Small
·
2025
·
IF 12.1
Xinran Wang,Heng Dai,Yichun Liu,Linglu Kuang,Hao Song,Zhaowei Teng,Dawei Wang,Ting Wang,Xuhui Xu
Near-infrared (NIR) luminescence has emerged as a powerful tool in biological imaging due to its nondestructive nature, high spatiotemporal resolution, and deep tissue penetration. However, traditional NIR imaging often fails to provide detailed information about hard tissues such as bones. In this study, an approach for simultaneous imaging of soft and hard tissues using Lu 1.5 Mg 1.5 Al 3.5 Si 1.5 O 12 : Yb 3+ as an NIR scintillator is presented. Under X-ray irradiation, Lu 1.5 Mg 1.5 Al 3.5 Si 1.5 O 12 : Yb 3+ scintillator emits NIR emission with a peak at 970 nm with thermal quenching resistance, which is strongly absorbed by soft tissues, enabling soft tissue imaging. Additionally, the scintillator provides a high signal-to-noise ratio for X-ray imaging, allowing for high-resolution imaging of hard tissues, unaffected by ambient light, with a spatial resolution of up to 203 µm. By leveraging X-ray as the sole excitation source, this method provides a comprehensive view of internal biological structures, including vascular and skeletal tissues, with high resolution and minimal interference. This innovation holds great promise for advancing medical imaging technologies and enhancing diagnostic capabilities.
研究领域:
医学影像学
·
生物物理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2025
·
IF 6.5
Myagmarsuren Baldan,Shuang Zhang,Qi Sun,Yan Su,Dong Mei,Ran Sun,Ao Zheng,Danni Liu,Jie Zhang,Ran Huo,Yang Tian,Le Han,Shibo Wang,Yaoqi Wang,Chunying Cui
Background Resistance to traditional treatments has spurred research into innovative therapeutic approaches for tumors. Among these innovative treatments, photothermal therapy (PTT) has gained increasing attention for its use of photothermal agents (PTAs) to convert light into heat for localized tumor ablation. However, PTT faces limitations due to heat shock protein 70 (HSP70)-mediated resistance in tumor cells. Combining PTT via indocyanine green (ICG) with siRNA HSP70 could reduce the thermal resistance of the tumor, thereby enhancing treatment efficacy. Albumin-based nanoparticles (NPs) can effectively deliver ICG and siRNA into tumor cells. When exposed to near-infrared (NIR) light, these nanoparticles trigger lysosomal escape and release, further enhancing gene silencing activity.Methods This study aimed to develop a biocompatible delivery system, HSA@ICG/siRNA NPs, for photothermal-enhanced tumor therapy. The nanoparticles were characterized for size, charge, surface functionalization, and photoconversion properties. In vitro antitumor efficacy was evaluated using MTT assay, calcein AM/PI staining, RT-PCR, and Western blot in 4T1 tumor cells. In vivo, we assessed photothermal effects, biodistribution, tumor inhibition, and biosafety following irradiation.Results Characterization confirmed the successful synthesis of uniform, stable HSA@ICG/siRNA NPs with effective photothermal conversion properties. Cellular uptake studies revealed high siRNA internalization, with laser-induced lysosomal escape enhancing cytoplasmic delivery. In vitro, gene silencing reduced mRNA and protein levels by 82.8% and 65%, respectively. In vivo, local tumor temperature increased to 42°C within 3 minutes, indicating a mild but effective photothermal effect. Tumor inhibition rates were 50.00% ± 9.16% for HSA@ICG and 71.26% ± 7.92% for HSA@ICG/siRNA, demonstrating enhanced tumor suppression. The treatment achieved sustained tumor targeting with minimal off-target toxicity.Conclusion As a dual-function photothermal therapy agent, HSA@ICG/siRNA NPs combine targeted gene silencing with photothermal effects, demonstrating significant therapeutic promise. This integrated approach addresses tumor resistance, offering a potential advancement in cancer treatment strategies.
研究领域:
生物医学工程
·
肿瘤学
·
基因治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2025
·
IF 7.9
Hewei Wei,Feifei Feng,Qiteng Ding,Junran Yang,Taojing Yu,Xiaoyu Wu,Xiaohang Sun,Chuanbo Ding,Yupeng Song
s Bone defects have long posed a challenge in trauma orthopedics. Despite advancements in bone tissue engineering, there remains a bottleneck in developing bone implants that are less toxic, more effective, and reduce the need for secondary surgeries. To address this, we devised a light-responsive bone-targeted smart nano-delivery system. This system integrates polydopamine (PDA)-coated TAX-loaded ZIF-8 nanoparticles into a hydrogel with strong bioadhesion and biocompatibility (TAX@ZIF-8@PDA/ODEX-HD, TZPG). When exposed to near-infrared light, TZPG + NIR demonstrated a high photothermal conversion efficiency of 51.79 %. It exhibited a 99 % inhibition rate against Staphylococcus aureus, while also enhancing the proliferation and differentiation of osteoblasts (MC3T3-E1), thereby accelerating bone defect repair in a rat cranial bone defect model. Additionally, TZPG + NIR accelerates bone tissue repair by upregulating osteogenic-related proteins (ALP, RUNX2, OSX, OCN) while enhancing the expression of COL-I and PDGFA proteins to promote angiogenesis. Overall, TZPG + NIR created an antimicrobial microenvironment in vitro , enabled intelligent controlled release, and programmed degradation during the bone repair cycle, achieving a one-time therapeutic effect. This study highlights the promising applications of near-infrared light-responsive material TZPG in regenerative medicine, offering a novel approach to developing multifunctional bone scaffolds for repairing bone defects as a viable alternative to autografts.
研究领域:
生物材料学
·
组织工程
·
纳米医学
·
骨科学
·
再生医学
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药物递送系统
·
生物相容性
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Kechen Zhang,Haojing Xu,Yuhe Shao,Zaisheng Wen,Ting Wang,Mingyue Chen,Zhen Song,Quanlin Liu
Achieving excitation-free, long-range target surveillance under complete darkness remains a critical challenge for night-vision technology. Here, a breakthrough is reported in near-infrared (NIR) persistent luminescence (PersL) materials designed specifically for this frontier. Through strategic bandgap engineering via Sm 3 ⁺ co-doping and In 3 ⁺ solid-solution incorporation in the novel Cr 3 ⁺-doped Mg 3 Ga 1.9 In 0.1 SnO 8 spinel phosphor, the afterglow intensity and duration are dramatically enhanced. The optimized material exhibits an ultra-long NIR PersL exceeding 168 h. Crucially, PDMS films embedded with this phosphor enabled real-time, persistent target detection at an unprecedented distance of 47.5 m in complete darkness, entirely without any external excitation source. This record-setting long-range performance demonstrates the material's potential as an enabling technology for passive, long-range nighttime surveillance systems. Comprehensive spectroscopic studies elucidate the underlying PersL mechanism. This work establishes a new pathway for designing ultra-long NIR PersL materials and paves the way for advanced applications in remote night-vision technologies.
研究领域:
材料科学
·
光学材料
·
光子学
·
夜视技术
·
远程传感
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Chemistry
·
2024
·
IF 6.7
Chengliang Lyu,Dashuai Sun,Zeyu Lyu,Sida Shen,Pengcheng Luo,Zhihang Yue,Zheng Lu,Luhui Zhou,Hongpeng You
Near-infrared (NIR) phosphor-converted light-emitting diodes (pc-LEDs) light sources have great potential for applications in information encryption , night vision, and non-destructive testing. However, designing efficient NIR phosphors with wide emission band remains a significant challenge. Here, we report a garnet-type NIR phosphor Gd 2 Mg 3 Ge 3 O 12 :Cr 3+ ,Yb 3+ (GMG:Cr 3+ ,Yb 3+ ). The GMG:0.06Cr 3+ phosphor shows a broadband emission peaking at 828 nm under 450 nm excitation, with a full width at half maximum (FWHM) of 188 nm. When Yb 3+ ions are introduced to construct Cr 3+ -Yb 3+ energy transfer, the obtained GMG:Cr 3+ ,Yb 3+ phosphor displays further widened emission band with a FWHM of 272 nm. Moreover, GMG:Cr 3+ ,Yb 3+ phosphor and commercial blue LED chips are combined to create NIR pc-LEDs, which have a photoelectric efficiency of 5.76% @ 100 mA and a maximum NIR output power of 17.21 mW @ 100 mA, demonstrating its potential applications in night vision, non-destructive testing, and information encryption.
研究领域:
材料科学
·
光电子学
·
固态照明
·
光子学
✓ 已验证
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2022
·
IF 4.171
Lin Xiang,Xianju Zhou,Yongjie Wang,Li Li,Sha Jiang,Guotao Xiang,Chuan Jing,Jingfang Li,Lu Yao
Near infrared (NIR) light emitting phosphors have attracted more and more attention with the development of science and technology . Herein, we report a series of environmentally-friendly low-cost Fe 3+ -activated ZnGa 2 O 4 phosphors which exhibit intense broadband NIR light emitting. According to density functional theory (DFT) calculations, ZnGa 2 O 4 host possesses an indirect wide bandgap. The emission of the Fe 3+ -doped phosphors demonstrates a wide band spanning from 650 to 850 nm, with the maximum at 720 nm and a full width at half maxima (FWHM) of 70 nm, showing a large overlap with the absorption of phytochromes (PR and PFR). The luminescence intensity remains at 71% when the temperature is raised to 423 K. The phosphors are fabricated into light emitting diodes (LEDs) which produces strong NIR emission with CIE color coordinates of (0.65, 0.31). All these results suggest that ZnGa 2 O 4 :Fe 3+ is a promising NIR luminescent material , which is expected to be a candidate for indoor plant culture LEDs.
研究领域:
材料科学
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光电子学
·
农业生物技术
·
固体物理
·
无机化学
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
·
2023
·
IF 4.6
Yi Zhang,Zhexuan Gao,Yingguang Li,Shuyang Chen,Mingxiao Han,Jie Li,Qihao Zhang,Yang Shen,Degang Deng,Shiqing Xu
The La2LiSbO6: xCr3+ phosphors were synthesized by means of a high-temperature solid-phase method. Based on the differences in ionic radius, valence state, and formation energy, the substitution sites of Cr3+ ions are discussed in detail. The optimized doping concentration of Cr3+ is determined to be 0.01. Under 517 nm excitation, the La2LiSbO6: 0.01Cr3+ phosphor presents a wide emission band (from 700 to 1350 nm) with a peak centered at 952 nm. Additionally, its corresponding full width at half-maximum is 155 nm, and the internal quantum efficiency reaches 62.4%. Meanwhile, the emission intensity of the La2LiSbO6: 0.01Cr3+ phosphor at 373 K is about 63.7% of that at room temperature, exhibiting good thermal stability. Aiming to fabricate a near-infrared phosphor-converted light-emitting diode device, the La2LiSbO6: 0.01Cr3+ phosphor is mixed with epoxy adhesive and cured on a green light-emitting diode chip. Under the irradiation of the fabricated light-emitting diode device, fruits and writing in the dark environment can be captured by a near-infrared camera. Hence, the La2LiSbO6: 0.01Cr3+ phosphor is promising for night vision.
研究领域:
材料科学
·
光学材料
·
固态照明
·
光子学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry C
·
2024
·Vol. 12
·期 30
·11386-11393
·
IF 5.7
Xinyao Dong,Na Zhou,Minfeng Tian,Yanan Ji,Jingxuan Wang,Jianing Fan,Heyang Li,Wen Xu,Ping Duan,Xiumei Yin
Rare-earth doped oxysulfides have gained considerable attention as a luminescence host material owing to its good chemical stability and high efficiency. In this study, Er3+-sensitized La2O2S nanoparticles are prepared by the high-temperature co-precipitation method. La2O2S:2%Er3+ is selected to construct La2O2S:Er3+@La2O2S core/shell structures through epitaxial growth, and the luminescence properties are studied. The surface defects of La2O2S:Er3+ are repaired by the inert protective shell, and the luminescence intensity of the core/shell nanocrystals is increased by 9.6 times. Finally, MAPbI3 is spin-coated over the La2O2S:Er3+@La2O2S film to construct narrow band near-infrared photodetectors. Under 1550 nm excitation, the response rate is 23 mA W−1, detection rate is 2.57 × 108 Jones, and response time is 220 ms.
研究领域:
材料科学
·
纳米技术
·
光电子学
·
光子学
·
稀土掺杂
✓ 已验证
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 53
·47427-47433
·
IF 3.289
Jinghua Liu,Xiaoqian Ge,Lining Sun,Ruoyan Wei,Jinliang Liu,Liyi Shi
A new kind of carbon dots with an average diameter of approximately 3–5 nm were synthesized using L-lysine. Subsequently, a series of lanthanide complex-functionalized carbon dots were designed and synthesized, denoted as Ln-CDs (Ln = Eu, Sm, Er, Yb, Nd). In addition, by changing the ratio of Eu complexes and carbon dots, four kinds of Eu complex-functionalized carbon dots were also obtained (Eu-CDs-1, Eu-CDs-2, Eu-CDs-3, Eu-CDs-4). The derived nanomaterials were characterized by Fourier-transform infrared (FT-IR) spectroscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and fluorescence spectroscopy. Upon visible-light excitation, these lanthanide complex-functionalized carbon dots show multicolor visible (Eu; with red, orange, grey and blue colors, respectively) and near-infrared (Sm, Er, Nd, Yb) luminescence (emission covered from 400 nm to 1700 nm spectral region).
研究领域:
材料科学
·
纳米技术
·
光学材料
·
光物理
✓ 已验证
DOI
高影响因子
TALANTA
·
2026
·
IF 6.7
Xue Yang,Yu Si,Shasha Jiang,Meng Zhuo,Tong Ren,Zijun Han,Xuetong Zhao,Xueyan Hou,Yongli Shi
In this study, an 808 nm near-infrared (NIR)-responsive hydrogel (NOR-MSN@MnO 2 -gel) was developed for the treatment of bacteria-infected wounds. The norfloxacin (NOR)-loaded manganese dioxide-modified mesoporous silica (NOR-MSN@MnO 2 ) nanoparticles were selected as a photothermal material and encapsulated in the furfuryl amine-modified hyaluronic acid hydrogel (HA-FA gel ). Studies found that MSN@MnO 2 -gel exhibited a three-dimensional porous network structure, favorable injectability, excellent water absorption & retention capacity, and desirable photothermal conversion efficiency. Benefiting from pH/NIR dual-responsive characteristics, NOR-MSN@MnO 2 -gel realized controllable NOR release and achieved efficient elimination of Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ) through synergistic photothermal therapy (PTT) and chemotherapy. In vivo infected wound studies demonstrated that NOR-MSN@MnO 2 -gel combined with NIR irradiation (NOR-MSN@MnO 2 -gel + NIR) could effectively inhibit bacterial growth, alleviate inflammation, accelerate re-epithelialization, and promote collagen deposition & angiogenesis, while maintaining satisfactory biological safety. Collectively, the NOR-MSN@MnO 2 -gel + NIR regimen provides a promising strategy for clinical treatment of bacterial infected wounds.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2025
·
IF 4.9
Jing Sun,Zhihao Huang,Yanrui Lu,Huadong Li,Shuangshuang Gong,Sen Liu,Chao Zhang,Jingjing Liu,Wei Ye,Hao Zhang
Bacterial infection poses a major challenge for medical implantable catheters, frequently causing serious complications. One effective approach to addressing this issue is a catheter surface coating strategy that combines robust antibacterial properties with long-term stability and excellent biocompatibility. In this work, we developed a multifunctional antibacterial coating (MSN@FeCO@PDA) for medical catheters through a sequential fabrication approach. Initially, mesoporous silica nanoparticles (MSNs) were functionalized as nanocarriers for the carbon monoxide (CO) donor iron dodecacarbonyl (Fe 3 (CO) 12 ), to yield MSN@FeCO nanoparticles. Subsequently, these nanoparticles were uniformly immobilized onto the catheter surface via polydopamine (PDA)-mediated adhesion, resulting in a stable and biocompatible MSN@FeCO@PDA nanocomposite coating. The PDA within the coating demonstrates photothermal activity upon near-infrared (NIR) irradiation, resulting in localized temperature elevation and subsequent controlled CO release from Fe 3 (CO) 12 . We conducted an investigation into the correlation between NIR-induced temperature variations and CO generation, followed by an evaluation of the antibacterial efficacy of combined CO therapy and photothermal therapy. Results show that upon 10-min NIR irradiation (808 nm), the nanocomposite coating concurrently facilitated CO release and induced moderate hyperthermia, resulting in a highly effective synergistic antibacterial efficiency (> 97 %). Furthermore, in vivo studies demonstrated that the coated catheter markedly attenuated inflammatory responses in murine models while exhibiting enhanced antibacterial efficacy. This nanomaterial-based composite coating represents a safe and effective multifunctional antibacterial strategy for medical implants, with promising clinical applications.
研究领域:
生物医学工程
·
纳米医学
·
抗菌材料
·
光热治疗
·
药物递送系统
✓ 已验证
DOI
高影响因子
Frontiers in Chemistry
·
2023
·
IF 5.5
Chen Huiying,Zhao Xinshuo,Cui Bingbing,Cui Haohao,Zhao Mengyang,Shi Jun,Li Jingguo,Zhou Zhan
Pathogenic microbial infections have been threatening public health all over the world, which makes it highly desirable to develop an antibiotics-free material for bacterial infection. In this paper, molybdenum disulfide (MoS2) nanosheets loaded with silver nanoparticles (Ag NPs) were constructed to inactive bacteria rapidly and efficiently in a short period under a near infrared (NIR) laser (660 nm) in the presence of H2O2. The designed material presented favorable features of peroxidase-like ability and photodynamic property, which endowed it with fascinating antimicrobial capacity. Compared with free MoS2 nanosheets, the MoS2/Ag nanosheets (denoted as MoS2/Ag NSs) exhibited better antibacterial performance against Staphylococcus aureus by the generated reactive oxygen species (ROS) from both peroxidase-like catalysis and photodynamic, and the antibacterial efficiency of MoS2/Ag NSs could be further improved by increasing the amount of Ag. Results from cell culture tests proved that MoS2/Ag3 nanosheets had a negligible impact on cell growth. This work provided new insight into a promising method for eliminating bacteria without using antibiotics, and could serve as a candidate strategy for efficient disinfection to treat other bacterial infections.
研究领域:
材料科学
·
生物医学工程
·
微生物学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）