Nature Communications
·
2026
·
IF 15.7
Cheng Kai,Zhang Fang,Zou Jia-Hua,Lei Xiao-Ling,Xie Xiao-Ting,Guo Yan-Bin,Wang Guo-Ping,Liu Bo,Zhao Yuan-Di,Xia Jiang,Fan Jin-Xuan
The significant challenges pose by the high recurrence and metastasis rates of colorectal cancer (CRC) persist in its diagnosis and treatment. Activating innate immunity in CRC treatment has the potential to reduce drug resistance and side effects. Here, we develop a biomimetic platform by utilizing antimicrobial peptide-functionalized CRC cell membranes to encapsulate a cobalt-based metal-organic framework (C), hereby called peptide-functionalized camouflage C (PfCC). When injected into tumour-bearing mice, PfCC will degrade under the acidic condition of the tumour microenvironment and release cobalt ions, which react with endogenous H 2 S to generate black stellate precipitates with good photothermal properties, recruiting NK cells and mitigates the immunosuppressive tumour-microenvironment. Simultaneously, the degradation of PfCC will release structure-protected antimicrobial peptides, inhibiting harmful bacteria, such as Desulfovibrio , and reducing H 2 S production. The abovementioned synergistic top-down regulation of H 2 S promote the polarization of macrophages and further activates the innate immune response. Moreover, experiments including the convex hull algorithm from AI deep learning of the segment anything model indicate that PfCC exhibites the most effective therapeutic effect compared with the single H 2 S-regulated therapeutic modality. Taken together, PfCC represents a potential anti-cancer therapy for CRC with the combined effect of immune-regulation and the regulation of the gut flora.
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高影响因子
Nanomaterials
·
2020
·Vol. 10
·期 6
·
IF 4.324
Fang Peng,Yan Sun,Weiwei Yu,Yue Lu,Jiaming Hao,Rui Cong,Jichao Shi,Meiying Ge,Ning Dai
In this work, the compositional optimization in copper oxide/tungsten trioxide (CuO/WO3) composites was systematically studied for hydrogen sulfide (H2S) sensing. The response of CuO/WO3composites changes fromp-type ton-type as the CuO content decreases. Furthermore, thep-type response weakens while then-type response strengthens as the Cu/W molar ratio decreases from 1:0 to 1:10. The optimal Cu/W molar ratio is 1:10, at which the sensor presents the ultrahighn-type response of 1.19 × 105to 20 ppm H2S gas at 40 °C. Once the temperature rises from 40 °C to 250 °C, the CuO/WO3(1:1) sensor presents thep-nresponse transformation, and the CuO/WO3(1:1.5) sensor changes from no response ton-type response, because the increased temperature facilitates the Cu-S bonds break and weakens thep-type CuO contribution to the total response, such that the CuS bond decomposition by a thermal effect was verified by a Raman analysis. In addition, with a decrease in CuO content, the CuO is transformed from partly to completely converting to CuS, causing the resistance of CuO to decrease from increasing and, hence, a weakening mode ofp-CuO andn-WO3to the total response turns to a synergistic mode to it.
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CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Chao Zhang,Kaidi Wu,Hanlin Liao,Marc Debliquy
Pristine Bi 2 WO 6 nanosheets and hierarchical WO 3 -Bi 2 WO 6 microflowers were prepared via a facile hydrothermal technique. WO 3 -Bi 2 WO 6 microflowers were assembled with thin nanosheets, where WO 3 nanoparticles were uniformly loaded. The H 2 S sensing properties of pristine Bi 2 WO 6 nanosheets and hierarchical WO 3 -Bi 2 WO 6 microflowers were systematically investigated at room temperature. 20 WO 3 -Bi 2 WO 6 microflowers sensor displayed the best sensing property towards ppb-level H 2 S compared with all other samples. The enhancement was ascribed to the catalytic effect of WO 3 nanoparticles and the modified microstructure with large specific surface areas. Moreover, the n–n heterojunction structures also increase the thickness of electron depletion layer and potential barrier height, which could efficiently improve the sensing properties. The practical application of 20 WO 3 -Bi 2 WO 6 microflowers sensor in detecting the volatiles of Pangasius was also studied in this work. Therefore, the hierarchical WO 3 -Bi 2 WO 6 microflower is a promising ppb-level H 2 S sensing material for environment monitoring and fish freshness detection.
研究领域:
材料科学
·
环境科学
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Science Advances
·
2022
·
IF 14.957
Zheng Su,Lingtong Kong,Yong Dai,Jin Tang,Jiawei Mei,Zhengzheng Qian,Yuanyuan Ma,Qianming Li,Shenghong Ju,Jiaxing Wang,Wenpei Fan,Chen Zhu
There is an increasingly growing demand for nonantibiotic strategies to overcome drug resistance in bacterial biofilm infections. Here, a novel “gas-sensitized hyperthermia” strategy is proposed for appreciable bacteria killing by the smart design of a metal-organic framework (MOF)–sealed Prussian blue–based nanocarrier (MSDG). Once the biofilm microenvironment (BME) is reached, the acidity-activated MOF degradation allows the release of diallyl trisulfide and subsequent glutathione-responsive generation of hydrogen sulfide (H2S) gas. Upon near-infrared irradiation, H2S-sensitized hyperthermia arising from MSDG can efficiently eliminate biofilms through H2S-induced extracellular DNA damage and heat-induced bacterial death. The generated H2S in the biofilm can stimulate the polarization of macrophages toward M2 phenotype for reshaping immune microenvironment. Subsequently, the secretion of abundant regeneration-related cytokines from M2 macrophages accelerates tissue regeneration by reversing the infection-induced pro-inflammatory environment in an implant-related infection model. Collectively, such BME-responsive nano-antibacterials can achieve biofilm-specific H2S-sensitized thermal eradiation and immunomodulatory tissue remodeling, thus realizing the renaissance of precision treatment of refractory implant–related infections.
研究领域:
纳米医学
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传染病学
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材料科学
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免疫学
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组织工程
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高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Xiaohui Wang,Yuqi Wan,Jingkun Li,Yukihiro Ozaki,Jiahua Wang,Fuwei Pi
Surface-enhanced Raman scattering (SERS) has extraordinary potential in detecting hydrogen sulfide (H 2 S) gas molecules due to its high sensitivity and specificity. However, constructing SERS substrates with strong Raman signal enhancement effects has been a major challenge. In this study, a gold/silver nanostars (Au/Ag NSs) islands chip was developed, leveraging the phenomenon that the SERS enhancement can be significantly improved by patterning plasmonic metals with micro/nanostructures. Compared to the SERS mapping spectrogram of the conventional homogeneous Au/Ag NSs chip, uniform and dense hot spots were formed on the surface of the island chip, which is the key to remarkable enhancement of Raman signal. Both chips were functionalized with 4-mercaptophenylboronic acid (4-MPBA) for the quantitative detection of H 2 S. The islands chip displays 1.6 folds and 2 orders higher blank Raman signal intensity and a limit of detection (LOD) for H 2 S than conventional homogeneous SERS chips, respectively. The islands chip is also used for on-line monitoring of spoilage in high-protein foods. The detection ranges for H 2 S were 2 × 10 −8 M – 2 × 10 −3 M, with a LOD of 1.9 nM. This sensing strategy provides not only a novel approach for on-ling gaseous hazards detection for food spoilage but also a potential possibility for monitoring gas molecules in the environment.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Mingzhen Shi,Wenjie Xiong,Zhuoheng Tu,Xiaomin Zhang,Xingbang Hu,Youting Wu
Developing environmental benign and efficient solvents for the natural gas sweetening is of great significance to the development of green chemistry. However, there is no task-specific deep eutectic solvents (DESs) for H 2 S absorption so far. Herein, we have for the first time developed a series of task-specific DESs for the selective separation of H 2 S, in which quaternary ammonium salts with free tertiary amine groups are designed as hydrogen bond acceptors (HBAs) and azoles as hydrogen bond donors (HBDs). Density, viscosity, and thermal decomposition temperature, as well as the solubility of H 2 S (0–1.0 bar), CO 2 (0–1.0 bar), and CH 4 (0–5.0 bar) were systematically determined. NMR paired with theoretical calculations are applied to characterize the interaction mechanism of H 2 S and DESs. A reaction equilibrium thermodynamic model (RETM) with a 1:2 stoichiometric reaction mechanism was screened to correlate H 2 S solubility data. It is found that [C 4 -TMHDA][Cl]-Im could achieve up to 0.996 mol H 2 S per mol DES at 303.2 K and 1.0 bar. Moreover, the captured H 2 S can be easily stripped out at elevated temperature and reduced pressure, with negligible loss in H 2 S capacities during four absorption–desorption cycles. The results obtained in this work indicate that these DESs are promising candidates for efficient and selective separation of H 2 S and CO 2 from natural gas. This work provides novel insights into the future design of high-performance task-specific DESs for the capture of H 2 S.
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CHEMICAL ENGINEERING SCIENCE
·
2019
·
IF 3.372
Piao Liu,Jianxin Cao,Zheng Xu,Chunliang Yang,Xiaodan Wang,Fei Liu
Core-shell structured ZSM-5@t-ZrO 2 catalysts were prepared by a hydrothermal coating method, and their physicochemical properties, catalytic performance, and deactivation behavior in thiolation reactions were studied using a ZSM-5/t-ZrO 2 physically-blended catalyst as a comparison. Reactions using the core-shell ZSM-5@t-ZrO 2 catalyst were carried out at a pressure of 0.7 MPa, 370 °C, a H 2 S:CH 3 OH molar ratio of 2:1, and a N 2 flow rate of 90 ml·min −1 . The conversion of CH 3 OH, and the selectivity and yield of CH 3 SH under these conditions were 92.07%, 90.89%, and 83.68%, respectively, and the catalytic lifetime was longer than 30 h. Compared with the ZSM-5/t-ZrO 2 physically-blended catalyst, the CH 3 SH yield and the catalytic lifetime of the core-shell structured ZSM-5@t-ZrO 2 catalyst were higher by 5.37% and 150%, respectively. The unique reaction pathway of the shell (t-ZrO 2 , Lewis (L) base active site)-core (ZSM-5, Brǿnsted (B) acid active site) and the Lewis-Brønsted acid active center based on a composite solid-solution interface were mainly responsible for the high activity of the thiolation reaction. Meanwhile, the formation of a micro-mesoporous system increased the diffusion of molecules and reduced the deactivation rate of carbon- and sulfur-containing deposits. Generally, carbon- and sulfur-containing substances deposited on catalysts were mainly composed of polymethylbenzene, polymethyl naphthalene, cyclic elemental sulfur, and other compounds containing C S and S S bonds. Finally, the core-shell structured catalysts showed excellent resistance to deactivation by carbon- and sulfur-containing deposits.
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RSC Advances
·
2016
·Vol. 6
·期 88
·85529-85537
·
IF 3.289
Sheng Chen,Chao Ma,Mao-Sen Yuan,Wenji Wang,Dong-En Wang,Shu-Wei Chen,Jinyi Wang
Hydrogen sulfide (H2S) and sulfite (SO32−) are two important sulfur-containing species that play different and important roles in industrial and biological processes. Accordingly, the development of efficient methods for simple, rapid, sensitive and selective monitoring of H2S and SO32− is of the utmost importance in both environmental and biological sciences. In this study, we developed a new dual functional probe NIR-DNP for discriminative detection of H2S and SO32−. This probe can sense H2S and SO32− via two different approaches, a significant near-infrared fluorescence enhancement and color change from purple to cyan induced by H2S as well as a visible color change from purple to colorless caused by SO32−. The detection limits of the probe NIR-DNP for H2S and SO32− in aqueous solutions were 36.53 nM and 33.33 nM, respectively. Competitive experiments demonstrated that the probe NIR-DNP had a high fluorescence selectivity for H2S and excellent colorimetric selectivity for SO32− over other analytes. The sensing mechanism of the probe toward H2S and SO32− was based on the H2S-induced thiolysis of dinitrophenyl ether and SO32−-induced nucleophilic addition, respectively. Further investigation showed that the probe NIR-DNP could be used to develop an easy-to-prepare and easy-to-detect paper-based test strip for cheap and effective detection of SO32−. Also, the probe NIR-DNP has the potential to image exogenous and endogenous H2S in living cells.
研究领域:
环境科学
·
生物化学
·
分析化学
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2017
·
IF 2.843
Jian Wang,Chao Yang,Ying-Rui Zhao,Hui-Ling Fan,Zhong-De Wang,Ju Shangguan,Jie Mi
Two types of cobalt oxide–silica composites were prepared by sol–gel method using different alcohols (n-butyl alcohol and ethylene glycol) in sol precursors. The corresponding adsorbents with 3DOM structure were also fabricated via a colloidal crystal template method. Physicochemical properties of the materials were characterized by means of numerous techniques, and the performance for hydrogen sulfide (H2S) removal were evaluated at room temperature. It was found that using n-butyl alcohol in sol precursors could achieve a material (SCN57-500) with plentiful ordered mesoporous in grains and thus had very large surface area (314.5 m2/g), whereas the sample obtained from ethylene glycol (SCE57-500) only possessed a smaller surface area. After introducing 3DOM structure into the bulk counterpart, the surface area improved remarkably as in the case of 3D-SCE57-500, which is consistent with our previous studies. However, 3D-SCN57-500 showed a decreased surface area compared with SCN57-500. The loss of surface area was due to the sharply decreased pores in grains, which is originated from sintering when the hard template was burning out during the preparation process. It can be deduced that the increased surface area after introducing 3DOM structure was ascribed to the excellent dispersion, i.e., the newly formed very small nanoscale grains. The results of adsorption experiments show that although SCN57-500 owned the highest surface area among these four adsorbents, however, it exhibited a poorest performance for H2S capture. Both 3DOM samples possessed very favorable breakthrough H2S capacity compared to the counterparts without 3DOM structure. The results indicated that size of crystalline or dispersion and not the surface area is what contributes to the reactivity of the adsorbent. The well-ordered and interconnected macropores play an important role as well. The breakthrough sulfur capacity of 3D-SCE57-500 could reach as high as 189 mg/g with Co3O4 utilization of 63%. The involved reactions for H2S removal by Co3O4 in experimental conditions were suggested.
研究领域:
材料科学
·
环境科学
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SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Zhidong Jin,Yue Mou,Jinbo Zhao,Chuanzhi Chen,Huan Zhou,Nan Xiang,Fenglong Wang,Zhou Wang,Jiurong Liu,Lili Wu
Regulation based on the crystalline structure modulations is capable of optimizing the band gap and chemisorbed oxygen components thus adjusting the gas sensing characteristics of sensing materials. Herein, In 2 O 3 hierarchical-assembled microspheres with diverse crystalline structures were synthesized via a simple hydrothermal method combined with calcinating procedure under different temperatures. The gas sensor based on rhombohedral In 2 O 3 (rh-In 2 O 3 ) microspheres assembled by pine needle shaped nanorods annealed at 350 ℃ (350-In 2 O 3 ) exhibited superior H 2 S sensing performances at relative low operating temperature of 100 ℃ with low detection limit (50 ppb) and optimized stability compared with cubic In 2 O 3 (c-In 2 O 3 ). Notably, H 2 S sensing characteristics of In 2 O 3 samples with different crystalline structures certificated that crystal structures can dominate the H 2 S sensing reactions with different mechanisms. This work enlightened a novel prospect for designing rh-In 2 O 3 based sensors and provides an innovative pathway for analyzing the feasible H 2 S sensing mechanisms.
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高影响因子
VETERINARY RESEARCH
·
2023
·Vol. 54
·期 1
·1-12
·
IF 4.4
Fu Shaodong,Wang Zhenglei,Han Xiangan,Xu Yuanyuan,Miao Jinfeng
Macrophages play a pivotal role in the inflammatory response to the zoonotic pathogen E. coli, responsible for causing enteric infections. While considerable research has been conducted to comprehend the pathogenesis of this disease, scant attention devoted to host-derived H2S. Herein, we reported that E. coli infection enhanced the expression of CSE in macrophages, accompanied by a significantly increased inflammatory response. This process may be mediated by the involvement of excessive autophagy. Inhibition of AMPK or autophagy with pharmacological inhibitors could alleviate the inflammation. Additionally, cell model showed that the mRNA expression of classic inflammatory factors (Il-1β, Il-6), macrophage polarization markers (iNOS, Arg1) and ROS production was significantly down-regulated after employing CSE specific inhibitor PAG. And PAG is capable of inhibiting excessive autophagy through the LKB1-AMPK-ULK1 axis. Interestingly, exogenous H2S could suppress inflammation response. Our study emphasizes the importance of CSE in regulating the macrophage-mediated response to E. coli. Increased CSE in macrophages leads to excessive inflammation, which should be considered a new target for drug development to treat intestinal infection.
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高影响因子
Acta Pharmaceutica Sinica B
·
2022
·
IF 14.903
Chuchu Lin,Chenyi Huang,Zhaoqing Shi,Meitong Ou,Shengjie Sun,Mian Yu,Ting Chen,Yunfei Yi,Xiaoyuan Ji,Feng Lv,Meiying Wu,Lin Mei
Hydrogen sulfide (H 2 S) is the most recently discovered gasotransmitter molecule that activates multiple intracellular signaling pathways and exerts concentration-dependent antitumor effect by interfering with mitochondrial respiration and inhibiting cellular ATP generation. Inspired by the fact that H 2 S can also serve as a promoter for intracellular Ca 2+ influx, tumor-specific nanomodulators ( [email protected] ) have been constructed by encapsulating calcium sulfide (CaS) and indocyanine green (ICG) into methoxy poly (ethylene glycol) -b- poly (lactide -co- glycolide) (PLGA-PEG). [email protected] can achieve tumor-specific biodegradability with high biocompatibility and pH-responsive H 2 S release. The released H 2 S can effectively suppress the catalase (CAT) activity and synergize with released Ca 2+ to facilitate abnormal Ca 2+ retention in cells, thus leading to mitochondria destruction and amplification of oxidative stress. Mitochondrial dysfunction further contributes to blocking ATP synthesis and downregulating heat shock proteins (HSPs) expression, which is beneficial to overcome the heat endurance of tumor cells and strengthen ICG-induced photothermal performance. Such a H 2 S-boosted Ca 2+ -involved tumor-specific therapy exhibits highly effective tumor inhibition effect with almost complete elimination within 14-day treatment, indicating the great prospect of CaS-based nanomodulators as antitumor therapeutics.
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