ENVIRONMENTAL RESEARCH
·
2025
·
IF 7.7
Song He,Junqing Zhu,Hongliang Sheng,Jiayi Tang,Tao He,Jinfeng Ji,Yajun Huang
The existence of TC residues in the environment and the resultant development of opposition mechanisms constitute a serious menace to both ecological systems and human health. In the present study, UiO-67-bpy-X gels were prepared by the introduction of H 2 bpydc ligands and acetic acid modifiers, followed by a systematic evaluation of their TC adsorption capabilities. Characterization results revealed that UiO-67-bpy-2.4 gel displayed raised specific surface area (1953 m 2 g −1 ) and a graded porous structure. When conditions were optimized, the material manifested a maximum TC adsorptive capacity of 404.1 mg g −1 , outperforming the performance of most reported adsorbents. The kinetic modeling and adsorption isotherm analyses implied that chemical adsorption constituted the dominant uptake pathway. The adsorptive mechanism was further analyzed by XPS, FT-IR, and DFT calculations, which can be attributed to the synergistic effects of metal coordination, electronic interaction, hydrogen bonding, and π-π interaction. Furthermore, the material exhibited good structural stability, retaining 85.945 % of its original adsorptive capacity after six cycles. These findings suggested that UiO-67-bpy-2.4 gel held significant promise as environmental remediation materials, offering high adsorptive capacity and ease of recycling, thereby presenting a novel approach to addressing TC contamination.
研究领域:
环境科学
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材料科学
·
化学工程
·
纳米技术
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
·
IF 3.232
Hongqi Chen,Wen Wang,Changchun Ji,Lun Wang
The core–shell NaGdF 4 :Yb,Er@NaGdF 4 :Yb,Nd upconversion nanoparticles (UCNPs) were successfully obtained with the method of co-precipitation, and the water-solubility of UCNPs was improved by the ligand exchange reaction between nitrosyl tetrafluoroborate (NOBF 4 ) and nanoparticles. The IR-783 dye with negative charge and NOBF 4 -UCNPs with positive charge can bind together by electrostatic action to sensitize UCNPs through the energy transfer from IR-783 to UCNPs. However, with the presence of Na 2 S (a commonly used H 2 S donor), a highly selective reaction between H 2 S and IR-783, which destoried the structure of IR-783 and blocked the energy transfer, thus led to the quenching of luminescent intensity. Based on this, a sensing system for determination of H 2 S has been constructed successfully. The linear range of H 2 S detection by this system is 0.5–15 μM, and the detection limit is 34.17 nM. Furthermore, the dye-sensitized core–shell NaGdF 4 :Yb,Er@NaGdF 4 :Yb,Nd upconversion nanoprobe was applied to real sample analysis with satisfactory results.
研究领域:
分析化学
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纳米技术
·
材料科学
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高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2024
·Vol. 31
·期 14
·22073-22086
·
IF 0
Wang Youqun,Cai Weiqian,Xiong Lingshan,Pei Jiaying,Zhang Zhibin,Xu Lin,Liu Yunhai,Cao Xiaohong
Inspired by its large specific surface area, and tunable chemical and physical properties, a hollow carbon-based mater8ial derived from ZIF-8 with phosphate groups (HCM-PO 4 ) was prepared for the elimination of U(VI). The structural and surface features of HCM and HCM-PO 4 were thoroughly examined using techniques such as SEM, TEM, and XRD. The resulting carbon material, HCM-PO 4 , exhibits a higher BET surface area of 571.2 m 2 ·g -1 , featuring a hollow structure. The removal procedure of HCM-PO 4 for U(VI) aligns with the quasi-secondary kinetic model. Furthermore, the theoretical sorption capacity of HCM-PO 4 was found to be 482.30 mg·g -1 at 298.15 K. The results obtained from XPS, FT-IR, and EDS analysis of HCM-PO 4 after adsorption revealed the coordination of the phosphate group for U(VI), contributing significantly to the adsorption process. In brief, the HCM-PO 4 demonstrates excellent adsorptive ability, positioning it as a hopeful expectant to remove U(VI) from wastewater.
研究领域:
环境科学
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材料科学
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核废物处理
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吸附技术
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DOI
Advanced Science
·
2025
·
IF 14.1
Long-Bo Yu,Peng Wang,Qing-Hua Shen,Qi-Xin Guan,Zhi-Yuan Li,Ying-Ying Han,Xin-Yi Zhang,Qing-Yuan Hu,Cai-Ping Tan
Photosensitizers engineered for spatiotemporal modulation of cluster of differentiation 47 (CD47) in hypoxic tumor microenvironments (TMEs) disrupt immunosuppressive circuits. Herein, we develop two Ir(III) complexes ( Ir1 and Ir2 ) that function as photodynamic therapy (PDT) agents via Type-I/II mechanisms, overcoming hypoxic constraints. Under 630 nm irradiation, Ir1 -mediated PDT ROS-dependently downregulates CD47, enabling spatial control that circumvents hematotoxicity. Concurrently, Ir1 -mediated PDT triggers immunogenic cell death (ICD) via ferroptosis-necroptosis synergy and blocks the CD47-SIRPα immune checkpoint, while promoting M1-polarization of tumor-associated macrophages. In 4T1 murine breast cancer models, Ir1 -PDT achieves potent tumor suppression and transforms immunologically “cold” tumors into “hot” lesions through the synergistic interplay of ICD and CD47 pathway disruption. Collectively, this work establishes a photodynamic CD47-signaling platform for precise immune modulation, offering a clinically translatable alternative to conventional CD47-targeting therapies.
研究领域:
肿瘤学
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光动力疗法
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免疫治疗
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无机化学
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分子医学
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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2015
·
IF 2.979
Lei Liu,Na Cao,Xingling Ma,Kaihe Xiong,Lili Sun,Qiaogen Zou,Lili Yao
The current study reports the development and validation of a stability-indicating reversed phase HPLC method for the separation and identification of potential impurities in vortioxetine, a recently developed antidepressant. The structures of a new compound and four process-related impurities formed during the synthesis were characterized and confirmed by NMR, MS, and IR spectroscopy analyses. The most probable formation mechanisms of the impurities identified were proposed. Based on the characterization data, the new compound was proposed to be 1-[4-[(2,4-dimethylphenyl)thio]phenyl]-piperazine. In addition, an efficient chromatographic method was optimized to separate and quantify the impurities, which were obtained in the 0.05–0.75 μg/mL range. The developed HPLC method was validated with respect to accuracy, precision, linearity, robustness, and limits of detection and quantitation.
研究领域:
药物分析
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分析化学
·
药学
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高影响因子
Materials Today Advances
·
2026
·
IF 8
Jiabao Xiong,Yuan Wang,Lijun Zhu,Zhong Du,Le Guo,Jiayi Ding,Chi Zhang,Siyiti Amuti,Junhua Hu,Chao Wang,Biao Dong,Nuernisha Alifu
Overcoming thermoresistance and achieving precise, efficient tumor therapy remain major challenges. Heat shock protein 70 (HSP70) expression and autophagy activation are two major cellular defense mechanisms associated with thermal resistance. However, strategies that target both mechanisms to improve tumor treatment efficacy remain limited. Herein, this study presents a novel type of near-infrared II (NIR-II)-responsive theranostic nanoplatform (IR-820@γ-PGA/Arg NPs, PIRA NPs) that integrates photothermal therapy (PTT), photodynamic therapy (PDT), nitric oxide (NO)-mediated gas therapy (GT), and dual-pathway inhibition mechanisms to overcome thermal resistance. The theranostic nanoplatform utilizes a γ-polyglutamic acid (γ-PGA) to encapsulate the NIR-II dye IR-820, which forms stable J-aggregates to improve NIR-II fluorescence emission and photothermal conversion efficiency. The nanoplatform adsorbs L-arginine (Arg) and releases NO under 808 nm laser excitation, exhibiting excellent photothermal properties and NIR-II fluorescence emission for precise tumor treatment. PIRA NPs overcome photothermal resistance via two pathways: suppressing HSP70-mediated thermoresistance and disrupting the autophagy-lysosomal degradation pathway (LC3B/p62 axis) through Arg-derived NO generation. This dual-pathway blockade effectively neutralizes tumor defenses, achieving a 92.7% tumor inhibition rate with minimal systemic toxicity. The γ-PGA framework enhances the stability of J-aggregates and their biocompatibility, further improving therapeutic efficacy. This work provides a versatile nanotherapeutic platform based on a promising strategy for reversing thermoresistance and achieving highly efficient cancer therapy.
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高影响因子
CHINESE JOURNAL OF CATALYSIS
·
2026
·
IF 17.2
Jinwei Wu,Junfei Chen,Mingkang Zhang,Zebao Rui
Sulfur-induced catalyst deactivation has been a challenge in the design of gaseous pollutants purified catalyst. As the mainstream strategy for anti-sulfur catalyst design, the incorporation of sacrificial components into the catalyst bulk still faces issues such as increased cost and rapid activity decline. Herein, the physical isolated island strategy is proposed to improve the sulfur resistance and cost-effectiveness of a lean methane oxidation catalyst at no cost of its high activity. The isolated Al 2 O 3 island suppresses the formation of sulfates on adjacent Ir@Pt nanoparticles and avoids the sulfation of Ir@Pt/TiO 2 . Meanwhile, the isolated Al 2 O 3 island draws little effect on the chemical states of active sites. The sulfur adsorption function of isolated Al 2 O 3 island and high activity of Ir@Pt/TiO 2 are synergistically combined, leading to both remarkably high CH 4 oxidation activity (TOF = 1.2 s ‒1 at 350 °C) and high sulfur resistance without observable activity loss during 50 h on-stream test under 50 ppm SO 2 and a space velocity of 30000 mL g ‒1 h ‒1 . Such isolated-island strategy provides a meaningful reference for the efficient sulfur resistance catalyst design.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Menghan Liu,Ruyu Zhang,Jie Wang,Huiting Zhang,Jingying Tan,Qingzhi Liu,Lei Han,Lihua Lu
Bimetallic nanozymes not only have strong synergistic catalysis ability but also may improve the catalytic specificity of the nanozymes. Herein, the oxidase (OXD)-mimic Ir/Co bimetallic nanozymes were prepared through a coordination reaction between the Ir(III) complex with the 2-methylimidazole (MeIm) ligands in ZIF-67 under mild conditions without the pyrolysis and physical doping procedures. It is found that the trace amount of Ir-modified ZIF-67 (Ir@ZIF-67) possesses 18.17-fold that of catalytic ability and 7.86-fold that of the reaction rate as those of pristine ZIF-67. On the other hand, compared with ZIF-67, the OXD-like specificity of Ir@ZIF-67 has been increased 9.7%. The theoretical simulation shows that the high-performance of Ir@ZIF-67 comes from its higher O2 adsorption ability. In virtue of the high performing OXD-like catalytic property, Ir/Co bimetallic nanozymes are employed to establish a simple and sensitive colorimetric pesticides detection platform without deleterious H2O2, which offers excellent “switch-on” malathion (MAL) detection in the linear range of 0.05–25 μM with a limit of detection (LOD) of 11.8 nM. Moreover, Ir/Co bimetallic nanozymes are successfully fabricated into the MAL test swabs. Assisted by a color-reading APP, the test swabs can detect MAL with the LOD as low as 18.5 nM. Surprisingly, such a simple test swab can achieve such high sensitivity for MAL detection. The real sample analysis verifies the high potential of the test swabs in practical application. The excellent performance of the fabricated test swabs can promote the formation of the situation where pesticides detection can be tested at any time and any place and can be carried out by anyone. This work not only provides a novel approach to designing polymetallic nanozymes but also displays the promising application of Ir/Co bimetallic nanozymes in the field of colorimetric sensing.
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RSC Advances
·
2017
·Vol. 7
·期 50
·31663-31670
·
IF 3.108
Hong Wang,Taotao Jiang,Lei Ma,Hanbing Wang,Xiaoliang Xu,Chunshan Lu,Xiaonian Li
In this study, we found that the phenylhydroxylamine intermediate could desorb more easily from an Ir surface than from a Pt surface, which is beneficial for inhibiting the over-hydrogenation of phenylhydroxylamine to aniline. On the other hand, the Brφnsted acid functionalized ionic liquids with sulfonic acid and bisulfate anions were acidic enough to catalyze the Bamberger rearrangement to form p-aminophenol from phenylhydroxylamine. On this basis, a new catalytic system constructed by Ir/C and Brφnsted acid functionalized ionic liquid was applied, for the first time, to the one-pot hydrogenation of nitrobenzene to p-aminophenol. Our results indicate that the PAP selectivity of Ir/C and [SO3H-bmim][HSO4] Brφnsted functionalized ionic liquid was far more than that of the traditional Pt/C and sulfuric acid catalyst system. Furthermore, the dually functionalized ionic liquid ([HSO3-b-N-Bu3][HSO4]) can be used simultaneously as an acid catalyst and also as a surfactant, due to its higher lipophilicity. Therefore, our new catalytic system has unique advantages in the hydrogenation of nitrobenzene to p-aminophenol.
研究领域:
催化化学
·
有机合成
·
绿色化学
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高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Yu Chen,Xiaodi Hao,Zhentan Lu,Dong Wang
Chronic wounds induced by bacterial infection have seriously affected the health of people in the world. So, it is meaningful to develop a novel strategy with real-time infection monitoring and excellent antibacterial performance for enhancing wound management. Herein, we constructed a composite hydrogel by loading the pH indicator bromothymol blue (BTB) and gold nanocages containing 2,2′-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (Au NCs@AIPH) into a polyacrylamide-co-poly(acrylic anhydride-modified oxidized sodium alginate) (PAM-co-PAOSA) hydrogel. In vitro and in vivo experimental results demonstrated that the composite hydrogel could effectively detect bacteria and diagnose the infection status of a wound in real time by showing visible color changes. In addition, the composite hydrogel containing Au NCs@AIPH possessed an excellent photothermal effect under near-IR (NIR) laser irradiation. The photothermal effect further activated AIPH to generate toxic free radicals to form combined antibacterial therapy for accelerating wound healing. Moreover, the composite hydrogel showed great biocompatibility. Therefore, the multifunctional hydrogel provided a novel wound management strategy for bacterial infection diagnosis and combined therapy in an infected wound.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Ying Ju,Chunling Yin,Yan Zhang,Xiangru Meng,Liuchuang Zhao,Leqian Hu
Quality evaluation and consistency evaluation of drugs are the keys to ensure the therapeutic effect and safety of drugs. In this study, attenuated total refraction infrared (ATR-IR) spectroscopy and near-infrared (NIR) spectroscopy combined with chemometrics were used for rapid detection and quality evaluation of active components of Shuang-Huang-Lian injection (SHLI), a traditional Chinese medicine preparation commonly used in China. Taking the chromatographic detection results as a reference, the partial least squares (PLS) model based on ATR-IR and NIR data was constructed by removing the bands with serious noise interference and low signal frequency band. The results showed that the PLS model achieved satisfactory results for the prediction of the three active components (chlorogenic acid, baicalin and phillyrin) in SHLI, indicating that the two spectral techniques combined with the PLS regression method could be successfully used for rapid quantitative analysis of the three active ingredients in SHLI. Relatively, the PLS model based on the ATR-IR spectrum has higher R 2 and smaller RMSE than it based on the NIR spectrum. Furthermore, based on the rapid quantitative analysis of the three active ingredients in SHLI, the quality of 140 SHLI samples from seven manufacturers was evaluated by TOPSIS (technique for order preference by similarity to the ideal solution) analysis, and the consistency of different batches of SHLI products from the same manufacturer was evaluated. The results showed that there were differences in the quality of SHLI produced by different manufacturers, and the quality of different batches of SHLI produced by the same manufacturer was not completely consistent. In conclusion, ATR-IR and NIR spectroscopy combined with chemometrics can be used for accurate and rapid quantitative analysis and quality evaluation of SHLI. This study provides a good idea for the rapid quantitative analysis and quality evaluation of drugs or food based on spectroscopic technology and chemometrics.
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Nanoscale
·
2023
·Vol. 15
·期 9
·4457-4468
·
IF 6.7
Chao Cai,Feng Tian,Junping Ma,Zipei Yu,Mo Yang,Changqing Yi
Precision medicine urges the development of theranostics which can efficiently integrate precise diagnosis and effective therapy. In this study, a facile synthesis of Ir/Gd bimetallic oxide nanotheranostics (termed BSA@Gd2O3/IrO2 NPs) with good biocompatibility was demonstrated using a biomineralization method where bovine serum albumin (BSA) served as a versatile template. BSA@Gd2O3/IrO2 NPs exhibited high longitudinal relaxivity (5.2 mM−1 s−1) and X-ray absorption capability (14.5 Hu mM−1), illustrating them to be a good contrast agent for magnetic resonance (MR) and computed tomography (CT) dual-modal imaging. Moreover, BSA@Gd2O3/IrO2 NPs can act as not only a photothermal conversion agent with ultrahigh efficiency (66.7%) as well as a good photosensitizer, but also an effective catalase to decompose endogenous H2O2 to produce O2, thus relieving hypoxia and enhancing the phototherapeutic effect. Both in vitro and in vivo experiments demonstrated the high effectiveness of BSA@Gd2O3/IrO2 NPs in MR/CT dual-modal imaging and photothermal and photodynamic synergistic tumor treatments. This work sheds new light on the development of versatile nanotheranostic systems using mild and robust biomineralization methods.
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高影响因子
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