COMBUSTION SCIENCE AND TECHNOLOGY
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2025
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IF 1.5
Baichen Chen,Yi Wang,Jianchen He,Xiaolan Song,Chongwei An
This article uses a combination of experimental and simulation methods for mutual verification to explore the possibility of nano aluminum thermite damaging chips and disrupting circuit systems. In terms of experiments, Fe2O3/SiO2/Al and SnO2/SiO2/Al aluminum thermites were prepared by physically mixing micro Al powder, nano SiO2, and nano metal oxide powder in a certain proportion. The binder was added and pressed into a charge column for ignition testing. The prepared aluminum thermite was characterized and its performance was tested using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray photoelectron spectroscopy(XPS), and constant pressure combustion experiments.In terms of molecular dynamics simulation, Materials Studio software was used to investigate the interaction relationships between atoms in the aluminum thermite. The reaction process and properties of the aluminum thermite under adiabatic conditions at different initial temperatures were explored from the perspectives of potential energy, radial distribution function, mean square displacement, and self diffusion coefficient. The simulation results were compared with experimental reaction phenomena. The results show that the aluminum thermite prepared by physical method is uniformly mixed, various materials are fully adhered, well dispersed, and there is no agglomeration phenomenon. In terms of combustion performance, the overall performance of Fe2O3/SiO2/Al thermite is better than that of SnO2/SiO2/Al thermite, with higher combustion efficiency, higher reaction temperature, and the ability to maintain high temperature for a longer period of time. The combustion of Fe2O3/SiO2/Al aluminum thermite is more complete, and the reaction generates more elemental Si, which plays a positive role in the damage of chips. In terms of molecular dynamics simulation, the aluminum thermal reaction of Fe2O3/SiO2/Al at different initial temperatures is more stable, with a faster energy release rate and a higher total energy content than SnO2/SiO2/Al. The aluminum thermal reaction generates oxides of elemental Fe/Sn, Si, and Al. Overall, the diffusion coefficients of both aluminum thermites increase with the increase of initial temperature, and the intensity of the reaction also increases with the increase of initial temperature. Temperature has an accelerating effect on their diffusion, and SnO2/SiO2/Al has stronger diffusion ability than Fe2O3/SiO2/Al. The Fe2O3/SiO2/Al aluminum thermite has a better damage effect on chips, and the simulation and experimental results are consistent.
研究领域:
材料科学
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计算化学
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工程学
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产品关联
DOI
高影响因子
Biomaterials Research
·
2025
·
IF 9.6
Chengpan Li,Jing Pan,Zhengdi Shi,Xinyan Zeng,Xiaoping Xia,Xiaogang He,Wei Wang,Bensheng Qiu,Weiping Ding,Dabing Huang
Endometrial clear cell cancer (ECCC) is an extremely rare and highly malignant subtype of endometrial cancer. For most ECCC patients, cancer metastasis is the major cause of death. To date, due to the complexity of cancer evolution and the small number of cases, the metastasis of ECCC at the early stage remains largely unknown. Herein, we modeled the early invasion-metastasis cascade of ECCC by coculturing the ECCC patient-derived tumor cells (PDTCs) and primary human vascular endothelial cells on a microfluidic chip. With the chip, we for the first time replicated the dynamic migration of PDTCs into the surrounding stroma, including the intravasation and extravasation of PDTCs through the capillaries/microvessels, and presented the changes in the morphology and permeability of capillaries, with the decreased diameter and the increased permeability after cancer metastasis. We found that PDTCs were more invasive than the common endometrial adenocarcinoma cells. In addition, we preliminarily explored the inhibition of drugs on the early PDTC infiltration. This study provides new ideas for better understanding of ECCC evolution.
研究领域:
肿瘤学
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生物医学工程
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细胞生物学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2025
·
IF 5.1
Chao Gao,Ziheng Song,Huijie Chen,Ling Wu,Zhibing Weng,Lei Jiang,Qingru Wang,Yingdong Han
Surface-enhanced Raman spectroscopy (SERS) is a powerful fingerprint spectroscopic technique capable of detecting trace molecules, which finds extensive application potential in diverse fields. The SERS substrates with excellent Raman signal enhancement, scalability in large-scale fabrication, and long-term stability is of significant scientific interest and practical value. Herein, we report a hybrid SERS substrate, namely tip-Si@MoSxOy, which integrates a periodic tip-patterned Si metasurface with MoSxOy semiconductor nanostructures, to develop novel noble-metal-free SERS substrate with sensitive molecule detection performance. The engineered periodic Si metasurface enables broadband matrix resonance by coupling with incident light, significanlty amplifying the localized near-field intensity at the inter-element nanogap regions. Theoretical calculations show that the maximum E-field enhancement can be up to 511 times. Meanwhile, the MoSxOy semiconductor leads to modification of the the polarization of probe molecules due to the charge-transfer interactions enabling chemical mechanism SERS effect. These combined effects make the detection of rhodamine 6G (R6G) at concentrations as low as 10-9 M and enhancement factor as high as 107. Moreover, the hybrid substrate exhibits superior antioxidation properties, eliminating the requirement of inert storage environments necessary for traditional noble-metal-based SERS substrates. Also, the MoSxOy semiconductor nanosructures are covalently bonded to the metasurface, ensuring structural stability without the need for post-transfer processes. Therefore, our work provides a novel approach to develop hybrid substrates with improved SERS performance, which is readily achievable and is expected to attract more research enthusiasm in the future.
研究领域:
分析化学
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纳米技术
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材料科学
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光学
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光谱学
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半导体物理
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产品关联
DOI
高影响因子
LAB ON A CHIP
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2025
·
IF 5.4
Xueqing Ren,Xin Wang,Xiaolu Cai,Yi Zou,Peng Chen,Bi-Feng Liu,Yiwei Li
Hydrogel microspheres, derived from natural or synthetic materials, serve as crucial platforms for three-dimensional (3D) cell culture and tissue engineering. While traditional production methods like emulsification and microfluidics are widely used, they often involve complex processes and oil phases that can compromise biocompatibility. Here, we present a novel centrifugal microfluidic device with an air gap for producing hydrogel microspheres. Centrifugal force provides a driving force for uniform parallel channels, enabling high-throughput microsphere generation while ensuring size uniformity. The system enables precise size control through centrifugal speed modulation, producing microspheres with diameters ranging from 140.6 ± 17.3 μm to 417.1 ± 34.4 μm with a coefficient of variation below 4.8%. The air gap within the microchannel establishes a step-structure that enables oil-free microsphere generation while ensuring biocompatibility. Moreover, by blending a collagen solution into sodium alginate as the matrix, oil-free microspheres with an interpenetrating polymer network (IPN) can be fabricated, which exhibit excellent biocompatibility to support the culture and adipogenic differentiation of mesenchymal stem cells (MSCs). When cells are cultured with a microsphere-formed scaffold, they exhibit aggregation behavior for enhanced cell–cell communication, which further elevated their adipogenic differentiation potential. Overall, this simplified, high-throughput approach offers a unique platform for applications in cell delivery, drug screening, and tissue engineering.
研究领域:
微流控
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生物医学工程
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组织工程
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细胞培养
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药物递送
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高分子科学
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干细胞研究
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2024
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IF 5.6
Jinlong Liu,Meiyan Qin,Yimin Shi,Rui Jiang,Zizhen Wang,Lingqian Zhang,Yang Zhao,Hang Gao,Mingxiao Li,Chengjun Huang
The evaluation of nanoparticles (NPs) cytotoxicity is crucial for advancing nanotechnology and assessing environmental pollution. However, existing methods for NPs cytotoxicity evaluation suffer from limited accuracy and inadequate information content. In the study, we developed a novel detection platform that enables the identification of cellular carbonyl metabolites at the organ level. The platform is integrated with a cell co-culture lung organ chip (LOC) and a micropillar concentrator. Notably, our work represents the successful measurement of the amounts of cellular metabolites on LOC system. The volatile carbonyl metabolites (VCMs) generated by cells exposure to various types of NPs with different concentrations were captured and detected by high-resolution mass spectrometry (MS). Compared with conventional cell viability and reactive oxygen species (ROS) analysis, our method discerns the toxicological impact of NPs at low concentrations by analyzed VCM at levels as low as ppb level. The LOC system based metabolic gas detection confirmed that low concentrations of NPs have a toxic effect on the cell model, which was not reflected in the fluorescence detection, and the effect of NP material is more significant than the size effect. Furthermore, this method can distinguish different NPs acting on cell models through cluster analysis of multiple VCMs.
研究领域:
生物医学工程
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毒理学
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分析化学
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产品关联
DOI
PubMed
高影响因子
CRYSTAL GROWTH & DESIGN
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2025
·
IF 3.4
Hui Guo,Meixuan Li,Ziqi Liu,Yitong Li,Jialin Chen,Xiaoxi Yu
The complexity and sensitivity of proteins make their crystallization a significant bottleneck in structural biology, materials science, and biopharmaceutical research. The development of microfluidics technology provides substantial advantages in studying protein crystallization, thanks to its low reagent consumption and high-throughput capabilities. In this study, a novel microfluidic chip was designed to enable continuous and precise control of concentration gradients in microdroplets. The structure of the microfluidic chip was designed by using COMSOL in the first place. The accuracy and continuity of droplet concentrations were further confirmed through fluorescence dye experiments. The designed microfluidic chip was then employed to high throughput map the crystallization phase diagram of the model protein lysozyme, demonstrating highly consistent results with 96-well plates. Additionally, a microarray was utilized to effectively screen the crystallization conditions of papain, resulting in the purification of papain through scale-up experiments.
研究领域:
结构生物学
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生物物理学
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分子生物学
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药物研发
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生物制药
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产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Feng Hong,Xiao-Yan Zhu,Wen-Ting Fan,Jing-Du Li,Yi-Fei Lu,Le-Bao Mao,Wei-Hua Huang,Yan-Ling Liu
High-fat foods are decomposed into fatty acids during digestion and absorption, primarily occurring in the gastrointestinal tract, and numerous studies have indicated that long-term high-fat diets significantly increase the incidence of intestinal disorders. As a critical intestinal hormone, serotonin (5-hydroxytryptamine, 5-HT) is involved in regulating intestinal peristalsis, secretion, and visceral sensitivity. However, due to the lack of methods capable of reproducing intestinal mechanical activities and in situ monitoring of 5-HT levels, the influence of high-fat diets on intestinal 5-HT release remains unclear. Herein, we presented a deformable peristalsis-mimicking intestinal epithelium chip with a built-in stretchable electrochemical sensor for in situ and quantitative 5-HT detection. Two high-fat diet models were established by pretreating the intestinal epithelium with saturated fatty acid (palmitic acid, PA) and unsaturated fatty acid (oleic acid, OA), respectively. Both PA and OA could promote epithelial 5-HT synthesis and increase 5-HT release during intestinal motility, while OA exhibited a stronger stimulatory effect on 5-HT release than PA, which might be associated with the OA-enhanced intestinal epithelial barrier. These results provide important insights into the differential roles of saturated and unsaturated fatty acids in regulating intestinal function.
研究领域:
生物医学工程
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微流控技术
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胃肠生理学
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生物传感器
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营养科学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
·
2025
·
IF 5
Hongqiang Chen,Quan Gao,Xiang Ma,Kai Li,Wangfang Du,Caifeng Li,Yonghai Zhang,Jinjia Wei
Phase change flow boiling heat transfer in microchannel is a very efficient thermal management mode for high-power electronics/devices cooling. However, achieving comprehensive enhancement of flow boiling heat transfer performance at low power consumption is still challenging. Herein, we devised and manufactured a teardrop-like micro-pin-fin coated stable copper hydroxide nanotubes array chip surfaces (S-Nanotube), demonstrating their exceptional enhancement in flow boiling heat transfer efficiency. A series of experiments were conducted using HFE-7100 as a working fluid within a semi-open microchannel. Compared to the smooth surface, the critical heat flux (CHF) and the maximum boiling heat transfer coefficient (HTC) of the S-Nanotube is increased by 82.1 % (from 45.1 to 72.9 and then to 82.1 W/cm 2 ) and 140.5 % (from 5955 to 11,325 and then to 14,316 W/m 2 ·K) at extremely low-pressure drop (≤4 kPa), showing a high coefficient of performance (COP). The temperature of the onset of nucleate boiling on the S-Nanotube surface is reduced by 26.4 %, and the heat flux is greatly increased in a small wall temperature variations (Δ T ≤ 10 °C). In situ observation and analysis of the surface properties and the bubble dynamics, the S-Nanotube chip promotes the phase change heat transfer process by providing massive nucleation sites, reducing bubbles size and residence time, and enhancing the wicking wetting capacity. These findings provide guidance for the rational design of boiling heat transfer-enhanced surfaces and heat sinks and point the way to achieving efficient thermal management of power devices.
研究领域:
电子冷却
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热管理
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材料科学
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传热学
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DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Haijing Tian,Ruo Wu,Qi Lv,Jie Shi,Xiaoqin Guo,Duo Li,Chunli Liu,Qi Li,Weijia Zheng,Haojun Fan,Xuexin Duan,Qiannan Xue
Blood potassium and creatinine levels are critical indicators for managing chronic kidney disease (CKD). In response to the need for home monitoring and emergency care, point-of-care diagnostic technologies based on microsystems have emerged, nevertheless they remain limited in portability and speed for direct in whole blood samples measurement. To enable direct blood detection of potassium and creatinine for effective CKD management, this study presents a novel on-chip self-driven dual-channel optical microsensor designed for real-time monitoring of potassium and creatinine levels in whole blood. Utilizing 3D printing technology to design and fabricate microstructures, and integrating microchannels with a filtration layer, this microsensor requires only 10 μL of blood for single-pass sample filtration and dual-parameter detection. A novel passive blood sample pumping method is proposed, utilizing internal and external pressure differentials along with internal hydrophilic properties to facilitate sample flow into the detection chambers. Light-emitting diodes (LEDs) and photodiodes, positioned on either side of the detection chamber, are employed to measure the concentrations of blood indicators. The detection results can be instantly handheld read and uploaded to the cloud via intelligent terminal, enabling seamless follow-up diagnostics and treatment. Through multiple rounds of testing on animal serum samples, whole blood samples, and real porcine blood samples, this microsensor demonstrated excellent linearity and accuracy. This innovative microsensor, designed for direct testing from a minimal volume of whole blood, holds significant potential for improving CKD management, offering a portable, reliable alternative for preoperative diagnostics and home-based chronic disease monitoring.
研究领域:
医学工程
·
生物医学
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Yannan Xue,Chen Li,Yuan Ma,Yongxin Hu,Meiyue Ma,Yixuan Wu,Lei Zhao,Wenxuan Jiang,Jiayu Yang,Xiao Liu,Tiantian Sun,Qi Gao,Shuai Meng,Qiang Liu,Tiehai Li,Chengli Zong
Conventional microarray chemistries are generally optimized for amine-bearing probes, whereas native polysaccharides and glycolipids often require prior derivatization for immobilization, which risks altering key carbohydrate epitopes. Here, we developed a dual-anchor microarray platform ( DAMP ) by modifying commercially available poly-L-lysine-coated slides with NHS esters and diazirine photo-crosslinkers. The key innovation of this platform is the complementary dual-chemistry design on a high-loading 3D surface: NHS chemistry enables efficient immobilization of amine-bearing probes, whereas diazirine-mediated photo-crosslinking enables derivatization-free capture of underivatized native glycans. The resulting platform enabled rapid immobilization of native polysaccharides and glycolipids under mild UV irradiation and showed markedly enhanced sensitivity for amine-bearing glycans:10 pg/mL for a synthetic glycan and 0.32 ng/mL for purified pneumococcal cell wall polysaccharide. DAMP also supported the immobilization of 29 structurally distinct carbohydrates with retained lectin recognition, as well as direct analysis of 13 native capsular polysaccharides for pneumococcal serotyping and vaccine-response profiling. This work establishes a practical and sensitive surface platform for high-fidelity carbohydrate immobilization and expands the utility of microarrays in polysaccharide research and glycan-based vaccine studies.
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产品关联
DOI
高影响因子
Acta Biomaterialia
·
2025
·
IF 9.6
Yushen Wang,Xinyu Li,Junlei Han,Feng Kong,Zhipeng Xu,Huili Hu,Li Wang
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver disease characterized by lipid zonation, which is closely linked to the functional zonation of liver lobules. However, existing models cannot faithfully replicate the oxygen gradient that regulates liver zonation, hindering a clear understanding of the progression and intervention mechanisms in MASLD. Here, we constructed a MASLD liver-zonation-on-a-chip that utilizes an engineering strategy based on “environmental oxygen convection and diffusion”, achieving a controllable oxygen concentration gradient (3.7%-8.9%) that closely mimics the in vivo hepatic microenvironment. This platform successfully recapitulates the typical features and clinicopathological phenotypes of the liver lobule while enabling continuous monitoring of liver injury. We found that upregulation of the oxygen-sensing factor HIF-2α does not directly promote lipid accumulation. Instead, it indirectly facilitates the progression of MASLD by enhancing the transcriptional activity of β-catenin through the WNT signaling pathway (e.g., AXIN2, DVL1 ). As regulators of the damage process, HIF-2α and β-catenin may be targeted to improve outcomes in MASLD. Significance of statement Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common liver disorder characterized by lipid zonation, which is closely related to the functional zonation of liver lobules. However, existing models are unable to accurately replicate the oxygen (O 2 ) gradients that regulate liver zonation, a limitation that hinders their ability to accurately reflect hepatocyte pathophysiology and obstructs understanding of the mechanisms underlying MASLD progression. This study constructs a liver-zonation-on-a-chip with a controllable physiological O₂ gradient and integrated biosensing for non-destructive injury monitoring. The O 2 gradient chip successfully replicates liver lobule zonation, providing an engineering approach to overcoming the challenge of low regional heterogeneity in liver organoids. The application of the liver-zonation-on-a-chip in pathological assessments has also been thoroughly evaluated, offering potential solutions for MASLD interventions.
研究领域:
生物医学工程
·
肝病学
·
微生理系统
·
分子生物学
·
代谢性疾病
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Yongshou Chen,Zhilin Luo,Xuejie Li,Huang Yan,Chenfeng Xia,Shuting Wu,Xiaopeng Hao,Zihua Wang,Zhiyuan Hu
Circulating tumor cells (CTCs) are critical biomarkers for cancer metastasis and recurrence; however, their extremely low abundance in peripheral blood and marked heterogeneity pose substantial challenges for accurate detection. Here, we present a CTC detection platform that combines covalent conjugation via click chemistry, dual-marker targeting (EpCAM and TROP2), and enzyme-mediated brightfield imaging for label-free CTC identification. The platform is based on vertically aligned silicon nanowire arrays modified with an amyloid-like BSA antifouling coating and tetrazine groups. This configuration enables stable immobilization of TCO-modified antibodies. Systematic optimization of key parameters, such as antibody ratio, dosage, nanowire architecture, and incubation time, enabled high-efficiency CTC capture. Compared to conventional antibody-functionalized chips, this platform achieved approximately 2-fold higher capture efficiency in tumor cell models. Under low-abundance conditions (3–10 cells/mL), the chip maintained reliable capture performance across multiple tumor cell lines, and in 1 mL peripheral blood samples from breast cancer patients, 1–5 CTCs were successfully identified with no false positives in healthy donors. Furthermore, benchmarking against representative CTC platforms (CellSearch, NanoVelcro, Parsortix, etc.) demonstrated a distinctive balance between capture performance, operational simplicity, and clinical feasibility. Notably, the brightfield imaging strategy eliminates the need for fluorescence microscopy, enabling cost-effective and rapid CTC detection. Together, these results validate the platform’s clinical applicability for low-abundance CTC detection and highlight its potential for real-world liquid biopsy–based cancer monitoring.
研究领域:
肿瘤学
·
生物工程
·
液体活检
·
纳米技术
·
癌症诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）