Advanced Composites and Hybrid Materials
·
2022
·Vol. 5
·期 2
·991-1002
·
IF 11.806
Xu Pei,Huang Bincheng,Tang Ruobing,Wang Zhenfeng,Tu Jiaying,Ding Yunsheng
The functionalization and distribution of conductive fillers and the interfacial compatibilization of polymer blends is the basic scientific problem of electromagnetic interference (EMI) shielding composites. Polylactic acid/polycaprolactone (PLA/PCL)-based nanocomposites containing polymerizable ionic liquid copolymer of poly(methoxy poly(ethylene glycol) monomethacrylate-co-1-vinyl-3-ethylimidazolium bromide) (PILs) and multi-walled carbon nanotubes (CNTs) were fabricated by the melt blending. The high affinity of MEPGMA segments of PILs for both phases and the interaction between the imidazole group of PILs and CNTs improved the dispersion and compatibility of CNTs in the matrix. PILs could expand to the interfacial layers as compatibilizers because of the high affinity of MEPGMA groups for polymer phases. The migration of CNTs from PLA to PCL phase was realized by the kinetic control and PIL-modified CNTs were selectively distributed at the co-continuous PLA/PCL interface and PCL phase of the PLA/PCL/4PIL/8CNT-6 m composite with blending time of 6 min. The selective localization of CNTs at interphase significantly can form effective conductive networks at the interface for PLA/PCL/4PIL/8CNT-6 m composite, which increase the electrical conductivity of the composite. The EMI shielding efficiency of the PLA/PCL/4PIL/8CNT-6 m composites, which can reflect and absorb microwaves with multiple times, reaches up to the maximum value 41 dB. Graphical abstract
The selective localization of CNTs at interphase forms effective conductive network. EMI SE of the PLA/PCL/4PIL/8CNT-6 m composite displays 41 dB.
研究领域:
材料科学
·
复合材料
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DOI
高影响因子
ACS Applied Polymer Materials
·
2023
·
IF 5
Jianing Lv,Anying Wang,Yinwen Li,Shoufang Xu,Xingjian Li
Beyond self-repairability and reprocessability, permanent shape reconfigurability in thermadapt shape memory polymers (TSMPs) is a prominent functionality in dynamic covalent polymer networks. The design and synthesis of TSMPs with a wide range of tunable macroscopic properties that do not require sophisticated chemistry or modification are highly desirable for real-world device applications but are a significant challenge. Herein, we present a straightforward yet efficient strategy to prepare TSMPs with adjustable properties, good reconfigurability, and self-repairability via ester–ester exchange. The class of TSMPs is engineered as the architecture of AB copolymer networks (AB-CPNs), which are composed of the semicrystalline polycaprolactone (PCL) as the A-segment and the poly(butyl acrylate) (PBA) as the B-segment. Regulating the weight content of the PCL segment in the thermadapt shape memory PCL-co-PBA networks can govern the network rearrangement kinetics, thermal properties, thermomechanical properties, switching temperature, and shape memory properties. The thermadapt shape memory AB-CPNs with ester–ester exchange do not require the introduction of extra hydroxyl groups, and their network structure is readily adjusted, allowing for considerable flexibility in the structure design and property adjustment. It is anticipated that a large family of thermadapt shape memory AB-CPNs with widely tunable macroscopic properties and the commercial availability of precursors will contribute significantly to real-world applications of SMP devices.
研究领域:
材料科学
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高分子化学
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DOI
高影响因子
Food Packaging and Shelf Life
·
2024
·
IF 8.5
Yue Zou,Siyang Chen,Hanzheng Dou,Wenxiu Zhu,Dongyun Zhao,Ying Wang,Haisong Wang,Xiaodong Xia
In this study, a colorimetric nanofibrous film was developed using polycaprolactone (PCL) and alizarin through electrospinning, and the film was subsequently employed for tracking shrimp freshness. Scanning electron microscopy (SEM) showed that the film was composed of beaded, continuous and smooth nanofibers. In the pH range of 4–13, the nanofibrous films displayed discernible color changes from yellow green to bluish-purple. Furthermore, when used together with shrimps, the films underwent a color change from yellow to purple, demonstrating a robust association with TVB-N and the pH value. Thus, the alizarin-based colorimetric nanofibrous films developed here could be potentially used as an indicator for tracking the freshness of shrimps.
研究领域:
食品科学
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材料科学
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高影响因子
Materials Today Communications
·
2023
·
IF 3.8
Yan Lin,Yanjing Ou,Minrui Xu,Jiang Chen
Surface modification can enhance the biological properties of polycaprolactone (PCL) scaffolds. In this study, bionic hydrolysis and biomimetic polydopamine (PDA) coating were investigated, individually and in combination, to enhance the bioactivity of inner cube 3D-printed PCL scaffolds. The modified scaffolds were evaluated for their bioactivity, and the underlying mechanism was studied based on their physiochemical properties. The modifications significantly improved the surface roughness , hydrophilicity, surface adhesion ability, and biological properties of the scaffolds. The hydrolyzed PCL scaffolds exhibited micro-cracks and pits on their surface, with carboxyl and hydroxyl groups present. PDA, in the form of micro-particles with phenolic hydroxyl and amino groups, was coated onto the PDA-coated scaffolds. The combination-treated scaffolds had shallower pits, smaller particles, and lower levels of phenolic hydroxyl and amino groups. PDA coating demonstrated the best properties in promoting the adhesion, proliferation, and osteogenesis of rat bone marrow mesenchymal stem cells. Although the combination-treated scaffolds showed better cell proliferation than the hydrolyzed scaffolds, they did not exhibit a synergistic effect on osteogenic induction, instead weakening the osteogenic induction ability of the PDA-coating and hydrolysis treatments. Therefore, the material’s characteristics and the substantial variation of different chemical reactions must be considered during biological material modification.
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高影响因子
Materials
·
2026
·Vol. 19
·期 9
·1740
·
IF 3.7
Bo Yang,Runhua Wang,Guang Yang,Zejia Zhang,Xiaohong Chen
Polycaprolactone (PCL) is widely utilized in bone tissue engineering due to its excellent biocompatibility and processability; however, its inherent bioinertness and hydrophobicity significantly restrict its clinical osteogenic efficacy. To overcome these limitations, we incorporated sol–gel synthesized silicate-based bioactive glass (BG) into a PCL matrix and fabricated a series of composite scaffolds with varying BG contents via direct ink writing (DIW) 3D printing. Rheological characterization confirmed that all ink formulations exhibited shear-thinning behavior, with viscosity increasing monotonically with BG content. DSC analysis revealed that BG incorporation progressively reduced the crystallinity of PCL from 51.47% to 36.23%. We systematically evaluated the physicochemical properties, mechanical resilience, and in vitro degradation behavior of these scaffolds. The results indicated that BG incorporation significantly improved the surface hydrophilicity, with the contact angle decreasing from 104.8 ± 2.81° to 69.8 ± 2.91°. Furthermore, as the BG content increased, the porosity and mechanical strength exhibited an initial increase followed by a subsequent decrease, yet all values remained within the range of human cancellous bone. Notably, cellular assays revealed that the introduction of 58SBG enhanced cell–matrix interactions; the PCL/BG scaffolds promoted superior cell attachment and more extensive morphological spreading compared to pure PCL. Among all groups, the PCL/30BG composite scaffold demonstrated the most optimal balance of mechanical integrity and biological response. Consequently, the PCL/30BG scaffold developed in this study exhibits immense potential as a bone graft substitute, providing a promising approach for clinical bone defect repair strategies.
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PubMed
高影响因子
Alexandria Engineering Journal
·
2025
·
IF 6.8
Yingming Mu,Haiya Zhang,Tao Ya,Liang Duan
Electrospun nanofiber membranes incorporating ZnO and Ag nanoparticles were developed using a coaxial electrospinning technique to address microbial contamination in urban water bodies. Polycaprolactone (PCL) served as the polymer matrix, and five formulations (S0–S4) with increasing nanoparticle concentrations were synthesized. Morphological analyses revealed uniform fiber formation with optimal distribution of ZnO and Ag at moderate loadings. S3 (3 wt% ZnO, 0.3 wt% AgNO₃) exhibited a mean fiber diameter of 487 nm, pore size of 2.0 µm, and porosity of 82.8 %. ATR-FTIR and XRD analyses confirmed the presence and dispersion of the incorporated nanoparticles without altering PCL’s structural integrity. Wettability improved significantly, with water contact angle decreasing from 114.3° (S0) to 93.4° (S4). Mechanical testing showed that S3 retained tensile strength (4.3 MPa) and ductility (180 % elongation). Antibacterial assays demonstrated a peak inhibition zone of 11.2 mm against Staphylococcus aureus and 10.4 mm against Escherichia coli . Filtration trials using simulated urban wastewater revealed that S3 achieved a log reduction value of 4.4 (corresponding to 99.996 % bacterial removal), reduced turbidity by 91.8 %, and lowered conductivity by 12.3 %. Despite reduced flux with increasing nanoparticle content, S3 maintained a satisfactory water flux of 112.6 L/m 2 ·h. These multifunctional membranes offer a promising route for enhancing microbial safety and improving physical water quality without the drawbacks of traditional disinfection. This study provides insights into nanoparticle–polymer interactions and offers design guidelines for practical, high-performance water purification systems in urban environments.
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高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2025
·
IF 4.7
Junqin Mao,Yutong Zhang,Tao Shen,Qiuyu Zeng,Wanli Zhang,Xinyu Zhang,Qiang Liu,Heng Zheng,Guoyu Lv
As gastric ulcers remain a significant clinical challenge, this study presents the development of a flexible microneedle system based on cerium/zinc-doped bioactive glass (CeZnBG) and a PCL/PLA matrix for targeted ulcer therapy. The design leverages the synergistic antioxidant and antibacterial properties of CeZnBG, combined with the localized drug delivery capability of microneedles, to enhance ulcer healing. CeZnBG was synthesized via high-temperature sintering at various temperatures (950 °C, 1050 °C, 1150 °C, and 1250 °C), and subsequently incorporated into PCL/PLA microneedles (PCMN) at doping concentrations of 0.5 %, 1.5 %, and 2.5 % to form composite materials. The structural and physicochemical characteristics of the CeZnBG-PCMN, were investigated using X-ray diffraction (XRD), scanning electron microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDS), mechanical properties, differential scanning calorimetry (DSC), and X-ray photoelectron spectroscopy (XPS). In vitro assays, including ROS scavenging and cytocompatibility, were used to assess the bioactivity of the composites. The results demonstrated that PCMN containing 1.5 % CeZnBG maintained excellent cytocompatibility (with relative cell viability exceeding 80 %) while exhibiting notable antibacterial performance, indicating promising potential for targeted gastric ulcer repair.
研究领域:
生物医学工程
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药剂学
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组织工程
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纳米医学
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消化病学
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材料科学
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转化医学
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DOI
高影响因子
PLoS One
·
2026
·Vol. 21
·期 1
·e0337192
·
IF 2.6
Yonghao Xiao,Han Wang,Yuhao Jiao,Yuehao Xing,Lin Ye,Ai-ying Zhang,Xue Geng,Fanshan Qiu,Zengguo Feng,Hongbo Chen,Yongquan Gu
Cardiovascular disease has become the leading cause of death. It is the common goal for researchers worldwide to develop small-diameter vascular grafts (SDVGs) which could meet clinical needs. In this study, PLGA@PCL core-shell structural fibrous SDVGs was fabricated by coaxial electrospinning process, and then the surface heparinization of the vascular material was carried out after H2N-PEG-NH2 fixed on sodium hydroxide-treated electro-spun PCL tubes. Finally, the long-term patency and tissue regeneration of the grafts were evaluated in vivo through the rabbit carotid artery replacement model. The results indicate that the heparin-modified PLGA@PCL core-shell structural fibrous SDVGs achieved long-term patency and the arrangement of collagen and elastin in the neointima was similar to the native vessel in the rabbits after 9 months. After 3 months postoperatively, endothelialization was almost complete, and vascular calcification was also observed. It can be concluded that surface heparinization is a feasible modification method for in situ tissue-engineered vascular grafts, and controlling the occurrence of vascular calcification is another important issue to be solved in the development of SDVGs, and it is also the focus of our next research work.
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高影响因子
COLLOID AND POLYMER SCIENCE
·
2019
·Vol. 298
·期 1
·103-111
·
IF 1.906
Lv Haitao,Tang Dongyan,Sun Zhaojie,Gao Jingru,Yang Xu,Jia Shuyue,Peng Jing
Shape memory polymers (SMP) with better biodegradability and better stability have great potential applications in biomedical fields, such as the drug carriers or the tissue engineering scaffolds. In this study, poly(ε-caprolactone)(PCL)-based polyurethane(PU) microfibers were fabricated with the containing of hydroxyapatite(HA) to enhance the biodegradability and to exhibit excellent shape memory performance. The composition, the morphology, the thermal stability, and the mechanical properties of the microfibers were characterized and detected using Fourier transform infrared spectroscopy (FTIR), 1 H nuclear magnetic resonance ( 1 HNMR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC). and dynamic mechanical analysis (DMA), etc. And dexamethasone was selected as drug model to investigate the delivery and release behaviors of the carrier of the microfibers. It was revealed that HA enhanced the degradation rate of the shape memory polyurethane (SMPU) fibers, and the fibers could guarantee a sustained long time drug release. The detection on the shape memory performance found that, with the different addition amounts of HA, the composite microfibers of (SMPU) and HA exhibited the different shape memory transition temperature ( T trans ) values. And with the addition of 3 wt% of HA, the excellent shape recovery ratios of R r (> 97%) and the shortest recovery time of ~ 6 s could be obtained. With further increase of the amounts of HA, the recovery force and the recovery time were reduced and prolonged, respectively. The obtained results proved that the biodegradable SMPU/HA composite microfibers have more valuable application prospects in biomedical fields.
研究领域:
生物材料
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药物递送
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组织工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Si-Yuan Zhou,Lei Li,Enzehua Xie,Mei-Xi Li,Jian-Hua Cao,Xiu-Bin Yang,Da-Yong Wu
The occurrence of acute thrombosis, directly related to platelet aggregation and coagulant system, is a considerable reason for the failure of small-diameter vascular grafts. Heparin is commonly used as a functional molecule for graft modification due to the strong anticoagulant effect. Unfortunately, heparin cannot directly resist the adhesion and aggregation of platelets. Therefore, we have prepared a heparin-aspirin compound by coupling heparin with aspirin, an antiplatelet drug, and covalently grafted it onto the surface of polycaprolactone/polyurethane composite tube. In this way, the graft not only showed a dual function of both anticoagulation and antiplatelet, but also effectively avoided the rapid drug release and excessive toxicity to other organs caused by simple blending the medicine with material matrix. The compound retained the original function of heparin, showing good hydrophilicity and biocompatibility, which could promote the adhesion and proliferation of endothelial cells (ECs) and facilitate the process of tissue regeneration . What's more, the compound showed more effective than heparin in reducing platelet activation and preventing thrombosis. The graft modified by this compound maintained completely unobstructed for one month of implantation, while severe obstruction or stenosis occurred in PCL/PU and PCL/PU-Hep lumen at the first week, verifying the effect of the compound on preventing acute thrombosis. In general, this study proposed a designing method for small-diameter vascular graft which could prevent acute thrombosis and promote intimal construction.
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高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 8
·7649
·
IF 5.6
Yanjing Liu,Xiyue Li,Yuezhou Liu,Yaping Huang,Fuming Wang,Yongfang Qian,Ying Wang
Due to their high porosity, large specific surface area, and structural similarity with the extracellular matrix (ECM), electrospun nanofiber membranes are often endowed with the antibacterial properties for biomedical applications. The purpose of this study was to synthesize nano-structured Sc2O3-MgO by doping Sc3+, calcining at 600 °C, and then loading it onto the PCL/PVP substrates with electrospinning technology with the aim of developing new efficient antibacterial nanofiber membranes for tissue engineering. A scanning electron microscope (SEM) and energy dispersive X-ray spectrometer (EDS) were used to study the morphology of all formulations and analyze the types and contents of the elements, and an X-ray diffraction (XRD), thermogravimetric analysis (TGA), and Fourier transform attenuated total reflection infrared spectroscopy (ATR-FTIR) were used for further analysis. The experimental results showed that the PCL/PVP (SMCV-2.0) nanofibers loaded with 2.0 wt% Sc2O3-MgO were smooth and homogeneous with an average diameter of 252.6 nm; the antibacterial test indicated that a low load concentration of 2.0 wt% Sc2O3-MgO in PCL/PVP (SMCV-2.0) showed a 100% antibacterial rate againstEscherichia coli(E. coli).Keywords:nano-textured;Sc2O3-MgO;antibacterial;electrospinning
研究领域:
生物医学工程
·
材料科学
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PubMed
高影响因子
Advanced Healthcare Materials
·
2020
·Vol. 10
·期 3
·2000604
·
IF 7.367
Jin Zhang,Xi Zhang,Chenyu Wang,Feihan Li,Ziwen Qiao,Liangdan Zeng,Zhonghan Wang,He Liu,Jianxun Ding,Huanghao Yang
Conductivity and alignment of scaffolds are two primary factors influencing the efficacy of nerve repair. Herein, conductive composite fibers composed of poly(ɛ-caprolactone) (PCL) and carbon nanotubes (CNTs) with different orientation degrees are prepared by electrospinning at various rotational speeds (0, 500, 1000, and 2000 rpm), and meanwhile the synergistic promotion mechanism of aligned topography and electrical stimulation on neural regeneration is fully demonstrated. Under an optimized rotational speed of 1000 rpm, the electrospun PCL fiber exhibits orientated structure at macroscopic (mean deviation angle = 2.78°) or microscopic crystal scale (orientation degree = 0.73), decreased contact angle of 99.2° ± 4.9°, and sufficient tensile strength in both perpendicular and parallel directions to fiber axis (1.13 ± 0.15 and 5.06 ± 0.98 MPa). CNTs are introduced into the aligned fiber for further improving conductivity (15.69–178.63 S m −1 ), which is beneficial to the oriented growth of neural cells in vitro as well as the regeneration of injured sciatic nerves in vivo. On the basis of robust cell induction behavior, optimum sciatic nerve function index, and enhanced remyelination/axonal regeneration, such conductive PCL/CNTs composite fiber with optimized fiber alignment may serve as instructive candidates for promoting the scaffold- and cell-based strategies for neural repair.
研究领域:
材料科学
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神经科学
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组织工程
·
生物医学工程
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PubMed
高影响因子
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