NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Fang Wang,Ziqi Xu,Lingqi Deng,Jiaqi Liu
In this study, chitosan (CS) microspheres incorporated with polyacrylamide (PAM)/gelatin (Gel) hydrogel were fabricated using sodium tripolyphosphate (TPP) as cross-linking agent. The addition of TPP based on the optimal CS microsphere concentration, significantly enhanced hydrogel mechanical properties. Specifically, the composite hydrogel exhibited an elongation at break and tensile strength of 900% and 268.26 kPa, respectively, compared to 135.56 kPa and 419.03% for the PAM/Gel hydrogel. Furthermore, compressive strength at 70% strain was 2.1 times greater than that of the unmodified hydrogel. The composite hydrogel's network structure, rich in non-covalent bonds such as electrostatic interactions, hydrogen bonds, π-π interactions, and metal coordination bonds, exhibits excellent self-healing and self-adhesion properties. Following 18 hours of self-healing at room temperature, 92.2% of the original tensile strength was recovered. Additionally, the PAM/Gel/CS hydrogels exhibited powerful self-adhesive ability. Even after five bonding cycles to porcine skin, a substantial adhesion strength of 36.43 kPa was maintained, corresponding to 54% of the initial strength. Finally, in vitro studies revealed a controlled and sustained release profile for both 5-Fluorouracil (5-FU) and Tetracycline hydrochloride (TH) from the composite hydrogel. The observed increase in water uptake under acidic conditions of PAM and chitosan further accelerate drug release. Therefore, this dual-drug delivery hydrogel system, exhibiting excellent mechanical properties, suggests promise for pH-responsive therapeutic applications.
研究领域:
药学
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材料科学
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生物医学工程
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高分子化学
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药物递送
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DOI
高影响因子
JOURNAL OF PHARMACEUTICAL SCIENCES
·
2026
·Vol. 115
·期 4
·104201
·
IF 3.9
Shanglun Li,Xiaoxuan Ji,Wei Huang,Haibing He,Yujing Huang,Zhixuan Li,Hongfei Liu,Guoqing Zhang,Ying Xu
Aripiprazole (APZ) injectable formulations have been developed to address the poor patient compliance associated with their oral dosage forms for the long-term treatment of schizophrenia. However, the solubility of APZ decreases as the pH increases, which limits its bioavailability when administered via intramuscular injection. Herein, we developed injectable microspheres consisting of a polyvinylpyrrolidone (PVP)-based APZ solid dispersion encapsulated in crosslinked collagen (APZ@PVP@CC) to solve the aforementioned problem. The preparation process for PVP-based APZ solid dispersion (APZ@PVP) was optimized using single-axial electrospraying. The resulting solid dispersion increased the solubility of APZ by 15-fold and enhanced the in vitro release rate. Crosslinked collagen (CC) was synthesized and coated onto APZ@PVP using coaxial electrospraying. The structural and physicochemical properties of APZ@PVP@CC were characterized using scanning electron microscope and X-ray diffraction. APZ@PVP@CC exhibited sustained release behavior over a period of 30 d, with the release kinetics fitted the Hixson-Crowell model, suggesting that the drug release was governed by surface erosion rather than simple diffusion. APZ@PVP@CC did not exhibit cytotoxicity. The pharmacokinetic study in New Zealand rabbits demonstrated that APZ@PVP@CC maintained long-acting release for 30 d and enhanced bioavailability by 225% compared to the APZ grinding microcrystallites. In conclusion, APZ@PVP@CC provides a modified option for the schizophrenia treatment.
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PubMed
高影响因子
Journal of Advanced Research
·
2026
·
IF 13
Mmi Xu,Jianwei Chen,Yi Sun,Han Yang,Hongli Ji,Tao Xu,Feng Lu,Yunfan He
Introduction Tissue engineering has become prominence in soft-tissue reconstruction. Adipogenesis and angiogenesis are important in the formation of engineering adipose tissue. Although acellular adipose matrix (AAM) possesses potential in adipogenic induction, obvious limitations remain in the realization of the authentic physiological regeneration. Matrix-bound nanovesicles (MBVs), located on the extracellular matrix (ECM) scaffold, provide cues for the adipogenesis property of AAM. The bioactive components within ECM are influenced by the isolation procedures. Objective This study aimed to extract and identify adipose-derived MBVs (Adipo-MBVs) from adipose ECM scaffolds and clarify their effective role in engineering adipose tissue formation. Methods Adipo-MBVs were extracted from two types of adipose ECM, including chemically decellularized matrix (i.e. AAM) and mechanically concentrated ECM (i.e. adipose collagen fragment, ACF). The influence of Adipo-MBVs on cell functions were estimated in vitro . In addition, AAM-hyaluronic acid methacrylate (HAMA) hybrid hydrogel (A/H) with polydopamine (PDA)-coated HAMA microspheres (PDA@HMs) was designed to sustainedly release Adipo-MBVs in an animal model. Results The results showed that Adipo-MBVs effectively recapitulated AAM effects on the construction of engineering adipose tissue. Crucially, mechanical Adipo-MBVs (M-AT-MBVs) derived from mechanically concentrated ECM exhibited a significantly stronger capacity to induce both adipogenesis and angiogenesis in vitro and in vivo , compared to chemical Adipo-MBVs (C-AT-MBVs) from chemically decellularized matrix. Furthermore, we developed a novel composite delivery system that ensured the sustained release of M-AT-MBVs and robustly promoted the regeneration of vascularized adipose tissue in a mouse model. This enhanced efficacy of M-AT-MBVs was associated with their distinct miRNA profile, particularly an enrichment of pro-adipogenic miR-143, and involved the downregulation of MAPK signaling pathway. Conclusion This study demonstrated Adipo-MBVs as key regenerative components of adipose ECM. It is shown that mechanical isolation yields superior M-AT-MBVs, and our engineered delivery system presents a novel strategy for soft tissue regeneration.
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PubMed
高影响因子
International Journal of Polymer Science
·
2018
·Vol. 2018
·期 1
·7584281
·
IF 1.718
Zhichuan Shen,Xinhua Zhou,Huina Qiu,Hua Xu,Huayao Chen,Hongjun Zhou
By using dopamine (DA) as the monomer, the model drug avermectin (AVM) was loaded on polydopamine microspheres (AVM/PDAMS) and polydopamine microcapsules (AVM@PDAMC) by the method of impregnation and encapsulation, respectively. The materials’ structures were systematically characterized using Fourier transform infrared spectroscopy (FTIR), zeta potential analysis, scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). The comparison of antiultraviolet capability as well as release behaviors under different pH values of the materials were studied. The results showed that a spherical appearance was observed from both materials. The use of AVM/PDAMS and AVM@PDAMC made the decomposition temperature of AVM increase to 235°C and 245°C, respectively. After being exposed to ultraviolet light for 1400 min, the residual ratios of AVM of AVM/PDAMS and AVM@PDAMC were 42% and 54%, respectively. Both AVM/PDAMS and AVM@PDAMC showed acid sensitivity. AVM/PDAMS and AVM@PDAMC took about 13 h and 60 h to reach the release rate of 50% under pH 3. The release process of AVM/PDAMS could be explained by the Weibull model at pH 3, while the release behavior of AVM@PDAMC fitted the Baker–Lonsdale equation. At pH 7 and pH 9, both of the delivery materials followed the Korsmeyer–Peppas model and belonged to the Fick diffusion.
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高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2019
·
IF 3.218
Sha Li,Qin Xiang,Muhammad Kashif Aslam,Yuan Cen,Chaozhong Guo,Jiahong Hu,Wei Li,Changguo Chen
For lithium‑sulfur batteries (LSBs), some barriers like low conductivity of sulfur, the large irreversible volume change and the “shuttle” issue, hinder its practical application. In this work, Fe-functionalized mesoporous carbonaceous microspheres with high conductivity and intensive chemical adsorption for polar polysulfide species (LiPSs) were successfully synthesized through economical, scalable solvothermal process and pyrolyzing method. Carbon microspheres with Fe/Fe 3 C components (denoted as CMS900) exhibit high conductivity and significantly enhance the electrochemical reaction kinetics despite 81 wt% sulfur loading. Furthermore, the proper amount surface oxygenic functional groups effectively immobilize sulfur via strong chemical entrapment and suppress the dissolution of LiPSs intermediates during cycling. The CMS900@S has demonstrated a high initial discharge capacity of 1269 mAh g −1 at 0.1C, over 200 cycles with the lowest average capacity fading rate of 0.06% per cycle, which can be treated as an alternative cathode material for LSBs with impressive electrochemical performance.
研究领域:
材料科学
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储能技术
·
电化学
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DOI
高影响因子
Small
·
2023
·Vol. 19
·期 47
·2303087
·
IF 13.3
Gengchen Yu,Qi Zhang,Jiayi Jing,Xu Wang,Yifan Li,Xue Bai,Tao Li
TiNb 2 O 7 , as a promising alternative of Li 4 Ti 5 O 12 , exhibits giant potential as low-temperature anode due to its higher theoretical capacity and comparable structural stability. However, the sluggish electronic conductivity still remains a challenge. Herein, bulk modification of Cu + doping in porous TiNb 2 O 7 microsphere is proposed via a simple one-step solvothermal method with subsequent calcination treatment. The results show that the electronic conductivity is improved effectively due to the reduced band gap after doping, while enhanced lithium-ion diffusion is achieved benefiting from the increased interplanar spacing. Therefore, the optimal sample of Cu 0.06 Ti 0.94 Nb 2 O 7 exhibits a high reversible capacity of 244.4 mA h g −1 at 100 mA g −1 after 100 cycles, superior rate capability, and long-term cycling stability at 1000 mA g −1 at room temperature. Particularly, it can also display good performance in a wide temperature range from 25 to –30 °C, including a reversible capacity of 76.6 mA h g −1 at –20 °C after 200 cycles at 200 mA g −1 . Moreover, Cu 0.06 Ti 0.94 Nb 2 O 7 //LiFePO 4 full cell can deliver a high reversible capacity of 177.5 mA h g −1 at 100 mA g −1 . The excellent electrochemical properties at both ambient and low-temperatures demonstrate the great potential of Cu + -doped TiNb 2 O 7 in energy-storage applications.
研究领域:
材料科学
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储能技术
·
电化学
·
纳米材料
·
锂离子电池
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DOI
高影响因子
TALANTA
·
2025
·
IF 6.1
Chenghao Lin,Qianyi Li,Gengliang Liu,Zixuan Xi,Xiaoxia Yan,Shijun Li,Liang He,Pengli Bai
Alzheimer’s Disease (AD), a most common neurodegenerative disease, has aroused people's great attention. Amyloid-β 1-42 (Aβ42) from serum/plasma has been listed as Core 1 biomarker in diagnostic guide and explore an ultrasensitive detection method of Aβ42 is of great significance for early AD diagnosis and treatment. Herein, an ultrasensitive fluorescent biosensor for Aβ42 detection is designed, which is composed of Fe 3 O 4 @MoS 2 microsphere and Au-Ag alloy. Compared with typical single gold nanoparticles in traditional fluorescent biosensor, alloy nanoparticles can generate a stronger electromagnetic field to enhance the fluorescence of quantum dots via surface plasmon resonance, achieve the effect of signal amplification. Importantly, our design significantly improved the limit of detection to 11 ag/mL, with a linear response ranging from 0.1 to 10 4 fg/mL. Moreover, by replacing the detection antibody in the biosensor, it can also be applied to other common AD biomarkers, such as Aβ40 (linear range: 0.1 to 10 5 fg/mL, LOD: 61 ag/mL) and total Tau protein (linear range: 0.1 to 10 5 fg/mL, LOD: 40 ag/mL). The biosensor exhibited excellent performance in both spiked and real serum samples. This fluorescent biosensor based on Au-Ag alloy strategy with ultra-sensitivity and good selectivity, provides a reliable solution for AD’s early diagnosis.
研究领域:
神经退行性疾病
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生物传感器
·
纳米材料
·
早期诊断
·
荧光检测
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2019
·
IF 1.911
Xiaomei Ling,Yiwei Xie,Xiaocheng Lin,Ling Li,Ting Qiu
To prepare polymer supported ionic liquids (PSILs) as effective catalysts for esterification, the free radical suspension copolymerization of vinylbenzyl chloride (VBC, monomer), styrene (St, monomer) and divinylbenzene (DVB, crosslinker) with the addition of n -heptane (porogen) was carried out for the fabrication of the porous polymer (PVD) microsphere as support, followed by the immobilization of sulfonic acid-functionalized ionic liquids by the successive treatment of benzimidazole (BIm), 1,3-propane sultone and sulfuric acid (H 2 SO 4 ) or trifluoromethanesulfonic acid (CF 3 SO 3 H). The effects of the compositions of DVB and n -heptane on the internal structure of the polymer supports were investigated, and it was found that the support with 40 wt% DVB and 60 wt% n -heptane (with relative to the monomer) could endow the final PSILs with the relatively optimal catalytic performance. The preliminary experiment in the batch reactor indicated that PSILs herein exhibited higher catalytic activities than commercial Amberlyst 46 resin for the esterification of propanoic acid (PROAc) with n -propanol (PROOH). Consequently, the optimal PSILs catalyst, PVD-[Bim-SO 3 H]HSO 4 , was selected for further study in the batch reactive distillation column because of low cost and its ease of preparation. The yield of propyl ropionate (PROPRO) could reach up to 97.78% at the optimized conditions of PROOH/PROAc molar ratio (2:1) and catalyst dosage (2.0 wt%). The investigation of the reaction kinetic manifested that the calculated results of second order pseudo-homogeneous kinetic model were in good agreement with experimental values. The pre-exponential factor and activation energy were 4.12 × 10 7 L·mol −1 ·min −1 and 60.57 kJ·mol −1 , respectively. It is worth noting that the PSILs catalyst could be simply recovered and reused with relatively satisfactory decrease in the catalytic activity, which made it an environmental friendly and promising catalyst in the industrial application.
研究领域:
化学工程
·
催化科学
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DOI
高影响因子
Nanoscale
·
2024
·Vol. 16
·期 6
·3043-3052
·
IF 5.8
Min Liu,Hai Li,Jie Yu,Shuo Zhang,Qi Chen,Wei Lu,Anbao Yuan,Li Zhong,Litao Sun
Due to limited mass loading, high-capacity electrode materials such as transition metal oxides (TMOs) are essential for microscale Li-ion batteries (LIBs) integrated in nano-/micro-electromechanical systems (N/MEMS). Unfortunately, their electrochemical performances are largely plagued by severe mechanical degradation and slow electron transport. Therefore, it is crucial to develop strategies that can improve the structural stability and electronic conductivity of TMO electrodes. In this work, double-carbon (carbon nanotubes and ketjen black) microsphere (DCMS) supported Co3O4 electrodes are fabricated simply through a spray drying and solvothermal method, which are designed to have a mesoporous three-dimensional (3D) hierarchical heterostructure containing well-dispersed Co3O4 nanoparticles within the DCMS framework. An in situ transmission electron microscopy (TEM) study reveals that the DCMS framework can not only provide facile strain accommodation, but also good electronic conductivity, leading to a much improved Li-storage performance compared to other Co3O4-based anodes. The hierarchical electrode exhibits maximum charge capacities of 1205.2 and 678.1 mA h g−1 at current densities of 0.1 and 2 A g−1, respectively, as well as a capacity retention of 92.2% at 0.3 A g−1 after 100 cycles. This study provides a low-cost, simple and general method for developing advanced high-capacity electrodes.
研究领域:
材料科学
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储能
·
电化学
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纳米材料
·
电池技术
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Shuyue Jia,Dongyan Tang,Yuhong Zhou,Yunchen Du,Jing Peng,Zhaojie Sun,Xu Yang
The usually inconvenient detection and uneasy recycling of polydopamine (PDA) with sphere morphology as an adsorbent restrict its actual applications in wastewater purification. Thus, novel composite fibers were fabricated via the electrospinning technique by integrating polydopamine microspheres (PDA-MPs) with pH/temperature dual-responsive copolymers. The insoluble fraction of the fabricated composite fibers can be maintained to a value above 89% after being immersed in aqueous solutions with different pH values. Also, the regeneration efficiency of the composite fibers can also remain above 80% after undergoing five adsorption–desorption cycles. These results both indicated that the fabricated composite fibers can avoid secondary pollution during the adsorption process effectively. In addition, the presence of abundant N-isopropyl acrylamide (NIPAM) units within the fibers could make it have a relatively higher water swelling ability of 4643%, which could further offer relatively larger inner spaces to accommodate the dye molecules. Meanwhile, by incorporating β-cyclodextrin (β-CD), methacrylic acid (MAA), PDA, and NIPAM components, plentiful active adsorption sites could be supplied to interact with methylene blue (MB) dye. So, the adsorption experiments of the composite fibers showed a maximum adsorption capacity of 1722.1 mg/g at pH 9.0 and a temperature of 55 °C. Furthermore, the pseudo-second-order kinetic model of adsorption suggested that it is a chemisorption process. Moreover, the adsorption experimental data can be better described by Langmuir models, inferring its monolayer adsorption. The adsorption thermodynamic studies revealed that adsorption is a spontaneous and endothermic process. Also, the increase of temperature facilitated the adsorption processes, owing to the increase of adsorbent’s hydrophobicity and molecules’ reactivity. The present work suggested that the combination of smart-responsive polymers and PDA-MPs could form an unprecedented system to be a promising candidate adsorbent for wastewater treatment.
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高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2020
·
IF 6.444
Kunpeng Qian,Qianfan Zhou,Hongmin Wu,Jianhui Fang,Miao Miao,Yuhuan Yang,Shaomei Cao,Liyi Shi,Xin Feng
Well established internal multilayered structures have been demonstrated to contribute greatly towards outstanding shielding effectiveness (SE) in electromagnetic interference (EMI) shielding systems. A specific encapsulation by intercalating carbonized cellulose microspheres into Ti 3 C 2 T x MXene layers (CCM@MXene) is elaborately designed. The CCM@void@MXene composite films with “egg-box” structure are ultimately achieved by annealing treatment with spherical CCM@MXene as “egg” and Ti 3 C 2 T x MXene layers as “box”. The unique structure with interior void space is attributed to internal multiple reflections of incident electromagnetic waves (EMW) and contributes to the enhancement of EMW absorption. Thanks to the electrically conductive network of Ti 3 C 2 T x MXene adhering to cellulose microspheres surface, the egg-box structure composite films exhibit superb electrical conductivity of 1672.0 ± 7.1 S cm −1 and excellent specific EMI shielding efficiency (up to 18637.14 dB cm 2 g −1 ) at an ultrathin thickness (12.1 ± 0.8 μm). This hierarchical porous egg-box structure offers an ideal potential for application in highly efficient EMI shielding systems.
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2018
·
IF 6.578
Zhen Li,Guangwei He,Zongyu Li,Yun Zhang,Jing Zhao,Mingzhao Xu,Shengming Xu,Zhongyi Jiang
Organic polymeric microspheres grafted with ionic brushes are fillers incorporated into imidazolium functionalized polysulfone (ImPSF) forming a composite membrane . The ionic brushes create continuous and bulky hydrophilic phases in the ImPSF forming a composite membrane with the aggregation of hydrophilic groups at the brush/polymer interfaces. The hydrophilic phases promote ionic transport with decreased activation energies from 14.45 to 11.42 kJ mol −1 and increased effective ionic mobility from 0.84 × 10 −4 to 2.19 × 10 −4 cm 2 s −1 V −1 compared to ImPSF with no brushes. The composite membrane shows increased hydroxide conductivities (up to 38.33 S cm −1 at 30 °C and 64.58 S cm −1 at 60 °C), which is 2.66 times and 2.01 times of the hydroxide conductivity of ImPSF membrane at the same conditions, respectively. Stability of the composite membrane is increased by replacing the imidazolium groups of polymer matrix and organic microsperes with more stable quaternary ammonium groups, such as N,N-dimethylhexylamine (DMHA). The residual hydroxide conductivity ratio of the composite membrane-DMHA is 83.4% after treating by 2.0 M aqueous NaOH at 80 °C for 96 h ( vs. only 28.6% for the composite membrane with imidazolium groups under the same conduction). Meanwhile, the doubling increment of hydroxide conductivity in the composite membrane vs. the control membrane can be still retained (23.87 mS cm −1 for the composite membrane-DMHA vs. 8.97 mS cm −1 for the control membrane-DMHA).
研究领域:
材料科学
·
化学工程
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高影响因子
危险品化学品经营许可证（带存储）