BIOMEDICINE & PHARMACOTHERAPY
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2015
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IF 2.023
Liandong Hu,Saixi Pang,Qiaofeng Hu,Deliang Gu,Dongqian Kong,Xiaoyun Xiong,Jianying Su
Background The current study aimed to investigate whether the novel folate (FT) modified nanoparticles (NPs) co-loaded with docetaxel (DT) and curcumin (CU) (named as FT-NPs) could enhance the delivery efficiency to tumor compared with the NPs without FT (non-targeted NPs). Methods FT-NPs were successfully formulated in this article. In vitro cytotoxic activity against A549 cells and in vivo antitumor activity of FT-NPs in S180 cell bearing mice were conducted. Cellular uptake test was used to evaluate uptake efficiency of FT-NPs. Histological observation was used to determine the lung security. Besides, the physical chemical properties such as stability, particle size, zeta potential , drug encapsulation efficiency, transmission electron microscopy (TEM) were also conducted. Results FT-NPs exhibited stronger growth inhibition effects on A549 cells compared with non-targeted NPs, moreover, the novel FT-NPs indicated more effective antitumor efficacy in inhibiting tumor growth. Confocal laser scanning microscopy indicated that the uptake of FT-NPs was facilitated and effective. Histological observation meant that FT-NPs were biocompatible and appropriate for pulmonary administration. Conclusion These results confirmed that FT-NPs with relatively high drug loading capacity could effectively inhibit tumor growth and reduce toxicity. The novel FT-NPs could produce as an outstanding nanocarrier for the targeted treatment of cancers .
研究领域:
药学
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纳米技术
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肿瘤学
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生物医学工程
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EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
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2014
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IF 4.245
Zheng Wang,Chao Chen,Qi Zhang,Min Gao,Ju Zhang,Deling Kong,Yanjun Zhao
To precisely manipulate the intracellular delivery of pleiotropic curcumin , this work reports two types of acid-responsive polymer–curcumin conjugates with different structures. One or two amphiphilic poly(ethylene glycol)-co-poly(lactic acid) (PEG-PLA) copolymer(s) were linked to curcumin via pH-liable hydrazone, producing a linear or phospholipid-like conjugate, respectively. Both conjugates efficiently self-assembled into micellar nanocarriers with enhanced stability in contrast to the paralleling PEG-PLA micelles. In comparison to the micelles assembled by phospholipid-like conjugates, the linear conjugate micelles exhibited similar size, doubled loading dose, higher release rate, and hence enhanced cellular uptake and cytotoxicity at the cost of increased critical micelle concentration. This work highlighted the importance of precise tuning of polymer–drug conjugate architecture in determining the pharmaceutical properties and thus delivery efficiency of the corresponding conjugate micelles.
研究领域:
药剂学
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生物医学工程
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高分子化学
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CHINESE JOURNAL OF CHEMISTRY
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2016
·Vol. 34
·期 7
·657-661
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IF 1.872
Zhengyi Li,Jinbei Yan,Yue Yin,Zhihui Zhang,Zhiming Wang,Defeng Xu,Xiaoqiang Sun
A simple and nontoxic fluorescent chemosensor of di- O -methyl curcumin has been prepared from curcumin. The sensor exhibited selective and sensitive fluorescent responses toward Al 3+ over a wide range of metal ions, such as Mn 2+ , Ce 3+ , Pt 2+ , Sn 4+ , Hg + , Sb 3+ , K + , Ca 2+ , Mg 2+ , Ba 2+ , Cu 2+ , Ni 2+ , Na + , NH 4 + , Ag + , Pb 2+ , Zn 2+ , Fe 2+ , Fe 3+ , Hg 2+ and Cr 3+ in ethanol/water. The free ligand showed quite weak fluorescence emission due to the isomerization of CO double bond in the excited state, however, after addition of Al 3+ , fluorescence emission results in a prominent fluorescence enhancement.
研究领域:
分析化学
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生物化学
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FOOD RESEARCH INTERNATIONAL
·
2014
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IF 3.05
Wei Xu,Weiping Jin,Chunlan Zhang,Zhenshun Li,Liufeng Lin,Qing Huang,Shuxin Ye,Bin Li
A facile approach to fabricate micro-complex in moderate condition via self-assembly of κ -carrageenan (CRG) and lysozyme (Lys) was investigated for the first time to encapsulate and protect curcumin . The interaction between CRG and Lys, size and morphology were studied by zeta potential, UV–vis spectroscopy, circular dichroism (CD), scanning electron microscope (SEM), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). A tentative interactive model was proposed for polysaccharide and protein. The results indicated that the spherical shaped CRG/Lys complex with 1 μm diameter was spontaneously formed by one spot incubating. Both CRG and Lys were participated in forming the shell of micro-complex synthesized through physical interactions. The encapsulation efficiency (EE) and loading capacity (LC) of curcumin for the CRG/Lys complex prepared with CRG/Lys ratio 2:1 were 71 ± 0.02% and 50.71 ± 0.71 μg ml − 1 respectively. The stability of curcumin loaded in complex was improved about 2.7 fold, 2 fold and 1.7 fold when disposed with 80 °C treatment for 1 min, 60 °C treatment for 30 min and ultraviolet radiation for 2 h. DPPH measurement verified the protection of bioactivity as encapsulated. The worthwhile endeavor elucidated proteins/polysaccharides complex was feasible to solubilize and protect sensitive amphiphilic bioactive compounds and has extensive potential in food and medicinal application with various purposes.
研究领域:
食品科学
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生物化学
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医药工程
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JOURNAL OF APPLIED POLYMER SCIENCE
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2017
·Vol. 135
·期 15
·46127
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IF 1.86
Hongxia Liu,Changbing Zhou,Xinyue Liu,Yang Xu,Simin Geng,Yunhua Chen,Chun Wei,Chuanbai Yu
We demonstrate a facile route to prepare novel composite microspheres based on Pickering emulsion template stabilized by cellulose nanocrystals prepared from sisal fiber (SCNCs). The oil phase of the Pickering emulsions contains hydrophobic drug curcumin and poly(methyl methacrylate) (PMMA). Curcumin loaded PMMA composite microspheres coated by SCNCs (Cur-loaded PMMA@SCNC CMs) were obtained after the evaporation of dichloromethane. The structure and morphology of CMs were characterized by polarized optical microscope (POM), confocal laser scanning microscope, scanning electric microscope, and Fourier transform infrared spectroscopy. The stability and release kinetics of curcumin were evaluated based on spectrophotometric measurements. Overall, these results show that Cur-loaded PMMA@SCNC CMs display long-term photostability and good encapsulating ability for curcumin. This work offers an effective route of preparing new functional microsphere for the delivery of bioactive compounds. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46127.
研究领域:
材料科学
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药物递送
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生物医学工程
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Nanoscale
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2016
·Vol. 8
·期 5
·3040-3048
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IF 7.76
Xiao Xi Yang,Chun Mei Li,Cheng Zhi Huang
Interactions between nanoparticles and viruses have attracted increasing attention due to the antiviral activity of nanoparticles and the resulting possibility to be employed as biomedical interventions. In this contribution, we developed a very simple route to prepare uniform and stable silver nanoparticles (AgNPs) with antiviral properties by using curcumin, which is a member of the ginger family isolated from rhizomes of the perennial herb Curcuma longa and has a wide range of biological activities like antioxidant, antifungal, antibacterial and anti-inflammatory effects, and acts as reducing and capping agents in this synthetic route. The tissue culture infectious dose (TCID50) assay showed that the curcumin modified silver nanoparticles (cAgNPs) have a highly efficient inhibition effect against respiratory syncytial virus (RSV) infection, giving a decrease of viral titers about two orders of magnitude at the concentration of cAgNPs under which no toxicity was found to the host cells. Mechanism investigations showed that cAgNPs could prevent RSV from infecting the host cells by inactivating the virus directly, indicating that cAgNPs are a novel promising efficient virucide for RSV.
研究领域:
纳米技术
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病毒学
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生物医学工程
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2023
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IF 4.4
Shen Zhang,Jinjia Bao,Ling Lv,Yongjie Bai,Yiming Zhang,Yaofang Zhang
The non-standard use of curcumin could cause some adverse drug reactions, such as diarrhea, nausea and skin allergies. Thus, the curcumin determination was fundamental to disease treatment and prevention. Herein, a facile and efficient fluorescent probe was developed based on carbon dots, which was prepared through hydrothermal method (o-phenylenediamine and N-isopropylacrylamide as the reaction raw materials). Characteristics of the as-fabricated carbon dots (NCDs) were studied through some analysis techniques, such as UV–vis absorption spectroscopy, transmission electron microscopy, Fourier transform infrared instrument, X-ray photoelectron spectroscopy and fluorescence spectrophotometer. Fluorescence quenching phenomenon could be observed after addition of curcumin. This as-prepared fluorescent probe displayed a significant response for the determination of curcumin with a satisfactorily lower detection limit of 0.017 μM and a considerable linear range of 0.5–50 μM compared to reported literatures. Because of the preeminent repeatability and anti-jamming capability, the as-developed CDs suggested mighty potentiality for actual applications of curcumin detection in real samples and temperature sensing.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2023
·
IF 5.8
Hui Shi,Shuo Huai,Huiling Wei,Ying Xu,Lei Lei,Hao Chen,Xingyi Li,Huixiang Ma
Intraocular inflammation seriously impairs vision, and the effectiveness of intraocular drug delivery is hampered by various physiological barriers, such as the corneal barrier. In this paper, we present a simple approach to fabricating a dissolvable hybrid microneedles (MNs) patch for the efficient delivery of curcumin to treat intraocular inflammatory disorders. Water-insoluble curcumin was first encapsulated into polymeric micelles with high anti-inflammatory capacities, and then were combined with hyaluronic acid (HA) to create a dissolvable hybrid MNs patch using a simple micromolding method. Curcumin was amorphously dispersed within the MNs patch as indicated by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) analyses. According to an in vitro drug release study, the proposed MNs patch provided sustainable drug release over 8 h. Following its in vivo topical application, the MNs patch demonstrated an extended pre-corneal retention time over 3.5 h and exhibited great ocular biocompatibility . Additionally, such MNs patch could reversibly penetrate the corneal epithelium, generating an array of microchannels on the corneal surface, thereby increasing ocular bioavailability. Of greater significance, the use of MNs patch demonstrated the improved therapeutic effectiveness in treating endotoxin-induced uveitis (EIU) in a rabbit model compared to curcumin eye drops via a significant reduction in the infiltration of inflammatory cells such as CD45 + leukocytes and CD68 + macrophages. Overall, the topical application of the MNs patch as an efficient ocular drug delivery system could potentially serve as a promising approach for treating different types of intraocular disorders.
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Pharmaceutics
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2023
·Vol. 15
·期 5
·1341
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IF 5.4
Yuze Sheng,Qin Yu,Yanping Huang,Quangang Zhu,Zhongjian Chen,Wei Wu,Tao Yi,Yi Lu
Nanocrystals (NCs) have the potential to enhance the oral bioavailability of Class IV drugs in the Biopharmaceutical Classification System (BCS) due to the absorption of the intact crystals. The performance is compromised by the dissolution of NCs. Drug NCs have recently been adopted as solid emulsifiers to prepare nanocrystal self-stabilized Pickering emulsions (NCSSPEs). They are advantageous in high drug loading and low side effects due to the specific drug loading mode and the absence of chemical surfactants. More importantly, NCSSPEs may further enhance the oral bioavailability of drug NCs by impeding their dissolution. This is especially true for BCS IV drugs. In this study, curcumin (CUR), a typical BCS IV drug, was adopted to prepare CUR-NCs stabilized Pickering emulsions using either indigestible (isopropyl palmitate, IPP) or digestible (soybean oil, SO) oils, i.e., IPP-PEs and SO-PEs. The optimized formulations were spheric with CUR-NCs adsorbed on the water/oil interface. The CUR concentration in the formulation reached 20 mg/mL, which was far beyond the solubility of CUR in IPP (158.06 ± 3.44 μg/g) or SO (124.19 ± 2.40 μg/g). Moreover, the Pickering emulsions enhanced the oral bioavailability of CUR-NCs, being 172.85% for IPP-PEs and 152.07% for SO-PEs. The digestibility of the oil phase affected the amounts of CUR-NCs that remained intact in lipolysis and, thus, the oral bioavailability. In conclusion, converting NCs into Pickering emulsions provides a novel strategy to enhance the oral bioavailability of CUR and BCS IV drugs.Keywords:curcumin;nanocrystals;Pickering emulsions;oral bioavailability;BCS IV;lipolysis
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E-POLYMERS
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2023
·Vol. 23
·期 1
·
IF 3.7
Xuya Fu,Tao Zhang,Wenshuo Zhang,Yuye Zhong,Shuliang Fang,Guannan Wang,Ying Li,Yajun Deng,Xinghai Liu,Houbin Li
Biomass films with ultraviolet (UV)-shielding ability have attracted considerable attention. Curcumin was introduced into castor oil-based polyurethane (CCPU) as a chain extender, which was melt with polylactic acid (PLA) as a reinforcement to obtain biomass UV-shielding film. The excellent UV absorption and antioxidant qualities of curcumin contributed to the impressive UV-shielding capacity (97.6% UV radiation absorption) and antioxidant (51% free radical scavenging) of PLA/CCPU-20 film. In the scanning electron microscopic images of film fracture, the mixing of CCPU elastomer into the PLA matrix caused the blend films to exhibit significant toughening fracture characteristics compared to the pure PLA film. The excellent thermal stability, low water swelling degree, and low water solubility of PLA/CCPU blend films were maintained after CCPU was added to the PLA matrix. Therefore, the PLA/CCPU blend films can be considered as a potential packaging material because of its favorable UV-shielding properties and film stability.
Graphical abstract
Schematic for the preparation of the PLA/CCPU blend films.
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Lingyu Zhao,Xiaowei Ding,Imran Mahmood Khan,Lin Yue,Yin Zhang,Zhouping Wang
Curcumin (Cur) is a natural pigment with excellent biological activity. The poor stability and insolubility of Cur in water severely limit its application. Therefore, to overcome these dilemmas which are big hindrances in their application, a novel derivative (COCS-Cur) was prepared by the esterification reaction of carboxylated chitosan (COCS) and Cur. The structure and properties of conjugate were determined through a series of characterizations. The derivatives had excellent solubility as well as stability. In addition, antioxidant and photodynamic antibacterial experiments proved that COCS-Cur had the excellent free radical scavenging ability and photodynamic antibacterial activity . The derivatives presented a better antibacterial effect on Staphylococcus aureus ( S. aureus ) than Escherichia coli ( E. coli ). Noteworthy, the COCS-Cur derivatives showed no obvious toxicity which makes them a stronger contender and potential antimicrobial agent or functional nutrient for application in the food industry.
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International Journal of Nanomedicine
·
2023
·
IF 8
Xuemei Zhang,Xuejuan Li,Hongchen Hua,Aiping Wang,Wanhui Liu,Youxin Li,Fenghua Fu,Yanan Shi,Kaoxiang Sun
Glioma has one of the highest mortality rates among primary brain tumors. The clinical treatment for glioma is very difficult due to its infiltration and specific growth locations. To achieve improved drug delivery to a brain tumor, we report the preparation and in vitro and in vivo evaluation of curcumin nanoparticles (Cur-NPs). The cyclic hexapeptide c(RGDf(N-me) VK)-C (cHP) has increased affinity for cells that overexpress integrins and was designed to target Cur-NPs to tumors. Functional polyethyleneglycol-modified poly(d,l-lactide-co-glycolide) (PEG-PLGA) conjugated to cHP was synthesized, and targeted Cur-NPs were prepared using a self-assembly nanoprecipitation process. The physicochemical properties and the in vitro cytotoxicity, accuracy, and penetration capabilities of Cur-NPs targeting cells with high levels of integrin expression were investigated. The in vivo targeting and penetration capabilities of the NPs were also evaluated against glioma in rats using in vivo imaging equipment. The results showed that the in vitro cytotoxicity of the targeted cHP-modified curcumin nanoparticles (cHP/Cur-NPs) was higher than that of either free curcumin or non-targeted Cur-NPs due to the superior ability of the cHP/Cur-NPs to target tumor cells. The targeted cHP/Cur-NPs, c(RGDf(N-me)VK)-C-modified Cur-NPs, exhibited improved binding, uptake, and penetration abilities than non-targeting NPs for glioma cells, cell spheres, and glioma tissue. In conclusion, c(RGDf(N-me)VK)-C can serve as an effective targeting ligand, and cHP/Cur-NPs can be exploited as a potential drug delivery system for targeting gliomas.
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