MICROPOROUS AND MESOPOROUS MATERIALS
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2024
·
IF 4.8
Xue-Juan Chen,Xi Hong,Bing Zhan,Xiu-Feng Hou
A series of nanosized “rice ball” like hierarchical beta zeolite aggregates (RBZ x A y , x = 6, 9, 12 or 15; y = 2, 4 or 6) with hierarchical structures are successfully synthesized via gel aging and hydrothermal method without mesoporous template. The as-prepared RBZ x A y zeolites possess two ranges of inter-crystalline mesoporous that formed by zeolite nanoparticles aggregation compared to the non-aged samples (B 12 Z 4 ). The effects of Si/Al ratio and crystallization time on the morphology, structure and surface acidic properties of RBZ x A y were systematically investigated. Meanwhile, RBZ x A y as catalysts were applied in the conversion of lactic acid (LA) to lactide (LT) to investigate their catalytic performance. Benefitting from smaller crystal size, hierarchical structures and higher acid content, the representative catalyst (RBZ 12 A 4 ) exhibited outstanding catalytic activity that the LA conversion was high to 98 % and the LT yield up to 94 %. In addition, RBZ 12 A 4 presented perfect regeneration ability after 10 times recycles. This work provides an effective and facile route to directly synthesis nanocrystals aluminosilicate zeolite with hierarchal structure, and constructs an approach for efficiently converting LA to LT, it has greatly significance for the development of polylactic acid industry.
研究领域:
化学
·
材料科学
·
催化
·
高分子科学
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DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Bihong Li,Yijie Ding,Weizhong Zheng,Weizhen Sun,Ling Zhao
Zeolites have emerged as the highly potential solid catalysts in isobutane (C4) alkylation due to their adjustable acidity and structural properties. The introduction of rare earth metal or transition metal can effectively regulate the acidic site distribution and strength of beta zeolite. The structural stability, acid properties and catalytic performance of low Si/Al ratio beta zeolites functionalized with various lanthanum and copper loadings are systematically investigated for the C4 alkylation through experimental characterization and catalytic evaluation. It is revealed that the optimal metal loading can impart superior acidic properties to beta zeolites. Lanthanum modification increases the total amount of Brønsted acid sites (BAS), and enhances the population of moderate and strong BAS compared to copper modification. Catalytic evaluation demonstrated that copper-modified beta zeolites achieve a higher research octane number (RON) up to 93 for alkylate, but exhibit a shorter catalyst lifetime. Lanthanide-modified counterparts exhibit a catalytic lifetime of 320 min and 65 wt% trimethylpentane (TMPs) selectivity with relatively stable RON of 90 during a prolonged stable operation, and meanwhile, the optimal lanthanide-modified HB-1 zeolites (0.35 wt% La@HB-1) demonstrate high level of catalytic lifetime and TMPs selectivity after three cycle experiment. The information obtained from this work will contribute to a better understanding of the metal-modified low-Si/Al-ratio beta zeolites for catalyzing the C4 alkylation.
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高影响因子
FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Liwei Zhao,Taijiao Xiang,Jiaoyu Wang,Ziming Xu,Danli Wang,Tinglan Yuan,Ling Li,Haina Yuan,Gongshuai Song,Mengna Zhang,Jinyan Gong
Protein-based emulsion gels with transglutaminase (TG)-catalyzed crosslinking exhibit great potential for delivering hydrophobic bioactive substances. However, effects of TG-catalyzed crosslinking modifications under different reaction times on the structural and textural characterization, stability, and delivery behavior have rarely been reported. This study investigated the effect of TG-catalyzed crosslinking on the physicochemical, structural, and functional properties of β-lactoglobulin (β-LG) - camellia oil (CAO) emulsion gels by cold-gelation under different reaction times. Results revealed that prolonged reaction times could improve the formation of intramolecular and intermolecular covalent bonds between lysine and glutamine residues. Rheological analysis showed an increase in both the storage modulus (G’) and loss modulus (G’’), indicating enhanced the gel elasticity and stability. Furthermore, the oxidative stability, the water-holding capacity, and functional stability (freeze-thaw, UV-light, thermal, and salt stability) of the emulsion gels were enhanced by the TG-catalyzed crosslinking. In the in vitro digestion process, the encapsulation efficiency and bioaccessibility of curcumin (Cur) were enhanced in the TG-catalyzed crosslinking β-LG-CAO emulsion gel system when the reaction time exceeded 3 h. The dense gel structure, improved stability, and great Cur delivery behavior of the emulsion gel could be formed by TG-catalyzed crosslinking at 4 h. This study benefited the encapsulation and release behavior of Cur in oil-in-water emulsions and the application in food and nutraceutical products.
研究领域:
食品科学
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生物化学
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DOI
高影响因子
RSC Advances
·
2024
·Vol. 14
·期 13
·9243-9253
·
IF 3.9
Shiyong Xing,Xiaofei Liu,Yan Cui,Yuehua Zhao,Ziheng Chen,Sigui Xiang,Minghan Han
Zeolite catalyzed alkylation of benzene with long-chain α-olefins is a promising method for the detergent industry. Considering the long-chain α-olefins from Fischer–Tropsch synthesis always contain some oxygenated organic compounds, the effect of which on the alkylation of benzene with 1-dodecene was comprehensively investigated over beta zeolite herein. n-heptanol, n-heptaldehyde and n-heptanoic acid were selected as the model oxygenated organic compounds, and it was revealed that an obvious decrease of lifetime occurred when only trace amount of oxygenated organic compounds were added into the feedstocks. The deactivated catalyst was difficult to regenerate by extraction with hot benzene or coke-burning. A series of characterization tests complementary with DFT calculations revealed that the deactivation was mainly caused by the firm adsorption of oxygenated organic compounds on the acid sites. Further, comparison with the open-framework MWW zeolite revealed a similar effect of oxygenated organic compounds and deactivation mechanism for both beta and MWW, but beta is less sensitive to the oxygenated organic compounds. The main reason lies in the three-dimensional framework of beta, wherein the much higher adsorption energy of 1-dodecene makes it difficult to be replaced by oxygenated organic compounds. Additionally, beta could be regenerated more easily by extraction with hot benzene compared with MWW. But coke-burning caused a sharp decrease of its lifetime, which is mainly due to the decreased acid sites after calcination.
研究领域:
催化化学
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材料科学
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表面科学
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产品关联
DOI
PubMed
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Cuicui Duan,Mengchun Qin,Lifan Liu,Yixue Sun,Lin Cai,Lin Ma,Xiaolei Li,Fumin Ma,Dan Li
Proanthocyanidin (PC) is with antioxidant, anticancer and neuroprotective effects. Cow’s milk beta-lactoglobulin (β-Lg) is reported with higher immunoregulatory activity but lower antioxidative function. In this study, a β-Lg-PC complex was prepared, and the interaction and structural characterization of β-Lg-PC complex were investigated by fluorescence spectral analysis, infrared spectroscopy and molecular docking, etc. PC quenched the intrinsic fluorescence and changed the conformation of β-Lg. The optimal ratio of β-Lg and PC (10:3, w/w) was determined by measuring the particle size and ζ potential. Molecular docking results implied that the covalent binding among complex was mainly concentrated on the binding of PC to amino acid residue ILE 71. Moreover, the antioxidant effects and mechanism of β-Lg-PC complex were explored using LPS-induced oxidative stress model of RAW264.7 cells. The results showed that β-Lg-PC could alleviate oxidative stress by slowing down the LPS-induced decline in SOD enzyme activity, increase in ROS level, loss of mitochondrial membrane potential and increase in apoptosis in RAW264.7 cells.
研究领域:
食品科学
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生物化学
·
免疫学
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产品关联
DOI
PubMed
高影响因子
FUEL
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2025
·
IF 7.5
Xiaowei Wu,Yuqin Li,Zhengquan Yang,Mingyu Peng,Tian Gui,Xiangshu Chen,Hidetoshi Kita
A beta zeolite membrane reactor was first applied to improve conversion on the esterification of oleic acid and n-butanol at low temperature by rapidly removing the by-product water. In the pervaporation (PV)-esterification at low temperature of 353 K, the final conversion of oleic acid was significantly improved to 99.2 % in a short reaction time of 4 h. Even at an incredibly low esterification temperature of 333 K, the conversion of oleic acid reached 95.7 % in 4 h. Besides, the beta zeolite membrane reactor exhibited good hydrothermal and acid stabilities with a high oleic acid conversion (maintained above 99 %) after 5 reaction cycles. Through XRD and SEM characterization, it was found that the membrane kept complete crystal structure. Process intensification through a beta zeolite membrane reactor aided by PV was successfully used to enhance the esterification at low temperature in a short time, which was a promising coupling technology.
研究领域:
化学工程
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材料科学
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Jiahong Chen,Yunzhu Qian,Heng Li,Wei Zuo,Wentao Sun,Danlei Xing,Xuefeng Zhou
Guided bone regeneration (GBR) technology has been widely used for the regeneration of periodontal bone defects. However, the limited mechanical properties and bone regeneration potential of the currently available GBR membranes often limit their repair effectiveness. In this paper, serum-derived growth factor lysophosphatidic acid (LPA) nanoparticles and dopamine-decorative nanohydroxyapatite (pDA/nHA) particles were double-loaded into polylactic-glycolic acid/polycaprolactone (PLGA/PCL) scaffolds as an organic/inorganic biphase delivery system, namely, PP-pDA/nHA-LPA scaffolds. Physicochemical properties and osteogenic ability in vitro and in vivo were performed. Scanning electron microscopy and mechanical tests showed that the PP-pDA/nHA-LPA scaffolds had a 3D bionic scaffold structure with improved mechanical properties. In vitro cell experiments demonstrated that the PP-pDA/nHA-LPA scaffolds could significantly enhance the attachment, proliferation, osteogenic differentiation, and mineralization of MC3T3-E1 cells. In vivo, the PP-pDA/nHA-LPA scaffolds exhibited great cytocompatibility and cell recruitment ability in 2- and 4-week subcutaneous implantation experiments and significantly promoted bone regeneration in the periodontal defect scaffold implantation experiment. Moreover, LPA-loaded scaffolds were confirmed to enhance osteogenic activities by upregulating the expression of β-catenin and further activating the Wnt/β-catenin pathway. These results demonstrate that the biphase PP-pDA/nHA-LPA delivery system is a promising material for the GBR.
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2013
·Vol. 1
·期 26
·3304-3313
·
IF 0
Tianyi Wu,Qingchun Zhang,Weiping Ren,Xiang Yi,Zubin Zhou,Xiaochun Peng,Xiaowei Yu,Meidong Lang
Infection of the bone (osteomyelitis) remains one of the most challenging problems in the field of orthopedic surgery. The limitations of systemic antibiotics administration include undesired side effects, systemic toxicity, patient discomfort, and development of bacterial resistance. In this study, we developed a bactericidal gentamicin-doped beta-tricalcium phosphate (TCP) scaffold reinforced with a gelatin/genipin hydrogel (G-TCP). Our data showed that the gentamicin-doped G-TCP had a much longer drug releasing period, while the gentamicin was completely released from pure TCP cements (B-TCP) within one day. In addition, the release profile of G-TCP exhibited an initial burst followed by a zero-order release. One standard strain, Staphylococcus aureus (S. aureus, ATCC25923) was selected to evaluate the antibacterial activity and therapeutic effect of this scaffold. G-TCP significantly inhibited growth of S. aureus both in vitro and in vivo. In a rat osteomyelitis model, osteomyelitis could be totally cured after implantation of G-TCP for three weeks. We propose that the gelatin/genipin–gentamicin TCP scaffold represents one of the promising gentamicin releasing bone scaffolds in treating osteomyelitis.
研究领域:
骨科手术
·
药剂学
·
生物材料
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DOI
PubMed
ACS Sustainable Chemistry & Engineering
·
2018
·
IF 6.14
Xiaomei Yang,Ying Liu,Xiaoxin Li,Jinxiu Ren,Lipeng Zhou,Tianliang Lu,Yunlai Su
Rapid synthesis of Sn-containing nanosized all-silica Beta zeolite was developed in this work. The method employed all-silica Beta (Si-Beta) as parent, which was crystallized in several hours by the hydrothermal method, and incorporated Sn to Si-Beta through grinding with SnCl4·5H2O and subsequent calcination procedure. The prepared Sn-Beta zeolites were analyzed by several methods including XRD, SEM, N2 physisorption, FT-IR spectroscopy of deuterated acetonitrile and pyridine adsorption, UV–vis DR, and XPS. The mechanism of incorporation of Sn sites into the framework of zeolite was revealed. The results show that the successful incorporation of Sn sites strongly depends on the crystallinity of the parent Si-Beta. Si-Beta with lower crystallinity (<90%) had a considerable amount of silanols which provided sites for Sn incorporation into the framework sites. For Si-Beta with higher crystallinity and less silanols, desilication was used to generate more silanols for the incorporation of Sn sites. The prepared Sn-Beta zeolites were effective for the transformation of glucose to methyl lactate (MLA). Its catalytic activity is better than those of Sn-Beta-P prepared by dealumination–stannation of Al-Beta and Sn-Beta-F synthesized through the traditional hydrothermal method. Turnover frequency (TOF) was calculated on the amount of framework Sn sites to measure the intrinsic and initial activity of active Sn sites. TOF values varied in the sequence of nano Sn-Beta ≫ Sn-Beta-F ≫ Sn-Beta-P. The high MLA yield for nano Sn-Beta is due to its higher mesoporosity. The prepared Sn-Beta zeolite was recycled eight times in the transformation of glucose to MLA without any decrease of catalytic activity. Additionally, the effect of potassium salt on the formation of MLA from glucose over Sn-Beta catalyst was studied.
研究领域:
材料科学
·
催化化学
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DOI
高影响因子
BIOMACROMOLECULES
·
2022
·
IF 6.978
Qimingxing Chen,Lili Su,Xiaoyan He,Jinwei Li,Yan Cao,Qingxia Wu,Jianchao Qin,Zongxing He,Xingxu Huang,Huiying Yang,Jianfeng Li
Base editing is an emerging genome editing technology with the advantages of precise base corrections, no double-strand DNA breaks, and no need for templates, which provides an alternative treatment option for tumors with point mutations. However, effective nonviral delivery systems for base editors (BEs) are still limited. Herein, a series of poly(beta-amino esters) (PBAEs) with varying backbones, side chains, and end caps were synthesized to deliver plasmids of BEs and sgRNA. Efficient transfection and base editing were achieved in HEK-293T-sEGFP and U87-MG-sEGFP reporter cell lines by using lead PBAEs, which were superior to PEI and lipo3k. A single intratumor injection of PBAE/pDNA nanoparticles induced the robust conversion of stopped-EGFP into EGFP in mice bearing xenograft glioma tumors, indicating successful gene editing by ABEmax-NG. Overall, these results demonstrated that PBAEs can efficiently deliver BEs for tumor gene editing both in vitro and in vivo.
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DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Chencheng Luo,Tianyi Yang,Yizhi Zhang,Lei Wu,Xiaoyu Zhu,Zhiyu Qian
Accurate detection of Alzheimer’s disease (AD) core biomarkers in body fluid is critical for identifying latent asymptomatic AD patients and prediction AD progress. Amyloid beta 1–40 (Aβ-40) as one of the core biomarkers, is expected to be an early diagnostic indicator for AD. Here, we establish a competitive method based on hairpin-structured aptamer for rapid and highly sensitive detection of Aβ-40 using square wave voltammetry (SWV). A hairpin aptamer with redox-active moiety methylene blue (MB) are immobilized on a gold working electrode as a recognition element. In the detection, a short complementary oligonucleotide strand is first introduced to switch on the hairpin, whereafter the targets Aβ-40 join in and selectively react with the aptamer in a competitive manner with the complementary strand, leading to the changes in the proximity of MB to the electrode and thereby in the electrochemical signal. Various parameters such as aptamer concentration, complementary chain length, incubation time, and temperature were optimized to achieve maximum sensing performance. By introducing a complementary chain, the sensor significantly reduces the detection limit to 7.14 pg/mL, with a dynamic range of 20 pg/mL to 200 ng/mL. Additionally, high selectivity of the sensor for Aβ-40 monomer (Aβ-40 m) over other forms of Aβ peptides has been validated. The hairpin-mediated detection method enables rapid, facile and highly sensitive detection of Aβ-40 using low-cost screen-printed electrode (SPE) platform, providing a wide range of possibilities for the early diagnosis of AD in point-of-care technologies (POCT).
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高影响因子
PHOTOCHEMISTRY AND PHOTOBIOLOGY
·
2014
·Vol. 90
·期 6
·1462-1466
·
IF 2.684
Ying Mei,Bing Yan
A special multifunctional ionic liquid compound (1-methyl-3-(2-(thiocarboxyoxy)-ethyl)-2H-imidazole-1,3-diium bromide (SHIL)) is used as the chemical bridge to link lanthanide beta-diketonates and polymer resin, which are designated as Ln(L) 4 -SHIL-WR/MR (Ln = Eu, Tb, Sm; L = thenoyltrifluoroacetonate (TTA), acetylacetonate (AA), dibenzoylmethane (DBM); WR = Wang resin, MR = Merrifield resin). Among SHIL and polymer resin are assembled to form covalently bonded system through condensation reaction. Then tetrakis lanthanide beta-diketonates are linked to SHIL through ion-exchange reaction. Physical characterization and especially the photoluminescent performance of the multicomponent hybrids are studied. The hybrid materials possess good stability and excellent luminescent property. The results provide useful path to obtain luminescent hybrids for further practical application.
研究领域:
材料科学
·
化学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）