DRUG DELIVERY
·
2016
·
IF 4.843
Zichao Luo,Ling Jin,Lu Xu,Zhao Liang Zhang,Jing Yu,Shuai Shi,Xingyi Li,Hao Chen
Development of efficient ocular drug delivery systems was still a challenging task. The objective of this article was to develop a thermosensitive PEG–PCL–PEG (PECE) hydrogel and investigate its potential application for ocular drug delivery of diclofenac sodium (DIC). PECE block polymers were synthesized by coupling MPEG-PCL co-polymer using IPDI reagent, and then its sol–gel transition as a function with temperature was investigated by a rheometer. The results showed that 30% (w/v) PECE aqueous solution exhibited sol–gel transition at approximately 35 °C. In vitro release profiles showed the entrapped DIC was sustained release from PECE hydrogels up to 7 days and the initial drug loading greatly effect on release behavior of DIC from PECE hydrogels. MTT assay results indicated that no matter PECE or 0.1% (w/v) DIC-loaded PECE hydrogels were nontoxic to HCEC and L929 cells after 24 h culturing. In vivo eye irritation test showed that the instillation of either 30% (w/v) PECE hydrogels or 0.1% (w/v) DIC-loaded PECE hydrogels to rabbit eye did not result in eye irritation within 72 h. In vivo results showed that the AUC0–48 h of 0.1% (w/v) DIC-loaded PECE hydrogels exhibited 1.6-fold increment as compared with that of commercial 0.1% (w/v) DIC eye drops, suggesting the better ophthalmic bioavailability could be obtained by the instillation of 0.1% (w/v) DIC-loaded PECE hydrogels.
研究领域:
药剂学
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生物医学工程
·
眼科研究
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DOI
PubMed
高影响因子
AAPS PHARMSCITECH
·
2022
·Vol. 23
·期 6
·1-11
·
IF 4.026
Meng Tingting,Li Yinghong,Tian Ying,Ma Mingxing,Shi Kequan,Shang Xuwei,Yuan Hong,Hu Fuqiang
Hypoxia is an important pathological phenomenon, and it can induce many tumor microenvironment changes, such as accumulations of intracellular lactic acid, decrease of tumor microenvironment pH value, and regulate a series of physiological and pathological processes such as adhesion, metastasis, and immune escape. Hypoxic tumor cells act as a key target for treating tumor. In this research, we designed and prepared PEG-nitroimidazole grafts, PEG-NI, and FA-PEG-NI. We first explored their physical and chemical properties to serve as a drug carrier. Then, the hypoxia-sensitive properties such as particle size changes and drug release were investigated. Finally, the tumor targeting ability was studied in vitro and in vivo , and anti-tumor capacity was determined. Both grafts showed excellent property as a nanodrug carrier and showed favorable drug encapsulation ability of sorafenib with the help of the hydrophobic chain of 6-(BOC-amino) hexyl bromide. The micelles responded to the hypoxic tumor environment with chemical and spatial structure changes leading to sensitive and fast drug release. With the modification of folic acid, FA-PEG-NI gained tumor targeting ability in vivo . FA-PEG-NI graft proved a potential targeting drug delivery system in the treatment of hypoxic hepatocellular carcinoma. Graphical Abstract
研究领域:
药理学
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肿瘤学
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分子生物学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
·
2025
·
IF 8
Dong Zhang,Meizhu Chen,Zongwu Chen,Pengxiang Li,Zhuhai Shao,Xingfei Liu,Pinpin Liu
Polyethylene glycol (PEG) demonstrates significant advantages in asphalt pavement thermal regulation owing to high latent heat and adjustable phase transition temperatures. However, its limitations, including liquid-phase leakage and low thermal conductivity, restrict practical applications. This study developed a functionalized expanded graphite (FEG) matrix via acid oxidation, where oxygen-containing groups establish hydrogen bonds with PEG, forming PEG/FEG CPCM with enhanced thermal conductivity and encapsulation stability. Structural characterization showed FEG interlayer spacing increased from 0.3379 nm to 0.3439 nm, with surface oxygen content rising from 2.66 % to 12.33 % (predominantly −OH/−COOH groups). Hydrogen bonds forming between FEG and PEG restrict molecular chain migration, thereby improving encapsulation stability. The optimized PEG/FEG CPCM exhibited latent heats of 141.60 J/g (melting) and 134.12 J/g (crystallization), a 24.9 % lower supercooling degree (11.39°C vs. 15.17°C), and 11.58-fold higher thermal conductivity (3.6257 W/(m·K) vs. 0.3132 W/(m·K)) compared to pure PEG. Hydrogen bonding increased the decomposition temperature of PEG/FEG CPCM by 10.7°C to 306.4°C, with only a 0.9 % reduction in phase transition temperature and a 1.0 % latent heat loss after 100 thermal cycles. Field tests showed that PEG/FEG-modified asphalt mixtures extended heating/cooling durations by 2.1 %/15.0 %, mitigating pavement thermal distress. The study advances the application of PEG-based CPCMs to enhance pavement durability, mitigate UHI effects, and conserve energy.
研究领域:
材料科学
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土木工程
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热工学
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化学工程
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产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2018
·
IF 5.08
Hongchun Li,Yongsheng Niu
A novel amphiphilic block polymer poly(ethylene glycol)-poly(propylene carbonate)-poly(ethylene glycol) (PEG-PPC-PEG) was synthesized via the dicyclohexylcarbodiimide condensation reaction of double PEG-bis-amine and HOOC-PPC-COOH. The obtained copolymer was characterized by NMR to determine its structure. Using the PEG-PPC-PEG as the carrier and using doxorubicin (DOX) as a model drug, DOX-loaded nanoparticles with core shell structure were synthesized by self-assembly in water. The nanoparticles properties such as particle size, drug loading, encapsulation efficiency (EE) and drug release behavior were investigated as a function of the hydrophobic block length of PPC segments and compared with each other. The results showed that the EE was up to 88.8%. Nanoparticles were found to have a certain effect on the controlled release of DOX.
研究领域:
药学
·
材料科学
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纳米技术
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2024
·
IF 5.5
Zhimin Luo,Yunan Yuan,Ling Li,Dayang Xie,Chong Liu,Tong Li,Zhaopei Guo,Kai Hao,Yanhui Li,Huayu Tian
Poly(amino acid)s (PAAs) are one kind of favorable biopolymer that can be used as a drug or gene carrier. However, conventional ring-opening polymerization of PAAs is slow and needs a strict anhydrous environment with an anhydrous reagent as well as the product without enough high molecular weight (Mn), which limits the expanding of PAAs’ application. Herein, we took BLG-NCA as the monomer to quickly synthesize one kind of high Mn amphiphilic copolymer, poly(ethylene glycol)-b-poly(γ-benzyl-l-glutamic acid) (PEG-PBLG), by relay polymerization with a simple one-pot method within 3 h in mild conditions (open air, moisture insensitive). In the polymerization process, ring-opening polymerization-induced self-assembly in sodium bicarbonate aqueous solution first occurred to obtain low Mn PEG-PBLG seeds without purification. Then γ-benzyl-l-glutamate N-carboxyanhydride (BLG-NCA) dichloromethane solution was added into PEG-PBLG seeds directly and stirred vigorously to form am emulsion; during this process, the amphiphilic PEG-PBLG seeds will anchor on the interface of DCM and water to ensure the concentration of α-helix rigid PBLG in DCM to maintain the following relay polymerization. Then, high Mn PEG-PBLG was obtained in mild conditions in one pot. We found that the α-helix rigid structure was essential for relay polymerization by studying the synthetic speed of amphiphilic copolymer with different secondary structures. MOE simulation results showed that PBLG and BLG-NCA tended to form a double hydrogen bond, which was beneficial to relay polymerization because of higher local concentrations that can produce more double hydrogen bonds. Our strategy can quickly obtain high Mn PEG-PBLG (224.9 KDa) within 3 h from PEG-NH2 and BLG-NCA in one pot and did not need an extra initiator. After deprotection, the poly(ethylene glycol)-b-poly(l-glutamate acid) (PEG-PGA) with high Mn as a second product can be used as an excellent antitumor drug carrier. The high Mn PEG-PGA can achieve an encapsulation rate of 86.7% and a drug loading rate of 47.3%, which is twice that of the low Mn PEG-PGA. As a result, the synthesis of PEG-PBLG by relay polymerization simplified the process of PEG-PAA polymerization and increased the Mn. In addition, this method opened a way to obtain other kinds of high Mn PEG-PBLG values in the future.
研究领域:
聚合物化学
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材料科学
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药学
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DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2019
·Vol. 7
·期 23
·14319-14327
·
IF 10.733
Xiaoqiao Fan,Lu Liu,Xin Jin,Wentao Wang,Shufen Zhang,Bingtao Tang
The latent heat storage of PCMs has gained increasing attention in the solar energy application field due to their high thermal energy storage density. However, the lack of energy conversion ability of the organic PCMs results in the low utilization efficiency of solar energy. Herein, we report a novel PEG/Ti3C2Tx layered composite PCM with superior photothermal storage capability, which consists of stacked Ti3C2Tx nanosheets and PEG filled within the spaces between the flakes. The resulting composites exhibited a strong absorption capacity for electromagnetic waves at the UV-Vis-NIR region. Notably, there are two enhanced absorption bands at the visible and near-infrared regions due to the localized surface plasmon resonance (LSPR) effect of the Ti3C2Tx nanosheets, which endows the composite PCM with excellent photo-to-thermal storage efficiencies (up to 94.5%) under actual solar light irradiation. In addition, the composite PCM also possesses a high energy storage density and form-stable property before and after the phase transition. These results indicate that the synthesized composite presents superior comprehensive properties suitable for solar energy storage applications.
研究领域:
材料科学
·
能源工程
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 20
·3372-3386
·
IF 4.776
Longbao Feng,Shina Yan,Qiyu Zhu,Jie Chen,Lian Deng,Yanfang Zheng,Wei Xue,Rui Guo
Drug/gene co-delivery carriers are a promising strategy for cancer treatment. Thus, herein, T7-conjugated redox-sensitive amphiphilic polyethylene glycol–polyethyleneimine–poly(caprolactone)-SS-poly(caprolactone)–polyethyleneimine–polyethylene glycol (PEG–PEI–PCL-SS-PCL–PEG) (PPPT) is designed to realize the co-delivery of pORF-hTRAIL and DOX efficiently into tumor cells. PPPT is synthesized via the ring opening polymerization (ROP) of ε-caprolactone followed by Michael addition polymerization and atom transfer radical polymerization (ATRP) of the maleic imide group of MAL-PEG-NHS. The PPPT micelles present a spherical or ellipsoidal geometry with a mean diameter of approximately 100–120 nm. Meanwhile, they also exhibit a redox-responsive drug release profile in vitro. The blood compatibility and complement activation tests reveal that the PPPT micelles do not induce blood hemolysis, blood clotting, or complement activation. The T7-modified co-delivery system shows a higher cellular uptake efficiency than the unmodified co-delivery system in human breast cancer MCF-7 cells and is accumulated in tumor more efficiently in vivo. These results suggest that the T7-targeted codelivery system of DOX and pORF-hTRAIL is a combined delivery platform that can significantly improve the treatment of breast cancer.
研究领域:
癌症治疗
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药剂学
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纳米技术
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
RENEWABLE ENERGY
·
2021
·
IF 8.001
Xiping Sun,Mengmeng Yi,Bing Feng,Ruowang Liu,Lijuan Sun,Lanlan Zhai,Hongwei Cao,Chao Zou
To synthesize PEG@TiO2 with excellent energy storage properties, polyethylene glycol (PEG) was in situ encapsulated for the first time into the pores of three-dimensional (3D) porous TiO2. PEG was surrounded by the hydrolysable precursor of TiO2 and wrapped in the pores of 3D nanoporous TiO2 skeleton after the hydrolysis and condensation of the precursor, which was utterly different from that PEG was passively absorbed into the pores through physical impregnation method adopted by the present references. The 3D TiO2 framework provided excellent shape stability and inhibited the outleakage of the melted PEG. The weight percentage of the encapsulated PEG was approximately 92 wt% of PEG@TiO2 composite. The phase transition enthalpies of the crystallization and melting processes of the composite were 147.1 J/g and 153.3 J/g, which approached those of the pure PEG. Besides, the thermal conductivity value of PEG@TiO2 was 0.39 W/(mK), about 26% enhancement compared with that of pure PEG. The enthalpies of crystallization and melting processes decreased only by 0.1% and 0.2% after 100 thermal cycles. This study revealed that PEG@TiO2 composite exhibited unique energy storage properties such as energy storage capability, thermal stability, thermal reliability and thermal conductivity.
研究领域:
材料科学
·
能源工程
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产品关联
DOI
高影响因子
POLYMER SCIENCE SERIES A
·
2016
·Vol. 58
·期 2
·196-205
·
IF 0.76
Luo Chunyan,Chen Weixing,Gao Ying
The crystallization behavior of poly(e-caprolactone)/poly(ethylene glycol) (PCL/PEG) blend was investigated by differential scanning calorimetry (DSC) and polarized microscopy (POM). Individual phase transition peaks in the DSC curves for both PEG and PCL in all the polymer blends with different PCL contents were observed. The crystallization and melting peak temperatures of PEG were at 41 and 65°C, respectively; while the crystallization and melting temperatures of PCL located at 28 and 56°C, respectively. In-situ POM results demonstrated that spherulites crystalline morphology was formed for both PCL and PEG homopolymers. In PEG/PCL blend, however, both the phase separation morphology and spherulitic morphology can be observed. In blends with 30 or 50 wt % PCL, the PCL component formed dispersed phase and crystallized at lower temperature. However, in blends with 70% PCL, the phase inversion behavior occurred. The continuous PCL phase crystallized at 35°C, while the PEG dispersed phase crystallized at a lower temperature. Fractional crystallization behavior of PEG and PCL was controlled by temperature. The spherulites growth rate of PEG was greatly influenced by temperature, instead of the content of PCL component in the PCL/PEG blends.
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
Acta Biomaterialia
·
2016
·
IF 6.008
Jianbing Wu,Zhaozhu Zheng,Gang Li,David L. Kaplan,Xiaoqin Wang
A one step, rapid method to prepare silk microspheres was developed, with particle size controlled by the addition of polyethylene glycol (PEG). PEG molecular weight (4.0 K–20.0 KDa) and concentration (20–50 wt%), as well as silk concentration (5–20 wt%), were key factors that determined particle sizes varying in a range of 1–100 μm. Addition of methanol to the PEG-silk combinations increased the content of crystalline β-sheet in the silk microspheres. To track the distribution and degradation of silk microspheres in vivo , 3-mercaptopropionic acid (MPA)-coated CdTe quantum dots (QDs) were physically entrapped in the silk microspheres. QDs tightly bound to the β-sheet domains of silk via hydrophobic interactions, with over 96% of the loaded QDs remaining in the silk microspheres after exhaustive extraction. The fluorescence of QDs-incorporated silk microspheres less stable in cell culture medium than in phosphate buffer solution (PBS) and water. After subcutaneous injection in mice, microspheres prepared from 20% silk (approx. 30 μm diameter particles) still fluoresced at 24 h, while those prepared from 8% silk (approx. 4 μm diameter particles) and free QDs were not detectable, reflecting the QDs quenching and particle size effect on microsphere clearance in vivo . The larger microspheres were more resistant to cell internalization and degradation. Since PEG is an FDA-approved polymer, and silk is FDA approved for some medical devices , the methods developed in the present study will be useful in a variety of biomedical applications where simple, rapid and scalable preparation of silk microspheres is required. Statement of Significance The work is of significance to the biomaterial and controlled release society because it provides a new option for fabricating silk microspheres in one simple step of mixing silk and polyethylene glycol (PEG), with the size and properties of microspheres controllable by PEG molecular weight as well as PEG and silk concentrations. Although fabrication of silk microspheres have been reported previously using spray-drying, liposome-templating, polyvinyl alcohol (PVA) emulsification , etc., applications were hindered due to harsh conditions (temperature, solvents, etc.) and complicated procedures used as well as low yield and less controllable particle size (usually <10 μm). Since PEG is an FDA-approved polymer, and silk is FDA approved for some medical devices, the methods developed in the present study will be useful in a variety of biomedical applications where simple, rapid and scalable preparation of silk microspheres is required.
研究领域:
生物材料学
·
控释系统
·
医学工程
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产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2019
·
IF 3.621
Chunyang Bao,Qiang Zhang
PEGylation and glycosylation are utilized in this research as different bioconjugation tools to modify proteins, yielding conjugates with different enzyme activity and assembled structure. Active succinimidyl esters are first synthesized through a facile one-step reaction for the alkyne-functionalization of proteins. Well-defined polymers with controlled MW, narrow dispersity and terminal azide groups, including thermoresponsive poly(PEG) and glycopolymers, are then synthesized via a combination of copper mediated living radical polymerization (Cu(0)-LRP) following azidation reaction. Copper catalyzed azide and alkyne cycloaddition reaction (CuAAC) is finally performed to conjugate poly(PEG) or glycopolymers with the alkyne-functionalized laccase from Trametes versicolor . The coupling of polymers induces further self-assembly of laccase-polymer conjugates into spherical nanoparticles with well dispersion stability and stimuli-responsive behaviours in water. Enzyme activity of the conjugates are also studied, during which the glycosylated laccase has shown relatively higher activity than the PEGylated laccase.
研究领域:
生物化学
·
材料科学
·
分子生物学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2018
·
IF 3.862
Hui-Yun Zhang,Cong-yong Sun,Michael Adu-Frimpong,Jiang-nan Yu,Xi-ming Xu
The anti-tumor efficacy of curcumin can be markedly improved by nano-drug self-delivery systems with high drug loading capacity and smart stimulus-triggered drug release in tumor cells. Herein, a type of novel, glutathione (GSH)-responsive, PEGylated prodrug nano-micelles (PPNMs) was prepared by self-assembly of curcumin-s-s-vitamin E/mPEG2k-DSPE mixture. The PPNMs (entrapment efficiency: 96.7%) was acceptably stable in water with a mean particle size of 29.84 nm. Compared with curcumin-loaded mPEG2k-DSPE nano-micelles (CUR-NMs), PPNMs showed a higher drug loading (1.68% vs 27.3%) and remarkably improved the chemical stability of curcumin in phosphate buffer saline (PBS) (pH = 7.4), 10% FBS culture medium, and rat plasma. In vitro release study showed that PPNMs could redox responsively control the release of curcumin from the prodrug. Moreover, PPNMs showed a cytotoxicity in HepG2 cells similar to that of the free curcumin; however, when the HepG2 cells were pretreated with 1 mM GSH, PPNMs displayed a markedly enhanced cytotoxicity and cellular uptake than the free curcumin. After intravenous injection, PPNMs showed an increased half-life in blood circulation (10.6-fold) and bioavailability (107-fold) compared with the free curcumin injection. Altogether, the prodrug nano-micelles represent a promising preparation for sustained and controlled delivery of curcumin with enhanced antitumor activity.
研究领域:
药学
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）