COLLOIDS AND SURFACES B-BIOINTERFACES
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2023
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IF 5.8
Shu Wu,Jinjing Shi,Xia Chen,Lu Bai,Qiuhua Wu,Guolin Zhang
Novel multi-responsive drug delivery vehicles (CDs/ [email protected] ) were prepared by grafting amino-terminated poly (N-vinyl caprolactam) (PNVCL-NH 2 ) and amino-rich carbon dots (CDs) on the surface of aldehyde-functionalized HMSNs (HMSNs-CHO) via Schiff base reaction. The CDs were prepared from L -arginine and their surfaces were rich in guanidine . Doxorubicin (DOX) was loaded into the nanoparticles to form drug loaded vehicles (CDs/ [email protected] ) and the drug loading efficiency was 58.38%. The drug release behaviors of CDs/ [email protected] showed temperature and pH responsiveness due to the poly (N-vinyl caprolactam) (PNVCL) and Schiff base bond. The high concentration of NO released in high concentration H 2 O 2 of tumor site could induce tumor cells apoptosis. The multi-responsive CDs/ [email protected] are intriguing drug carriers, which combine drug delivery and NO release in one.
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PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
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2023
·
IF 11.4
Ting Xue,Lvcun Chen,Kanglu Li,Ben Lei,Hong Wang,Fan Dong,Yan Yang
The coexistence of NO and CH3CHO in the air is considered to produce secondary peroxyacetyl nitrate (PAN) under sunlight irradiation, threatening the ecological environment and public health. Herein, we provide a simple strategy for the photocatalytic removal of NO and acetaldehyde (CH3CHO) on Sr2Sb2O7. In comparison with the single removal, the nearly complete removal of NO is reached by deep oxidation to NO3– with the assistance of CH3CHO. The underlying mechanism is revealed by GC–MS, in situ DRIFTS, and density functional theory calculations. The intermediates •CH3 from CH3CHO and NO2– from NO tend to bond and further oxidize to CH3ONO2, thus promoting NO removal. CH3NO2 and CH3ONO2 are the key products instead of PAN on Sr2Sb2O7 from the synergistic degradation of NO and CH3CHO. This work brings new insights into reaction pathway regulation for promoting performance and suppressing byproducts during synergistic air pollutant removal.
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JOURNAL OF CONTROLLED RELEASE
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2022
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IF 11.467
Baizhu Chen,Xiaoge Zhang,Lili Cheng,Xiaomei Chen,Junjie Tang,Peng Zhang,Chen Wang,Jie Liu
The use of bacteria as living vehicles has attracted increasing attentions in tumor therapy field. The combination of functional materials with bacteria dramatically facilitates the antitumor effect. Here, we presented a rationally designed living system formed by programmed Escherichia Coli MG1655 cells (Ec) and black phosphorus (BP) nanoparticles (NPs). The bacteria were genetically engineered to express tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), via an outer membrane YiaT protein (Ec-T). The Ec-T cells were associated with BP NPs on their surface to acquire [email protected] The designed living system could transfer the photoelectrons produced by BP NPs after laser irradiation and triggered the reductive metabolism of nitrate to nitric oxide for the in situ release at tumor sites, facilitating the therapeutic efficacy and the polarization of tumor associated macrophages to M1 phenotype. Meanwhile, the generation of reactive oxygen species induced the immunogenic cell death to further improve the antitumor efficacy. Additionally, the living system enhanced the immunological effect by promoting the apoptosis of tumor cells, activating the effect of T lymphocytes and releasing the pro-inflammatory cytokines. The integration of BP NPs, MG1655 cells and TRAIL led to an effective tumor therapy. Our work established an approach for the multifunctional antitumor living therapy.
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高影响因子
Processes
·
2022
·Vol. 10
·期 12
·2562
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IF 3.352
Yuxi Gao,Baofang Jin,Xiaodong Wu,Zhenguo Li,Rui Ran,Duan Weng
Two Mn0.15Ce0.85O2−δmixed oxides were synthesized by a co-precipitation method using Mn(NO3)2and KMnO4as the manganese precursors, respectively. Structural analyses by X-ray powder diffraction and Raman spectroscopy reveal the formation of MnOx-CeO2solid solutions. The Mn0.15Ce0.85O2−δcatalyst prepared from the high-valent manganese precursor exhibits higher activity for the catalytic oxidation of NO. The advantage of KMnO4is related to the improved redox property of the catalyst as supported by H2temperature-programmed reduction (TPR) and O2temperature-programmed desorption (TPD). The Mn-Ce interactions create more Mn4+, Ce3+and oxygen vacancies on the KMnO4-synthesized mixed oxides based on the Raman and X-ray photoelectron spectra (XPS).Keywords:solid solutions;precursor;oxidation state;lattice defects;NO oxidation
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Materials Today Bio
·
2022
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IF 10.761
Yi Feng,Hanxi Zhang,Xiaoxue Xie,Yu Chen,Geng Yang,Xiaodan Wei,Ningxi Li,Mengyue Li,Tingting Li,Xiang Qin,Shun Li,Fengming You,Chunhui Wu,Hong Yang,Yiyao Liu
Therapeutic approaches of combining conventional photodynamic therapy (PDT) with other adjuvant treatments to sensitize PDT represent an appealing strategy. Herein, a novel synergetic “nanobomb” strategy based on glutathione (GSH)-responsive biodegradation was proposed to effectively destroy tumors expeditiously and accurately. This “nanobomb” was rationally constructed via the simultaneous encapsulation of methylene blue (MB) and l -arginine (L-Arg) into polyethylene glycol (PEG) modified mesoporous organosilicon nanoparticles (MON). The resulting L-Arg/ [email protected] initially exhibited prolonged blood circulation, improved bioavailability, and enhanced tumor accumulation in mice after tail vein injection according to the pharmacokinetic investigations, before the nanoparticles were entirely excreted. Under laser irradiation, L-Arg/ [email protected] produced remarkable reactive oxygen species (ROS) directly for PDT therapy, while a portion of ROS may oxidize L-Arg to generate nitric oxide (NO) not only for gas therapy (GT) but also serve as a biological messenger to regulate vasodilation to alleviate the tumor hypoxia. Subsequently, the rapidly released NO was further oxidized to reactive nitrogen species, which together with ROS promote immunogenic cell death by inducing G2/M cell-cycle arrest and apoptosis in cancer cells, and eventually resulting in enhanced anti-tumor immune responses. Moreover, the GSH depletion in tumor tissues induced by L-Arg/ [email protected] biodegradation can cooperate with GT to amplify the therapeutic effect of PDT. These results demonstrate that this “nanobomb” provides new ideas for clinical translation to treat tumor patients in terms of synergistic PDT-GT nanotherapy in hypoxic-solid tumors.
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Materials Chemistry Frontiers
·
2022
·Vol. 6
·期 10
·1269-1281
·
IF 8.683
Xiaohui Wang,Xiaoyue Feng,Mengjie Sun,Mingzhu Wang,Wei Wang,Zhi Yuan
Poor perfusion and low accumulation of drugs caused by abnormal tumor blood vessels significantly reduce the chemotherapy efficacy. Nowadays, the synergistic therapy of vascular normalization and chemotherapy has become an ideal choice to increase the tumor inhibition rate. Delivering an appropriate amount of NO around tumor vessels proved to be an effective vascular normalization strategy. In order to meet the demand for continuous and stable production of NO at the tumor site, herein, we developed a strategy to normalize tumor blood vessels by catalyzing NO generation from endogenous NO donors (RSNO). Concretely, the surface of copper-doped mesoporous silica was modified with PAA by electrostatic interactions to form CuMSN-PAA nanoparticles. The system was simple in structure and could catalyze NO production by exposing the CuMSN surface in response to a slightly acidic environment. In vivo, the NO level in the tumor increased 5.8-fold after CuMSN-PAA treatment, and blood perfusion increased by 70%, which in turn induced vascular normalization. Consequently, DOX accumulation of the CuMSN-PAA group increased 2.4-fold compared with the control group. More importantly, after the synergistic treatment of vascular normalization and chemotherapy, the anti-tumor efficacy was increased by 37.2% compared with the DOX-treated group with no overt toxicity observed.
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Molecular Catalysis
·
2021
·
IF 5.062
Yu Guan,Yinhe Liu,Qiang Lv,Bo Wang
The selective catalytic reduction of nitrogen oxides (NO x ) by carbon monoxide (CO-SCR) is a promising way to deal with exhaust gasses. And Effective redox cycle and NO dissociation ability are crucial factors for catalytic reduction of NO x . Herein, Fe decorated CeO 2 microsphere catalysts with surface oxygen defect were synthesized by solvothermal and calcination method. Among all catalysts, 0.5Fe-CeO 2 sample showed excellent catalytic performance with efficiency near 96% for NO reduction under the condition of 550 ppmv NO, 1200 ppmv CO, and 40,000 h − 1 of GHSV. It was found that Fe doping could efficiently regulate Ce 4+ /Ce 3+ redox couple and oxygen vacancy for catalytic activity. XRD, Raman, XPS, EPR and H 2 -TPR etc. were employed to explore the physicochemical properties of samples. The results showed that Fe had been incorporated into CeO 2 by XRD, and the results of Raman spectrum and XPS indicated that Ce 4+ /Ce 3+ redox couple existed in 0.5Fe-CeO 2 catalyst. Furthermore, the H 2 -TPR spectrum displayed the formation of oxygen vacancy in the samples. N 2 adsorption-desorption isotherms indicated that the doping of Fe could enlarge the specific surface area, pore volume and pore dimeter of the samples, and thus greatly enhanced the NO adsorption and further NO catalytic reduction on catalysts. In addition, other characterization of physicochemical properties and density functional theory (DFT) calculation were performed to reveal the mechanism of NO + CO reaction. As a result, a mechanism was proposed to elucidate highly efficient NO reduction over the catalysts of Fe decorated CeO 2 microspheres. Finally, the synergistic effects of redox center and oxygen vacancy on catalytic activity enhancement were revealed. This work provides a promising way to the design of efficient catalysts for NO reduction.
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CHEMICAL ENGINEERING RESEARCH & DESIGN
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2021
·
IF 3.739
Han Wang,Shulan Wang,Jingqiao Zhang,Han Wang,Hui Li,Yi Zhao
Several mesostructured cellular foams (MCFs) were prepared and modified for NO adsorption. TMB, NH 4 F and n -heptane were used as swelling agents, and APTES was used as the modified agent. The morphological structure, chemical composition, thermostability were tested to study the effects of the preparation process on the characterizations of materials. NO adsorption ability of the materials were studied and discussed. NH 4 F and n -heptane had better pore swelling effects compared to TMB, however adding TMB together with NH 4 F and n -heptane could not enlarge the pore structure further. The MCFs materials could keep steady below 800 °C, but after grafting APTES on the surface of the materials, the thermogravimetric curve of materials began to decrease at 300 °C. The materials using NH 4 F and n -heptane as the swelling agents, and modified by APTES had better NO adsorption ability, and the selectivity of the materials were decided by the molecular polarity of the adsorbates. After the modification, the hydrophobic effect of the samples could increase because of the alkyl groups in APTES. The adsorption capacity of the materials could keep steady for ten times without the coexisting component, H 2 O, CO 2 and SO 2 all had negative effects on the regeneration of the materials.
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Journal of Environmental Sciences
·
2020
·
IF 4.302
Runping Wu,Qing Ye,Kai Wu,Hongxing Dai
To improve the removal capacity of NO + O 2 effectively, the alkaline earth metal-doped order mesoporous carbon (A-C-FDU-15(0.001) (A = Mg, Ca, Sr and Ba)) and Mg-C-FDU-15( x ) ( x = 0.001−0.003) samples were prepared, and their physicochemical and NO + O 2 adsorption properties were determined by means of various techniques. The results show that the sequence in (NO + O 2 ) adsorption performance was as follows: Mg-C-FDU-15(0.001) (93.2 mg/g) > Ca-C-FDU-15(0.001) (82.2 mg/g) > Sr-C-FDU-15(0.001) (76.1 mg/g) > Ba-C-FDU-15(0.001) (72.9 mg/g) > C-FDU-15 (67.1 mg/g). Among all of the A-C-FDU-15(0.001) samples, Mg-C-FDU-15(0.001) possessed the highest (NO + O 2 ) adsorption capacity (106.2 mg/g). The species of alkaline earth metals and basic sites were important factors determining the adsorption of NO + O 2 on the A-C-FDU-15( x ) samples, and (NO + O 2 ) adsorption on the samples was mainly chemical adsorption. Combined with the results of (NO + O 2 )-temperature-programmed desorption ((NO + O 2 )-TPD) and in situ diffused reflectance infrared Fourier transform spectroscopy (DRIFTS) characterization, we deduced that there were two main pathways of (NO + O 2 ) adsorption: one was first the conversion of NO and O 2 to NO 2 and then part of NO 2 was converted to NO 2 − and NO 3 − ; and the other was the direct oxidation of NO to NO 2 − and NO 3 − .
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Molecular Catalysis
·
2018
·
IF 0
Jun Huang,He Huang,Licheng Liu,Hongtao Jiang
MnO x based catalysts exhibit excellent low-temperature activity in the selective catalytic reduction (SCR) of NO x by NH 3 . The effect of Mn oxidation state (chemical valence) on the NH 3 -SCR activity is an interesting topic and important for designing an active catalyst. This study aimed to clarify the intrinsic effect of Mn valence in NO-SCR reaction. For this purpose, the pure MnO x (MnO, Mn 3 O 4 , Mn 2 O 3 , MnO 2 ) and physical mixed 30% MnO x /TiO 2 catalysts, as well as three Mn/TiO 2 catalysts prepared by impregnation, were investigated for the low temperature NO-SCR with NH 3 in the presence of excess O 2 . The catalysts were characterized by N 2 adsorption, X-ray diffraction (XRD), X-ray Absorption Fine Structure (XAFS), and temperature programmed reduction of H 2 (H 2 -TPR) to probe the physical and chemical properties of catalysts. The MnO x with different chemical valence exhibited distinct intrinsic activity. The Mn 3 O 4 and MnO/TiO 2 showed the highest intrinsic activity (TOR) for the unsupported and supported catalysts, respectively. The MnO x species with low chemical valence (MnO, Mn 3 O 4 ) exhibited overall high intrinsic SCR activity (larger than 0.012 NO h −1 nm −2 MnOx ). The MnO x with different valence normally changed to higher oxidation state after physically mixed with TiO 2 . The content of MnO x species with different valence depended on their loading and Mn precursor, showing a totally different constitution. This work provides new insights into the Mn valence effect on the intrinsic activity for low-temperature SCR.
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JOURNAL OF CATALYSIS
·
2018
·
IF 6.759
Houlin Wang,Shuting Luo,Meisheng Zhang,Wei Liu,Xiaodong Wu,Shuang Liu
Though the catalytic oxidation of CO, NO and soot over CeO 2 could be understood within a similar Mars-van Krevelen-type mechanism, these reactions were likely to be driven by different active phases. In this work, several CeO 2 and Ag/CeO 2 nanorods with different contents of surface oxygen vacancies (V O-s ) and active oxygen species (O x − ) were designed as model catalysts. Their catalytic performance indicated that, CO oxidation was determined by pre-existing ceria V O-s , while O x − participated in NO and soot oxidation directly. Besides, by loading silver onto the high-temperature aged CeO 2 nanorods, Ag/CeO 2 catalysts with high availability of ceria lattice oxygen were obtained, whose low-temperature oxidation activity was proven comparable to that of the platinum catalysts. In this sense, the model designing in this work not only provided methods to find out proper reactivity descriptors, but also conferred low-cost catalysts with high practical potential.
研究领域:
催化
·
材料科学
·
化学工程
·
环境化学
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高影响因子
BIOSENSORS & BIOELECTRONICS
·
2013
·
IF 5.437
Li Wang,Peiyu Hu,Xiaocui Deng,Fang Wang,Zilin Chen
As a transcellular messenger molecule, nitric oxide (NO) is involved in many physiological and pathological processes. The accurate quantitative detection of NO in vivo is particularly important. In this work, a novel electrochemical NO sensor was fabricated via electro-polymerization of ethylenediamine (EDA) on multi-walled carbon nanotubes (MWNTs) film. The sensor combined the porous structure and good conductivity of MWNTs with the good electro-catalytic ability of p-EDA film. For the detection of NO, it has a linear range from 95 nM to 11 μM and the limit of detection reaches 95 nM with excellent reproducibility. So it was successfully applied to monitor NO release from rat liver sample for investigating the inhibition or promotion effect of drugs including oleanolic acid (OA), baicalin and Nω-nitro- l -arginine methyl ester ( l -NAME) on nitric oxide synthase (NOS). The results showed that OA could promote NO release and the amount of NO increases about 1.9 times, but baicalin and l -NAME could inhibit the release of NO and the amount of NO decreased by two-thirds and 37.5%, respectively.
研究领域:
生物医学工程
·
分析化学
·
药理学
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