JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Jilong Kang,Zhiying Wang,Jinhua Li,Zuoling Fu
Rare-earth-doped luminescent materials have attracted extensive attention owing to their unique 4 f electronic configuration and optical properties. However, the research has largely remained confined to single application domains, and developing multifunctional luminescent systems and elucidating energy transfer mechanisms are essential for broadening their applicability. Herein, we select the double perovskite tungstate Ca 2 MgWO 6 as a host material, leveraging the intrinsic W-O charge transfer band to achieve efficient self-activated blue emission. The W-O charge transfer band further serves as an efficient energy transfer channel to activate the luminescence of lanthanide-based trivalent cations (Ln 3 + ), overcoming the limitation posed by mismatched excited-state energy levels among different Ln 3+ ions (i.e., Er 3+ , Ho 3+ , and Tm 3+ ). By introducing Yb 3+ as an energy sensitizer, the fluorescence intensity of Ln 3+ in visible and near-infrared regions under 980 nm excitation is significantly enhanced. Switching the excitation wavelength enables tunable photoluminescence signals, which leverage to design multimodal decodable anti-counterfeiting labels and information storage systems. Moreover, a sensitizer-mediated NIR-II ratiometric optical thermometer is constructed by means of phonon-assisted energy transfer, exhibiting a relative sensitivity of 0.52% K −1 . This work demonstrates a strategy for designing next-generation, high-performance lanthanide luminescent materials that can be employed in various sensing and photonics applications.
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ANALYTICAL CHEMISTRY
·
2026
·Vol. 98
·期 31
·23119-23129
·
IF 7.3
Zhang Lei,Liao Yuqin,Zhu Lvyun,Li Yingying,Yu Lilei,Yang Yanbing,Yuan Quan
Near-infrared II (NIR-II, 1000–1700 nm) fluorescence
imaging
enables deep-tissue analysis, but conventional “always-on”
probes suffer from high background that compromises the signal-to-background
ratio for low-abundance targets. Activatable probe strategies could
mitigate this issue, yet most existing designs rely on fluorescence
resonance energy transfer with acceptors confined to the visible region,
hampering efficient signal quenching in the NIR-II window. Here, we
present a generalizable strategy based on morphology-engineered nanometal
surface energy transfer (NSET) to construct a NIR-II core–satellite
nanoprobe for intracellular miR-21 detection. By systematically tuning
the branch aspect ratio of gold nanostars (AuNSs), their localized
surface plasmon resonance (LSPR) absorption can be red-shifted to
achieve precise spectral overlap with the NIR-II emission of Ag 2 S quantum dots. Guided by DNA self-assembly, an AuNS@Ag 2 S core–satellite structure with controllable interparticle
spacing is established, enabling an initial fluorescence quenching
efficiency of up to 88%. Upon target recognition, miR-21-triggered
strand displacement reaction induces the dissociation of Ag 2 S quantum dots from the AuNS surface, resulting in a pronounced NIR-II
fluorescence “turn-on” response. The nanoprobe exhibits
exceptional performance, including a low detection limit of 75.8 pM,
robust linearity, single-base mismatch discrimination capability,
and enables visualization of differential miR-21 expression in living
cells. Notably, high-contrast NIR-II signals are retained at penetration
depths of up to 15 mm in tissue-mimicking experiments. This work establishes
an NSET-based analytical platform through precise spectral matching
and rational structural engineering, providing a robust strategy for
high signal-to-background biosensing and in situ analysis of low-abundance
miR-21 in deep tissues.
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CERAMICS INTERNATIONAL
·
2026
·
IF 6
Qi Chen,Rongyi Kuang,Yinyue Cao,Zezhong Yang,Siran Tao,Binchang Wu,Lin Huang,Bo-Mei Liu,Jing Wang
The second near-infrared window (NIR-II, 1000-1700 nm) phosphor-converted LEDs (pc-LEDs) show great potential for portable spectroscopic detection. However, high-performance long-wavelength (>1350 nm) NIR-II phosphors that combine broadband emission, high thermal stability, and efficient blue-light excitation, are still relatively scarce. Herein, a Lu 3 Ga 5 O 12 :Cr 3+ ,Ni 2+ phosphor was developed via a Cr 3+ sensitization strategy. Cr 3+ and Ni 2+ stably occupy the [GaO 6 ] octahedral sites, enabling efficient energy-transfer from Cr 3+ to Ni 2+ . The optimal sample exhibits broadband NIR-II emission at 1427 nm with an FWHM of 277 nm, an EQE of 23.1%, and excellent thermal stability (I 373K /I 293K = 81.5%). The pc-LED based on this NIR-II phosphor achieves penetration imaging and non-destructive identification of daily necessities. More notably, rapid spectral differentiation of common plastics (PA, PE, PP, PVC and PET) was successfully realized using the NIR-II luminescence of the as-prepared phosphor. This work provides guidance for constructing high-performance NIR-II phosphors and promotes the practical deployment of NIR spectroscopy in resource recycling.
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Acta Biomaterialia
·
2025
·
IF 9.6
Yating Wang,Yixuan Xu,Dejia Chen,Xin Li,Dalong Yin,Lifeng Yan
Photothermal therapy (PTT) utilizes localized hyperthermia above 50 °C generated by nanomaterials upon exposure to near-infrared (NIR) laser light for effective cancer cell eradication. Yet, in high-temperature PTT, tumor cells develop heat stress tolerance due to elevated heat shock protein (HSP) levels, diminishing therapeutic efficacy. Moreover, excessive heat can trigger inflammatory conditions and promote cancer metastasis. Targeting the glycolytic pathway in highly metabolically active tumor cells offers a promising strategy for inducing starvation therapy, capitalizing on their vigorous energy demands amidst rapid proliferation. Here, we synthesized a highly luminous NIR-II dye, FNF, followed by its encapsulation alongside myricetin (My) within amphiphilic polypeptide carriers through a self-assembly method. The resulting nanoparticles exhibited great NIR-II imaging capabilities and boasted a notable photothermal conversion efficiency of 55.58 %. Furthermore, My effectively impeded glucose transport facilitated by glucose transporter protein 1 (GLUT1), curtailing glucose supply to tumor cells. This interference disrupted mitochondrial energy production, resulting in decreased adenosine triphosphate (ATP) synthesis and subsequent downregulation of HSP70 expression. By leveraging this approach, which targeted HSP expression via GLUT1 inhibition, we enhance the efficacy of PTT while achieving a synergistic effect for mild photothermal therapy through starvation. Statement of significance High expression of heat shock proteins (HSPs) in cancer cells impairs the efficacy of photothermal therapy (PTT) and triggers inflammation or metastasis, among other effects. Rapid malignant proliferation of tumor cells results in high energy metabolism, so interfering with their glucose metabolism to inhibit the glycolytic process is a feasible route for tumor starvation therapy. Here, we employed an amphiphilic polypeptide encapsulated photosensitizer (FNF) and myricetin (My) to construct nanoparticles with both NIR-II imaging capability and high photothermal conversion efficiency (55.58 %). Among them, My blocked glucose transport mediated by glucose transporter protein 1 (GLUT1), reduced the glucose supply and ATP synthesis in cancer cells, and then down regulated HSP70 expression. Thus, this strategy achieves starvation synergistic mild photothermal therapy through metabolic disruption.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
·
IF 5.6
Mengyao Zhang,Xin Hu,Yudai Huang
Compared to the first near-infrared (NIR-I) window (650–1000 nm), the second near-infrared (NIR-II) window (1000–1700 nm) is more valuable for photothermal treatment (PTT) due to its deeper tissue penetration and lower phototoxicity. However, the therapeutic efficacy of PTT remains suboptimal owing to the inherently low photothermal conversion efficiency (PCE) of existing materials. Therefore, the development of nanomaterials with high PCE is a promising strategy for improving anti-tumor therapy. In this study, hollow semimetal PtTe 2 nanorods were synthesized. Their unique electronic properties and hollow structure contribute to achieving high PCE under NIR-II irradiation, while simultaneously promoting reactive oxygen species (ROS) generation. Additionally, PtTe 2 catalyzed the endogenous conversion of hydrogen peroxide (H 2 O 2 ) into oxygen (O 2 ) and hydroxyl radicals (•OH), further enhancing anti-tumor effects via chemodynamic therapy (CDT). In vivo experiments confirmed the excellent biocompatibility of PtTe 2 , and laser treatment following PtTe 2 administration significantly inhibited tumor growth, demonstrating its favorable therapeutic efficacy. This study establishes a new nanoplatform for the treatment of malignant tumors through photothermal/photodynamic/chemodynamic therapy, providing valuable insights for future research on multifunctional cancer therapies.
研究领域:
肿瘤学
·
纳米医学
·
生物材料学
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Qing Li,Ning Liu,Dayu Wang,Lie Ma,Mingzhou Wu,Enna Ha,Junqing Hu,Zhe Zhang,Shuqing He
Silver sulfide (Ag 2 S) quantum dots (QDs), which emit light in the near-infrared II window (NIR-II, 1000–1700 nm), exhibit unique and remarkable potential in bioluminescence. However, their widespread application in experimental research is currently limited by a relatively low quantum efficiency. Cation exchange reactions have emerged as a remarkably versatile approach for synthesizing nanomaterials with adjustable structures and customizable compositions. In this study, we developed a NIR-II fluorescent probe based on Sn-doped silver sulfide (Sn-Ag 2 S) QDs via a straightforward cation exchange method. The stoichiometric ratios of precursors play a crucial role in tailoring the optical properties of the resultant materials during structural modifications involving cation exchange processes. By optimizing the ratio of Ag and Sn, we obtained ca. 16-fold quantum yields enhancement of Sn-Ag 2 S QDs in the NIR-II range, specifically around strong emission peak at ca. 1200 nm. Following hydrophilic modification, the Sn-Ag 2 S-GSH/MPA QDs exhibited high NIR-II fluorescence signal signal-to-noise ratio (S/N) with a ca. 1.7-fold increase compared to Ag 2 S-GSH/MPA QDs in the femur of mice, showing significant potential for bone imaging. To further investigate the QDs biodistribution mechanisms within osseous microenvironments, we devised a comprehensive multimodal analytical approach incorporating: (1) optical spectral analysis, (2) ultrastructural validation through transmission electron microscopy (TEM), and (3) spatial resolution mapping via laser scanning confocal microscopy (LSCM). These integrated methodologies consistently demonstrated preferential QDs accumulation within trabecular bone marrow compartments, revealing distinct biodistribution patterns in mineralized tissues.
研究领域:
生物医学工程
·
材料科学
·
光学成像
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Hua Yu,Zhexuan Gao,Huanping Wang,Shilong Zhao,Degang Deng,Shiqing Xu
Developing phosphor-converted light-emitting diodes (pc-LEDs) for portable near-infrared (NIR) spectroscopy applications has generated significant demand for NIR-II phosphors. However, developing a NIR-II phosphor with both broadband emission and good thermal stability remains a significant challenge. Herein, we report a novel Ni 2+ -doped Mg 4 Nb 2 O 9 (MNO) phosphor that exhibits a full-width at half maximum (FWHM) of 213 nm, covering a wavelength range of 1100–1700 nm, with a peak at 1319 nm when excited by 405 nm ultraviolet (UV) light. The optimized phosphor exhibited an internal quantum efficiency (IQE) of 38.31 %. By combining first-principles calculations with experimental analysis, we established that Ni 2+ ions occupy the three octahedral cation sites in the MNO host. Notably, the MNO: 0.004Ni 2+ phosphor maintains 102 % of its initial emission intensity at 423 K compared to room temperature (RT), exhibiting a zero-thermal-quenching property, which can be attributed to the thermal energy transfer from oxygen vacancy defects to activator ions, large thermal energy barrier, as well as the high rigidity of the MNO host. An NIR-II pc-LED device was constructed by encapsulating the optimized phosphor within a UV LED chip. The application of nondestructive NIR spectroscopy in detection, night vision, and bioimaging further demonstrates the potential of this device.
研究领域:
材料科学
·
光学
·
光电子学
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iScience
·
2025
·
IF 4.1
Wenhui Zhang,Min Zhao,Leqiang Wang,Jiaqi Wang,Xiaoguang Ge,Junzhi Liu,Bin Chen,Shi Gao,Jingbin Lu
Metal-organic frameworks (MOFs) based on nanomaterials have attracted attention for tumor microenvironment (TME)-responsive therapy. However, they lack intrinsic imaging capabilities to monitor drug release and predict therapeutic outcomes. Herein, metal-phenolic nanosheets (Cu/EA-MOF) with photoacoustic (PA) imaging property in the second near-infrared window were constructed to achieve diagnosis and treatment for H 2 S-enriched tumors. Endogenous H 2 S triggers the decomposition of Cu/EA-MOF into the ellagic acid (EA) and copper sulfide (Cu 2-x S), which can be used for chemotherapy and chemodynamic therapy, respectively. Moreover, EA can enhance the efficiency of chemodynamic therapy by boosting superoxide dismutase activity. Importantly, the degradation of Cu/EA-MOF can be indicated via the change of ratiometric PA signal intensity. Furthermore, the NIR-II fluorescent molecule benzobisthiadiazole (BBT) was further introduced into Cu/EA-MOF to investigate the degradation process and drug release. As a promising theranostic nanomaterial, Cu/EA/BBT-MOF is successfully used to achieve effective synergistic therapy and predict therapeutic outcomes.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
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Cell Reports Physical Science
·
2025
·
IF 7.3
Mengxuan Du,Binge Huang,Songlin Xin,Liqin Wu,Xiaojun He
Multidrug-resistant bacterial pneumonia (MDR-BP), particularly involving biofilm eradication, presents therapeutic challenges. While reactive oxygen species (ROS)-mediated chemodynamic therapy offers antibacterial potential, limitations in biocatalytic performance and nanotherapeutic efficacy hinder traditional approaches. We developed nitrogen-doped ruthenium single-atom catalysts (Ru-N-SACs) as a dual-functional nanotherapeutic platform. This nanozyme exhibits peroxidase-mimicking catalytic activity, generating ROS selectively. Near-infrared laser stimulation further enhances its activity and provides photothermal disruption of biofilms. The resulting synergistic action achieves complete biofilm eradication and improves survival in pneumonia models. Comprehensive multi-omics analyses elucidated the therapeutic effectiveness and regulatory mechanisms of Ru-N-SACs against MDR-BP pathogenesis. This work demonstrates a paradigm combining catalytic ROS generation and photothermal therapy for managing deep-tissue infections. It advances the design of precision-engineered nanozymes within antimicrobial nanomedicine, addressing the critical need for innovative strategies against MDR pathogens.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Jian Li,Xinhui Su,Nian Liu
Organic molecules with strong absorption in the near-infrared (NIR)-II region are highly desired for cancer photothermal theranostics. However, it remains challenges to construct NIR-II photothermal agents with desired optical properties. This study reports a donor engineering approach to simultaneously manipulate the absorption and nonradiative transitions of croconaine dyes. By introducing different donor units with increasing electron donating ability to the backbone, the absorption of the synthesized croconaines were gradually red-shifted to NIR-II region, especially the benzo[ c , d ]indolium conjugated croconaine (CR1045). The extensive conjugation of CR1045 had a narrower HOMO-LUMO energy gap and strong NIR-II light responsiveness. Importantly, the steric repulsion between this large planar donor and croconate acceptor of CR1045 promotes the formation of a twisted intramolecular charge transfer (TICT) state, making it more prone to direct the absorbed energy towards heat-producing non-radiative decay rather than other dissipative pathways. And the nanoformulated CR1045 exhibits excellent optoacoustic generation capability and ultrahigh photothermal conversion efficiency (∼84%). In vitro and in vivo investigations confirm good optoacoustic imaging and effective photothermal treatment of tumors. Therefore, this work offers insights into donor regulation for the future development of efficient NIR-II photothermal agents.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
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Nano Today
·
2022
·
IF 18.962
Qi-Xian Wang,Yuan-Fan Yang,Xiang-Fei Yang,Yue Pan,Ling-Dong Sun,Wen-Yuan Zhang,Yulei Shao,Jie Shen,Jian Lin,Lele Li,Chun-Hua Yan
Heterostructures of NaLnF 4 and porphyrinic metal-organic frameworks (MOF) have been reported as a promising platform for near-infrared (NIR)-driven photodynamic therapy (PDT), while the energy transfer from NaLnF 4 to MOF greatly decreased the upconversion emissions. To develop NaLnF 4 and MOF heterostructures with significantly improved PDT and imaging simultaneously is important to track their location to implement therapy accurately. Herein, we constructed Er 3+ -doped NaLnF 4 @MOF [email protected] nanoparticles to integrate NIR-driven PDT and NIR-II imaging. NaLnF 4 nanoparticles are designed with upconversion and NIR emission simultaneously under a single 980 nm excitation, where the upconversion luminescence (UCL) overlaps well with the absorption of Zr-based porphyrin MOF, enabling efficient energy transfer from NaLnF 4 to the MOF shell to generate 1 O 2 . And the NIR luminescence, which gave out under a lower excitation power than that of UCL, could be used to track the location and distribution of the heterostructures via NIR-II imaging. Moreover, antiprogrammed death-ligand 1 (α-PD-L1) immunotherapy was introduced synergistically to improve antitumor immunity efficacy. The combination of NaLnF 4 @MOF and α-PD-L1 not only inhibited primary tumors but also suppressed distant one, leading to an effective tumor inhibition rate of 95%. This work provides an integrated nanoplatform for boosting NIR-II imaging-guided PDT/immunotherapy efficacy toward tumor treatment.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-16
·
IF 15.7
Li Yibin,Qu Fei,Wan Fang,Zhong Cheng,Rao Jingyi,Liu Yijing,Li Zhen,Zhu Jintao,Li Zhong’an
Near-infrared (NIR)-II fluorescence imaging-guided photodynamic therapy (PDT) has shown great potential for precise diagnosis and treatment of tumors in deep tissues; however, its performance is severely limited by the undesired aggregation of photosensitizers and the competitive relationship between fluorescence emission and reactive oxygen species (ROS) generation. Herein, we report an example of an anionic pentamethine cyanine (C5T) photosensitizer for high-performance NIR-II fluorescence imaging-guided PDT. Through the counterion engineering approach, a triphenylphosphine cation (Pco) modified with oligoethylene glycol chain is synthesized and adopted as the counterion of C5T, which can effectively suppress the excessive and disordered aggregation of the resulting C5T-Pco by optimizing the dye amphipathicity and enhancing the cyanine-counterion interactions. Dynamic tuning of fluorescence characteristics and ROS generation is achieved at the aggregate level, resulting in an impressive type I ROS generation under 760 nm light irradiation, accompanied by efficient NIR-II fluorescence emission excited at 808 nm. As a result, excitation wavelength selective NIR-II fluorescence imaging-guided PDT has been successfully demonstrated for tumor diagnosis and therapeutics of female mice.
研究领域:
生物医学工程
·
分子影像
·
诊疗学
·
材料科学
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