APPLIED SURFACE SCIENCE
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2024
·
IF 6.3
Huiyuan Cheng,Jingwei Hu,Zihan Liu,Guangping Lei,Guojun Xi,Yayun Zhang,Hantao Liu,Xuhuan Guo,Huiyun Ren
Developing novel adsorbents for CO 2 capture and separation offers an efficient approach to relieving global environmental problems. To promote CO 2 capture from flue gas, novel Cr 3 O@MIL-101(Cr) composites was synthesized through packing [Cr 3 O(HCOO) 6 (H 2 O) 3 ]NO 3 into MIL-101(Cr) cages. The resultant composite Cr 3 O@MIL-101(Cr) presents higher CO 2 uptakes at lower pressure ranges, benefiting from the increased content of unsaturated Cr(III) ions and micropores relative to MIL-101(Cr). Meanwhile, IAST selectivity for CO 2 /N 2 mixture reached 50.2 under standard temperature and pressure, outperforming most of the reported materials. Further GCMC simulations reveal that the synergistic effect of [Cr 3 O(HCOO) 6 (H 2 O) 3 ] + , NO 3 − and MIL-101 (Cr) could effectively facilitate the interactions with CO 2 molecules and hinder N 2 molecules from approaching the optimal adsorption sites. Thus the [Cr 3 O(HCOO) 6 (H 2 O) 3 ]NO 3 encapsulated MIL-101(Cr) can be recommended as a promising adsorbent for superior CO 2 /N 2 separation.
研究领域:
材料科学
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环境科学
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化学工程
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产品关联
DOI
高影响因子
BIOPHYSICAL CHEMISTRY
·
2025
·
IF 2.2
Jing Zhang,Qiang Ma,Honghui Wang,Bin Chen,Yan Li,Yingmin Liao
The rubber antioxidant, N -(1,3-dimethylbutyl)- N ′-phenyl- p -phenylenediamine (6-PPD), as an emerging pollutant, is receiving more and more attention recently. This study investigated the intermolecular interactions of 6-PPD with two key biological macromolecules, human serum albumin (HSA) and alpha-glucosidase (AG), to understand the transport and toxic effects of 6-PPD. Using multiple spectroscopic methods and molecular docking technology, the results demonstrated that 6-PPD could bind to both HSA and AG, thereby inducing fluorescence quenching and conformational changes in both proteins. The binding constants were determined to be (5.93 ± 0.20) × 10 5 and (3.17 ± 0.15) × 10 4 L mol −1 respectively for HSA-6-PPD and AG-6-PPD systems at 298 K, revealing strong binding affinities. Molecular docking identified specific binding sites and non-covalent interactions of the two systems. MD and Energy decomposition analysis revealed the dynamics conformational changes of the complexes and identified van der Waals and electrostatic interactions as primary binding drivers for both systems, while polar solvation energy impeded complex formation. TYR161, ILE142, and TYR138 dominated HSA-6-PPD stabilization, whereas AG-6-PPD was driven by hydrophobic interactions with TRP1369 and VAL1373, with ARG1377 incurring substantial desolvation penalties. Synchronous fluorescence and circular dichroism spectroscopy indicated that 6-PPD binding did not disrupt the microenvironment of Tyr and Trp residues in HSA and AG, while induced structural alterations in HSA and AG that could affect their physiological function. In-vitro tests showed that 6-PPD inhibited AG activity in a dose-dependent manner, with an IC 50 of 8.22 ± 0.44 μmol L −1 . ADMET and PASS online tools was used to predict physicochemical properties and multiorgan toxicity. This work provided insights into the transport and molecular toxicity of 6-PPD, highlighting the adverse biological effects associated with this common rubber additive.
研究领域:
环境毒理学
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分子生物学
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药物代谢
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生物化学
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结构生物学
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生态风险评估
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2020
·Vol. 43
·期 20
·3921-3930
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IF 2.878
Qamar Subhani,Nadeem Muhammad,Zhouman Huang,Muhammad Asif ,Irshad Hussain,Muhammad Zahid,Cui Hairong,Yan Zhu,Dandan Guo
This study aims to introduce a simple, sensitive, and cost-effective method for the simultaneous determination of acetamiprid and its main metabolite 6-chloronicotinic acid in environmental samples by using a nonsuppressed ion chromatography hyphenated with an online postcolumn photoinduced fluorescence detection system. The fluorescence detector wavelengths λ ex /λ em = 257/382 nm was set for up to 6.0 min for acetamiprid, while λ ex /λ em = 231/370 nm programmed for 6-chloronicotinic acid for the rest of the analysis time. Both samples were treated by applying miniaturized quick, easy, cheap, effective, rugged, and safe method before the separation of analytes on an IonPac ® AS11-HC column by pumping 40 mM NaOH having minuscule content of acetonitrile (5%, v/v) as an eluent. Both intrinsically nonfluorescent analytes were turned-on by online postcolumn photoinduced derivatization, avoiding the need for complex chemical derivatization or addition of a postcolumn extra pump. The developed method was appraised for the analysis of environmental samples, exhibiting excellent linearity (0.050-10 μg/mL) with a correlation coefficient greater than 0.9993 for both analytes. Whereas, obtained limit of detection (0.025-0.0072 μg/mL), recoveries (98.02-116.00%), and inter- and intraday precision (≤3.02 %) were satisfactory for both compounds in environmental samples.
研究领域:
分析化学
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环境科学
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2023
·Vol. 34
·期 5
·1-9
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IF 2.8
Zhang Xiaochen,Zhang Zijian,Zhang Xueqi,Sun Haiquan,Hu Quan,Wang Haibao
Shuttle-like vanadium selenide was prepared via carbonizing the vanadium-based metal organic frameworks for supercapacitors. Its morphology and structure were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction and N 2 adsorption–desorption isotherm. Its electrochemical performance was investigated by cyclic voltammetry and galvanostatic charge–discharge test in three electrode configurations for supercapacitor. Compared with those in pure KOH electrolyte, the supercapacitive performances can be greatly enhanced when adding a certain amount of K 3 Fe(CN) 6 in KOH. A high specific capacitance of 512 F g −1 can be achieved at a scan rate of 0.2 mV −1 in 1 M KOH + 0.02 M K 3 Fe(CN) 6 , while only 164 F g −1 can be obtained in pure 1 KOH electrolyte. Furthermore, the VSe 2 also exhibits stable long-term cycling, 84.7% capacitance retention after 6500 cycles at a current density of 2 A g −1 . Those results provide a facile yet effective method for high performance energy storage devices.
研究领域:
材料科学
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电化学
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DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2024
·
IF 3.8
Mingzhe Jiang,Hao Tan,Lixin Jiang,Jintang Duan,Xueping Gu,Lianfang Feng,Cailiang Zhang
The anionic ring-opening polymerization of ε-caprolactam (CL) offers significant potential for producing polyamide 6 (PA6). To establish optimal conditions for designing an efficient and continuous PA6 production process, this study examines the anionic polymerization of CL at temperatures above the crystallization point of PA6. The focus is on the effects of the temperature, activator type and concentration, and catalyst concentration on the polymerization process and product characteristics. At 220 °C, the use of bifunctional methylene diphenyl diisocyanate (MDI) as an activator initiates cross-linking reactions, producing insoluble, nonmelting PA6. In contrast, anionic polymerization without an activator prevents gel formation but results in uncontrollably high molecular weights. The introduction of monofunctional N-acetyl caprolactam (AcCL) as an activator eliminates cross-linking reactions at temperatures above 220 °C while allowing precise control of the product’s molecular weight through adjustments in AcCL concentration.
研究领域:
高分子化学
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材料科学
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产品关联
DOI
高影响因子
Scientific Reports
·
2024
·Vol. 14
·期 1
·1-9
·
IF 3.8
Yuan Fang-Fang,Wang Pei,Han Xiao-Jie,Qin Ting-Ting,Lu Xin,Bai Hai-Jiao
The microreactor with two types of immobilized enzymes, exhibiting excellent orthogonal performance, represents an effective approach to counteract the reduced digestion efficiency resulting from the absence of a single enzyme cleavage site, thereby impacting protein identification. In this study, we developed a hydrophilic dual-enzyme microreactor characterized by rapid mass transfer and superior enzymatic activity. Initially, we selected KIT-6 molecular sieve as the carrier for the dual-IMER due to its three-dimensional network pore structure. Modification involved co-deposition of polyethyleneimine (PEI) and acrylamide (AM) as amine donors, along with dopamine to enhance material hydrophilicity. Remaining amino and double bond functional groups facilitated stepwise immobilization of trypsin and Glu-C. Digestion times for bovine serum albumin (BSA) and bovine hemoglobin (BHb) on the dual-IMER were significantly reduced compared to solution-based digestion (1 min vs. 36 h), resulting in improved sequence coverage (91.30% vs. 82.7% for BSA; 90.24% vs. 89.20% for BHb). Additionally, the dual-IMER demonstrated excellent durability, retaining 96.08% relative activity after 29 reuse cycles. Enhanced protein digestion efficiency can be attributed to several factors: (1) KIT-6’s large specific surface area, enabling higher enzyme loading capacity; (2) Its three-dimensional network pore structure, facilitating faster mass transfer and substance diffusion; (3) Orthogonality of trypsin and Glu-C enzyme cleavage sites; (4) The spatial effect introduced by the chain structure of PEI and glutaraldehyde’s spacing arm, reducing spatial hindrance and enhancing enzyme–substrate interactions; (5) Mild and stable enzyme immobilization. The KIT-6-based dual-IMER offers a promising technical tool for protein digestion, while the PDA/PEI/AM-KIT-6 platform holds potential for immobilizing other proteins or active substances.
研究领域:
生物化学
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蛋白质组学
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产品关联
DOI
PubMed
高影响因子
Journal of Neuroinflammation
·
2025
·Vol. 22
·期 1
·1-19
·
IF 10.1
Chi Zhexi,Lu Bo,Liu Rongjun,Pan Chen,Meng Bo,Xing Xiuzhong,Yuan Hui,Wu Xuewei,Chen Yushan,Ren Yuxuan,Wu Wenwei,Miao Mengmeng,Chen Junping,Chen Xiaowei
Neuropathic pain, a debilitating nerve injury-induced condition, remains a significant clinical challenge. This study evaluates the effect of histone deacetylase 6 (HDAC6) inhibition in a spared nerve injury (SNI) mouse model. Systemic administration of the selective HDAC6 inhibitor ACY-1215 (20 mg/kg/day, 14 days), alleviated SNI-induced pain in mice of both sexes. ACY-1215 increased acetylated signal transducer and activator of transcription 3 (Ac-STAT3) and reduced phosphorylated STAT3 (p-STAT3) in the lumbar spinal cord of SNI mice. HDAC6 and p-STAT3 were expressed in spinal dorsal horn neurons, and SNI-enhanced HDAC6/STAT3 interaction was reversed by ACY-1215. Neuronal STAT3 overexpression induced pain hypersensitivity and elevated p-STAT3, tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β), effects suppressed by ACY-1215. Cytokine profiling identified CC-chemokine ligand 7 (CCL7) as a key downstream effector of the HDAC6/STAT3 axis, with ACY-1215 attenuating SNI-induced CCL7 upregulation. HDAC6 knockdown in neurons reduced p-STAT3, while HDAC6 or STAT3 knockdown diminished CCL7 production. These findings demonstrate that ACY-1215 mitigates neuropathic pain by modulating STAT3 acetylation/phosphorylation and suppressing HDAC6/STAT3-driven CCL7 and cytokine release. This study underscores the role of the HDAC6/STAT3/CCL7 signaling axis in neuropathic pain and highlights the therapeutic potential of HDAC6 inhibitors for pain management.
研究领域:
神经科学
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药理学
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DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2025
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IF 4.7
Yan-Li Lu,Yue Ma,Xi-Nan Yang,Jie Gao,Xiao-Qian Chen,Xin Xiao,Pei-Hua Ma
In this paper, a crystalline supramolecular organic framework was constructed based on cyclopentanocucurbit[6]uril (CyP 6 Q[6]) and five benzimidazole compounds [2-aminobenzimidazole (G1), 2-methylbenzimidazole (G2), 2-hydroxymethylbenzimidazole (G3), 2-phenylbenzimidazole (G4), 2-(2-pyridyl) -benzimidazole (G5)] through host-guest interaction, with the Single crystal X-ray diffraction analysis showing that CyP 6 Q[6] and Gn(n=1-5) formed 1:1 host-guest inclusion complexes by hydrogen bonding, respectively. The type of substituent (R group) in the guest determines the mode of interaction with CyP6Q[6], where the benzimidazole rings of G1-G4 are encapsulated in the cavity of CyP6Q[6] with the R group located outside its ports, whereas the R group (pyridinyl group) of G5 enters the cavity of CyP6Q[6] with the benzimidazole ring exposed outside its ports. Interestingly, under the ion-dipole interaction, the inclusion complexes form an '8′ shaped supramolecular organic framework by stacking, and due to the different characteristics of the R group and the binding mode, supramolecular channels with different sizes are formed.
研究领域:
超分子化学
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晶体工程
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材料科学
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主客体化学
·
X射线衍射分析
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DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2025
·
IF 7.4
Wen-Jie Jin,Bao-Ping Dong,Xian-Wei Cheng,Jin-Ping Guan,Shu-Sheng Xiong
A highly efficient and reactive flame retardant (FR) agent was developed and in situ self-polymerized on polyamide 6 (PA6) fabrics, yielding a durable and multifunctional textile. The FR agent, designated DOPO-pCA, was synthesized using bio-based p-coumaric acid and DOPO. The treated PA6 exhibited outstanding flame retardancy and anti-dripping performance, with a limiting oxygen index of 31.0% and a reduced damaged length of 12.3 cm. Cone calorimetry confirmed significant fire-safety improvements, with the peak heat release rate and total heat release reduced by 30.7% and 23.8%, respectively. The superior fire resistance should be attributed to the enhanced quenching effect of phenoxy and phosphoroxy radicals. Owing to its self-polymerization and reactivity, DOPO-pCA imparted durable FR functionality, with only slight deterioration observed after 30 laundering cycles. Moreover, the treated PA6 fabrics exhibited excellent resistance to UV resistance and antibacterial activity against S. aureus . The PA6 fabrics treated with 40 g/L DOPO-pCA achieved a high UV protection factor (UPF) of 52.4 and an antibacterial rate of 92.3%. Here, this work proposes a cleaner and novel strategy for developing durable and multifunctional PA6 fabrics.
研究领域:
高分子科学
·
材料工程
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消防安全
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纺织化学
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生物基化学品
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产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2017
·
IF 4.159
Jinyu Li,Guoxin Tan,Bingchao Cheng,Dandan Liu,Weisan Pan
To facilitate the hydrophobic drugs modeled by coumarin-6 (Cou-6) acrossing the cornea to the anterior chamber of the rabbit eye, chitosan (CS) derivatives including chitosan-N-acetyl- l -cysteine (CS-NAC), chitosan oligosaccharides (COS) and carboxymethyl chitosan (CMCS) modified nanostructured lipid carriers (NLCs) were designed and characterized. We found that, with similar size distribution and positive charges, different CS derivatives based on NLCs led to distinctive delivery performance. In vivo precorneal retention study on rabbits revealed that these CS derivatives coating exhibited a stronger resistant effect than Cou-6 eye drops and Cou-6-NLC (P < 0.05), moreover, the AUC (0−∞) , C max and MRT (0−∞) of them followed the sequence of CMCS-Cou-6-NLC < COS-Cou-6-NLC < CS-NAC-Cou-6-NLC. Confocal laser fluorescence microscopy (CLSM) for in vitro corneal penetration study showed that COS-, and CS-NAC-coated NLCs penetrated through the whole corneal epithelium barrier (about 40 μm), while CMCS failed to significantly enhance the intraocular drug penetration as expected, displayed a negligible fluorescence at 30 μm deep. In addition, penetration through the intact cornea was achieved and the penetration levels through the ocular tissues were increased thoroughly for the COS and CS-NAC coating ones compared with CMCS-NLC (P < 0.05), and successfully reduced the conjunctival-to-corneal permeability ratio (ratio (C - S/C) ) thus resulted in a higher bioavailability, which was confirmed by ex vivo fluorescence imaging on ocular tissues. In summary, CS-NAC-NLC and COS-NLC are promising ocular drug delivery systems to achieve prolonged precorneal retention, higher corneal permeability and enhanced ocular bioavailability. And comparatively speaking, CS-NAC-NLC possesses the highest potential for ocular drug delivery.
研究领域:
药剂学
·
眼科研究
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Jie Ni,Tao Liu,Qianzhi Shi,Mengjiao Zhu,Xudong Wang,Lina Kang,Zhenyu Chu,Biao Xu,Wanqin Jin
Interleukin-6 (IL-6) is an essential serum biomarker in the diagnosis of the septic cardiomyopathy, which causes acute shock to increase the fatality rate of patients to about 80 %. However, due to the time-consuming nature of current clinical assay techniques, the on-site and rapid test of IL-6 during the surgery and emergencies remains a major challenge to save lives. In this work, we proposed an ultrasensitive electrochemical immunosensor to rapidly determine serum IL-6 within just 20 min, relying on the hollow carbon coated NiCo alloy nanocubes (NiCo@C). This NiCo@C architecture is derived from a Prussian blue analogue through a controlled pyrolysis process, which facilitates the in-situ reduction of the NiCo alloy inside the cavity while preserving the nanocubic carbon skeleton. This unique structure offers outstanding electrocatalysis and conductivity for the generation and amplification of the immune signal, as well as provides abundant binding domains for the immobilization of antibody. The resulting IL-6 immunosensor demonstrates a wide detection range from 0.1 pg/mL to 100 ng/mL and an ultralow detection limit of 0.03 pg/mL, as well as high reliability for assay and dynamic monitoring in human serum samples. This immunosensor will show tremendous potentials for the early-warning and monitoring of patients' vital signs in emergency settings.
研究领域:
医学诊断
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纳米材料科学
·
生物传感技术
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产品关联
DOI
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 6.8
Wenchen Pu,Xianyan Shen,Xin Fan,Yuanyuan Zheng,Xuesha Liu,Jiao Li,Jian-Kang Zhou,Juan He,Rong Wei,Yanqiu Gong,Qingquan Zheng,Yao Luo,Yingli Guo,Min Ai,Yue Ming,Zixia Ye,Yun Zhao,Chun Wang,Yong Peng
Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths globally, and the need for effective systemic therapies for HCC is urgent. Our previous work reveals that Pin1 is a potential anti-HCC target, which regulates miRNA biogenesis and identifies API-1 as a novel Pin1 inhibitor to suppresses HCC. However, a great demand in HCC therapy as well as the limited chemical stability and pharmacokinetic feature of API-1 motivated us to find improved Pin1 inhibitors. Herein, we designed and synthesized diverse 6-O-benzylguanine derivatives and discovered API-32 as a novel Pin1 inhibitor with better stability and pharmacokinetic property over API-1. API-32 directly interacted with the Pin1 PPIase domain to inhibit Pin1 activity. API-32 significantly suppressed the cell proliferation and migration of HCC cells by blocking Pin1’s downstream signal. Moreover, API-32 exhibited an enhanced inhibitory function against the HCC tumor in mice models without obvious toxicity, making it a promising drug candidate for HCC treatment.
研究领域:
肿瘤学
·
药理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）