JOURNAL OF LIPID RESEARCH
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2025
·
IF 4.1
Shaojun Pei,Wen Wang,Tingze Feng,Qiuping Wang,Yuhan Wang,Hong-Xu Liu,Xinmiao Liang,Hai-long Piao
S -palmitoylation is a dynamic and reversible post-translational modification that plays crucial roles in cancer progression. Here, we found the oncogene of metadherin (MTDH) modulates lipid metabolism and ferroptosis by its S -palmitoylation. We demonstrate that MTDH is S -palmitoylated at Cys-75 in the endoplasmic reticulum by ZDHHC1/9 and S -depalmitoylated by APT1. The flexible loop and the α-helix length in the MTDH N-terminus affect its S -palmitoylation level. In addition, metabolomics analysis found that the S -palmitoylated MTDH increases intracellular levels of triglycerides, phosphatidylethanolamines, and phosphatidylcholines. However, the non- S -palmitoylation form of MTDH-CS enhanced the interaction of between MTDH and the ferroptosis enhancer of Acyl-CoA synthetase long-chain family member 4 (ACSL4), thereby reducing ferroptosis sensitivity in breast cancer cell. Taken together, targeting MTDH S -palmitoylation may represent a novel strategy for breast cancer therapy.
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FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES
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2025
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IF 1.8
Xiao Song,Rui Xiong,Runqian Yang,Yining Jiang,Qian Chen,Liping Ruan
Biomass carbon materials have good application prospects in the field of electromagnetic wave absorption and shielding because of their environmental protection and low cost, but not good absorption of low-frequency S-band. In this article, the microwave activation of different mass ratios of zinc chloride and peach pit carbon is studied to improve the low-frequency wave absorption performance. It is found that with the addition of zinc chloride, the electromagnetic absorption performance of peach pit carbon in S-band is significantly improved after microwave activation. The sample with a mass ratio of zinc chloride to peach pit carbon of 3:1 has the best performance. Its minimum reflection loss (RL) is −14.13 dB (4.60 mm, 3.92 GHz), and the maximum effective absorption bandwidth is 1.24 GHz (2.10–3.34 GHz, 5.80 mm). The results of scanning electron microscopy (SEM), X-ray powder diffraction (XRD) and other tests show that the absorption properties of S-band are closely related to the ZnO and basic zinc chloride components generated by microwave activation. In this study, the absorption of carbon material in S-band is achieved by simple microwave activation without the addition of magnetic materials, which can provide a new way for the low-frequency absorption enhancement of materials.
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WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
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2017
·Vol. 33
·期 5
·1-8
·
IF 1.658
Pan Lan-jia,Tang Xiao-da,Li Chun-xing,Yu Guang-wei,Wang Yin
Sulfamethazine (SM2) is an antimicrobial drug that is frequently detected in manure compost, is difficult to degrade at high temperatures and is potentially threatening to the environment. In this study, a thermophilic bacterium was isolated from the activated sludge of an antibiotics pharmaceutical factory; this bacterium has the ability to degrade SM2 at 70 °C, which is higher than the traditional manure composting temperature. The strain S-07 is closely related to Geobacillus thermoleovorans based on its 16S rRNA gene sequence. The optimal conditions for the degradation of SM2 are 70 °C, pH 6.0, 50 rpm rotation speed and 50 mL of culture volume. More than 95% of the SM2 contained in media was removed via co-metabolism within 24 h, which was a much higher percentage than that of the type strain of G. thermoleovorans . The supernatant from the S-07 culture grown in SM2-containing media showed slightly attenuated antibacterial activity. In addition, strain S-07 was able to degrade other sulfonamides, including sulfadiazine, sulfamethoxazole and sulfamerazine. These results imply that strain S-07 might be a new auxiliary bacterial resource for the biodegradation of sulfonamide residue in manure composting.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
·
IF 9.4
Yilin Wang,Kai Wang,Qiming Liu,Jie Wang
Transition metal sulfides have emerged as compelling anode materials for sodium-ion batteries (SIBs), leveraging their abundant elemental reserves and high theoretical capacities. However, the reaction of sulfur with Na ions is usually accompanied by significant volume dilation, which hinders their further development and application. Hence, constructing bimetallic sulfide (FeSn)/S for SIBs anode material greatly alleviates the circulation attenuation caused by volume expansion. Through constructing bimetallic heterojunction materials from nanocube precursors, the (FeSn)/S anode material retains a high specific capacity of 578 mAh/g at an intense current density of 2 A/g after 1000 cycles, and exhibits an great rate capability, delivering 796 mAh/g at 100 mA/g. The excellent electrochemical performance of the heterojunction material presents a promising solution to the enduring quest for enhanced anode material for SIBs.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
·
IF 5.162
Lei Wang,Cunzhi Zhang,Hui He,Hongxiang Zhu,Wei Guo,Shile Zhou,Shuangfei Wang,Joe R. Zhao,Jian Zhang
A novel cellulose-based colorimetric sensor (DAC-Tu) with N, S sites for Ag + was prepared. The DAC-Tu exhibited excellent selectivity and sensitivity for Ag + with a naked eyes color change from white to black in mixed metal ions aqueous solutions. The naked-eye in-situ detection limit of DAC-Tu for Ag + was 10 −6 mol/L within 10 min. The cellulose matrix and the grafted functional groups ( C S, NH 2 ) of DAC-Tu all contributed to the low naked-eye in-situ detection limit. The mechanism of the visual recognition of DAC-Tu sensor for Ag + was proposed, the N and S atoms of DAC-Tu preferentially coordination chelated with Ag + to form N Ag, S Ag, and Ag 2 S, and enriched on the cellulose matrix, thus the DAC-Tu presented different color change in response to different concentrations of Ag + . The as-prepared DAC-Tu colorimetric sensor showed a great application prospect for in-situ naked eyes detection of Ag + .
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Polymer Chemistry
·
2017
·Vol. 8
·期 21
·3261-3270
·
IF 5.375
Jun Zhang,Yan Xiao,Xueli Luo,Lianlei Wen,Andreas Heise,Meidong Lang
Double hydrophilic block copolymers (DHBCs) based on poly(ε-caprolactone)s, poly(6-acetoxyl-ε-caprolactone)-b-poly(4-N-piperilactone) (PCCL-b-PPIL), were synthesized via ring-opening polymerization and deprotection. The self-assembly behaviour of these block copolymers in aqueous solutions was thoroughly explored via a combination of UV-vis spectroscopy, zeta potential measurement, 1H NMR spectroscopy, dynamic light scattering (DLS) and transmission electron microscopy (TEM). It was observed that “schizophrenic” aggregations were formed and triggered by pH, i.e., the copolymers could self-assemble into PCCL-core micelles at acidic pH and PPIL-core micelles at alkaline pH. In addition, pendant groups in each block of copolymers facilitated further chemical modification with fluorescent dyes such as 1-(hydroxymethyl)pyrene and FITC. The fluorescence properties of pyrene-functionalized copolymers were closely related to their aggregate morphology, which could be adjusted simply by altering the environmental pH values. Meanwhile, it is expected that this novel type of degradable schizophrenic block copolymer holds potential application in stimuli-responsive fluorescent probes.
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ACS Sustainable Chemistry & Engineering
·
2019
·
IF 6.97
Yan Zhang,Yin-Qi Wu,Na Xu,Qian Zhao,Hui-Lei Yu,Jian-He Xu
Enzymatic asymmetric sulfoxidation using molecular oxygen as the oxidant is a promising green chemistry approach to chiral sulfoxide production. Despite the broad substrate spectrum of cyclohexanone monooxygenases (CHMOs), some unnatural substrates with bulky functional groups, such as the pharmaceutically relevant omeprazole sulfide, cannot be effectively accepted by CHMOs. Herein, we describe a set of variants derived from an Acinetobacter calcoaceticus CHMO (AcCHMO), whose active sites adjacent to the substrate tunnel were altered to shift the substrate specificity from cyclohexanone monooxygenation toward omeprazole sulfide sulfoxidation. We performed homologous modeling and molecular docking to identify key residues that might affect the substrate specificity. Two libraries of residues lining the active center of AcCHMO were then constructed and screened by an effective halo-based selection method using the solubility difference between the substrate (omeprazole sulfide) and product (esomeprazole). Functional evaluation of the resultant variants showed that the substrate specificity of AcCHMO was markedly altered from the small natural substrate (cyclohexanone) toward the desired bulky substrate (omeprazole sulfide) despite the extremely poor activity detected even for the best variant, M2 (0.61 U/gprot). The crystal structure of M2 complexed with a flavin adenine dinucleotide (FAD) prosthetic group was determined, which provided insight into the altered substrate specificity. To improve the activity of enzyme M2 toward pharmaceutical precursor omeprazole sulfide, we performed both local and global protein engineering among the two CASTing libraries surrounding FAD+ and NADP+ prosthetic groups and an error-prone PCR library of the full-length AcCHMO. As a result, variant M6 was obtained, giving a 50-fold higher activity compared to M2. This structure-guided protein engineering of AcCHMO provided a promising candidate for converting omeprazole sulfide into (S)-omeprazole using a green biocatalytic method.
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JOURNAL OF MATERIALS SCIENCE
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2025
·
IF 3.9
Wang Zhaokun,Li Chen,Pan Yanrui,Ma Yue,Ye Mingfu,Shi Xixi,Zhang Hongzhou,Song Dawei,Zhang Lianqi
Lithium-sulfur (Li–S) batteries are considered as one of the most promising next-generation energy storage devices. However, due to the high working current density and the shuttle of polysulfides, a large number of dendrites and corrosion are formed on Li anode, restricting the wide application of Li–S battery. Herein, a triple-component gel polymer electrolyte (PHMA) comprising poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP)–polyacrylonitrile (PAN)–polymethyl methacrylate (PMMA) is developed, the excellent processability and Li ion conductivity of PVDF-HFP, the excellent polysulfide adsorption capability of PAN and the excellent wettability of PMMA are significantly enhanced after compositing, then uniform Li ions deposition is regulated and the growth of Li dendrite is greatly suppressed. In addition, the shuttle effect of polysulfides is greatly suppressed through physical, chemical and weak hydrogen bonding adsorption provided by the diversification of polar groups. Given these advantages, an ionic conductivity of 4.0 × 10 –3 S cm −2 is achieved and a minor polarization voltage of 15 mV is exhibited for Li//Li cell after 1000 h cycling, in situ optical microscope-electrochemical cell further robustly confirms the enhanced stability of Li foil. As a result, S/PHMA/Li battery delivers stable cycling performance with a capacity decay of 0.5% per cycle after 100 cycles at 0.2 C. Graphical
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LANGMUIR
·
2025
·
IF 3.9
Daqiang Liu,Xingliang Yin,Leilei Li,Chuanwu Chen,Qiu-Xia Lin,Hong-Xin Zhang,Erkang Liu,Jun-Feng Wang
Ammonia is in high demand and widely used, yet its production still predominantly relies on the energy-intensive Haber–Bosch process, highlighting the urgent need for a milder alternative technology. Photocatalytic N2 fixation shows great promise in this regard despite the challenge of developing high-efficiency catalysts. In this study, we successfully prepared micronano spherical Bi2MoO6/Bi2MoO6–x S-Scheme homojunctions using a simple solvothermal-calcination coupling method, which offer unique advantages for nitrogen fixation catalysis: (i) the micronano structure mitigates the agglomeration issue common in nanomaterials, thereby exposing more active sites; (ii) the in situ constructed S-Scheme homojunction features a high-quality surface and interface structure, enhancing the spatial separation and transport of photogenerated charges and preserving strong redox capabilities; and (iii) the oxygen-rich vacancy structure promotes the N2 adsorption and activation. Thanks to those favorable properties, the Bi2MoO6/Bi2MoO6–x (BMO/BMOOV) S-Scheme homojunction demonstrates exceptional ammonia production efficiency, with a NH4+ generation rate of 238.7 μmol g–1 h–1 under simulated sunlight, which is over 5.2 times higher than that of pristine Bi2MoO6 (BMO) and significantly outperforms other reported similar catalytic systems (see Table S1). This work introduces a simple and versatile method for synthesizing homojunctions, potentially inspiring the development of more efficient photocatalysts for nitrogen fixation and beyond.
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Cell Metabolism
·
2025
·
IF 30.9
Zezhao Chen,Xiaosong Gu,Hongbo Chen,Huijing Zhang,Jianping Liu,Xiaohua Yang,Yuping Cai,Mengmeng Zhang,Lingjie Yan,Yuanxin Yang,Bing Shan,Zheng-Jiang Zhu,Yixiao Zhang,Jinyang Gu,Daichao Xu
The capacity of cells to sense and respond to nutrient availability is essential for metabolic homeostasis. Failure in this process may cause cell death and associated diseases. While nutrient sensing in metabolic pathways is well understood, the mechanisms linking nutrient signals to cell death remain unclear. Here, we show that RIPK1, a key mediator of cell death and inflammation, senses methionine and its metabolite, S -adenosylmethionine (SAM), to dictate cell survival and death. SAM-mediated symmetrical dimethylation at RIPK1 Arg606 by PRMT5 functions as a physiological protective brake against RIPK1 activation. Metabolic perturbations, such as methionine restriction or disrupted one-carbon flux, reduce SAM levels and unmask Arg606, promoting RIPK1 self-association and trans -activation, thereby triggering apoptosis and inflammation. Thus, RIPK1 is a physiological SAM sensor linking methionine and one-carbon metabolism to the control of life-or-death decisions. Our findings suggest that RIPK1 could be a potential target for diseases associated with disrupted SAM availability.
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ADVANCED MATERIALS
·
2025
·
IF 26.8
Guobin Yu,Xiaoya Liu,Weiyuan Huang,Shixin Wang,Jiqiang Zhan,Lu Ma,Hongpeng Li,Xiaojing Lin,Tongchao Liu,Khalil Amine,Hongsen Li
Rechargeable aluminum-sulfur batteries (Al-S) are emerging as a promising alternative energy storage system beyond lithium-ion batteries due to their high energy density, abundant material resources, and economic efficiency. However, their practical application remains challenged by sluggish conversion kinetics, polysulfide shuttling, and low sulfur cathode utilization. While extensive studies have focused on enhancing polysulfide adsorption through catalytic strategies, the roles of electronic structure in dictating catalytic performance remain underexplored. Here, this work unveils the critical effect of unpaired electronic structure on the catalytic performance of single atom ferromagnetic transition metals through a systematic evaluation of three typical atomically dispersed ferromagnetic single atoms—Fe, Co, and Ni—supported on porous carbon (denoted as PC-SAFAs). Comprehensive characterizations and density functional theory (DFT) calculations reveal that the PC-SAFe catalysts, exhibiting the highest spin polarization arising from unpaired electrons, demonstrate the strongest interactions with polysulfide, thereby facilitating rapid and reversible polysulfide conversion reactions. Consequently, Al-S batteries incorporating the optimized PC-SAFe cathode achieve an impressive specific capacity of 508.8 mAh g −1 at 1.0 A g −1 after 500 cycles, along with much improved rate capability. This work provides a deeper understanding of the role of electronic structure in catalytic chemistry, and offers new insights for developing high-performance Al-S batteries.
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Joule
·
2025
·
IF 35.4
Xinran Li,Tengsheng Zhang,Gaoyang Li,Boya Wang,Hongrun Jin,Yanyan Zhang,Xin Liu,Yutong Feng,Yifeng Wang,Wanhai Zhou,Jingwen Zhao,Wei Li,Hongjin Fan,Dongyuan Zhao,Dongliang Chao
Aqueous manganese ion batteries (AMIBs) have recently garnered attention due to the abundance of manganese and their intrinsic safety. However, the development of current AMIBs remains plagued by restrictive actual capacities. Herein, we propose an energetic Mn 2+ -S redox electrochemistry with a solid-liquid-solid redox pathway. Operando X-ray absorption fine spectroscopy and synchrotron X-ray diffraction unveil the Mn 2+ storage mechanism of S 8 ↔ MnS 4 ↔ MnS 2 ↔ MnS. A capacity of 1,242 mAh g −1 with a high sulfur utilization of 74.3 wt % can be achieved, surpassing the capacity limitations of previously reported AMIBs. As a proof of concept, a system intergrating the S/MnS and MnO 2 /Mn 2+ redox couples delivers an energy density of 396 Wh kg S+MnO2 −1 and cycles for 800 cycles stably at 4 A g −1 . We have elucidated the mechanism underlying the redox of Mn 2+ -S and may open an avenue for the next high-energy AMIBs.
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