JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
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2016
·Vol. 72
·期 4
·464-472
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IF 5.476
Zheng Shan-Qing,Huang Xiao-Bing,Xing Ti-Kun,Ding Ai-Jun,Wu Gui-Sheng,Luo Huai-Rong
Coffee and tea, two of the most popular drinks around the world, share many in common from chemical components to beneficial effects on human health. One of their shared components, the polyphenols, most notably chlorogenic acid (CGA), was supposed to account for many of the beneficial effects on ameliorating diseases occurred accompanying people aging, such as the antioxidant effect and against diabetes and cardiovascular disease. CGA is also present in many traditional Chinese medicines. However, the mechanism of these effects was vague. The aging signaling pathways were conservative from yeast and worms to mammals. So, we tested if CGA had an effect on aging in Caenorhabditis elegans. We found that CGA could extend the lifespan of C. elegans by up to 20.1%, delay the age-related decline of body movement, and improve stress resistance. We conducted genetic analysis with a series of worm mutants and found that CGA could extend the lifespan of the mutants of eat-2, glp-1, and isp-1, but not of daf-2, pdk-1, akt-1, akt-2, sgk-1, and clk-1. CGA could activate the FOXO transcription factors DAF-16, HSF-1, SKN-1, and HIF-1, but not SIR-2.1. Taken together, CGA might extend the lifespan of C. elegans mainly via DAF-16 in insulin/IGF-1 signaling pathway.
研究领域:
生物化学
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分子生物学
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衰老研究
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DOI
PubMed
高影响因子
GREEN CHEMISTRY
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2016
·Vol. 18
·期 10
·3075-3081
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IF 8.506
Dezhang Ren,Zhiyuan Song,Lu Li,Yunjie Liu,Fangming Jin,Zhibao Huo
A novel approach for the production of 2,5-hexanedione (HDN) and 3-methyl-2-cyclopenten-1-one (3-MCO) from 5-hydroxymethylfurfural (HMF) by water splitting with Zn is reported for the first time. The use of high temperature water (HTW) conditions is the key for the efficient conversion of HMF to HDN and 3-MCO. Parameters regarding the Zn amount, temperature and reaction time are optimized and HDN and 3-MCO are produced in 27.3% and 30.5% yields, respectively. The roles of HTW and ZnO obtained by oxidation of Zn in water for the conversion of HMF, together with intermediate structures, are discussed to understand the mechanism of the reaction.
研究领域:
化学工程
·
有机化学
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DOI
高影响因子
BIODEGRADATION
·
2018
·Vol. 29
·期 2
·129-140
·
IF 2.41
Mao Fei,Liu Xiaohong,Wu Kang,Zhou Chen,Si Youbin
Because of extensive sulfonamides application in aquaculture and animal husbandry and the consequent increase in sulfonamides discharged into the environment, strategies to remediate sulfonamide-contaminated environments are essential. In this study, the resistance of Shewanella oneidensis MR-1 and Shewanella sp. strain MR-4 to the sulfonamides sulfapyridine (SPY) and sulfamethoxazole (SMX) were determined, and sulfonamides degradation by these strains was assessed. Shewanella oneidensis MR-1 and Shewanella sp. strain MR-4 were resistant to SPY and SMX concentrations as high as 60 mg/L. After incubation for 5 days, 23.91 ± 1.80 and 23.43 ± 2.98% of SPY and 59.88 ± 1.23 and 63.89 ± 3.09% of SMX contained in the medium were degraded by S. oneidensis MR-1 and Shewanella sp. strain MR-4, respectively. The effects of the initial concentration of the sulfonamides and initial pH of the medium on biodegradation, and the degradation of different sulfonamides were assessed. The products were measured by LC–MS; with SPY as a substrate, 2-AP (2-aminopyridine) was the main stable metabolite, and with SMX as a substrate, 3A5MI (3-amino-5-methyl-isoxazole) was the main stable metabolite. The co-occurrence of 2-AP or 3A5MI and 4-aminobenzenesulfonic acid suggests that the initial step in the biodegradation of the two sulfonamides is S–N bond cleavage. These results suggest that S. oneidensis MR-1 and Shewanella sp. strain MR-4 are potential bacterial resources for biodegrading sulfonamides and therefore bioremediation of sulfonamide-polluted environments.
研究领域:
环境科学
·
微生物学
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DOI
PubMed
高影响因子
eScience
·
2023
·
IF 0
Yuxuan Wang,Wen Chen,Jingchao Fu,Yueli Liu
Adsorbent-assisted air water harvesting (AWH) may help alleviate the current global freshwater scarcity crisis. However, the weak sorption capacity of various adsorbents and the high energy required to release water are two long-standing problems. Herein, we propose a class of green and clean adsorbent, TpPa-1@LiCl composite, whose sorption capacity is greatly improved to 0.37 and 0.80 g g −1 under 30% and 90% relative humidity (RH), respectively, and which has excellent stability, showing only a slight decrease (0.79%) after 10 sorption–desorption cycles (1400 min). This TpPa-1@LiCl composite can reach equilibrium within 2 h and undergo complete desorption in 30 min under air mass 1.5 G irradiation. A corresponding solar-driven AWH device can complete up to 4 sorption–desorption cycles per day, with each cycle capable of collecting 0.34 g g −1 water without additional energy input, which implies TpPa-1@LiCl composite has the potential for achieving sorption-assisted AWH with high efficiency and rapid cycling.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
MICROPOROUS AND MESOPOROUS MATERIALS
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2020
·
IF 4.551
Yuanchao Shao,Hongjuan Wang,Xuefei Liu,Philip Ryan Haydel,Tianduo Li,Jianbin Chen,Peng Huang,Qiang Xiao,Takashi Tatsumi,Jingui Wang
Hierarchically porous zeolites are a type of very hot catalyst with improved catalytic performances as compared with conventional microporous-only zeolites due to the improved mass transportation among the hierarchical meso/macropores, which are expected to be the next-generation catalysts for conversion of bulky molecules and/or polymers. Moreover, hierarchical zeolites with the single crystalline structure that is an identical registry of micropores within the entire particle identified the less pore blockage and less diffusion limitation compared to an aggregated structure of nano-zeolites. The developed synthetic methods were mostly conducted in a liquid-phase system and usually required expensive additives, such as silanes or mesoporogons, etc. Finding facile and cost-effective synthetic methods have been still challenging. Here, a facile and cost-effective strategy by controlling the growth/crystallization in a solidified hydrogel system was reported for the synthesis of Ti-containing MFI-type zeolites (TS-1) to simultaneously achieve hierarchical porosity , single-crystalline structure, and high catalytic performance in alkene oxidations . The synthesized zeolites were characterized by XRD , SEM, TEM , Nitrogen adsorption analysis, DRUV spectroscopy, IR spectroscopy , etc. The growth processes were also tracked and well-characterized. It was found that the solid-phase transformation mechanism was dominated for forming the hierarchical structure. This strategy could directly produce TS-1 with abundant intracrystalline continuous mesopores and large amounts of active framework titanium species, contributing to higher activity for epoxidation of alkenes compared to the traditional microporous-only TS-1 zeolites.
研究领域:
催化
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材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
Materials Today Energy
·
2024
·
IF 9
Xiaotong Liu,Zheng Han,Siying Zhao,Haoqing Tang,Tian Tian,Qiang Weng,Xiaohuan Liu,Tao Liu
Aqueous zinc-ion batteries (AZIBs) are considered to be one of the alternatives for large-scale energy storage devices due to unique advantages. However, the harmful Zn dendrites generation of Zn anodes seriously hinders the development of AZIBs. Herein, Cu 3 (BTC) 2 (HKUST-1) as a compact functional interface layer on the surface of bare Zn foil is shown to improve the reversibility of Zn-plating/stripping process. Interestingly, HKUST-1 possesses high porosity, large number of water molecule vacancies, and Cu active center, which help to enhance the diffusion kinetics of Zn 2+ and reduce the surface free energy of Zn electrode. Combining theoretical calculations with experiments, the HKUST-1 can contribute to the desolvation process of Zn[(H 2 O) 6 ] 2+ and balance Zn 2+ concentration, which thus accelerate Zn 2+ transfer kinetics, lower interfacial energy, and homogenize ion-distribution. Attributed to these superiorities, the HKUST-1@Zn symmetric cells demonstrate excellent stable plating/stripping for over 250 h under ultra-high current density (20 mA/cm 2 and 20 mAh/cm 2 ). Furthermore, a HKUST-1@Zn||MnO 2 full cell exhibits an enhanced long-cycling performance with a discharge capacity of 114 mAh/g after undergoing 500 cycles. All results demonstrate the potential application of HKUST-1 coating in AZIBs.
研究领域:
材料科学
·
电化学
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产品关联
DOI
高影响因子
Chemical Engineering Journal Advances
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2022
·
IF 0
Hiu Lam So,Wei Chu
Degradation of 1-Naphthol by combined photocatalysis and adsorption in column reactor was studied, and the performance could be predicted by employing a proposed multiple regression model. The model includes four variables: concentration of 1-Naphthol, concentration of peroxymonosulfate (PMS), FeOOH dosage and pH, along with their second-order effects and interactions. Statistical analyses were performed to verify the statistical significance of the regressors, and extra experimental sets were conducted to validate the proposed model. The mathematical model proposed exhibited good reproducibility with no significant statistical difference between the experimental and predicted values. Response surface methodology was used to explore the relationship between the four variables and the response. The process optimal ranges can be further refined at pH 2–2.5; [PMS] = 1.2–1.4 mM; and FeOOH 2.75–3 g respectively, according to the proposed overlaid contour plots.
研究领域:
环境科学
·
化学工程
✓ 已验证
DOI
Current Computer-Aided Drug Design
·
2024
·
IF 1.5
Na An,Dongxing Zhang,Jile Xin,Xinyi Zhang,Zhijuan Zhang,Ligang Ma,Le Zhao,Huimin Wu,Weisheng Feng,Xiaoke Zheng
Background: Si-Ni-San (SNS) is the formula prescription of Traditional Chinese Medicine (TCM) with anti-depression properties, but its underlying mechanisms remain unclear. Objective: This study provides novel approaches for the study of Traditional Chinese Medicine (TCM) and offers new opportunities for exploring the pharmacological properties of SNS. Methods: The ingredients in SNS implicated in the treatment of depression were identified and studied using network pharmacology. SwissTargetPrediction and molecular docking were used to study the interaction of SNS ingredients and their targets. The protective effect of these ingredients and their cocktail in rat pheochromocytoma cells (PC12) exposed to corticosterone (Cor) were evaluated using the CCK-8 assay, Hoechst 33342 staining, 2',7'-dichlorodihydro fluorescein diacetate (H2DCFDA) staining, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, and in-cell Western analysis. Results: The network pharmacology study showed that the HIF-1 signaling pathway was the most crucial pathway implicated in the anti-depressive property of SNS. MAPK1 (ERK2), MAPK3 (ERK1), AKT1, VEGFA, STAT3, and EGF were identified as hub target proteins in the HIF-1 signaling pathway. Quercetin, naringenin, licochalcone A, and kaempferol from SNS, which targeted the six proteins mentioned above, were used to create a cocktail. This cocktail exerted protective properties, decreased the oxidative stress in PC12 exposed to Cor, and successfully regulated the expressions of AKT1, p-AKT1, ERK1, ERK2, p-ERK1/2, STAT3, p- STAT3, and VEGFA induced by Cor exposure. The SwissTargetPrediction and molecular docking study showed that the cocktail may regulate the HIF-1 signaling pathway by directly binding with AKT1 and MAPK1. Conclusion: The cocktail from SNS comprised of quercetin, naringenin, licochalcone A, and kaempferol exerts anti-depression potentiality by modulating the HIF-1 signaling pathway via direct interactions with AKT1 and MAPK1.
研究领域:
神经药理学
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传统中药研究
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分子生物学
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药效学
·
细胞信号传导
✓ 已验证
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2022
·
IF 10.753
Yun Luo,Baoqin Zhang,Ningbo Geng,Shuai Sun,Xiaoyao Song,Jiping Chen,Haijun Zhang
The toxicity of pyrene (Pyr) and its chlorinated species have not be comprehensively and clearly elucidated. In this study, an integrated approach of metabolomics and transcriptomics were applied to evaluate the hepatotoxicity of Pyr and 1-chloropyrene (1-Cl-Pyr) at human exposure level, using human L02 hepatocytes. After 24 h exposure to Pyr and 1-Cl-Pyr at 5–500 nM, cell viability was not significantly changed. Transcriptomics results showed that exposure to Pyr and 1-Cl-Pyr at 5 and 50 nM obviously altered the gene expression profiles, but did not significantly induce the expression of genes strongly related to the activation of aryl hydrocarbon receptor (AhR), such as CYP1A1 , CYP1B1, AHR, ARNT . Pyr and 1-Cl-Pyr both induced a notable metabolic perturbation to L02 cells. Glycerophospholipid metabolism was found to be the most significantly perturbed pathway after exposure to Pyr and 1-Cl-Pyr, indicating their potential damage to the cell membrane. The other significantly perturbed pathways were identified to be oxidative phosphorylation (OXPHOS), glycolysis, and fatty acid β oxidation, all of which are related to energy production. Exposure to Pyr at 5 and 50 nM induced the up-regulation of fatty acid β oxidation and OXPHOS. The similar result was observed after exposure to 5 nM 1-Cl-Pyr. In contrast, exposure to 50 nM 1-Cl-Pyr induced the down-regulation of OXPHOS by inhibiting the activity of complex I. The obtained results suggested that the modes of action of Pyr and 1-Cl-Pyr on energy production remarkably varied not only with molecular structure change but also with exposure concentration.
研究领域:
环境科学
·
毒理学
·
生物信息学
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2010
·Vol. 119
·期 4
·1923-1930
·
IF 1.203
Pengqing Liu,Ting Wu,Meiwu Shi,Guangdou Ye,Jianjun Xu
A series easily soluble polyarylates were synthesized from either 1,1-bis(4-hydroxyphenyl)-1-phenylethane or tetramethylbisphenol A with various aromatic diacid chlorides by the two-phase interfacial polycondensation. These polyarylates have the inherent viscositiesin the range of 0.36–0.97 dL/g, and their number-average and weight-average molecular weights determined by gel permeation chromatography are 14,200–43,200 and 31,900–102,500, respectively. All these polyarylates are readily soluble in a wide range of organic solvents, thus these polymers can be convenient to process into heat resistance films by cast, spin- or dip-coating. The polyarylates have the glass transition temperatures in the range of 165.0–201.6°C. The pendent phenyl-containing polyarylates reveal excellent thermal stability, and their initial degradation temperatures are all above 480°C and char yields at 700°C are 37.97–40.53% in nitrogen atmosphere. However, the polymers prepared from tetramethylbisphenol A have a large decrease in thermal stability, and their initial degradation temperatures in nitrogen are only about 440°C. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
研究领域:
高分子科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
FUEL
·
2025
·
IF 7.5
Xuemeng Yang,Jiadong Wang,Subing Fan,Qingxiang Ma,Xinhua Gao,Jianli Zhang,Tian-Sheng Zhao
The derivatives of primary Fischer-Tropsch synthesis (FTS) products are indispensable to the sustainable FTS run. For the one-pot conversion of FTS-based 1-octene to nonanol, nitrogen-doped cobalt oxides were obtained through hydrothermal synthesis followed by ammonia atmosphere thermal treatment (AATT) at 325 °C with varying treatment time. The AATT significantly affected the phase structure and the surface element valence states of the synthetic samples. The resulting (Co 3 O 4 ) x N showed high catalytic activity toward the reaction of 1-octene with CO + H 2 to nonanol through a successive hydroformylation-hydrogenation process, with conversion of 98 % and selectivity of close to 80 %. The crucial role of the CoO phase and the enhanced adsorption of the reactant molecules by the induced oxygen vacancy (O v ) were discussed based on multiple physicochemical properties characterization and activity evaluation.
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Xiaohang Sun,Zhengzuo Liu,Shuairen Qian,Kaiqi Nie,Zhengwen Li,Weiming Wan,Binhang Yan
Designing an active Cu/ZnO interface is crucial for efficient catalytic hydrogenation of CO 2 to methanol. In this study, we introduce a straightforward impregnation method to synthesize HKUST-1-derived inverse ZnO x /Cu catalysts. The resulting ZnO x /Cu interface exhibits outstanding methanol space-time yield and selectivity, surpassing conventional Cu/ZnO catalysts synthesized via the co-precipitation and impregnation methods. In situ characterization reveals that small, well-dispersed ZnO x nanoparticles are located on moderately sized Cu nanoparticles, which is attributed to the high specific surface area and ligand coordination of HKUST-1. The inverse ZnO x /Cu structure promotes the formation of reduced ZnO x nanoparticles, which significantly enhance CO 2 and H 2 activation, resulting in increased methanol production. Additionally, the moderate size of Cu nanoparticles minimizes CO* intermediate formation, further enhancing methanol selectivity. This work not only offers valuable insights for the development of new Cu/ZnO catalysts but also provides guidance for the synthesis of inverse metal oxide/metal catalysts for other catalytic systems.
研究领域:
催化化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）