RSC Advances
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2017
·Vol. 7
·期 14
·8484-8490
·
IF 3.108
Hui Xue,Lun Peng,Yishi Dong,Yuqing Zheng,Yafei Luan,Xiang Hu,Gaojian Chen,Hong Chen
In this paper, novel star glycopolymers were synthesized via Cu(0)-mediated radical polymerisation at ambient temperature. The reaction was fast with little star–star coupling. Moreover, star glycopolymers can be obtained without removing oxygen from the polymerisation mixture. The effects of solvent and the ratio of initiator/catalyst/ligand on polymerisation were investigated, and the optimal conditions for the synthesis of star glycopolymer were determined. In addition, the binding ability between synthesised glycopolymers and concanavalin A (ConA) was studied using a turbidity test and quartz crystal microbalance-dissipation (QCM-D). Compared with linear glycopolymers, star glycopolymers showed higher binding ability to specific lectins and the strongest binding was obtained when the molecular weight was medium.
研究领域:
高分子化学
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材料科学
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生物化学
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DOI
高影响因子
JOURNAL OF MATERIALS CHEMISTRY
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2011
·Vol. 21
·期 28
·10390-10398
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IF 5.101
Kunmin Yang,Hui Liang,Jiang Lu
A well-defined multifunctional star polymer consisting of reactive and thermoresponsive poly(N-isopropylacrylamide-co-acrolein) arms and an aluminum tris(8-hydroxyquinoline) (Alq3)-bearing fluorescently labeled core was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization using the “arm-first” method. Acrolein, a commercially available aldehyde-bearing monomer, was copolymerized with N-isopropylacrylamide (NIPAM) via RAFT technique in a controlled way to give well-defined linear trithiocarbonate terminated poly(NIPAM-co-acrolein) macro-RAFT agent. The preformed linear macro-RAFT agent was then cross-linked by a tri-vinyl Alq3-containing cross-linker (Alq3 cross-linker) in conjunction with N,N′-methylenebisacrylamide to give the desired reactive, thermoresponsive, and fluorescently labeled star polymer. The resultant star polymer exhibits a lower critical solution temperature at ∼29.8 °C in water, and displays intense greenish-yellow fluorescence with maximum emission peak around 520 nm in both organic solvent (i.e., THF) and water. Moreover, the highly reactive aldehyde functions in the arms of the star polymer could provide the key intermediates to conjugate biomolecules, and the conjugation with an aminooxy-functionalized BSA model protein was also demonstrated as an example of how the novel star polymer can be utilized to conjugate bioactive molecules, constructing fluorescently labeled “smart” polymer-protein conjugates.
研究领域:
高分子化学
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生物材料
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生物化学
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DOI
高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
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2009
·
IF 0.72
Shenwen Fang,Ming Duan,Chunyong Jiang,Liehui Zhang,Jian Zhang
Water-soluble thioxanthone-terminated poly(ethylene imine) (PEI 600, PEI 1800, PEI 3000 and PEI 10000; 600, 1800, 3000 and 10000 are the weight-average molecular weights of the above PEIs, respectively). Macrophotoinitiators were synthesized by introducing a certain amount of thioxanthone (TX) moieties into the periphery of PEI, and the products were confirmed by 1H-NMR, FT-IR, and elemental analysis. Star polyacrylamides (PAMs) were prepared using the obtained macrophotoinitiator as a core via photopolymerization. The effect of the molecular weight of the macrophotoinitiator on photoinitiation efficiency of the resulting polymers was investigated. The result shows that the choice of the macrophotoimitator has no influence on the rate of polymerization. In addition, three plots of characteristic properties with the star polymer were studied to confirm the existence of arms in the resulting star PAM.
研究领域:
高分子化学
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光化学
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材料科学
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DOI
高影响因子
International Review of Financial Analysis
·
2024
·
IF 7.5
Shengpeng Zhang,Yaokuang Li,Yu He,Ruixin Liang
In this study, we investigate whether vocal cues expressed by management in IPO online roadshows in the SSE STAR Market play an information role. Using deep learning techniques, we classify the emotional tendencies of vocal cues in IPO online roadshows and construct quantitative proxy variables. After a series of empirical analyses, we find that vocal emotions are positively associated with first-day stock returns after IPO. In addition, we find that vocal emotions have predictive power for future operating performance after IPO. Our findings still hold after a series of robustness checks. Through additional analyses, we provide evidence that information content in the prospectus and investor sentiment play moderating and mediating roles, respectively, in the relationship between vocal emotions and the first-day stock returns after IPO. Moreover, we find that the vocal emotions expressed in the presentation section and the management tone in the Q&A section develop synergistic effects. Finally, we find that the information role played by vocal emotions exhibits timeliness. Our findings elucidate the information role of vocal cues and highlight the importance of IPO online roadshows in the SSE STAR Market.
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DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2018
·
IF 3.997
Conglian Yang,Yuting Qin,Kun Tu,Chenfeng Xu,Zhen Li,Zhiping Zhang
Multidrug resistance (MDR) remains as an obstacle for effective cancer treatment. Herein, we developed a novel and efficient nanomedicine by virtue of the carrier characters and MDR inhibition effects of β-cyclodextrin (β-CD) and d-α-tocopheryl polyethylene glycol succinate (TPGS). A series of star-shaped polymers CD-g-TPGS with different TPGS substitution degree were synthesized for doxorubicin (DOX) delivery, where β-CD was identified as a core and TPGS as branches. These star polymers can self-assemble into nanoparticles with DOX . These nanoparticles showed no significant differences in size, zeta potential and morphology except for in vitro stability. They demonstrated good biocompatibility and enhanced cellular uptake in both drug sensitive and resistant cancer cells. Notably, the nanoparticles exhibited superiority of cytotoxicity in drug resistant cancer cells against free DOX . In vivo antitumor effect also demonstrated the improved cancer inhibition effect. This work suggests that star-shaped polymers CD-g-TPGS are promising drug carriers to overcome MDR in cancer treatment.
研究领域:
药学
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纳米技术
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癌症研究
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DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Rongxin Zhao,Hengtong Xia,Shaojie Gong,Jiawei Yang,Jie Wang,Xiaoshuang Yin,Ying Liu,Wenzhong Yang,Hui Xu
This study presents a green scale inhibitor design paradigm through the precision synthesis of β-cyclodextrin-grafted poly (tert-butyl acrylate) (P t BA) star polymers via atom transfer radical polymerization (ATRP), followed by hydrolysis to yield poly (acrylic acid) (β-CD-PAA). Structural characterization by FTIR 1 H NMR and GPC confirmed well-defined architectures with tunable PAA arm lengths ( Mₙ = 12–58 kDa, Đ = 1.05–1.15). The star topology demonstrated exceptional dual functionality: (1) Scale inhibition – achieving 86.36 % CaCO 3 inhibition at 55 mg/L and 96.87 % CaSO 4 inhibition at 6 mg/L, outperforming linear polyacrylic acid by 15–32 % efficiency; (2) Scale dissolution – maintaining excellent conductivity recovery via colloidal stabilization. Systematic evaluation revealed robust performance across harsh conditions (pH 4–12, 60–90 °C). Multiscale characterizations (i.e., SEM, XRD) unveiled a dual mechanism: multidentate Ca 2+ chelation and 3D steric hindrance that distorted crystal nuclei and promoted metastable vaterite formation. This work establishes star-shaped polysaccharide derivatives as next-generation scale inhibitors, offering a sustainable alternative to phosphorus-based inhibitors while advancing molecular-level understanding of topology-dependent scaling control.
研究领域:
高分子化学
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材料科学
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环境科学
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化学工程
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表面科学
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产品关联
DOI
高影响因子
FUEL
·
2024
·
IF 6.7
Xinjie Sun,Lingli Jia,Xinyuan Li,Shanrong Zhang,Yiting Wang,Mingwang Fan,Jun Xu
Wax precipitation causes numerous challenges in the transportation and refining of crude oil. Wax deposition can be decreased and the flowability of waxy crude oil in cold temperatures can be increased by addition of polymer additives in the crude oil. Sequentially well-structured polymers synthesized by reversibly additive fragment chain transfer (RAFT) polymerization enhance the capability to inhibit the growing of wax crystals. In this paper, star chain-transfer agents (star-CTA) was synthesized by esterifying polyol with a tri-thiocarbonate RAFT reagent. Then, poly octadecyl acrylate-maleic anhydride (POM) copolymers with linear and star structure (3, 4, 6 arms) were synthesized via RAFT polymerization. The chemical structures were then characterized using FT-IR, 1 H NMR and GPC approaches. The effects of star copolymers on wax crystallization and cold flowability were analyzed by DSC, XRD, polarized light microscopy and rheology. The transformation from lamellar to fibrous crystals and a decrease in fractal dimensions of crystal growth upon adding all polymers were observed through kinetics of isothermal crystallization and non-isothermal crystallization (NIC) using DSC. Upon further calculations, the crystallization activation energy of NIC increased from 34.40 kJ/mol to 63.22 kJ/mol with the increase of arms. Revealed by XRD, both of the relative crystallinity index and the grain size of crystals are reduced by polymers. Further, the growth along the x and z axes is suppressed, resulting in fibrous growth. The viscosity initially decreases and then increases as the number of arms of polymer increases, with 4-arms POM (4X-POM) reducing the viscosity by 64.63 %. The present work reveals the mechanism of inhibiting wax crystal growth by star polymers, providing valuable theoretical guidance for the practical application.
研究领域:
化学工程
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材料科学
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产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
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2020
·
IF 3.862
Mi Zhou,Feng Ling,Jie Li
We now report a star-shaped supramolecular copolymer for diagnosis and treatment by chelated with Gd 3+ ion as magnetic resonance imaging (MRI) contrast agent and drug-carried for controlling release agent. The copolymer is prepared by the host-guest inclusion complexation between the host polymer polycaprolactone-β-cyclodextrin (4sPCL-CD) and the guest polymer adamantylamine-poly-L-lactic-block-poly(N-isopropylacrylamide-co-2-hydroxyethylmethacrylate-diethylenetriamine penta acetic acid) (AD-PLLA- b -P(NIPAM- co -HEMA-DTPA)) and can self-assemble into spherical micelles in aqueous solution. By adding 2-adamantylamine hydrochloride (AD-NH 2 ), the supramolecular copolymer can be disassembled to the host and guest polymers and its molecular weight will be decreased. When the polymeric micelles are chelated with Gd 3+ ion, they exhibit T 1 relaxivity as a kind of contrast agent for MRI. This contrast agent can maintain a large molecular size to stay in vivo and also can reduce its molecular size quickly and metabolize rapidly from the body by disassembled. Also, as the copolymer carries drugs, it displays burst release and thermal-response release behaviors, due to its dis-assembly and thermal-response PNIPAM chain respectively. Thus, the supramolecular copolymer from the host-guest inclusion complexation is expected to realize diagnosis and treatment feature for clinic.
研究领域:
材料科学
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医学影像
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药物递送
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DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Fangyuan Guo,Dongxue Huang,Wei Zhang,Qinying Yan,Qingliang Yang,Yan Yang,Hanbing Li,Junxian Yun,Weiyong Hong,Gensheng Yang
Elastomers are largely developed for biomedical applications; however, little is reported on them although they are an effective and controllable delivery system for proteins. In the present study, we investigated the pharmacokinetics, biosecurity, and hypoglycemic effect of an insulin-loaded elastomer formulation in diabetic rats. Cylindrical insulin-loaded elastomers were fabricated using a UV cross-linking process based on methyl-acrylic- star -poly(ε-caprolactone- co -D,L-lactide) cyclic ester and methyl-bi-acrylic-poly(ε-caprolactone-b-polyethylene glycol-b-ε-caprolactone) (CLPEGCLMA). The encapsulated insulin was well protected during the formulation. An in vitro pharmacokinetic study revealed that the rate of insulin release from the elastomers was affected by the hydrophilicity/hydrophobicity of the system and controlled by the CLPEGCLMA (hydrophilic prepolymer) composition. It was observed that insulin release followed the Higuchi model. In addition, the more hydrophilic elastomers showed higher degradation rates in vivo . Furthermore, in the pharmacodynamic study, all the elastomers, except those that contained star -poly(ε-caprolactone- co -D,L-lactide) (number-average molecular weight, Mn), polyethylene glycol (PEG) (kMn), ε-caprolactone/PEG (mol/mol), and CLPEGCLMA (weight, %) at a ratio of 3432:10:20:30, respectively, decreased blood glucose concentration and maintained it at a stable level. It was observed that the hypoglycemic effect of the drug-loaded elastomers was directly proportional to the rate of in vitro insulin release; however, emaciation was not observed. Moreover, elastomers play a positive role in biosecurity. Therefore, the elastomers might be effective carriers for the delivery of peptide drugs in the form of implants.
研究领域:
生物医学工程
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药物学
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材料科学
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DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2017
·Vol. 17
·期 7
·1600522
·
IF 3.238
Li Zhang,Dongjian Shi,Chunling Shi,Liangliang Dong,Xiaojie Li,Mingqing Chen
Novel biodegradable polymers with specific properties, structures, and tailorable designs or modifications are in great demand. Poly(phosphoester)s with good biocompatibility and degradability, as well as other adjustable properties have been studied widely because of their potential in biomedical applications. To meet more versatile and diverse biomedical applications, a novel multiarm star-shaped phosphorester triblock copolymer poly(amido amine)- block -poly(2-butynyl phospholane)- block -poly(2-methoxy phospholane) (PAMAM-PBYP-PMP) is synthesized via organo-catalyzed sequential ring-opening polymerization. Supramolecular micelles with good architectural stability are self-assembled into uniform spherical morphology in aqueous solution. Doxorubicin (DOX) can be encapsulated into the micelles with efficient loading capacity. A slow and sustained release in the environment of simulated intracellular lysosome (pH 5.0 with phosphodiesterase I) is observed. In addition, the copolymers and DOX-loaded supramolecular micelles exhibit low cell-toxicity and excellent anticancer activity toward HeLa cells. As a consequence, this multiarm star-shaped PAMAM-PBYP-PMP has great potential in drug delivery system for tumor treatment.
研究领域:
材料科学
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生物医学工程
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药学
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
Polymer Chemistry
·
2017
·Vol. 8
·期 27
·4043-4051
·
IF 5.375
Wenhua Yang,Changmin Yu,Chunxian Wu,Shao Q. Yao,Shuizhu Wu
MicroRNAs (miRNAs) are small regulatory noncoding RNAs that control a variety of biological processes. The regulation of many endogenous miRNAs is tightly associated with various diseases. Thus, the design of miRNA delivery systems with minimal endolysosomal trapping, efficient delivery and controlled miRNA release is urgently needed. Herein, we have developed a new star polymer which consists of a β-cyclodextrin (βCD) core and multiple cell-penetrating poly(disulfide) (CPD) arms. By subsequently loading the system with miRNAs and small molecule drugs, we have successfully proven that this novel drug delivery platform could efficiently enter mammalian cells (<2 h) without apparent endolysosomal trapping. The global Pearson's R value was calculated to be 0.31 between our complex and endolysosome, which is far below the threshold of >0.5 required for correlation. In addition, the GSH-triggered degradation of CPD arms and the subsequent intracellular release of miR-203 and CPT, as well as the combination therapeutic effects have been successfully demonstrated. In this way, we show that this novel platform could be used in future to minimize potential cytotoxicity encountered by many existing cationic branched polymer systems in miRNA delivery. Our results provide important starting points for using CPD-based polymers to design personalized delivery platforms.
研究领域:
药学
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生物技术
·
分子生物学
·
药物递送系统
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DOI
高影响因子
CHIRALITY
·
2021
·Vol. 34
·期 1
·61-69
·
IF 2.437
Hui Zou,Wen-Quan Liang,Qi-Liang Wu,Li Zhou,Xiao-Hua Hou,Na Liu,Zong-Quan Wu
Helical polymers present some interesting and distinctive properties, and one of the most distinguished applications of them is the chiral recognition and resolution of enantiomers. In this work, star-shaped hybrid helical poly (phenyl isocyanide) (PPI) with polyhedral oligomeric silsesquioxanes (POSS) as the core was designed and synthesized by “grafting to” strategy. The homoarm star-shaped hybrid POSS-(PPI) 8 was first obtained by the click reaction between azide-modified POSS (POSS-(N 3 ) 8 ) and alkynyl-modified PPI (PPI-Alkynyl). The hybrid POSS-(PPI) 8 was with predominated left-handed helical conformation and exhibited excellent ability in the enantioselective crystallization of racemic compounds. In the meantime, heteroarm star-shaped hybrid (PEG) 4 -POSS-(PPI) 4 was prepared by the click reaction of POSS-(N 3 ) 8 with PPI-Alkynyl and alkynyl-modified poly (ethylene glycol) (PEG-Alkynyl). The hybrid (PEG) 4 -POSS-(PPI) 4 was amphiphilic, and it could self-assemble to form spherical micelles in aqueous solutions.
研究领域:
高分子化学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）