Materials Chemistry Frontiers
·
2022
·Vol. 6
·期 10
·1269-1281
·
IF 8.683
Xiaohui Wang,Xiaoyue Feng,Mengjie Sun,Mingzhu Wang,Wei Wang,Zhi Yuan
Poor perfusion and low accumulation of drugs caused by abnormal tumor blood vessels significantly reduce the chemotherapy efficacy. Nowadays, the synergistic therapy of vascular normalization and chemotherapy has become an ideal choice to increase the tumor inhibition rate. Delivering an appropriate amount of NO around tumor vessels proved to be an effective vascular normalization strategy. In order to meet the demand for continuous and stable production of NO at the tumor site, herein, we developed a strategy to normalize tumor blood vessels by catalyzing NO generation from endogenous NO donors (RSNO). Concretely, the surface of copper-doped mesoporous silica was modified with PAA by electrostatic interactions to form CuMSN-PAA nanoparticles. The system was simple in structure and could catalyze NO production by exposing the CuMSN surface in response to a slightly acidic environment. In vivo, the NO level in the tumor increased 5.8-fold after CuMSN-PAA treatment, and blood perfusion increased by 70%, which in turn induced vascular normalization. Consequently, DOX accumulation of the CuMSN-PAA group increased 2.4-fold compared with the control group. More importantly, after the synergistic treatment of vascular normalization and chemotherapy, the anti-tumor efficacy was increased by 37.2% compared with the DOX-treated group with no overt toxicity observed.
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DOI
高影响因子
Molecular Catalysis
·
2021
·
IF 5.062
Yu Guan,Yinhe Liu,Qiang Lv,Bo Wang
The selective catalytic reduction of nitrogen oxides (NO x ) by carbon monoxide (CO-SCR) is a promising way to deal with exhaust gasses. And Effective redox cycle and NO dissociation ability are crucial factors for catalytic reduction of NO x . Herein, Fe decorated CeO 2 microsphere catalysts with surface oxygen defect were synthesized by solvothermal and calcination method. Among all catalysts, 0.5Fe-CeO 2 sample showed excellent catalytic performance with efficiency near 96% for NO reduction under the condition of 550 ppmv NO, 1200 ppmv CO, and 40,000 h − 1 of GHSV. It was found that Fe doping could efficiently regulate Ce 4+ /Ce 3+ redox couple and oxygen vacancy for catalytic activity. XRD, Raman, XPS, EPR and H 2 -TPR etc. were employed to explore the physicochemical properties of samples. The results showed that Fe had been incorporated into CeO 2 by XRD, and the results of Raman spectrum and XPS indicated that Ce 4+ /Ce 3+ redox couple existed in 0.5Fe-CeO 2 catalyst. Furthermore, the H 2 -TPR spectrum displayed the formation of oxygen vacancy in the samples. N 2 adsorption-desorption isotherms indicated that the doping of Fe could enlarge the specific surface area, pore volume and pore dimeter of the samples, and thus greatly enhanced the NO adsorption and further NO catalytic reduction on catalysts. In addition, other characterization of physicochemical properties and density functional theory (DFT) calculation were performed to reveal the mechanism of NO + CO reaction. As a result, a mechanism was proposed to elucidate highly efficient NO reduction over the catalysts of Fe decorated CeO 2 microspheres. Finally, the synergistic effects of redox center and oxygen vacancy on catalytic activity enhancement were revealed. This work provides a promising way to the design of efficient catalysts for NO reduction.
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DOI
高影响因子
CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2021
·
IF 3.739
Han Wang,Shulan Wang,Jingqiao Zhang,Han Wang,Hui Li,Yi Zhao
Several mesostructured cellular foams (MCFs) were prepared and modified for NO adsorption. TMB, NH 4 F and n -heptane were used as swelling agents, and APTES was used as the modified agent. The morphological structure, chemical composition, thermostability were tested to study the effects of the preparation process on the characterizations of materials. NO adsorption ability of the materials were studied and discussed. NH 4 F and n -heptane had better pore swelling effects compared to TMB, however adding TMB together with NH 4 F and n -heptane could not enlarge the pore structure further. The MCFs materials could keep steady below 800 °C, but after grafting APTES on the surface of the materials, the thermogravimetric curve of materials began to decrease at 300 °C. The materials using NH 4 F and n -heptane as the swelling agents, and modified by APTES had better NO adsorption ability, and the selectivity of the materials were decided by the molecular polarity of the adsorbates. After the modification, the hydrophobic effect of the samples could increase because of the alkyl groups in APTES. The adsorption capacity of the materials could keep steady for ten times without the coexisting component, H 2 O, CO 2 and SO 2 all had negative effects on the regeneration of the materials.
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DOI
高影响因子
Journal of Environmental Sciences
·
2020
·
IF 4.302
Runping Wu,Qing Ye,Kai Wu,Hongxing Dai
To improve the removal capacity of NO + O 2 effectively, the alkaline earth metal-doped order mesoporous carbon (A-C-FDU-15(0.001) (A = Mg, Ca, Sr and Ba)) and Mg-C-FDU-15( x ) ( x = 0.001−0.003) samples were prepared, and their physicochemical and NO + O 2 adsorption properties were determined by means of various techniques. The results show that the sequence in (NO + O 2 ) adsorption performance was as follows: Mg-C-FDU-15(0.001) (93.2 mg/g) > Ca-C-FDU-15(0.001) (82.2 mg/g) > Sr-C-FDU-15(0.001) (76.1 mg/g) > Ba-C-FDU-15(0.001) (72.9 mg/g) > C-FDU-15 (67.1 mg/g). Among all of the A-C-FDU-15(0.001) samples, Mg-C-FDU-15(0.001) possessed the highest (NO + O 2 ) adsorption capacity (106.2 mg/g). The species of alkaline earth metals and basic sites were important factors determining the adsorption of NO + O 2 on the A-C-FDU-15( x ) samples, and (NO + O 2 ) adsorption on the samples was mainly chemical adsorption. Combined with the results of (NO + O 2 )-temperature-programmed desorption ((NO + O 2 )-TPD) and in situ diffused reflectance infrared Fourier transform spectroscopy (DRIFTS) characterization, we deduced that there were two main pathways of (NO + O 2 ) adsorption: one was first the conversion of NO and O 2 to NO 2 and then part of NO 2 was converted to NO 2 − and NO 3 − ; and the other was the direct oxidation of NO to NO 2 − and NO 3 − .
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DOI
PubMed
高影响因子
FOOD SCIENCE AND BIOTECHNOLOGY
·
2016
·Vol. 25
·期 4
·1115-1122
·
IF 0.699
Feng Yanli,Chen Wanping,Chen Fusheng
Monacolin K (MK) produced by Monascus spp. is mostly used to regulate cholesterol level, while it can be contaminated by citrinin, a mycotoxin yielded by some Monascus strains. To develop production of citrinin-free MK, an M . sp. MS-1 strain, identified as M. pilosus by morphologies and internal transcribed spacer sequences analysis, was isolated from red fermented rice. After 14 days of fermentation, yields of citrinin-free MK could be up to 0.58 mg/mL and 16.45 mg/g in liquid- and solidstate fermentation products under optimal conditions, respectively. Further determination revealed that no citrinin biosynthesis related genes such as ctnA , pksCT , ctnE , and ctnR were detected. Thus, HPLC combined with citrinin-related gene analyses can be used for rapid screening of non-citrinin production Monascus strains.
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DOI
PubMed
高影响因子
JOURNAL OF CATALYSIS
·
2018
·
IF 6.759
Houlin Wang,Shuting Luo,Meisheng Zhang,Wei Liu,Xiaodong Wu,Shuang Liu
Though the catalytic oxidation of CO, NO and soot over CeO 2 could be understood within a similar Mars-van Krevelen-type mechanism, these reactions were likely to be driven by different active phases. In this work, several CeO 2 and Ag/CeO 2 nanorods with different contents of surface oxygen vacancies (V O-s ) and active oxygen species (O x − ) were designed as model catalysts. Their catalytic performance indicated that, CO oxidation was determined by pre-existing ceria V O-s , while O x − participated in NO and soot oxidation directly. Besides, by loading silver onto the high-temperature aged CeO 2 nanorods, Ag/CeO 2 catalysts with high availability of ceria lattice oxygen were obtained, whose low-temperature oxidation activity was proven comparable to that of the platinum catalysts. In this sense, the model designing in this work not only provided methods to find out proper reactivity descriptors, but also conferred low-cost catalysts with high practical potential.
研究领域:
催化
·
材料科学
·
化学工程
·
环境化学
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DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2013
·
IF 5.437
Li Wang,Peiyu Hu,Xiaocui Deng,Fang Wang,Zilin Chen
As a transcellular messenger molecule, nitric oxide (NO) is involved in many physiological and pathological processes. The accurate quantitative detection of NO in vivo is particularly important. In this work, a novel electrochemical NO sensor was fabricated via electro-polymerization of ethylenediamine (EDA) on multi-walled carbon nanotubes (MWNTs) film. The sensor combined the porous structure and good conductivity of MWNTs with the good electro-catalytic ability of p-EDA film. For the detection of NO, it has a linear range from 95 nM to 11 μM and the limit of detection reaches 95 nM with excellent reproducibility. So it was successfully applied to monitor NO release from rat liver sample for investigating the inhibition or promotion effect of drugs including oleanolic acid (OA), baicalin and Nω-nitro- l -arginine methyl ester ( l -NAME) on nitric oxide synthase (NOS). The results showed that OA could promote NO release and the amount of NO increases about 1.9 times, but baicalin and l -NAME could inhibit the release of NO and the amount of NO decreased by two-thirds and 37.5%, respectively.
研究领域:
生物医学工程
·
分析化学
·
药理学
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DOI
高影响因子
BIOORGANIC CHEMISTRY
·
2021
·
IF 5.275
Xiuhan Guo,Haoze Yu,Wanjie Shen,Rui Cai,Yueqing Li,Guangzhe Li,Weijie Zhao,Shisheng Wang
Photodynamic therapy (PDT) is a non-invasive treatment method for tumors by exciting photosensitizers (PS) upon light irradiation to generate cytotoxic reactive oxygen species (ROS). However, the low oxygen concentration near the tumor tissue limits the therapeutic effect of PDT. Herein, we synthesized six chlorin e6 derivatives containing NO-donors to enhance their antitumor activity by synergistic effect of ROS and NO. The results revealed that the new NO-donor containing photosensitizers (PS-NO) exhibited more potent photodynamic activity than chlorin e6, and the introduction of NO donor moieties to chlorin e6 increased the level of NO and ROS in cells. The addition of Ferrostatin-1, a ferroptosis inhibitor, markedly reduced the photodynamic activity of PS-NO as well as the level of NO and ROS in cells. Mechanism studies further showed that PS-NO could reduce intracellular GSH level, inhibit GPX4 activity and promote malondialdehyde (MDA) accumulation upon light irradiation, which suggested the ferroptosis mechanism underlying the PDT effect of PS-NO.
研究领域:
癌症生物学
·
药理学
·
光化学
·
细胞生物学
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DOI
PubMed
高影响因子
Biomaterials Science
·
2021
·Vol. 9
·期 17
·5824-5840
·
IF 6.843
Mengchao Ding,Kai Shao,Lijuan Wu,Yuping Jiang,Bing Cheng,Lili Wang,Jinsheng Shi,Xiaoying Kong
Nitric oxide (NO) gas treatment offers a promising strategy for tumor therapy; however, its practical application is still limited due to its poor efficacy and biotoxicity which were caused by gas leakage during blood delivery. Herein, a nano-platform (CMH-OBN) composed of chlorin e6-melanin-hyaluronic acid nanoparticles (Ce6-MNP-HA, CMH) and oxidized bletilla striata polysaccharide microcapsules (Oxi-BSP) carrying NO donors was prepared for responsive and cascaded release of NO, reactive oxygen species (ROS) and its secondary metabolite reactive nitrogen species (RNS) in tumor sites. Melanin not only endowed CMH with good photothermal properties, but also helped Ce6 to produce a large number of ROS under near-infrared (NIR) irradiation. OBN microcapsules, which were sensitive to ROS, can release NO donors under the stimulation of ROS released by CMH nanoparticles under NIR irradiation and can further release NO in the tumor microenvironment (TME) with high expression of glutathione (GSH). NO could further up-regulate soluble guanylate cyclase-cyclic guanosine monophosphate (sGC-cGMP) signal pathways to relieve hypoxia, thus further enhancing the photodynamic therapy (PDT). Moreover, the cascaded release of ROS and NO could produce RNS with higher lethality, which could sequentially initiate the cellular apoptotic procedure and promote immunotherapy by activating T cells at the tumor sites. More interestingly, the CMH-OBN nano-platform could supply magnetic resonance imaging (MRI) and infrared photothermal imaging guidance for tumor therapy. In conclusion, the development of a CMH-OBN nano-platform provides a satisfactory demonstration by combining NO therapy with photothermal therapy (PTT), PDT and immunotherapy for the treatment of cancer.
研究领域:
癌症治疗
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纳米技术
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生物医学工程
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药学
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DOI
PubMed
高影响因子
CHEMISTRY OF NATURAL COMPOUNDS
·
2020
·Vol. 56
·期 5
·842-844
·
IF 0.653
Ding Weijia,Wu Zhihui,Qin Chan,Xie Jiayan,Chen Min,Li Chunyuan
A new phenolic derivative, ethyl 4-ethoxy-2-hydroxy-3,6-dimethylbenzoate ( 1 ), was obtained from the fungus Nigrospora sphaerica ZMT05 isolated from Oxya chinensis Thunberg. Its structure was elucidated by comprehensive spectroscopic analyses. This compound showed high antifungal activity against Penicillium italicum and moderate activity against Fusarium oxysporum, Colletotrichum musae, and Fusarium graminearum.
研究领域:
微生物学
·
天然产物化学
·
植物病理学
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DOI
高影响因子
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
·
2015
·
IF 3.615
Dongsheng Zhou,Bo Li,Zhaoxia Ma,Xiaodong Huang,Xiaobin Zhang,Hangsheng Yang
A synergy between FeO X and CuO X was confirmed in FeCuO X /TiO 2 -hBN composites for selective catalytic reduction of NO with NH 3 . Accordingly, the reducibility of composites was modified to promote the NO to NO 2 oxidation but suppress the NH 3 to NO over oxidation, which is of benefit to the NO reduction. Also the optimal operation temperature could be controlled by tuning the Fe:Cu atomic ratio, and Fe 10 Ti 85 BN 5 , Fe 7.5 Cu 2.5 Ti 85 BN 5 and Fe 2.5 Cu 7.5 Ti 85 BN 5 achieved the best NO removal above 90% at 375 °C, 300 °C and 250 °C, respectively. From the NO 2 and NH 3 adsorption behaviors over FeCuO X /TiO 2 -hBN, the reaction followed Langmuir–Hinshelwood mechanism below 275 °C, but followed Eley–Rideal mechanism above 350 °C. The influence of SO 2 on NO removal was found to be temperature dependent, at temperature below 325 °C, slight deactivation was observed, while a promotion was achieved above 350 °C.
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DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 77
·49091-49096
·
IF 3.108
Lina Xue,Ka Xiong,Haijun Chen,Kyeongjae Cho,Weichao Wang
Hydrothermal aging tests are important to carry out when evaluating the hydrothermal durability of heterogeneous catalysts in vehicle exhaust emission. Here, we explored the effect of aging on an efficient Mn-based mullite catalyst (SmMn2O5) of NO oxidation. The mullite catalyst was prepared via the hydrothermal method and was subsequently aged in air with a 10% H2O stream at 750 °C for 16 hours. The fresh and aged catalysts were structurally characterized using Powder X-ray diffraction(XRD), Raman, X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM), high resolution-transmission electron microscope (HR-TEM), Brunauer–Emmett–Teller (BET) and temperature programmed desorption (TPD). For the performance evaluations, the samples were placed into a U-shape reactor furnace, and NO and NO2 concentrations were in situ recorded with an NOx analyzer. In contrast to fresh mullite, the aged sample showed a 25 °C higher light-off temperature and 11% conversion loss at its maximum conversion temperature of 300 °C. O2-TPD of the aged sample displayed a large decrease of the desorption area, consistent with an ∼3-fold loss of the BET specific surface area. Moreover, HRTEM, XPS and Raman spectroscopy results together indicated that a small portion of the mullite decomposed into perovskite SmMnO3 and Mn2O3, which further reduced the total quantity of Mn active sites. The reduction of the BET surface area and mullite decomposition together caused the decrease of the catalytic performance. We therefore expect maintaining the specific surface area to be important for preventing the loss of catalytic performance during the hydrothermal aging process.
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高影响因子
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