JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2019
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IF 3.218
Yanjie Chen,Shupei Zhang,Xiuhua Li,Hong Dai,Yanyu Lin
A versatile TiO 2 mesocrystals trigged signal amplification photoelectrochemical (PEC) sensing platform was designed for sensitive and accurate determination of α-fetoprotein (AFP). To construct such a biosensor, Bi 2 S 3 nanosheets with notable visible light photoactivity and biocompatibilities were employed as electron transfer mediator as well as a substrate for AFP antigen immobilization. Meanwhile, the Polyethylenimine (PEI) functionalized TiO 2 mesocrystals was used to anchor AFP antibody and the resulting composite Ab-TiO 2 -PEI was utilized as trace tag for signal amplification. The trace tag anchored onto the electrode interface via indirect competitive recognition between free target AFP and immobilized AFP to combine Ab-TiO 2 -PEI. As a result, a cascade structure of band-edge levels formed between TiO 2 mesocrystals and Bi 2 S 3 nanosheets, which notably promoted the photo-to-current conversion efficiency and enhance photocurrent response significantly. By merit of these, the concentration of AFP could be accurately determined through an indirect competitive reaction immunoassay . Upon the optimal condition, this PEC biosensor performed favorable sensitivity, selectivity and reproducibility. Hence, the designed indirect competitive PEC immunoassay possesses a potential application for clinical test and will inspire more development of simple and practical PEC sensor toward different biomolecules.
研究领域:
分析化学
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生物传感器
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光电化学
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免疫分析
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DOI
高影响因子
Journal of Materials Chemistry A
·
2025
·
IF 9.5
Xiangying Li,Haibo Yang,Yanlong Ma,Ying Lin
Dielectric polymer capacitors are widely used in electronic power systems, pulse power systems, and hybrid vehicles due to their excellent charging-discharging rates as well as ultrahigh power density. However, a grimness challenge is to achieve both high energy storage density (Ue) and high efficiency (η). Herein, we report a three-layer structured polymer-based nanocomposite, in which the outer insulation-layers are composed of boron nitride nanosheets (BNNSs) with polyetherimide (PEI), while Ba0.6Sr0.4TiO3 nanofibers (BSTNFs) with PEI as the inner polarization-layer. The three-layer structure effectively combines the advantages of each functional layer, offering high interfacial polarization and high breakdown strength, and consequently leading to an enhanced Ue of the nanocomposites. Consequently, an ultrahigh Ue of 20.96 J/cm3 accompanied with an outstanding η of 95.74% can be obtained in the optimized composition with the inner layer containing 5 vol% BSTNFs, which is 4.78 times as high as that of the pure PEI film (4.38 J/cm3). Notably, the nanocomposite obtains a satisfactory high-temperature performance even under harsh environments (Ue = 10.84 J/cm3, η > 80%, 150 °C), thereby manifesting a substantial application potential. Therefore, this study offers a novel and promising route to high-performance polymer-based dielectrics.
研究领域:
材料科学
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电气工程
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Congcong Pei,Aaron Albert Aryee,Keke Zhu,Rong Wang,Runping Han
Treatment of colored effluent is necessary for the textile industry. In this study, a magnetically recyclable composite (MnFe 2 O 4 @cCNTs-PEI) was prepared by coprecipitation and grafting methods, and its efficiency for removal of light green SF (LG) from solution assessed via the adsorption and advanced oxidation techniques. The experimental results indicated that the maximum adsorption capacity of MnFe 2 O 4 @cCNTs-PEI towards LG could reach 371 mg‧g −1 at solution pH 3 and 303 K. The adsorption equilibrium results could be well fitted by Koble-Corrigan, Temkin, and Freundlich isotherm models whereas the adsorption kinetic process follows the Elovich equation and Double Constant model. This implies the adsorption process be heterogeneous multimolecular layer adsorption, accompanied by heterogeneous diffusion. The adsorption process was spontaneous, endothermic and entropy increasing which was majorly controlled by the electrostatic attraction and π-π stacking mechanisms. MnFe 2 O 4 @cCNTs-PEI can catalyze and activate H 2 O 2 to achieve a heterogeneous Fenton-like degradation of LG. MnFe 2 O 4 @cCNTs-PEI as a catalyst could achieve a higher removal rate of LG (90 %) within a broad pH range (3–10) which could be ascribed to the presence of active radical species such as ‧OH and 1 O 2 . After three adsorption and degradation regeneration cycles, the removal rate of LG was still higher than 60 %. It is potential for MnFe 2 O 4 @cCNTs-PEI to be economically viable for practical applications.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Fan Zhang,Qi Zheng,Yachao Tan,Fan Wang,Khalid A.M. Salih,Ningchao Zheng,Mohammed F. Hamza,Shunyan Ning,Yuezhou Wei,Xiangbiao Yin
Currently, the primary approach for treating radioactive isotopes all over the world is a great challenge. The impact of this treatment is to transform liquid radioactive wastewater (present in huge volume) into low-volume solid radioactive waste. The current work presents synthesis and application of novel adsorbent using β-lactoglobulin fibrils (βFs) on SiO 2 particles and activated carbon particles (AC particles), which considered as facile and ecologically conscious. βFs were produced by denaturing inexpensive β-lactoglobulin. This method of filtering was used for radioactive waste, which differs from most prior adsorption techniques. Polyethyleneimine (PEI) was grafted onto protein fibrils using polydopamine (PDA). The produced material shows highly removal performance of TcO 4 - under both acidic and alkaline conditions (up to 99.76 %, with filtering time of just 5–6 min). This membrane exhibits a superior preference for TcO 4 - over certain common competing ions, including SO 4 2- , NO 3 – , and Cl - . The hybrid membrane achieves maximum adsorption performance for the substituted ion ReO 4 - of 533 mg/g, which is higher than the most commonly used fiber materials. Furthermore, βFs-PDA + PEI fibrils can efficiently treat up to 8000 kg of wastewater per kg and exhibit remarkable reusability performance. This membrane’s simple production, efficient performance, and excellent selectivity make it ideal to be implemented in both hospitals and nuclear power plants.
研究领域:
环境科学
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核工程
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材料科学
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废物管理
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DOI
高影响因子
Materials Research Express
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2020
·Vol. 7
·期 2
·025010
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IF 1.929
Hong-Wei He,Xin-Yuan Li,Zhao-Jun Zhao,Xu Yan
Polymer template method is a general and facile to fabricate nano-structural matters. Some amphiphilic polymers or co-polymers were used as templates to synthesize nano-silica. In this contribution, polymethacrylate (PMMA) employed was a commercial hydrophobic acrylate polymer and grafted with a strong hydrophilic polyethyleneimine (PEI, a densely amino-groups polymer) via aminolysis reaction, which was monitored and identified by means of FT-IR. The aminolysis reaction was optimized and the suitable reaction time was 12 h at 110 °C. The obtained copolymer, PMMA-co-PEI was applied as a template to prepare nano-silica spheres that was characterized by a scanning electron microscope (SEM). When the dosage was 1 wt% of purified PMMA-co-PEI, the resultant nano-silica had uniform particle size, and average diameter of 311 nm. When the dosage of PMMA-co-PEI was increased to 2 wt% or 4 wt%, the resultant particles became bigger and inclined to aggregate. Nano-silica afforded by this template method will be a promising material in application of catalysis, energy, biology and chromatographic analysis and the copolymer of PMMA-co-PEI will be a template for producing metal oxide nano-spheres.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
ANALYST
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2025
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IF 3.3
Lingling Li,Doudou Lei,Pengyue Song,Qingbin Xu,Lihua Huang,Xiao Ma,Lidong Zhou,Ping Zhang,Weijun Kong
Sensitive detection of carbendazim (CBZ), a widely monitored bactericidal pesticide globally, is critical to reduce risks to human health. In this study, Eu ions were embedded into a rigid metal–organic framework (MOF), to prepare Eu-MOF as a fluorescence signal source, which was subsequently post-modified with polyethyleneimine (PEI) for efficient coupling with anti-CBZ monoclonal antibodies (mAbs). On this basis, a PEI@Eu-MOF-mAbs fluorescent probe-based lateral flow immunosensor (LFIS) was developed for CBZ analysis, enabling dual-mode detection: rapid visual qualitative observation by the naked eye and intelligent fluorescence quantitative analysis by using a smartphone. PEI modification not only effectively improved the zeta potential, fluorescence intensity, quantum yield, and biological coupling ability of the Eu-MOF to mAbs, but also significantly enhanced the stability and anti-interference performance of PEI@Eu-MOF. The introduction of PEI@Eu-MOF-mAbs probes characterized by strong fluorescence emission, long fluorescence lifetime, and low background interference, markedly improved the detection sensitivity of the LFIS platform for trace CBZ. Under optimal conditions, the detection limit for smartphone-assisted fluorescence analysis was as low as 1.3 pg mL−1 with a wide linear detection range of 0.25–125 ng mL−1 for CBZ. The recoveries in spiked Panax notoginseng samples were 93.40–106.0% with RSD <1.69%, indicating outstanding reliability of the newly developed LFIS platform for accurate detection of CBZ. In comparison with seven other common pesticides, CBZ produced significantly weakened and stable fluorescence, indicating good specificity and stability of the developed platform over 4 weeks. Compared with current analytical methods, the smartphone-assisted PEI@Eu-MOF-mAbs dual-modal LFIS platform exhibited advantages of simple construction, easy operation, rapid response, obvious visualization to the naked eye, and intelligent quantitative analysis, highlighting its broad application potential for rapid screening and accurate point-of-care detection of CBZ in a large number of foods and agricultural products.
研究领域:
分析化学
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食品安全
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生物传感
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免疫学
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环境监测
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药物残留检测
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纳米材料应用
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即时检测技术
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DOI
PubMed
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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2018
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IF 2.559
Yaqiong Wang,Ping Cao,Shicui Li,Xiaofeng Zhang,Jin Hu,Mingyue Yang,Sujuan Yao,Feng Gao,Ao Xia,Jian Shen,Xiaohua Huang
The upconversion luminescence (UCL) marker based on upconversion nanoparticles (UCNPs) shows unique advantages over traditional fluorescence markers, such as enhanced tissue penetration, better photostability, and less autofluorescence . Herein, we constructed a new UCL gene-delivery nonviral vector via layer-by-layer self-assembly of poly(ethylene imine) (PEI) with UCNPs. To reduce the cytotoxicity of PEI, citric acid (CA) was introduced for aqueous modification, and PEI assembly was introduced on the UCNP surface. Our data show that the nonviral vector for UCL gene-delivery demonstrates excellent photostability, low toxicity, and good stability under physiological or serum conditions and can strongly bind to DNA . Moreover, this UCL PEI-based vector could serve as a promising fluorescent gene-delivery carrier for theranostic applications.
研究领域:
生物医学工程
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分子生物学
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DOI
PubMed
高影响因子
NANO
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2025
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IF 1.1
Nana Li,Alexpandi Rajaiah,Kuanjie Ma,Guochao Lu,Yucong Yu,Yurong Cai
To address the need for rapid protein desorption in protein adsorption applications, we developed and characterized polyethyleneimine-functionalized calcium carbonate nanoparticles coated with ferrosoferric oxide (PEI-Fe 3 O 4 @CaCO 3 ) . This hybrid nanostructure integrates the pH-sensitive properties of calcium carbonate with the magnetic responsiveness of Fe 3 O 4 , enabling quick separation by an external magnetic field within 1 min. In adsorption experiments with bovine serum albumin (BSA) as a model protein, PEI-Fe 3 O 4 @CaCO 3 achieved a notable adsorption capacity of 197.6 mg/g at 1 h, representing 77% of its maximum adsorption potential. Saturation was reached at 256.1 mg/g within 4 h. Importantly, the pH-responsive nature of the calcium carbonate component facilitated efficient desorption, achieving a release efficiency of 95.67% ± 2.41% within 1 min in a sodium acetate–acetic acid buffer at pH = 6.2. This pH-responsive and magnetically responsive system demonstrates significant potential for applications requiring fast, controlled protein adsorption and desorption, offering a promising tool for targeted protein recovery in various biochemical and industrial processes.
研究领域:
纳米材料
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蛋白质纯化
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生物分离
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响应性材料
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磁性纳米颗粒
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产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
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2024
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IF 7.4
Yujiao Zou,Chenyu Li,Ni Li,Yili Zhao
Silver nanoparticles (Ag NPs)-based nanomaterials are effective catalysts for a wide range of reactions. The recyclability and efficient catalytic properties of Ag-based nanocatalysts have been the focus of significant research interest. Herein, to address these challenges, we incorporated Fe 3 O 4 nanoparticles (NPs) into a polyvinyl alcohol/polyethyleneimine (PVA/PEI) solution to fabricate PVA/PEI@Fe 3 O 4 nanofibrous mats via electrospinning. Subsequently, the magnetic nanofibrous mats were homogenized to produce short magnetic nanofibers, which can be easily separated from the solution using a magnet. These short PVA/PEI@Fe 3 O 4 nanofibers were then immersed in an aqueous solution of AgNO 3 to adsorb and reduce Ag ions, resulting in the formation of Ag NPs with an average diameter of approximately 15 nm, uniformly dispersed on the nanofiber surface. The resulting short PVA/PEI@Fe 3 O 4 /Ag nanofibers exhibit excellent catalytic activity for the reduction of 4-NP, achieving a high conversion rate of 97.0 %. Furthermore, they demonstrated remarkable recyclability, maintaining high catalytic activity throughout six consecutive cycles. The short magnetic nanofibers proposed in this study are anticipated to facilitate the practical application of electrospun nanofibers in the catalytic removal of pollutants.
研究领域:
材料科学
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环境科学
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DOI
高影响因子
TALANTA
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2024
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IF 5.6
Kai Hu,Xiaobing Liu,Huifen Ma,Di Zhao,Junying Song,Huahui Zeng,Zhenqiang Zhang
A magnetic MXene aerogel (Fe 3 O 4 @MXene@PEI) was prepared by crosslinking amino modified MXene with polyethyleneimine using epichlorohydrin as a cross-linker. Adsorption properties of Fe 3 O 4 @MXene@PEI aerogel for phenolic acids were evaluated by adsorption kinetics and isotherms experiments, showing that the high adsorption affinity was governed by multilayer chemisorption process. An efficient MSPE/HPLC method was developed for the determination of phenolic acids with excellent selectivity, good linearity (0.025–5.0 μg mL −1 ), low LODs (0.007–0.017 μg mL −1 ), and satisfactory recoveries (80.0–120.0 %). Moreover, the antioxidant activity of the Fe 3 O 4 @MXene@PEI purified compounds was superior to that of the conventional method as demonstrated by the results of scavenging experiments on 2,2 -diphenyl-1-picrylhydrazyl radical scavenging assay. Finally, 65 organic acids were identified in the Fe 3 O 4 @MXene@PEI treated honeysuckle extracts by UHPLC-Q-Exactive Orbitrap MS/MS analysis. The proposed sorbent exhibits remarkable promise for the selective separation and purification of organic acids from herbal products.
研究领域:
分析化学
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植物化学
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材料科学
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DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2026
·Vol. 26
·期 7
·e70220
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IF 4.2
Luwei Zhang,Yuduo Gao,Zhenghao Hu,Yiqing Chen,Chengfan Wu,Qi Shuai,Yunfeng Yan
Nanoparticle (NP) carriers are critical for enhancing the stability and cellular uptake of mRNA, enabling its therapeutic potential. However, conventional mRNA NP carriers enter cells via endocytosis, followed by endosome-lysosome trafficking, which leads to inefficient mRNA release into the cytoplasm. This insufficient endosomal escape has become a challenge in improving mRNA delivery efficiency for polymer and lipid NP carriers. In this study, we design a novel class of lipoic acid derivative (LA-Der) composite NPs with surface disulfide bonds that anchor onto cell membranes through disulfide exchange with cell surface thiols, bypassing endosomal degradation and directly releasing mRNA into the cytoplasm. We synthesized 25 LA-Ders with diverse chemical structures via amidation and incorporated 10 kDa polyethyleneimine (PEI) to form composite NPs for optimal mRNA loading. In vitro optimization identified three LA-Der/PEI formulations, LA-4A1, LA-5A1, and LA-6A2, as the most effective for mRNA delivery. Mechanistic studies revealed that thiol-mediated uptake is the predominant internalization pathway, facilitating the bypass of endosomal barriers. In vivo experiments confirmed high luciferase expression in the spleen and liver following intravenous injection of NPs carrying luciferase mRNA. These LA-Der/PEI composite NPs provide a promising strategy for overcoming intracellular endosomal escape barriers, advancing the clinical translation of mRNA therapeutics.
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PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2026
·
IF 5
Hao Wang,Shuang Wang,Guohua Wang,Dawei Chen,Ming Zhao,Haiyang Hu
Chronic refractory wounds present a significant global healthcare challenge, characterized by persistent inflammation and impaired tissue repair that conventional dressings often fail to adequately modulate. While Dragon ’s blood (Dra), a traditional Chinese medicine, offers potent anti-inflammatory and angiogenic properties highly suitable for this complex microenvironment, its clinical translation is severely hindered by inherent hydrophobicity and low bioavailability. To address these limitations and bridge the therapeutic gap, we developed a novel Dra-loaded polyethyleneimine/polyacrylic acid (PEI/PAA) xerogel powder. We first optimized the solubility of Dragon ’s blood extract (Dra-Ext) using solid dispersion and inclusion complex technologies. Comparative analysis indicated that solid dispersion with PVPK30 achieved superior solubility enhancement (12.12 μg/mL, a 46-fold increase) compared to the HP-β-CD inclusion complex. The optimized xerogel powder (Dra-SD/PEI/PAA powder) exhibited rapid gelation (<30 s), high fluid absorption (340.5% ± 10% within 30 s), excellent self-healing capabilities, and sustained drug release (85.8% ± 0.3% over 48 h at pH 7.4). Furthermore, the dressing demonstrated superior hemostatic activity (coagulation time = 0.85 ± 0.07 min) and favorable biocompatibility. In a rat model of chronic refractory wounds, the Dra-SD/PEI/PAA treatment significantly accelerated wound closure (99.50% healing rate at day 14), promoted collagen deposition, and downregulated pro-inflammatory cytokines (IL-1β by 61.25% and IL-6 by 84.85%). These findings indicate that the Dra-SD/PEI/PAA platform effectively integrates solubility enhancement with rapid hemostasis and inflammation modulation, offering a promising therapeutic strategy for chronic wound management. Download: Download high-res image (210KB) Download: Download full-size image
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高影响因子
危险品化学品经营许可证（带存储）