ACS Nano
·
2025
·
IF 16
Jimin Qiu,Yuchen Ji,Wenfang Li,Yuhang Li,Wenguang Zhao,Yunxing Zuo,Weiyuan Huang,Chen Zhu,Mingjian Zhang,Guorui Zheng,Luyi Yang,Feng Pan,Zu-Wei Yin
Lithium cobalt oxide (LiCoO2) cathodes suffer serious structure instability when charged to high voltage (>4.5 V), including H1-3 phase transition, cobalt dissolution, and interfacial side reactions, which are closely related to the instability of surface lattice oxygen. Herein, an interfacial B–O complexing strategy was proposed to stabilize the surface lattice oxygen of LiCoO2 at 4.6 V, through the preferential coordination between derived products of the tris(pentafluorophenyl)borane electrolyte additive and LiCoO2. Combining a series of in situ and ex situ characterization methods with temporal and spatial resolution, it was revealed that the emergence of peroxy-like species (O22–) at high potentials is one of the origins of the instability of LiCoO2, which can be well inhibited thanks to interfacial B–O complexing. Thus, oxygen loss and interfacial side reactions can be drastically retarded, which consequently provides a more stable chemical environment for Co element, avoiding the dissolution and valence reduction of Co. Owing to the well-anchored Co and O elements, undesirable phase transition and local coordination structure change are suppressed, hence improving the capacity retention and rate performance of LiCoO2 at 4.6 V. This study provides an interfacial complexing strategy to stabilize the high-voltage LiCoO2 cathode.
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高影响因子
Cell Host & Microbe
·
2024
·
IF 20.6
Xin Wang,Huihui Kong,Bingxin Chu,Qian Yang,Chaohui Lin,Rui Liu,Changxu Chen,Yang Gao,Guojun Wang,Dayan Wang,Chen Qin,Xiaohua Ye,Lifei Yu,Xiangfei Xu,Jie Jin,Ren Sun,Hualan Chen,Xudong Wu,Zeli Zhang
Identifying broadly reactive B precursor cells and conserved epitopes is crucial for developing a universal flu vaccine. In this study, using influenza neuraminidase (NA) mutant probes, we find that human pre-existing NA-specific memory B cells (MBCs) account for ∼0.25% of total MBCs, which are heterogeneous and dominated by class-unswitched MBCs. In addition, we identify three NA broad-inhibition monoclonal antibodies (mAbs) (BImAbs) that block the activity of NA derived from different influenza strains, including the recent cow H5N1. The cryoelectron microscopy (cryo-EM) structure shows that the BImAb targets the conserved NA enzymatic pocket and a separate epitope in the neighboring NA monomer. Furthermore, the NA BImAbs protect mice from the lethal challenge of the human pandemic H1N1 and H5N1. Our work demonstrates that the NA broad-inhibition precursor MBCs exist in healthy adults and could be targeted by the NA-based universal flu vaccine.
研究领域:
免疫学
·
病毒学
·
结构生物学
·
疫苗开发
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PubMed
高影响因子
ChemMedChem
·
2021
·Vol. 16
·期 15
·2354-2365
·
IF 3.466
Fang Yan Guo,Chang Ji Zheng,Meiyuan Wang,Jiangping Ai,Lan Ying Han,Liu Yang,Ye Fang Lu,Yu Xuan Yang,Ming Guan Piao,Hu-Ri Piao,Chun-Mei Jin,Cheng Hua Jin
Graphical Treating fungal infection : A series of imidazole fused imidazo[2,1- b ][1,3,4]thiadiazoles were synthesized as potent, selective inhibitors of fungal for Candida albicans reduced chronic dermatomucoso candidiasis. The most potent compound, 21 a , showed druglike properties with low cytotoxicity and hemolysis. Three series of new imidazole-fused imidazo[2,1- b ][1,3,4]thiadiazole analogues (compounds 20 a – g , 21 a – g , and 22 a – g ) have been synthesized, and their antibacterial and antifungal activities have been evaluated. All the target compounds showed strong antifungal activity and high selectivity for the test fungus Candida albicans over Gram-positive and -negative bacteria. N -((4-(2-Cyclopropyl-6-(4-fluorophenyl)imidazo[2,1- b ][1,3,4]thiadiazol-5-yl)-5-(6-methyl-pyridin-2-yl)-1 H -imidazol-2-yl)methyl)aniline ( 21 a ) showed the highest activity against C. albicans (MIC 50 =0.16 μg/mL), 13 and three times that of the positive control compounds gatifloxacin and fluconazole, respectively. Compounds 21 a and 20 e did not show cytotoxicity against human foreskin fibroblast-1 cells, and compound 21 a was as safe as the positive control compounds in hemolysis tests. These results strongly suggest that some of the compounds produced in this work have value for development as antifungal agents.
研究领域:
药理学
·
微生物学
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PubMed
高影响因子
Frontiers of Environmental Science & Engineering
·
2021
·Vol. 16
·期 3
·1-16
·
IF 4.357
Zhao Shuangyang,Chen Chengxin,Ding Jie,Yang Shanshan,Zang Yani,Ren Nanqi
Fabrication of easily recyclable photocatalyst with excellent photocatalytic activity for degradation of organic pollutants in wastewater is highly desirable for practical application. In this study, a novel ternary magnetic photocatalyst BiVO 4 /Fe 3 O 4 /reduced graphene oxide (BiVO 4 /Fe 3 O 4 /rGO) was synthesized via a facile hydrothermal strategy. The BiVO 4 /Fe 3 O 4 with 0.5 wt% of rGO (BiVO 4 /Fe 3 O 4 /0.5% rGO) exhibited superior activity, degrading greater than 99% Rhodamine B (RhB) after 120 min solar light radiation. The surface morphology and chemical composition of BiVO 4 /Fe 3 O 4 /rGO were studied by scanning electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, UV visible diffuse reflectance spectroscopy, Fourier transform infrared spectroscopy, and Raman spectroscopy. The free radicals scavenging experiments demonstrated that hole (h + ) and superoxide radical (O 2 •− ) were the dominant species for RhB degradation over BiVO 4 /Fe 3 O 4 /rGO under solar light. The reusability of this composite catalyst was also investigated after five successive runs under an external magnetic field. The BiVO 4 /Fe 3 O 4 /rGO composite was easily separated, and the recycled catalyst retained high photocatalytic activity. This study demonstrates that catalyst BiVO 4 /Fe 3 O 4 /rGO possessed high dye removal efficiency in water treatment with excellent recyclability from water after use. The current study provides a possibility for more practical and sustainable photocatalytic process.
研究领域:
环境科学
·
材料科学
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2019
·Vol. 55
·期 2
·701-712
·
IF 3.442
Yang Wangyang,Shen Honglie,Min Huihua,Ge Jiawei
In recent years, Ti 3+ self-doped TiO 2 (B-TiO 2 ) exhibits great potential as a photocatalyst. In this work, Ti vapor-assisted annealing is first demonstrated for Ti 3+ doping and improving the visible absorption of TiO 2 . TEM results exhibit the formation of disordered layer, indicating the successful fabricating of B-TiO 2 . The absorption increase in TiO 2 caused by Ti vapor annealing reaches nearly 50% in the visible wavelength range. Benefiting from the absorption increase, the photocatalytic performance of TiO 2 after Ti vapor annealing increases by 60–70%. Surface modification of Ag onto B-TiO 2 is also carried out to further improve its optical property. Ag-modified Ti 3+ self-doped TiO 2 (B-TiO 2 @Ag) exhibits great visible photodegradation behavior to RhB. The RhB degradation rate reaches 97.76% after 60 min of visible light irradiation. Electrochemical performance tests demonstrate that as-prepared TiO 2 @Ag has lower resistance than W-TiO 2 . The results indicate that B-TiO 2 @Ag has great potential in solar photocatalytic degradation of pollutant.
研究领域:
材料科学
·
环境科学
·
化学工程
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高影响因子
ENZYME AND MICROBIAL TECHNOLOGY
·
2014
·
IF 2.966
Chuan-Yang Shang,Wei-Xun Li,Rui-Feng Zhang
ZnO nanowires were successfully introduced into a macroporous SiO 2 by in situ hydrothermal growth in 3D pores. The obtained composites were characterized by SEM and XRD, and used as supports to immobilize Candida antarctica lipase B (CALB) through adsorption. The high specific surface area (233 m 2 /g) and strong electrostatic interaction resulted that the average loading amount of the composite supports (196.8 mg/g) was 3–4 times of that of macroporous SiO 2 and approximate to that of a silica-based mesoporous material. Both adsorption capacity and the activity of the CALB immobilized on the composite supports almost kept unchanged as the samples were soaked in buffer solution for 48 h. The chiral resolution of 2-octanol was catalyzed by immobilized CALB. A maximum molar conversion of 49.1% was achieved with 99% enantiomeric excess of ( R )-2-octanol acetate under the optimal condition: a reaction using 1.0 mol/L ( R , S )-2-octanol, 2.0 mol/L vinyl acetate and 4.0 wt.% water content at 60 °C for 8 h. After fifteen recycles the immobilized lipase could retain 96.9% of relative activity and 93.8% of relative enantioselectivity .
研究领域:
生物化学
·
材料科学
·
催化工程
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PubMed
高影响因子
International Journal of Nanomedicine
·
2017
·
IF 4.3
Guangtao Xu,Huan Gu,Bo Hu,Fei Tong,Daojun Liu,Xiaojun Yu,Yongxia Zheng,Jiang Gu
Brain ischemia/reperfusion (I/R) injury (BI/RI) is a leading cause of death and disability worldwide. However, the outcome of pharmacotherapy for BI/RI remains unsatisfactory. Innovative approaches for enhancing drug sensitivity and recovering neuronal activity in BI/RI treatment are urgently needed. The purpose of this study was to evaluate the protective effects of tumor necrosis factor (TNF)-α-loaded poly(ethylene glycol)-b-(poly(ethylenediamine L-glutamate)-g-poly(L-lysine)) (TNF-α/PEG-b-(PELG-g-PLL)) nanoparticles on BI/RI. The particle size of PEG-b-(PELG-g-PLL) and the loading and release rates of TNF-α were determined. The nanoparticle cytotoxicity was evaluated in vitro using rat cortical neurons. Sprague Dawley rats were preconditioned with free TNF-α or TNF-α/PEG-b-(PELG-g-PLL) polyplexes and then subjected to 2 hours ischemia and 22 hours reperfusion. Brain edema was assessed using the brain edema ratio, and the antioxidative activity was assessed by measuring the superoxide dismutase (SOD) activity and the malondialdehyde (MDA) content in the brain tissue. We further estimated the inflammatory activity and apoptosis level by determining the levels of interleukin-4 (IL-4), IL-6, IL-8, IL-10, and nitric oxide (NO), as well as the expression of glial fibrillary acidic protein (GFAP), intercellular adhesion molecule-1 (ICAM-1), and cysteine aspartase-3 (caspase-3), in the brain tissue. We provide evidence that TNF-α preconditioning attenuated the oxidative stress injury, the inflammatory activity, and the apoptosis level in I/R-induced cerebral injury, while the application of block copolymer PEG-b-(PELG-g-PLL) as a potential TNF-α nanocarrier with sustained release significantly enhanced the bioavailability of TNF-α. We propose that the block copolymer PEG-b-(PELG-g-PLL) may function as a potent nanocarrier for augmenting BI/RI pharmacotherapy, with unprecedented clinical benefits. Further studies are needed to better clarify the underlying mechanisms.
研究领域:
药理学
·
神经科学
·
生物材料学
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PubMed
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Danping Wu,Quan Chen,Min Wu,Peng Zhang,Liping He,Yihui Chen,Bo Pan
The reactivity of pyrogenic carbon has attracted a great deal of research attentions recently. The oxygen-containing structures are rich on the surface of biochars, and involved in accepting and donating electrons during the interactions between biochar and organic contaminants . In this work, the species and content of oxygen-containing functional groups on biochar surface were regulated through chemical modification, and batch sorption/degradation experiments were carried out for rhodamine B (RhB). Based on the comparison of surface functional groups, biochars produced below 200 °C mediated RhB degradation through phenol hydroxyl group, while semiquinone and carboxylic acid groups were the main reaction active sites for biochars produced at higher than 500 °C. Considering that various biochar properties play roles in mediating organics degradation , the strategies in manipulating biochar properties should be carefully considered.
研究领域:
环境科学
·
材料科学
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高影响因子
OPTICAL MATERIALS
·
2022
·
IF 3.754
Hao Hu,Chengdong Xu,Jiacheng Jin,Mingchen Xu,Yue Cheng,Weiwei Ji,Zhencen Ding,Min Shao,Yushan Wan
In this paper, BiOIO 3 and Bi 2 O 4 nanosheet monomers were synthesized and used to prepare several BiOIO 3 /Bi 2 O 4 composites by an ultrasonic impregnation method. The resulting photocatalytic materials were characterized by XRD , SEM, TEM, XPS , FTIR, PL , UV–Visible diffuse reflectance spectroscopy (DRS), and BET. The photocatalytic activity of the BiOIO 3 /Bi 2 O 4 composites was evaluated by the degradation of rhodamine B (RhB) and ciprofloxacin (CIP) under simulated sunlight and compared to the activities of BiOIO 3 and Bi 2 O 4 operating alone. The results showed that Bi 2 O 4 was closely attached to the surface of BiOIO 3 , and the composite had a good degradation effect on RhB and CIP, with the best performing material being a 0.9-BiOIO 3 /Bi 2 O 4 composite, which achieved 97.6% degradation of RhB within 60 min and 85.6% degradation of CIP within 120 min. The observed degradation performance was considerably higher than that of other composite samples and monomers due to the good energy level matching of the BiOIO 3 /Bi 2 O 4 composite, which broadened the light response interval, improved the electron transfer rate and enhanced the photocatalytic activity. Free radical capture experiments showed that the ·O 2 - and h + free radicals significantly contributed to the degradation of pollutants. Cyclic tests showed that the composite also had good stability. The results of this study showed that bismuth-based photocatalysts might be used for environmental remediation.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
Nanoscale
·
2015
·Vol. 7
·期 19
·8955-8961
·
IF 7.394
Tao Yang,Xiwang Chang,Junhong Chen,Kuo-Chih Chou,Xinmei Hou
B-doped 3C-SiC nanowires have been synthesized via a facile and simple carbothermal reduction method at 1500 °C for 2 h in a flowing purified argon atmosphere. The obtained nanowires possess a single crystalline and finned microstructure with fins about 100–200 nm in diameter and 10–20 nm in thickness. The diameter of the inner core stem is about 80 nm on average. Due to the smaller band gap, the finned microstructure and the single crystalline nature, the B-doped 3C-SiC nanowires demonstrate efficient activity as high as 108.4 μmol h−1 g−1 for H2 production, which is about 20 times higher than that of 3C-SiC nanowhiskers and 2.6 times higher than the highest value reported in the literature for SiC materials.
研究领域:
材料科学
·
能源科学
·
光催化技术
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DOI
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Wantao Li,Yunlan Xu,Dengjie Zhong,Danli Tang,Tanxia Xiang,Chunmiao Fan,Yuanfang Yang
In this study, CoFe2O4 anchored by MoS2 modified biochar (CoFe2O4@MoS2–BC) was synthesized using a hydrothermal approach and utilized to activate peroxymonosulfate (PMS) to degrade rhodamine B (RhB). The effects of pH value, catalyst and PMS dosage, RhB concentration, and coexisting compounds were systematically investigated. Within 7 min, CoFe2O4@MoS2–BC achieved a removal rate of 99.63% for 100 mg·L–1 RhB. The outstanding stability and environmental compatibility of CoFe2O4@MoS2–BC was verified by cycling and metal ion leaching experiments. The contribution of 1O2, SO4•–, •OH, and •O2– in the degradation procedure was revealed by quenching experiments, among which 1O2 was the predominant active species. Electrochemical characterization indicated that CoFe2O4@MoS2–BC exhibited enhanced current density, redox activity, and superior electron transfer capability. Comprehensive characterization analysis and experimental data revealed that the high efficiency of CoFe2O4@MoS2–BC was attributed to Co2+/Co3+, Fe2+/Fe3+, and Mo4+/Mo6+ redox cycling on the CoFe2O4@MoS2–BC surface. The cycles of Co2+/Co3+ and Fe2+/Fe3+ were enhanced by Mo, while unsaturated S increased the reactivity of Mo, thereby accelerating the redox of metal ions; oxygen vacancies (Ov) enhance the mobility of surrounding oxygen ions mobility and promoted the conversion from lattice oxygen (Olat) to reactive oxygen species (O*), thereby activating PMS effectively. This research is expected to provide innovative insights that will inform the design and development of excellent activity and stability of heterogeneous metal-based catalysts.
研究领域:
环境科学
·
材料科学
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高影响因子
Journal of Materials Chemistry A
·
2016
·Vol. 4
·期 47
·18432-18443
·
IF 8.262
Mingjing Zhu,Heejun Kim,Yu Jin Jang,Sungmin Park,Du Yeol Ryu,Kyungkon Kim,Ping Tang,Feng Qiu,Dong Ha Kim,Juan Peng
Organic photovoltaics (OPVs) have drawn an extensive amount of attention due to their low cost, processibility and flexibility. However, a cell based on a blend of poly(3-hexylthiophene) (P3HT) and [6,6]-phenyl-C61-butyric acid methyl ester (PC61BM) has a limited power conversion efficiency (PCE) due to the short exciton diffusion length of ∼10 nm. We address this issue by designing a series of all-conjugated diblock copolymers, poly(3-hexylthiophene)-b-poly(3-(6-diethylphosphonatohexyl)thiophene) (P3HT-b-P3PHT), intended for use as additives to improve the performance of P3HT:PC61BM-based photovoltaic devices. The PCE of the devices improved from 3.30% to 4.03% with the addition of P3HT-b-P3PHT (3 : 1). The thermal stability of devices with P3HT-b-P3PHT additives improved significantly relative to that of the P3HT:PC61BM reference device, where the devices including a copolymer with a higher P3PHT content exhibited a better thermal stability. It was found that the fill factor (FF) could be regulated by simply varying the block ratio of P3HT-b-P3PHT and played a crucial role in improving both the PCE and the thermal stability. The P3HT-b-P3PHT diffused at the P3HT:PC61BM interface, improved the miscibility between P3HT and PC61BM, optimized the nanoscale morphology of the photoactive layer, and reduced the active layer roughness, all of which improved the FF and thus contributed to an improvement in device performance.
研究领域:
材料科学
·
能源科学
·
高分子化学
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高影响因子
危险品化学品经营许可证（带存储）