ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Peng Wei,Xueping Sun,Minhui Wang,Jiahao Xu,Zhimin He,Xiaogang Li,Fangyuan Cheng,Yue Xu,Qing Li,Jiantao Han,Hui Yang,Yunhui Huang
Tungsten carbide (W2C) has emerged as a potential alternative to noble-metal catalysts toward hydrogen evolution reaction (HER) owing to its Pt-like electronic configuration. However, unsatisfactory activity, dilatory electron transfer, and inefficient synthesizing methods, especially for nanoscale particles, have severely hindered its large-scale applications. Herein, a novel heterostructure composed of W2C and tungsten phosphide (WP) embedded in nitrogen-decorated carbon (W2C/WP@NC) was constructed as an efficient HER electrocatalyst. The as-prepared W2C/WP@NC catalyst exhibits remarkable electrocatalytic activity and robust durability toward HER both in acids and bases. More notably, the W2C/WP@NC catalyst demonstrates low overpotentials of 116.37 and 196.2 mV to afford a current density of 10 mA cm–2 and reveals slight potential decays of about 6.4 and 7.64% over 12 h continuous operation in bases and acids, respectively. The overall water-splitting performance was further evaluated using the W2C/WP@NC catalyst as the cathode and commercial RuO2 as the anode in an electrolyzer, which can realize an overall current density of 10 mA cm–2 and maintain long durability of more than 12 h with a small cell voltage of 1.723 V. This work opens up new opportunities for exploring cost-efficient electrocatalysts in sustainable energy conversion.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CLAY SCIENCE
·
2020
·
IF 4.605
Ming Lei,Weian Huang,Jinsheng Sun,Zixuan Shao,Tongliang Wu,Junyi Liu,Yu Fan
To achieve potent inhibition, reduced environmental impacts and excellent compatibility between drilling fluid and shale inhibitors, an eco-friendly amphoteric inhibitor based on carboxymethyl chitosan (CMCS) was synthesized. The molecular structure of CMCS was characterized by potentiometric titration, Fourier transform infrared spectroscopy and nuclear magnetic resonance, and the carboxymethyl substitution degree was revealed to be approximately 0.94. The inhibition performance was evaluated through linear swelling and hot-rolling dispersion tests, and the results were compared with those obtained with low-molecular-weight cationic polyether diamine, high-molecular-weight non-ionic polysaccharide encapsulator, and potassium chloride. The interaction between clay particles and CMCS molecules was investigated by X-ray diffraction, scanning electron microscopy, surface wettability , particle size distribution , zeta potential and surface tension tests. The results showed that CMCS with a specific amphoteric molecular structure exhibited a different inhibition behaviour compared with conventional inhibitors, more effectively prevented clay hydration and swelling and inhibited shale disintegration at both 77 °C and 150 °C. CMCS could absorb onto the clay surface via electrostatic force and hydrogen bonding, and an encapsulation film was formed through intermolecular interactions to immobilize outer free water molecules and to provide hydrophobic characteristics. CMCS intercalates into clay lattice, expels inner water and reduces the interlayer space . Additionally, CMCS reduces the surface tension of the bulk solution and hinders fluid invasion. Furthermore, CMCS was compatible with bentonite dispersion and improved the rheological and filtration properties at a suitable concentration.
✓ 已验证
DOI
高影响因子
Frontiers in Pharmacology
·
2020
·
IF 4.225
Shi Peiying,Xie Yunjiao,Xie Rongfang,Lin Zuan,Yao Hong,Wu Shuang
In this paper, the integrated pharmacokinetics (PK) of an Acanthopanax senticosus extract preparation (ASEP, named as Ciwujia injection in clinic in China) was explored by combining with multi-component PK in rats, virtual screening, systems pharmacology and molecular docking. Firstly, the ingredients in ASEP with high contents and detectable property in rat plasma were selected. Next, the PK study of the resulted ingredients was performed in rats (1.76 ml/kg and 3.52 ml/kg of 5 times concentrated ASEP, single i.v.). Meanwhile, the drug targets for the ingredients screened out were predicted by using a target fishing online server, PharmMapper (http://www.lilab-ecust.cn/pharmmapper/) with a fit filtration threshold of z’-score >0. Next, the network pharmacology, molecular docking, diseases ontology (DO) analysis, and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis were performed respectively for the predicted targets. Finally, the supporting evidences were obtained to characterize the PK markers and carry out the integrated PK study with “plasma-drug concentration sum” or “plasma-drug AUC weighted” methods. As a result, 6 ingredients, involving 5-caffeoylquinic acid (5-CQA), 3-CQA, 4-CQA, protocatechuic acid, eleutheroside B, and gentiopicroside were selected, and their PK profiles were elucidated. The 6 ingredients were highly related to arteriosclerotic cardiovascular disease and atherosclerosis and could mainly interact with similar targets, e.g., GSK3B, PDPK1, PLAU, etc., or pathways, e.g., Insulin, VEGF, FoxO, etc, providing the basis for integrating plasma drug concentration. Ultimately, the 6 ingredients were considered as PK markers and the whole in vivo process of ASEP were characterized. Our study would enhance understanding of the therapeutic effects and mechanisms of ASEP against cardiovascular diseases, and provided useful insights for future integrated PK study on anti-cardiovascular diseases TCM injections.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYST
·
2025
·
IF 3.3
Xu-Fei Sun,Yuqi Luo,Xunan Dong,Hu Luo,Ke-Jing Huang
The rapid and reliable quantitative detection of biological targets encounters challenges such as limited driving forces in reactions, low overall strand utilization, and the synthetic complexity of multi-modal materials. To address these issues, the design concept “entropy–enthalpy coupling with dual-mode decoupling” is introduced for the first time. Using miRNA-21 as a model analyte, an entropy–enthalpy co-driven decoupled dual-mode biosensor was developed by integrating independent photoelectrochemical (PEC) and fluorescent (FL) modules to assess its feasibility. Specifically, an output strand was designed within a three-stranded substrate/output complex, in which the terminal bases form hairpin structures through complementary pairing. This configuration enables the establishment of an entropy–enthalpy coupling driving force—increased entropy for the substrate strand and decreased enthalpy for the output strand—during cyclic amplification reactions. Additionally, by conjugating the substrate, fuel and output strands separately to magnetic beads, photosensitive materials, and fluorophores, complete decoupling of the PEC and FL modes was achieved, allowing independent PEC and FL signal outputs. In the developed biosensor, the device demonstrated well-defined linear correlation for PEC and FL within the 10 aM to 10 nM range, and the detection limits for miRNA-21 were established at 4.2 aM (PEC) and 5.3 aM (FL). Experimental results demonstrated the substantial potential of the “entropy–enthalpy coupling with dual-mode decoupling” framework for rapid and reliable quantitative detection of biological targets, while also providing new design paradigms for sensors in fields such as food safety and agriculture.
✓ 已验证
DOI
PubMed
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2025
·Vol. 131
·期 11
·1-12
·
IF 2.8
Song Ziyan,Ma Ruolong,Zheng Xiaodan,Zhang Limeng,Ruan Chuanda,Yan Xiaohui,Tian Fei
In this study, Fe 3 O 4 @C@Cu 2 O was synthesized using a solvothermal method. The morphology and structural characteristics of the material were systematically investigated through various characterization techniques, including TEM, XPS, FT-IR, DLS, and VSM. Its antibacterial efficacy was assessed through colony counting. Results showed that at a concentration of 0.5 mg/mL, Fe 3 O 4 @C@Cu 2 O nanoparticles with a copper atomic percentage of 2.42% achieved bactericidal rates of 98.45% against E. coli and 90.58% against S. aureus . Compared to pure Fe 3 O 4 @C and Cu 2 O, the composite material demonstrated a 100% bactericidal rate against E. coli and 99.23% against S. aureus . Notably, after five cycles, the composite nanoparticles maintained effective bactericidal rates, with 82.16% against S. aureus and 94.72% against E. coli . SEM images of bacterial morphology and EPR tests confirmed that the antibacterial mechanism primarily involves the generation of reactive oxygen species(ROS).
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2014
·
IF 5.9
Weijun Ke,Guojia Fang,Jing Wang,Pingli Qin,Hong Tao,Hongwei Lei,Qin Liu,Xin Dai,Xingzhong Zhao
A perovskite solar cell with a thin TiO2 compact film prepared by thermal oxidation of sputtered Ti film achieved a high efficiency of 15.07%. The thin TiO2 film prepared by thermal oxidation is very dense and inhibits the recombination process at the interface. The optimum thickness of the TiO2 compact film prepared by thermal oxidation is thinner than that prepared by spin-coating method. Also, the TiO2 compact film and the TiO2 porous film can be sintered at the same time. This one-step sintering process leads to a lower dark current density, a lower series resistance, and a higher recombination resistance than those of two-step sintering. Therefore, the perovskite solar cell with the TiO2 compact film prepared by thermal oxidation has a higher short-circuit current density and a higher fill factor.
研究领域:
材料科学
·
能源技术
✓ 已验证
DOI
高影响因子
ANALYST
·
2019
·Vol. 144
·期 8
·2550-2555
·
IF 4.019
Huiwen Xiong,Jingwen Gao,Ying Wang,Ziyi Chen,Miao-Miao Chen,Xiuhua Zhang,Shengfu Wang
In this study, an ultrasensitive electrochemiluminescence (ECL) aptasensor based on Ru(bpy)32+-doped silica nanoparticles (Ru@SiO2 NPs) coupled with gold nanoparticles (Au NPs) was developed for the determination of ractopamine (Rac). TPrA is used as the coreactant, the Ru@SiO2 NPs serve as the ECL luminophores, and the Au NPs work as a catalyzer in the redox reaction as well as the carrier that immobilizes the aptamer. Meanwhile, the complete incorporation of the Ru@SiO2 NPs and Au NPs increases the localized surface plasmon resonance (LSPR) probability, thus promoting ECL emission. The ractopamine (Rac) target molecules are specifically captured on the electrode surface by aptamer recognition. The ECL signal is quenched by energy transfer from the luminophore to benzoquinone compounds, which are oxidative products of Rac from the electrochemical scanning process. The proposed ECL aptasensor exhibits ultrahigh sensitivity and excellent selectivity for Rac detection. The linear response ranged over Rac concentrations from 1.5 × 10−12 M to 1.5 × 10−8 M with a detection limit of 4.1 × 10−14 M (S/N = 3). The detection recovery of Rac in real meat samples confirmed the satisfactory performance of the method. This study describes a versatile ECL aptasensor based on the combined functions of luminous nanospheres and Au NPs, indicating its potential application for the ultrasensitive analysis of targets in diverse systems.
研究领域:
分析化学
·
纳米技术
·
食品安全
·
生物传感器
✓ 已验证
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2014
·
IF 6.451
Tao Wang,Zhen Yang,Chong Lei,Jian Lei,Yong Zhou
A Dynabeads-labeled magnetic immunoassay (MIA) has been developed by using an integrated giant magnetoimpedance (GMI) biosensor for the detection of alpha-fetoprotein (AFP). The GMI biosensor (Cr/Cu/NiFe/Cu/NiFe/Al 2 O 3 /Cr/Au films) integrated magnetic sensing elements and a biomolecular immunoplatform. Au film was modified with 11-Mercaptoundecanoic acid (11-MUA) for the immobilization of AFP monoclonal antibody . Double antibody sandwich immunoassay was used to specifically capture and label AFP antigen. Functionalized Dynabeads were conjugated to AFP antigen by streptavidin–biotin binding assay. GMI responses were measured for sensitive detection of AFP from 1 to 10 ng/ml. Our results revealed that the presence of AFP on the biosensor improved the GMI effect owing to the induced magnetic dipole of superparamagnetic Dynabeads, and the GMI ratio was greatly increased at high frequency. Specificity of MIA was tested through the use of 1% bovine serum albumin (BSA). The underlying biophysical mechanisms responsible for the enhanced GMI effect in the detection of AFP were discussed. This work provides a complex lab-on-chip MIA for the detection of biomarker, which may open up a new way for the development of GMI-based MIA in clinical trials .
研究领域:
生物医学工程
·
分子诊断学
✓ 已验证
DOI
PubMed
高影响因子
ACS Nano
·
2026
·
IF 17.3
Jia-Xin An,Ying Tang,Jinlian He,You-Teng Qin,Xian-Zheng Zhang
Cancer vaccines represent a promising approach for tumor immunotherapy. It requires effective tumor antigen delivery, specific antigen recognition, and the induction of a strong and durable immune response. Inspired by recent advances in hydrogel-based vaccine systems and growing research leveraging adoptive cells as therapeutic agents, a strategy of constructing intracellular gelated macrophage (GM)-based vaccines has been proposed. Proinflammatory macrophages were introduced as cellular therapeutics and hydrogelated through direct intracellular permeation of poly(ethylene glycol) diacrylate (PEGDA) monomers and UV-initiated radical polymerization to trap a large number of tumor antigens and immune adjuvants (GMAGs). The GMAGs could accumulate in both tumor tissues and tumor-draining lymph nodes, forming favorable immunization spots to continuously codeliver antigens and adjuvants, recruit dendritic cells for antigen presentation, and prime T cell activation. In murine breast cancer and melanoma models, the GMAGs were able to induce strong and durable immunity, inhibit tumor progression, and extend the overall survival. This strategy synergistically inherits the targeting ability and biocompatibility of macrophages alongside the drug-loading and sustained-release properties of hydrogels, representing a promising and multifunctional approach to cancer vaccines.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2026
·
IF 18.1
Wang Jiachuang,Wei Shuai,Qin Nan,Tao Tiger H.
Compound eyes feature unique optical structures and high-efficiency image processing. The opto-olfactory nervous system of Drosophila has the characteristics of lightweight and low power consumption. Significant efforts have been dedicated to the design and manufacturing of artificial compound eye system. However, it is still challenging to construct a bionic visual-olfactory compound eye microsystem with sensitive photoelectric response and accurate olfactory perception in insect-scale, mimicking the biological multimodal fusion decision-making mechanism. Here, we report a miniature apposition compound eye that integrates 1027 ommatidia on 1.5×1.5 mm 2 by manufacturing a bionic micro-lens array onto flexible photodetectors via femtosecond laser two-photon polymerization, further construct the colorimetric olfactory sensor array through inkjet printing to achieve integrated perception of vision and smell. The bionic compound eye (bio-CE) enables wide field-of-view imaging (azimuth angle 180°), natural interocular isolation, a 1 kHz flicker fusion frequency and color response to various hazardous chemicals, resulting in high sensitivity to moving objects and rapid response to environmental gases. The microsystem can serve as a wide-angle close-range obstacle avoidance detector and a device for monitoring visual and olfactory information of moving targets. The insect-scale bionic apposition compound eye shows great potential applications in unmanned platform navigation and bionic robot intelligence.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
·
2016
·
IF 3.905
Longguang Jiang,Lin Lin,Rui Li,Cai Yuan,Mingming Xu,Joy H. Huang,Mingdong Huang
Platelet endothelial cell adhesion molecule 1 (PECAM-1) is a cell surface receptor widely distributed on endothelium and hematopoietic-derived cells, and maintain the integrity of the blood vessels. PECAM-1 is widely recognized as an endothelial cell marker. The homophilic interaction through its extracellular domain of PECAM-1 (soluble PECAM-1, or sPECAM-1) is important to its functions. However, structural details for such dimerization are not fully understood. Here we report the production of recombinant sPECAM-1 in large quantity by Drosophila expression system and the small-angle X-ray diffraction (SAXS) study. The recombinant sPECAM-1 was found to form one population of dimer, but not oligomer, and was able to bind to heparin immobilized on a chip in surface plasmon resonance imaging (SPRi) binding experiments. The results of SAXS demonstrated that sPECAM-1 formed a symmetric homodimer of Ω-shape in solution, and each protomer adopted an extended conformation. The dimer is mediated through the intermolecular interactions through the first N-terminal domain (D1) of sPECAM-1. This model provides new structural information for its homophilic interaction mechanism.
研究领域:
分子生物学
·
结构生物学
·
免疫学
·
血管生物学
·
生物化学
·
转化医学
✓ 已验证
DOI
高影响因子
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
·
2014
·Vol. 53
·期 38
·10147-10149
·
IF 11.336
Lili Ren,Sumin Cui,Fengchao Cao,Qinghui Guo
Inorganic oxide aerogels have unique thermal, optical, electrical, magnetic, and chemical properties, which result in them potentially having a broad range of applications. However, their preparation is commonly based on a supercritical drying method, which greatly limits real applications of aerogels and their commercialization. Here we demonstrate a general method for drying wet gels to form aerogels that is based on the sublimation of organic solvent. The organic solvent must have a low surface tension, undergo sublimation easily, and have a high freezing point to allow the rapid synthesis of monolithic inorganic oxide aerogels under vacuum conditions. This cost-effective process will facilitate application of aerogel materials. This approach may also be used for the preparation of other porous materials, whose theoretical and practical applications should be investigated. Graphical Not cracking up : A drying method based on the sublimation of organic solvent allows the rapid synthesis of the monolithic inorganic oxide aerogels without cracks from wet gels. The method proceeds by endothermic evaporation of organic solvent at the outer surface followed by sublimation of solidified solvent (see picture).
研究领域:
材料科学
·
纳米科技
·
化学工程
·
功能材料
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）