deep eutectic solvent (DES) catalyst were prepared by a “tailoring” mixing procedure of Brønsted acidic hydrogen bond donors (HBD) and Lewis acidic hydrogen bond acceptor (HBA). It is found that the hydrogen bonded cluster with thermal stability and adjustable acidity has an excellent flexible hydrogen bond “assembly mode”, providing a suitable coordination microenvironment for Zn active center. The functionalized DESs were investigated to produce caprolactam from cyclohexanone oxime. The results showed that DES [ZnCl 2 ][ChCl][TCA] 2 had an excellent catalytic performance for the reaction with 100% cyclohexanone oxime conversion and ε-caprolactam 99.4% selectivity at 80 °C for 1.5 h, attributing to the strong complexing ability of Zn active center and the synergistic effect of BrØnsted and Lewis acid sites of DES, which also decreased the energy barriers of the intermediates and transition states, thus reducing the reaction energy ( E a = 29.22 kJ mol −1 and Δ G = –32.8 kJ mol −1 ). Otherwise, the recovered DES [ZnCl 2 ][ChCl][TCA] 2 was reused seven times with no significant decrease in its catalytic performance. The advantages of this method, such as high yield, short reaction time, and easy catalyst recovery, make the DES catalytic system a potential method for Beckmann rearrangement.
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ACS Omega
·
2023
·
IF 4.1
Yunhui Liao,Feng Chen,Haishan Tang,Wubliker Dessie,Zuodong Qin
Aucubin (AU) is an active ingredient that exerts strong antioxidant and anti-inflammatory effects in the treatment of several diseases. In order to improve the efficiency of resource utilization of traditional biomass waste, Eucommia ulmoides seed-draff (EUSD) waste biomass was used as the raw material, and a series of deep eutectic solvents were selected to evaluate the extraction efficiency of aucubin from EUSD. A response surface experiment was designed based on a single-factor experiment to optimize the extract conditions. The results showed that the best conditions for aucubin extraction were an HBD–HBA ratio of 2.18, a liquid–solid ratio of 46.92 mL/g, a water percentage of 37.95%, a temperature of 321.03 K, and an extraction time of 59.55 min. The maximum amount of aucubin was 156.4 mg/g, which was consistent with the theoretical value (156.8 mg/g). Then, the performance of 12 resins for adsorption and desorption was contrasted. The results revealed that HPD950 resin exhibited the best performance, with an adsorption capacity of 95.2% and a desorption capacity of 94.3%. Additionally, the pseudo-second-order model provided the best match to the kinetics data, the Langmuir model provided the best fit to the isotherm data, and adsorption was a beneficial, spontaneous, exothermic, and physical process. In the recyclability test, the HPD950 resin had great potential and excellent sustainability in aucubin recovery. In the antioxidant activity study, the aucubin extract exerted a strong antioxidant ability with scavenging capabilities for four free radicals. Furthermore, the antifungal activity study found that the aucubin extract exhibited a good antifungal effect against 5 tested pathogens. The research results can provide a theoretical basis for the extraction of high-value components from waste biomass by deep eutectic solvent and a certain application value for the development and utilization of natural aucubin products.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2021
·
IF 5.279
Yina Huang,Qin Yang,Xuan Mi,Liang Qiu,Xueying Tao,Zhihong Zhang,Jun Xia,Qinglong Wu,Hua Wei
Ripened Pu-erh tea (RPT) has been shown to be an effective natural ingredient to defend against experimentally induced colitis. We hypothesized that RPT would alleviate dextran sulfate sodium (DSS) induced colitis via modulating intestinal microbiota. The effect of RPT on mice gut microbiota was evaluated using 16S rRNA gene amplicon sequencing, broad-spectrum antibiotic (ABX) treatment, and fecal microbiota transplantation (FMT). Pretreatment with RPT enhanced intestinal barrier function, reduced colonic and serum proinflammatory cytokine and macrophage infiltration, and preserved the resilience of gut microbiota in mice during a DSS challenge. Administration of either RPT-regulated or healthy control-derived gut microbiota showed similar protection against colitis, and such protection could not be recapitulated with fecal microbiota from ABX-treated mice, suggesting a key role of protective consortium in the disease protection. Mechanistically, cecal contents of short-chain fatty acids (SCFAs) and colonic peroxisome proliferator activated receptor-γ (PPAR-γ) expression in colitis mice increased significantly by RPT intervention. Collectively, RPT treatment improved DSS-induced colitis by partially reversing the dysbiosis state of gut microbiota, which might be associated with an increase in SCFA level and PPAR-γ expression.
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FOOD AND CHEMICAL TOXICOLOGY
·
2021
·
IF 6.025
Qiuhong Kong,Ruifen Zhang,Lijun You,Yongxuan Ma,Lan Liao,Sandra Pedisić
In this study, polysaccharides from Sargassum fusiforme (SFP) were obtained by cellulase assisted hot water extraction. The chemical composition, structural characteristics, and in vitro fermentation properties of SFP were investigated. Results showed that the contents of total carbohydrate , protein, uronic acid and sulfate in SFP were 83.25%, 1.42%, 12.80% and 7.81%, respectively. It mainly consisted of fucose glucose and galactose , with molecular weight of 255.83 kDa. UV spectrum, FTIR , SEM and AFM results showed that SFP was a typical sulfate polysaccharide with relative smooth surface and regular shape. After in vitro fermentation for 24 h, the pH value of fermentation medium declined significantly ( p < 0.05), utilization of carbohydrate was 53.17%. The contents of total SCFAs increased by 10.77 times. Moreover, SFP fermentation could change obviously the microbiota composition. It significantly increased the abundance of Faecalibacterium (increased by 49.07% compared with the Blank24 group) , Phascolarctobacterium (increased by 88.06%) , Bifidobacterium (increased by 139.13%), Ruminococcaceae_UCG-014 (increased by 177.78%) , and Lactobacillus (increased by 400.00%) , decreased the abundance of Prevotella_9 (decreased by 34.54%) and Blautia (decreased by 40.79%) at genus level. These results showed that SFP could be utilized by microbiota in human feces, and may have the potential to improve intestinal health.
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Materials Today Communications
·
2021
·
IF 3.383
Xuping Wang,Pengfei Zhou,Xiaojing Lv,Yongjia Liang
Recently, the development of solution processing of chitin/chitosan in natural deep eutectic solvents (NADESs) is one of the most promising strategies for handling insoluble biopolymers. A facile and efficient approach including choline chloride-based and betaine-based NADESs, were designed as solvents for chitin/chitosan with various degree of deacetylation (DD). The maximum solubility of chitin/chitosan (10.2 g/100 g) was obtained in NADESs composed of choline chloride-lactic acid (ChLa). The relationships between the solubility, crystallinity index (CrI), and DD of the dissolved chitin/chitosan with different pH values of NADESs were discussed, and the results indicated that DD of chitin/chitosan dominated its solubility. Furthermore, mechanistic analysis showed that the hydrogen-bonding interactions contained NH⋯OH or OH⋯OH between chitin and NADESs was the possible reason for better solubility of chitin in ChLa. The NADESs-chitin processing platform in this text reveals the potential of NADESs for the environmentally-aware research and developing chitin-based industrial processes and products.
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JOURNAL OF HAZARDOUS MATERIALS
·
2021
·
IF 10.588
Xiaofang Li,Susu Zhang,Ying Wu,Luying Jiang,Wenxi Zhang,Xiaoqiang Qiao,Hongyuan Yan,Hongjian Zhou,Baokun Tang
DNA toxic compounds (DNA-T-Cs), even in trace amounts, seriously threaten human health and must be completely eliminated. However, the currently used separation media face great challenges in removing trace DNA-T-Cs. Based on the functional advantages of deep eutectic solvents (DESs) and the natural features of biomass (BioM), a series of Poly(DES)@BioMs functioning as adsorbents were prepared for the removal of aromatic/hetero-atomic DNA-T-Cs at the ppm level. After optimisation of experimental conditions, the removal efficiency for DNA-T-Cs ranged from 92.4% to 96.0% with an initial concentration of 20.0 ppm, a temperature of 30 °C, duration of 30 min, and pH of 7.0. The removal processes between the DNA-T-Cs and Poly(DES)@BioMs are well described in the Temkin equilibrium and second-order kinetic adsorption models, and the desorption processes are well shown in the Korsmeryer–Peppas equilibrium and zero-order kinetic models. Molecular simulations revealed that the removal interactions include hydrogen bonding, π–π stacking, and hydrophobic/hydrophilic effects. The removal efficiency for the DNA-T-Cs at 8.0 ppm in industrial sewage ranged from 69.7% to 102%, while the removal efficiency for the DNA-T-Cs standing alone at 20.0 ppm in a methyl violet drug solution was 95.4%, confirming that the Poly(DES)@BioMs effectively removed trace DNA-T-Cs in field samples.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2021
·
IF 5.816
Wei-Chang Chen,Gang Yang,Yue Zhao,Gao-Qing Yuan,Jian-Shan Ye,Hai-Yang Liu,Xin-Yan Xiao
This work has manufactured a series of M-N X /C (M = Fe, Cu, Ni) ORR catalysts by the pyrolysis of metal tetraphenylporphyrin (MTPP) adsorbed onto N-doped porous carbon polyhedrons (NPCP) derived from ZIF-8. The comprehensive characterization data shows that the prepared M-N X /C catalysts have hierarchical porous structure with high specific surface area and abundant M-N X moieties. All prepared M-N X /C catalysts exhibit good ORR performance. The ORR half-wave potentials E 1/2 of Fe-N X /C, Cu-N X /C and Ni-N X /C catalyst are 0.885, 0.801 and 0.755 V respectively. The rotating ring-disk electrode (RRDE) test reveals that the ORR of Fe-N X /C is a four electron process. While a two and four electron mixing ORR process are observed for Cu-N X /C and Ni-N X /C. In an alkaline medium , E 1/2 of Fe-N X /C is observed 44 mV higher than that of commercial Pt/C. Also, Fe-N X /C catalyst has outstanding long-term durability and good methanol resistance.
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JOURNAL OF SOLID STATE CHEMISTRY
·
2021
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IF 3.498
Tian Zhao,Hexin Zhu,Wei Geng,Minmin Zou,Ming Dong,Jie Ying
Propionic acid could efficiently affect the formation of Cr-benzenedicarboxylate metal-organic frameworks (MOFs), giving rise to yielding products with various structures. Generally, nano-sized crystals of MIL-101(Cr) can be prepared with comparatively lower concentration of propionic acid (0.6 M), which possessed high porosity (S BET = 2720 m 2 /g). The hierarchically porous (HP) MIL-101(Cr) was obtained with medium concentration of propionic acid (1.2 M), and micro-rod like crystals of MIL-88B(Cr) was formed in high concentration of propionic acid (1.8 M). Compare to bulk MIL-101(Cr) and nano-sized MIL-101(Cr), HP-MIL-101(Cr) showed much higher uptake of methylene blue (119.1 mg/L) in aqueous. This approach can offer a facile and effective pathway to synthesize stable hierarchically porous Cr-benzenedicarboxylate MOF for the applications in pollutant treatment fields.
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Journal of Functional Foods
·
2021
·
IF 4.451
Xiaolan Chen,Bingyan Cai,Jing Wang,Zhicun Sheng,Haifeng Yang,Dada Wang,Jiahao Chen,Qingqing Ning
Mulberry leaf polysaccharide (MLP) possess many biological characteristics, such as immunomodulatory and antioxidant properties, but whether MLP can impact the distribution and characteristics of the gut microbiota is not yet clear. In this study, the effects of MLP on diversity- and immune-related factors and short-chain fatty acids (SCFAs) of the gut microbiota in mice were investigated. The results showed that MLP could restore the indexes of the thymus and spleen, the damaged intestinal barrier and levels of inflammatory cytokines in cyclophosphamide (CTX)-treated mice, and alleviate oxidative damage to the liver. Additionally, MLP were associated with a relatively higher abundance of Bacteroidetes but lower levels of Firmicutes, Butyricimonas and Eubacterium in CTX-treated mice. Moreover, MLP restored the levels of acetic acid, propionic acid, and n-butyric acid reduced by CTX. These results indicated that MLP, as a special ingredient, might regulate the immune response by altering the spatial structure of the gut microbiota and the production of SCFAs.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2021
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IF 4.952
Xiao-Guo Ji,Kun-Lin Chang,Mai Chen,Liang-Liang Zhu,Arwa Osman,Hao Yin,Li-Ming Zhao
Chitooligosaccharides (COS), with a specific degree of polymerization, were evaluated for their effect on human fecal microbiota, as well as their metabolite, using an in vitro anaerobic batch fermentation model. COS increased the richness and diversity of the gut microbial community. More importantly, the microbial community structure of the COS groups was significantly different from the control and fructooligosaccharides (FOS) groups. COS specifically enriched the butyric and propionic acid-producing microbiota and targeted Faecalibacterium , Clostridium_sensu_stricto_1 , C._sensu_stricto_13 , and Fusicatenibacter . Furthermore, COS increased the acetic, propionic, and butyric acid contents. The production of propionic acid was greater than that obtained using FOS. Metabolome analysis suggested that COS could upregulate allocholic acid, 1,3-butanediol, 3,4-dihydroxybutanotic acid, and 2-hydroxybutyric acid production and downregulate putrescine, ethanamine, hexanoic acid, and branched chain amino acid ( l -valine and l -leucine) production in the fermentation broth. These differential metabolites were closely related to lipid, glucose, and amino acid metabolism. These results should inform further development of COS as potential raw materials for functional foods and health products.
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JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
·
2021
·Vol. 25
·期 04
·298-306
·
IF 1.811
Dingwa Zhang,Xueren Huang,Jiangen Huang,Yuting Li,Jinhua Cai
Porphyrin nanostructures are widely used in the field of visible light catalysis due to their superior light absorption properties and good controllability in size, shape and function. In this paper, the development of various morphologies in three types of porphyrins with three different phenyl substituents (designated as H 2 TTP, H 2 TPP and H 2 TCPP, respectively) is demonstrated. The formation mechanism proposed was based on the evolution of morphology as functions of molecular structure and solvent mixture. These nano/micro assemblies are well characterized by SEM, IR, UV-vis, X-ray diffraction and photoelectric conversion. The photocatalytic oxidation reactions under visible light irradiation of 1,5-dihydroxynaphthalene (DHN) in water is utilized to evaluate the photoactivity of the as-prepared porphyrin assemblies. The photocatalytic results indicate that the obtained porphyrin assemblies exhibit enhanced visible-light photocatalytic activity. In addition, the photocatalyst is easy to separate and recover, and has good stability. The possible photocatalytic degradation mechanism of DHN by the porphyrins nanopolyhedron photocatalyst was also proposed.
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