Journal of Materials Research and Technology-JMR&T
·
2022
·
IF 6.267
Fang Wang,Zhe Chen,Zhenzhou Zhu,Jia Guo
Antibiotics in pharmaceutical and aquaculture wastewater is a growing threat to the environment of world, due to the induction of drug-resistant bacteria and the harm to the aquatic organisms. Photocatalytic membrane, which has immobilized photocatalyst on membrane is an effective and environmentally friendly technology for antibiotics degradation. In this study, a novel photocatalytic membrane was prepared by loading ZnO/N-g-C 3 N 4 composite on commercial polymer membrane with glutaraldehyde as a crosslinker through pressure driven filtration. The loading of the photocatalyst over the membranes was validated by Fourier transform infrared spectroscopy, scanning electron microscope and X-ray photoelectron spectroscopy. The photocatalytic properties of ZnO/N-g-C 3 N 4 composite membrane were observed efficient for degradation of tetracycline, ciprofloxacin and ofloxacin in both immersion and filtration model under visible light (λ > 420 nm). Especially, a ZnO/N-g-C 3 N 4 loading amount of 1.12 g/cm 2 and glutaraldehyde concentration of 45% led to the degradation rate of 100% and 80% for tetracycline at 5 mg/L and 10 mg/L, respectively. Low trans-membrane pressure (0.005 MPa) and narrow membrane size (50 kDa) were favorable for antibiotics degradation in filtration model due to long reaction time on membrane surface. Construction and performance of ZnO/N-g-C 3 N 4 composite membrane might provide new strategy for energy saving wastewater treatment.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
Materials Reports: Energy
·
2025
·
IF 13.8
Wei Fang,Zeping Ou,Yifan Wang,Xiaoxue Lin,Hao Yang,Yujie Zheng,Jing Li,Lei Wang,Lijun Hu,Chen Li,Jianyong Ouyang,Kuan Sun
Thermocells are attracting growing interest as a promising thermoelectric technology for low-grade heat harvesting. However, the scarcity of high-performance redox couples featuring intrinsically high thermopower ( S e ) and fast redox kinetics hinders thermocells rapid development. Identifying potential intrinsically high-performance redox couples remains a significant challenge. This work introduces a novel n-type copper (Ⅰ/Ⅱ) chloride (CuCl/CuCl 2 ) redox couple with intrinsically high performance. Through tailored electrolyte design, long-term stability was significantly improved by reducing proton concentration to suppress cuprous ion photo-oxidation, while ammonium chloride solvation enhanced cuprous ion solubility. The resulting system achieves a S e value closely aligned with theoretical predictions and exhibits rapid redox kinetics. Consequently, the optimized CuCl/CuCl 2 intrinsic system demonstrated a high S e of 1.52 mV K ‒1 and a record-high normalized power density P max (Δ T ) ‒2 of 0.399 mW m ‒2 K ‒2 , surpassing previously reported intrinsic n-type thermocells and rivaling the performance of p-type pristine 0.4 M ferri/ferrocyanide systems. A prototype module comprising 30 p-n units successfully powered a line of light-emitting diodes or a thermohygrometer. This work introduces a valuable redox couple for further advancing high-performance thermocells and demonstrates a viable strategy for developing novel redox systems.
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高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 6
·976
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IF 5.719
Haiyan Qi,Qiuying Li,Jing Jing,Tao Jing,Chuntong Liu,Lixin Qiu,Rokayya Sami,Mahmoud Helal,Khadiga Ahmed Ismail,Amani H. Aljahani
In our study, a unique ratiometric fluorescent sensor for the rapid detection of arginine (Arg) and acetaminophen (AP) was constructed by the integration of blue fluorescent N-CDs and yellowish-green fluorescent calcein. The N-CD/calcein ratiometric fluorescent sensor exhibited dual emission at 435 and 519 nm under the same excitation wavelength of 370 nm, and caused potential Förster resonance energy transfer (FRET) from N-CDs to calcein. When detecting Arg, the blue fluorescence from the N-CDs of the N-CD/calcein sensor was quenched by the interaction of N-CDs and Arg. Then, the fluorescence of our sensor was recovered with the addition of AP, possibly due to the stronger association between AP and Arg, leading to the dissociation of Arg from N-CDs. Meanwhile, we observed an obvious fluorescence change from blue to green, then back to blue, when Arg and AP were added, exhibiting the “on–off–on” pattern. Next, we determined the detection limits of the N-CD/calcein sensor to Arg and AP, which were as low as 0.08 μM and 0.02 μM, respectively. Furthermore, we discovered that the fluorescence changes of the N-CD/calcein sensor were only responsible for Arg and AP. These results suggested its high sensitivity and specificity for Arg and AP detection. In addition, we have successfully achieved its application in bovine serum samples, indicating its practicality. Lastly, the logic gate was generated by the N-CD/calcein sensor and presented its good reversibility. Overall, we have demonstrated that our N-CD/calcein sensor is a powerful sensor to detect Arg and AP and that it has potential applications in biological analysis and imaging.
研究领域:
生物化学
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分析化学
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医学检测
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DOI
高影响因子
ChemCatChem
·
2022
·Vol. 14
·期 13
·e202200311
·
IF 5.497
Yuyao Zeng,Bowei Wang,Fanyong Yan,Wensheng Xu,Guoyi Bai,Yang Li,Xilong Yan,Ligong Chen
Graphical Through a convenient impregnation method, highly-distributed and stable Cu nanoparticles were dispersed on the boron doped γ-Al 2 O 3 support, which catalyzed continuous reductive amination of levulinic acid to corresponding N-substituted pyrrolidinones. The reductive amination of biomass-derived levulinic acid (LA) to value-added N-substituted pyrrolidinones with amine and molecular hydrogen over heterogeneous catalyst represents an atom-economical and scalable route. In this paper, a series of boron doped Cu/Al 2 O 3 catalysts via kneading and impregnation method are developed for the continuous reductive amination of LA. Compared with Cu/Al 2 O 3 , Cu 10 /AlB 3 O catalyst exhibits greatly improved catalytic performance for this reaction at low operation temperature. Structure-property correlation investigations were performed with diverse characterization methods, and the results revealed that the excellent catalytic performance of boron doped Cu/Al 2 O 3 catalysts was mainly attributed to the synergistic effect of its well-dispersed Cu nanoparticles, appropriate surface Cu electronic state and surface acidic sites nearby. Besides, Cu 10 /AlB 3 O shows great stability during the reaction over 200 h. This work provides a low-cost, efficient and environmentally friendly heterogeneous catalytic system for the continuous production of N-substituted pyrrolidinones.
研究领域:
催化化学
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绿色化学
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生物质转化
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DOI
高影响因子
BIOORGANIC CHEMISTRY
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2025
·
IF 4.7
Shuaishuai Cui,Cunxin Guo,Liang Yan,Yujian He,Li Wu
The incorporation of D-amino acids can influence the structure and enzymatic stability of proteins or peptides, especially when they are introduced at enzyme cleavage sites, significantly inhibiting the enzymatic hydrolysis of peptides. The abnormal accumulation of these peptides has been linked to age-related conditions, including cataracts and Alzheimer's disease. N-terminal acetylation, an essential post-translational modification, significantly enhances the physicochemical properties of peptides and plays an essential role in regulating their performance within biological systems. This research examined the impact of N-terminal acetylation on the enzymatic hydrolysis of peptides incorporating D-amino acids. Enzymatic activity assessments showed that N-terminal acetylation greatly promoted the enzymatic breakdown of these peptides by Proteinase K (PROK), with the substrate decay rate constant for the acetylated peptide Ac-6-w increasing by 17.5 times. This enhancement was specific to serine-type proteases, which exhibited a comparable cleavage pattern. Molecular docking further demonstrated that N-terminal acetylation improved interactions within the catalytic triad of serine proteases, leading to faster enzymatic degradation. The results provide novel insights into the impact of N-terminal acetylation on the enzymatic behavior of peptides incorporating D-amino acids, and they propose a potential approach for targeting these peptides to preserve normal physiological functions.
研究领域:
生物化学
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医学
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分子生物学
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DOI
PubMed
高影响因子
OPTICAL MATERIALS
·
2021
·
IF 3.08
Xin Li Wang,Jin Li,Wei Meng Liu
The disadvantage of bismuth vanadate (BiVO 4 ), a metal oxide semiconductor photocatalytic material, can be overcome by constructing nitrogen-doped graphene-based nanocomposites. Here we state to synthesis pyridinic-N doped graphene/BiVO 4 nanocomposite (N-rGO/BiVO 4 ). Because of many defects were existed pyridinic N-rGO, more tiny particle size and interaction from abundant interfacial, between BiVO 4 and N-rGO sheets, can produce synergistic effects and enhance photocatalytic performance. N-rGO/BiVO 4 composite has a large light absorption range and high photocatalytic activity compared with BiVO 4 and rGO/BiVO 4 . XPS, PXRD , HRTEM , FESEM, UV–vis, PL . etc analytical methods are used to characterize samples and the change of bandgap of samples is verified through theoretical analysis and simulation. After photocatalytic testing, the decomposition of methylene blue dye just required only 80 min under visible light and photocatalytic degradation efficiency of 99.3%. N-rGO/BiVO 4 has great potential for the removal of refractory pollutants from wastewater.
研究领域:
材料科学
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环境科学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Jie Li,Maoli Yin,Xi Wang,Lei Chen,Yangfeng Wang,Wei Li,Xun Zhang,Zhenzhen Xu,Xiaojuan Li
To address the clinical challenge of wound infection and secondary injury caused by frequent dressing changes during wound healing, this study aims to develop a chitosan-based aerogel dressing with on-demand dissoluble and efficient antibacterial functionality. A low-temperature alkaline urea dissolution strategy enabled the fabrication of chitosan aerogels (CS) through thermally induced gelation, solvent exchange, and freeze-drying. Subsequent ultrasonic-assisted adsorption of N-halamine 1,3-dichloro-5,5-dimethylhydantoin (MC) yielded functionalized N-halamine-loaded chitosan aerogels (CS-MC). Systematic optimization established 2.0 % CS (based on apparent density, porosity, and ethanol adsorption) and 1.5 % MC loading (determined via swelling kinetics, chlorine release profiles, and antibacterial efficacy) as optimal parameters. 2.0 % CS-1.5 % MC had high effective antibacterial effect. The killing rates of E. coli and S. aureus were 78.57 % and 80.30 % at 1 min, respectively, and the killing rates of both bacterial reached 100 % within 5 min. CS-MC dressings were completely dissolved in a dilute acetic acid solution within 20 min. CS-MC aerogels maintain high fibroblast viability, above the 70 % defined by ISO 10993-5 cytotoxicity threshold, achieving an optimal balance between efficient bactericide and histocompatibility. In summary, CS-MC exhibit high antibacterial efficacy and on-demand dissoluble properties, making them suitable for medical dressings.
研究领域:
生物医学工程
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材料科学
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医学
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产品关联
DOI
PubMed
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2025
·
IF 4.7
Xiaoxu Cui,Zherui Wan,Zhonghao Li,Fengxia Wang,Pengshuai Wei,Guang Yang
Herein, intelligent N, S-doped fluorescent carbon dots (N, S-CDs) were constructed by using l -cysteine and carboxymethyl cellulose (CMC) polymer as precursors through a one-step hydrothermal method. The designed N, S-CDs displayed strong fluorescence (FL) emission with a FL quantum yield of 44.48 % and could be utilized for the quantitative tracing of TCs and Al 3+ via the “On-OFF-ON” FL transition with wide linear detection range (1.66–104.5 μM for TCH, 1.66–163.2 μM for OTC, 1.66–69.5 μM for DOX and 33–104.3 μM for Al 3+ ). The detection limits (LODs) of TCH, OTC, DOX and Al 3+ were calculated to be 53.02 nM, 95.61 nM, 41.87 nM and 57.69 nM, respectively. On the basis of the FL “On-OFF-ON” strategy, multiple logical gate operations including “NOR” and “INHIBIT”, were constructed successfully. Additionally, N, S-CDs uploaded to hydrogen bars were utilized for the recognition of TCs and Al 3+ in a portable manner, which revealed great application potential in the field of anti-counterfeiting and encryption.
研究领域:
分析化学
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材料科学
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环境科学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF TOXICOLOGY
·
2023
·
IF 2.2
Xu Fang,Wei Zhu,Huiying Zhao,Wencheng Yin,Xiao Song,Fengxin Liu
Lacto-N-triose II (LNT II), an essential human milk oligosaccharide and precursor to lacto-N-tetraose (LNT) and lacto-N-neotetraose (LNnT), was evaluated for safety. Genotoxicity was assessed through in vitro tests including Bacterial Reverse Mutation Test and mammalian cell micronucleus test, and a subchronic oral gavage toxicity study was conducted on juvenile Sprague-Dawley rats. In this study, LNT II was administered at dose levels of 0, 1,500, 2,500, or 5,000 mg/kg body weight (bw)/day for 90 days, followed by a 4-week treatment-free recovery period. LNT II was non-genotoxic in the in vitro assays. No compound-related effects were observed across all dosage levels based on various measures, including clinical observations, body weight gain, feed consumption, clinical pathology, organ weights, and histopathology. Consequently, the highest dosage of 5,000 mg/kg bw/day was established as the no-observed-adverse-effect-level (NOAEL). These results suggest the safe use of LNT II in young children formula and as a food ingredient, within the limits found naturally in human breast milk.
研究领域:
营养学
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毒理学
·
儿科学
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DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2015
·
IF 2.912
Jun Huang,Haihua Xie,Sheng Hu,Tian Xie,Jinyan Gong,Chengjun Jiang,Qing Ge,Yuanfeng Wu,Shiwang Liu,Yanli Cui,Jianwei Mao,Lehe Mei
Chitosan was prepared by alkaline N-deacetylation of β-chitin from squid pens, and N-carboxyethylated derivatives (N-CECS) with different degrees of substitution (DS) were synthesized. The carboxyethylation of the polysaccharide was identified by Fourier transform infrared, 1H and 13C nuclear magnetic resonance (NMR), and X-ray diffraction analyses. The DS of the derivatives was calculated by 1H NMR and elemental analysis. All three N-CECS samples showed good water solubility at pH > 6.5. The antioxidant properties and bile acid binding capacity of the derivatives were studied in vitro. The highest bile acid binding capacity of all N-CECS reached 36.9 mg/g, which was 2.6-fold higher than that of chitosan. N-CECS showed a stronger scavenging effect on 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical ability, and EC50 values were below 2 mg/mL. The scavenging ability of N-CECS against superoxide radicals correlated well with the DS and concentration of N-CECS. These results indicated that N-carboxyethylation is a possible approach to prepare chitosan derivatives with desirable in vitro biochemical properties.
研究领域:
生物化学
·
材料科学
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DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2017
·
IF 1.9
Kwanghyok Jong,Benzhi Ju,Shufen Zhang
In this study, a novel type of pH-responsive polymer PyHES-NAC (2-hydroxy-3-(2-propynyloxy) propyl hydroxyethyl starch (PyHES)) – (N-acetyl-cysteine (NAC)) was synthesized. First, PyHES was prepared via hydrophobic modification of hydroxyl groups in hydroxyethyl starch (HES) with propynylglycidyl ether (PGE), and then pH-responsive carboxylic acid group was connected to propynyl group via thiol-yne click reaction with NAC. Aqueous PyHES-NAC solutions exhibited a good transference between hydrophobic (or self-assembly) and hydrophilic static along with the change of pH value and protective properties of drugs under acidic conditions. 10.0% DOX was released under artificial gastric fluid after 2 h, whereas an immediate release (above 80%) was observed under artificial intestinal fluid. Drug loading capacity of PyHES-NAC was increased by the increase of degree of substitution (DS) of hydrophobic propynyl groups in PyHES, and 41 wt% DOX Loading capacity was the highest value in our study area.
研究领域:
药剂学
·
生物材料学
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DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Jia-Xi Shen,Rui Guo,Miao-Yan Wang,Hai-Liang Zhu,Hao-Xiang Jiang,Han-Bin Cui,Kai Wang
Cardiovascular disease, a chronic and progressive arterial wall disease, is increasingly recognized for its clinical significance. Aminopeptidases N (APN), crucial in the pathophysiological processes of vulnerable plaque, have been linked to endothelial dysfunction, oxidative stress, and plaque formation, thus highlighting their potential as biomarkers for disease progression. However, current detection methods for APN in body fluids and in vivo have limitations, including insufficient sensitivity and specificity, time delays, and the inability to directly reflect enzyme activity in plaques. To address these challenges, we developed an optical probe, HD-APN, for in vivo imaging of aminopeptidases, providing a potential implementation in cardiovascular disease. Our work demonstrated the applicability of HD-APN for specific monitoring of aminopeptidase levels in plaques and serum, shedding light on its potential for further research in cardiovascular disease.
研究领域:
心脏病学
·
分子生物学
·
生物医学工程
·
成像科学
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DOI
PubMed
高影响因子
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