Advanced Healthcare Materials
·
2018
·Vol. 7
·期 22
·1800830
·
IF 5.609
Li Song,Xinghua Dong,Shuang Zhu,Chunfang Zhang,Wenyan Yin,Xiao Zhang,Xiangfeng Liu,Zhanjun Gu
Although various types of photothermal agents are developed for photothermal cancer therapy, relatively few photothermal agents exhibit high tumor inhibition rate under relatively mild conditions. Herein, a multifunctional Bi 2 S 3 –Tween 20 nanoplatform loaded with PI3K inhibitor LY294002 is designed as a novel photothermal agent for inhibitor and photothermal synergistic therapy of tumors under mild photothermal therapy conditions. The LY294002 of PI3K inhibitor, after being loaded by Bi 2 S 3 –Tween 20 nanodots, exhibits greatly increased drug utilization and reduced side effects on normal tissues. In vivo, Bi 2 S 3 –Tween 20@LY294002 upon near-infrared 808 nm laser irradiation shows potent antitumor activity under relatively mild conditions (power density: 0.6 W cm −2 ). Moreover, the mechanism studies also demonstrate that Bi 2 S 3 –Tween 20@LY294002 potently kills LoVo cancer cells under low-power near-infrared light irradiation, by downregulating the expression of heat shock protein 70 (HSP70) so as to increase the sensitivity of tumor cell hyperthermia and activating BAX/BAK-regulated mitochondrial apoptosis pathway. The results demonstrate that the newly synthesized multifunctional nanoplatform paves a new avenue for accurate therapy of photothermal-resistant cancer.
研究领域:
纳米技术
·
癌症治疗
·
药学科学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2023
·
IF 7.2
Wenjing Zhang,Dekang Liu,Wei Jin,Dekai Zhang,Tao Sun,Enzhou Liu,Xiaoyun Hu,Hui Miao
Bi 2 O 2 S has gradually attracted the interest of researchers due to its excellent carrier mobility and light absorption property . However, its application in photoelectrochemical water splitting is very limited. In this work, hydrothermal treatment is performed on the obtained Bi 2 O 2 S film. Bi 2 S 3 nanowires are in-situ evolved by the topological transformation of Bi 2 O 2 S, and heterojunction with atomic-level contact interface is constructed. The photocurrent density of Bi 2 O 2 S/Bi 2 S 3 photoelectrode at 1.23 V vs. RHE is 3.82 mA/cm 2 , which is 14 times that of monomer Bi 2 O 2 S. The Bi 2 O 2 S/Bi 2 S 3 heterojunction co-shared by Bi atoms has a close contact coupling interface, which stimulates stronger interfacial charge transfer. In addition, the 2D/1D morphology of the synthesized Bi 2 O 2 S nanosheets combined with Bi 2 S 3 nanowires by fine tuning builds a channel for fast carrier transport. This study provides reference and inspiration for the preparation of highly active heterostructures, and expands new paths for the design and application of Bi 2 O 2 S based photoelectrodes.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Jiafeng Xi,Xiaojuan Liu,Liang Zhang,Zuwang Zhang,Junchen Zhuo,Ting Du,Yajie Zhang,Jinyou Duan,Hongliang Dong,Jianlong Wang
Within the illustrious and renowned MXene family, Niobium carbide (Nb 2 C) has astounded researchers by exhibiting an extraordinary level of photothermal conversion efficiency and photothermal stability, all while maintaining the possibility of biodegradability. However, the absence of band gaps hindered Nb 2 C as an attractive photoresponsive material for sterilization purposes. To overcome this obstacle, we engineered a Schottky heterojunction in Nb 2 C by introducing Ru and Bi 2 S 3 based on the work function theory to generate an internal electric field (IEF) in Ru@Bi 2 S 3 /Nb 2 C, thus enhancing the photocatalytic sterilization performance by improving the charge transfer efficiency. The strategic doping of Ru also improved the carrier separation as an electron trap, apart from enhancing the light absorption efficiency by exploiting the Localized Surface Plasmon Resonance (LSPR). The results of Ultraviolet Photoelectron Spectroscopy (UPS) and X-ray photoelectron spectroscopy (XPS) divulge the stark difference in work function, which facilitates the directional transfer of carrier and subsequently augments the formation of Schottky heterojunction. This unique structure which is beneficial to the generation of reactive oxygen species (ROS). As a result, the in vitro sterilizing efficiency of the Ru@Bi 2 S 3 /Nb 2 C exceeds 99.87%, and in vivo experiments demonstrated wound healing effects in mouse wound models. These results have confirmed the significant implications of Schottky heterojunction for the use of Nb 2 C in the biomedical sector.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Bing Xing,Ting Wang,Xiaobo Han,Kun Zhang,Benxia Li
The rational integration of semiconductor quantum dots (QDs) with anatase TiO 2 nanostructures is a promising strategy to develop efficient photocatalysts. Herein, Bi 2 S 3 QD/TiO 2 photocatalyst was constructed by controllably depositing Bi 2 S 3 QDs on flower-like TiO 2 nanostructures and used for the photocatalytic redox-coupling reaction of H 2 evolution and oxidative transformation of benzyl alcohol. The abundant amino groups in TiO 2 nanostructures served as the anchoring sites for uniform growth of Bi 2 S 3 QDs. The anchoring of Bi 2 S 3 QDs onto TiO 2 nanostructures not only enhanced the photoabsorption ability and the photogenerated charge separation efficiency but also afforded powerful photogenerated charge carriers and abundant active sites for the photocatalytic reaction. As a result, the Bi 2 S 3 QD/TiO 2 photocatalyst exhibited a favorable performance in the redox-coupling reaction, providing the high production rates of H 2 up to 4.75 mmol·g cat −1 ·h −1 and benzaldehyde up to 6.12 mmol·g cat −1 ·h −1 , respectively, as well as an excellent stability in the long-term photocatalytic reaction. Meanwhile, a trace amount of water in the reaction system could act as a promoter to accelerate the photocatalytic redox-coupling reaction. The photocatalytic mechanism following S-scheme heterojunction was proposed according to the systematic characterizations and experimental results. This work offers some insight into the rational construction of efficient and cost-effective photocatalysts for the conversion of solar to chemical energy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Nianqi Meng,Peijing Xu,Changchun Wen,Huihui Liu,Cunji Gao,Xing-Can Shen,Hong Liang
Bismuth sulfide is widely used as an n -type semiconductor material in photocatalytic reactions. However, bismuth sulfide has poor absorption in the near-infrared region and low charge separation efficiency, limiting its application in phototherapy and sonodynamic therapy (SDT). In this study, we successfully synthesized an “all-in-one” phototheranostic nanoplatform, namely Bi 2 S 3-x [email protected] , based on a single second near-infrared (NIR-II) light-responsive Schottky-type Bi 2 S 3-x -Au heterostructure for photoacoustic (PA) imaging-guided SDT-enhanced photodynamic therapy (PDT)/photothermal therapy (PTT). Bi 2 S 3-x [email protected] exhibits excellent NIR-II plasmonic and photothermal properties, rendering it with NIR-II PA imaging capabilities for accurate diagnosis. Additionally, the high-density sulfur vacancies constructed on the Bi 2 S 3 surface cause it to possess a reduced band gap (1.21 eV) that can act as an electron trap. Using the density functional theory, we confirmed that the light and ultrasound-induced electrons are more likely to aggregate on the Au nanoparticle surface through interfacial self-assembly, which promotes electron-hole separation and enhances photocatalytic activity with increased reactive oxygen species (ROS) generation. With a further modification of hyaluronic acid (HA), Bi 2 S 3-x [email protected] can selectively target cancer cells through HA and CD44 protein interactions. Both in vitro and in vivo experiments demonstrated that Bi 2 S 3-x [email protected] effectively suppressed tumor growth through SDT-enhanced PTT/PDT under a single NIR-II laser and ultrasound irradiation with negligible toxicity. Our findings provide a framework for fabricating Schottky-type heterostructures as single NIR-II light-responsive nanotheranostic agents for PA imaging-guided cancer phototherapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Hongguo Zhai,Yue Wang,Lingjun Geng,Qi Guo,Yuhao Zhang,Qingqing Yang,Xia Sun,Yemin Guo,Yanyan Zhang
In this paper, an electrochemiluminescence (ECL) biosensor was constructed using Bi 2 S 3 @Au nanoflowers as the based nanomaterial and [email protected] and CdS QDs as independent ECL emission signal respectively. As the substrate of the working electrode, Bi 2 S 3 @Au nanoflowers improved the effective area of electrode and accelerated electron transfer rate between gold nanoparticles and aptamer, provided a good interface environment for the loading of luminescent materials. Then, the [email protected] functionalized DNA2 probe was used as an independent ECL signal source under positive potential and recognized Cd(II), while the CdS QDs functionalized DNA3 probe was used as an independent ECL signal source under negative potential and recognized ampicillin. The simultaneous detection of Cd(II) and ampicillin in different concentrations are realized. This sensor not only has good selectivity and high sensitivity in real sample detection, but also open up a novel way to construct multi-target ECL biosensor for simultaneous detection.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2022
·Vol. 19
·期 7
·2206231
·
IF 15.153
Zi Qiao,Jie Ding,Chengheng Wu,Ting Zhou,Kai Wu,Yusheng Zhang,Zhanwen Xiao,Dan Wei,Jing Sun,Hongsong Fan
The past decades have witnessed the rational design of novel functional nanomaterials and the potential to revolutionize many applications. With the increasing focus on electronic biological processes, novel photovoltaic nanomaterials are highly expectable for empowering new therapeutic strategies such as establishing a link between endogenous electric field (EEF) and electrotherapy. Compared to traditional invasive stimulation, the light-initiating strategy has the advantages of non-invasion, non-power supply, and precise controllability. Whereas, common photoactivated materials require short-wavelength light excitation accompanied by poor tissue penetration and biohazard. Herein, by the construction of p-n heterostructured Bi 2 S 3 /TiO 2 /rGO (BTG) nanoparticles, broadener light absorption and higher light conversion than regular UV excitation are realized. Simultaneously, the photoelectric performance of BTG heterostructure, as well as the synergistic effect of Bi 2 S 3 morphology, are revealed. Besides, the rationally designed biomimetic hydrogel matrix consisting of collagen and hyaluronic acid provides appropriate bioactivity, interface adhesion, mechanical matching, and electron transfer. Therefore, the photovoltaic BTG-loaded matrix provides a platform of light-driven electrical stimulation, coupling the EEF to modulate the electrophysiological and regeneration microenvironment. The implementation of photoelectric stimulation holds broad prospects for non-drug therapy and electrical-related biological process modulation including osseointegration, nerve regeneration, electronic skin, and wound healing.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2022
·Vol. 414
·期 24
·7277-7289
·
IF 4.478
Wang Min,Hou Li,Chen Xiaoyu,Lin Tianran
A simple homogeneous photoelectrochemical (PEC) sensing platform based on an alkaline phosphatase (ALP)–mediated pesticide assay was established for the sensitive detection of omethoate (OM). The Bi 2 S 3 @Bi 2 Sn 2 O 7 heterojunction was used as a photoactive material to provide stable background photocurrent signals. The inhibition of OM on ALP and PEC determination was carried out in the homogeneous system. In the absence of OM, dephosphorylation of L-ascorbic acid 2-phosphate trisodium salt (AAP) was catalyzed by ALP to produce the enzyme-catalyzed product (L-ascorbic acid, AA). AA, as an electron donor, could capture photogenerated holes on the Bi 2 S 3 @Bi 2 Sn 2 O 7 heterojunction, thus inhibiting the recombination of electron holes to achieve an increase of the photocurrent signal. When the OM was introduced, the enzyme activity of ALP was reduced due to the organophosphorus pesticides (OPs)–based enzyme inhibition, and the AA produced by catalytic hydrolysis was also reduced, thus reducing the photocurrent signal. Compared with the traditional PEC sensor for OPs, this homogeneous PEC sensor avoided immobilization procedures, covalent labeling, separation, and the steric hindrance effect caused by immobilized biomolecules, which achieved high recognition efficiency and caused a reduction in analysis time. Additionally, an ALP-mediated pesticide assay for the determination of OPs with a simplified experimental process further improved the stability and reproducibility of the PEC sensor. The PEC sensor showed high sensitivity to the target OM within a dynamic range of 0.05 ~ 500 ng mL −1 , and the detection limit was 0.0146 ng mL −1 . Additionally, the PEC biosensing system showed good selectivity and anti-interference ability, and exhibited a satisfactory result in spinach and mustard samples. Graphical abstract A homogeneous PEC biosensor based on ALP inhibition strategy was constructed for OM detection in vegetable samples via Bi 2 S 3 @Bi 2 Sn 2 O 7 heterojunction as the photoactive substrate material
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2021
·
IF 8.067
Jun Guo,Yu-Ke Zhu,Lin Chen,Zi-Yuan Wang,Zhen-Hua Ge,Jing Feng
Bi 2 S 3 -based alloys are considered promising thermoelectric materials due to their large Seebeck coefficient and low lattice thermal conductivity . However, low electrical conductivity usually leads to poor electrical transport properties, which seriously restricts their further application in thermoelectric refrigeration and/or power generation. In this work, Bi 2 S 3 with high electrical transport properties is synthesized hydrothermally via Se and Cl co-doping. The maximum electrical conductivity value of 483 S cm −1 was obtained for the Bi 2 S 2.4 Se 0.4 Cl 0.20 sample at room temperature. The significant improvement of electrical conductivity gives rise to a high average power factor of 411 μW m −1 K −2 during the measuring temperature range and a peak value of 456 μW m −1 K −2 at 673 K. Benefiting from the largely improved electrical transport properties, a superior ZT value of approximately 0.66 and ZT ave . of 0.36 were obtained for Bi 2 S 2.4 Se 0.4 Cl 0.20 , and the theoretically calculated conversion efficiency reached 5.7%. The results indicate that Bi 2 S 3 is a promising candidate for thermoelectric applications at medium temperatures.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Qianwei Liang,Sittipranee Ploychompoo,Jingda Chen,Tingting Zhou,Hanjin Luo
Rational design strategy and facile synthesis method of photocatalysts with high efficiency and stability have been still a significant challenge for the removal of environmental contaminants. In this study, a three dimensional (3D) all-solid-state Z-scheme heterojunction photocatalytic system containing bismuth sulphide (Bi 2 S 3 ) and bismuth vanadate (BiVO 4 ) was constructed as Bi 2 S 3 -BiVO 4 graphene aerogel (SVGA) by a facile hydrothermal method. The potential application of as-synthesized SVGA was demonstrated to remove Cr(VI) and bisphenol A (BPA) simultaneously in aqueous media via the synergy of adsorption and photocatalysis under visible light irradiation. The removal rates of Cr(VI) and BPA both nearly reached 100% after adsorption for 40 min and photocatalysis for 120 min under visible light (λ > 420 nm), which was much better than the removal efficiency of individual Bi 2 S 3 and BiVO 4 , as well as Bi 2 S 3 graphene aerogel (SGA) and BiVO 4 graphene aerogel (VGA) samples. The rGO played an important role as photoinduced electron transfer mediator between Bi 2 S 3 and BiVO 4 , which promoted the photogenerated electrons transfer efficiency and enhanced photocatalytic ability of SVGA efficiently. The harmful Cr(VI) was conserved into hypotoxic Cr(III) and BPA was degraded into CO 2 and H 2 O after photocatalysis on SVGA, and the fabricated SVGA also presented favorable stability and satisfactory application effect in practical water samples, implied that such photocatalyst has a promising application for simultaneous removal of heavy metals and organics from aqueous environment.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2014
·Vol. 182
·期 1
·241-248
·
IF 3.719
Wang Mo,Yang Zhiqing,Guo Yunlong,Wang Xinxu,Yin Huanshun,Ai Shiyun
We demonstrate a photo-electrochemical biosensor for the sensitive and specific detection of microRNA using Bi 2 S 3 nanorods as a photoactive material and streptavidin as the unit that inhibits photocurrent. Bi 2 S 3 nanorods were synthesized hydrothermally in organic phase and displayed excellent light-to-current conversion efficiency. The Bi 2 S 3 was deposited on an indium tin oxide (ITO) slice and then modified with gold nanoparticles onto which biotinylated hairpin probe DNA was deposited as a monolayer. Following hybridization between the biotinylated probe DNA and the target microRNA, the stem-loop structure of the probe DNA was unfolded and the biotin directed outwards into the solution. Streptavidin was then added to bind to biotin via the strong streptavidin-biotin interactions. This causes the photocurrent of the modified ITO to decrease due to steric hindrance that blocks the transfer of electrons from added ascorbic acid to the surface of the electrode. The method has a detection limit as low as 3.5 fM of microRNA and can excellently discriminate even singly mismatched microRNA. The method was successfully applied to investigate the effect of abscisic acid on the expression level of microRNA-159a in seeds of Arabidopsis thaliana . We conclude that the assay presented here has a large potential as a method for quantification of microRNA and for studying the epigenetic regulation of flowering plants.
The photocurrent generation and decrease mechanism of the PEC biosensor.
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Yan Sang,Jingwei Xue,Junjie Hu,Peng Zhang,Fugang Zhao,Yanping He
High-low heterojunctions derived from metal-organic frameworks (MOFs) have promising applications in photocatalytic wastewater treatment because of their high photo-redox ability and boosted charge separation efficiency. Herein, Bi-MOF derived porous hierarchical Bi 2 O 3 /Bi 2 S 3 nanoflower-like heterojunctions were prepared by the calcination-hydrothermal method. The optimized Bi 2 O 3 /Bi 2 S 3 -2 composite showed a higher degradation rate of Cr (VI) (99.79 % in 30 min) than the pure substance. Moreover, comprehensive studies were conducted on the kinetics, stability and recycling of Bi 2 O 3 /Bi 2 S 3 , as well as optical characteristics . The active species trapping experiments confirmed that e - plays a dominant role in the elimination of Cr (VI). These findings provided novel strategies for construction of porous hierarchical heterojunctions with advanced visible-light-induced degradation performance. The enhanced photo-degradation efficiency of the optimal nanocomposite was assigned to the higher visible-light absorbance, separation of photogenerated carriers, reduced recombination of photo-induced carriers, and enhanced redox capability owing to the construction of porous hierarchical heterojunctions amongst the components.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）