SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Jianhong Liu,Xinyue Zhao,Li Zhang,Haowen Zhou,Xudong Li,Guorui Zheng,Xibin Zhou,Yongjin Peng,Jie Zhang
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by progressive joint destruction, where early diagnosis is crucial for impeding disease progression. Peroxynitrite (ONOO⁻), a key reactive nitrogen species, is critically involved in the pathogenesis of RA and represents a promising diagnostic target for early detection. Herein, we developed MRN, a mitochondria-targeting ratiometric fluorescent probe based on a Förster resonance energy transfer (FRET) mechanism for the dynamic monitoring of ONOO⁻ in RA inflammatory models. The probe integrates a rhodamine-naphthalimide FRET pair and a hydrazide group as the specific recognition unit, which facilitates a rapid, ONOO⁻-triggered ratiometric response within 30 seconds and achieves a detection limit of 7.5 nM. Furthermore, the conjugation of a triphenylphosphonium group ensures precise mitochondrial localization. Cellular assays demonstrated excellent biocompatibility and specific mitochondrial targeting. We successfully applied MRN for real-time ratiometric imaging of both endogenous and exogenous ONOO⁻ fluctuations in live BV-2 cells. Importantly, in a Complete Freund's Adjuvant (CFA)-induced rheumatoid arthritis mouse model, MRN enabled in situ ratiometric fluorescence imaging of ONOO⁻ at articular sites, revealing a strong positive correlation between the fluorescence signal intensity and the degree of inflammatory severity. This work establishes MRN as a novel and robust molecular tool for the early diagnosis of RA.
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高影响因子
Journal of Environmental Chemical Engineering
·
2025
·Vol. 14
·期 1
·120662
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IF 7.2
Bin Ou,Hongwei Rong,Baihui Cui,Jie Zhang,Fang Zhang,Dabin Guo
The coordination calcination method is used to form a coordination complex between Co 2 + and thiophene, which is adsorbed on carbon black (CB) and then calcined to prepare Co-S-C/CB single atom catalyst. Co-S-C/CB could efficiently activate peroxymonosulfate (PMS) by forming Co-S 3 coordination structure and Co-S 3 is the active site for activating PMS. Electron rich region was formed on the Co atom and the Co atom could keep in a low valence state during the catalytic process and donate electrons to PMS to produce radicals (•OH and SO 4 •- ) through a single-electron-reduction. Co-S-C/CB could not only promote PMS to generate •OH and SO 4 •- , but also inhibit the generation of 1 O 2 and O 2 •- . The radical pathway has the lowest Gibbs free energy (ΔG) compared to the 1 O 2 pathway and the Co(IV)=O pathway. Therefore, Co-S-C/CB could regulate the radical pathway of PMS. •OH and SO 4 •- are mainly responsible for the removal of Rhodamine B (RhB). Co-S-C/CB could be applied to efficiently degrade various organic pollutants and has good stability. Macro preparation of Co-S-C/CB could be achieved from both the preparation process and raw material aspects.
研究领域:
环境催化
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高级氧化技术
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材料化学
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纳米催化剂
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水处理
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高影响因子
MACROMOLECULES
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2025
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IF 5.2
Shengli Chen,Xuelei Dong,Yuhong Cui,Mingxue Xing,Min Wang,Xiongwei Qu,Fenfen Wang
Stimuli-responsive nanoparticles capable of reversible morphological transformations is a challenge in the field of intelligent polymers. This work presents a novel strategy termed “thermo-driven dynamic reversible self-assembly”, which enables efficient and reversible interconversion between polymersomes and worms, with over 95.0% structural retention after three cycles. This was achieved by grafting crystalline polycaprolactone (PCL) side chains onto the backbone of poly(4-vinylpyridine)-b-polystyrene via polymerization-induced self-assembly. Multiscale mechanistic analysis reveals that the crystallization and melting behavior of brush PCL side chains dynamically modulates the hydrophilic–hydrophobic balance. At low temperatures, the crystalline domains function as physical cross-linking points that stabilize the vesicles. Upon heating, the melting of these domains enhances chain segment mobility, thereby promoting a transition to low-curvature worms. Leveraging this temperature responsiveness, a radical inhibitor was encapsulated within the vesicle cavity, achieving a loading capacity of 13.4%, and constructed an active safety protection system. When applied to an acrylic acid polymerization system, the abrupt temperature increase caused by a runaway reaction triggered the vesicle-to-worm transition, resulting in the rapid release of 98.0% of the inhibitor and effectively preventing gelation. This work demonstrates thermo-driven reversible self-assembly of micelles, and integrates this capability with chemical safety protocols, offering a self-triggered, energy-free protective mechanism.
研究领域:
高分子化学
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材料科学
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智能响应材料
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化学工程
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纳米医学
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药物递送
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过程安全
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高影响因子
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
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2025
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IF 10.3
Weixia Wang,Yongji Zhang,Fei Zhao,Libo Wang,Fanpeng Meng,Shuchao Qin,Jinsheng Zhao
Carrier recombination in polymer photocatalysts involves both undissociated exciton decay and charge recombination, which are the main obstacles limiting their photocatalytic activity. Achieving efficient charge generation and separation in a polymer system is a fundamental strategy for the potential success of solar energy conversion to hydrogen, but it remains a huge challenge. In this study, we propose an innovative intermolecular π–π stacking strategy to construct a π-delocalized all-polymer S-scheme heterojunction for photocatalytic hydrogen evolution. Two conjugated porous polymers (CPPs)—PyB, composed of benzo[1,2-b:4,5-b′]dithiophene (BDT) and pyrene units, and PhB, composed of BDT and benzene—were synthesized and integrated with CN nanosheets. The highly planar and π-extended structure of PyB facilitated strong interfacial π–π stacking with CN, forming an extended π-delocalized network that enhanced the internal electric field (IEF), improved charge separation, and boosted visible-light absorption. As a result, the optimized PyB/CN-20 composite achieved a remarkable hydrogen evolution rate (HER) of 23.84 mmol⋅h −1 ⋅g −1 under visible light, approximately 287 times higher than that of pristine CN. This work underscores the critical role of polymer planarity and π-conjugation in heterojunction efficiency, and provides new insights into the rational design of π-delocalized S-scheme systems and establishes a general strategy for developing highly efficient, metal-free photocatalysts by leveraging molecular-level structural control.
研究领域:
材料化学
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光催化
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高分子科学
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能源材料
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纳米材料
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物理化学
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太阳能转换
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Wenbo Che,Yufeng Miao,Yifan Liu,Runxuan Wang,John Moyo,Youming Yu,Wenhui Bao,Yunyan Peng
Stimulus-responsive actuators play a crucial role in the next-generation intelligent systems. However, challenges such as complex fabrication processes, limited sustainability, and poor tolerance to complex deformations remain. This study introduces a sustainable “top-down” self-splicing strategy to fabricate spliced transparent wood film (TWF) for programmable hygromorphic soft actuators. Natural wood was subjected to delignification followed by TEMPO-mediated oxidation, yielding TWF with exceptional hygroscopicity. Two adhesive-free self-splicing methods: biomimetic “Mortise and Tenon” interlocking and self-adhesion using oxidized wood fibers enable arbitrary shaping and large-scale integration of spliced TWF. Since hydrogen bonding dominates interfacial bonding strength, the self-spliced TWF exhibits excellent tensile strength (up to 131.8 MPa), surpassing most plastic films and TWF joined with commercial adhesives. Interestingly, benefiting from the hygroscopicity and designability of self-splicing TWF, the resulting hygromorphic soft actuator achieves continuous rapid deformation and recovery, and programmable morphing into complex configurations ( e.g. , spirals, biomimetic mimosa and petals). This adhesive-free self-splicing approach enables the scalable production of TWF and yielding soft actuators with versatile morphing capabilities, low production cost, and sustainability, highlighting their potential in soft robotics and smart materials.
研究领域:
材料科学
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软体机器人
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智能材料
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可持续工程
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仿生学
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高影响因子
CARBOHYDRATE POLYMERS
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2025
·
IF 12.5
Chuhang Liu,Xiaojie Shi,Bo Lin,Zekun Song,Feng jiang,Mei-Chun Li,Chaozheng Liu,Changtong Mei
3D printing of cellulose-based porous materials with tailored architecture is of significant interest for advanced thermal insulation applications. However, most existing approaches lack internal hierarchical porosity, thereby limiting their insulation efficiency. Here, we propose an emulsion gel ink strategy based on high internal phase Pickering emulsions (HIPPEs) stabilized by lignin-containing cellulose nanofibrils (LCNFs) and reinforced with sodium alginate (SA). This approach integrates emulsion templating with direct ink writing (DIW), enabling simultaneous control of macroscopic geometry and microscopic pore structure. LCNFs with tunable lignin content and surface charge effectively stabilize oil–water interfaces, while SA provides a viscoelastic matrix, ensuring high printability. After freeze-drying, the printed porous monoliths exhibit low density (~17.7 mg·cm −3 ), high porosity (> 98 %), and hierarchical pores templated by emulsified droplets and LCNF-SA network. The resulting structures combine excellent mechanical resilience and low thermal conductivity (~0.031 W·m −1 ·K −1 ). This work provides a scalable route to bio-based 3D-printed porous materials with programmable porosity and multifunctional performance.
研究领域:
材料科学
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增材制造
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高分子科学
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热工工程
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可持续材料
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PubMed
高影响因子
Acta Biomaterialia
·
2025
·
IF 9.6
Wenjin Dai,Mengjun Zeng,Lu Zhang,Guangwei Shi,Hong Wang,Chengyi Xu,Riguang Zhao,Cong Zhang,Jiu Wang,Liqun Jiang
An intelligent hydrogel system that can rapidly release local anesthetics in response to simple mechanical kneading offers a patient-friendly solution for managing osteoarthritis (OA) pain during acute flare-ups. Conventional stimuli-responsive hydrogels often require specialized devices (e.g., near-infrared emitters and ultrasound generators), limiting their accessibility in real-world settings. A kneading-responsive hydrogel composed of oxidized hyaluronic acid (OHA) and carboxymethyl chitosan, incorporating pressure-sensitive multivesicular liposomes (pMVLs) loaded with phosphoric acid and benzocaine covalently linked to OHA, was developed in this study. Mechanical kneading (0.25 ±0.03 kg/cm²) ruptured the pMVLs, releasing acid to lower the gel pH from 7.4 to 6.7, thereby cleaving Schiff base bonds and accelerating benzocaine release by 2.26-fold in vitro . In OA-rat models, periarticular injection of the hydrogel significantly increased pain thresholds, and kneading raised benzocaine accumulation in the synovial fluid by 3.88-fold, improving locomotor activity and joint function. The release was gated by a predefined pressure threshold : the hydrogel remained quiescent under physiological interstitial pressures but was activated by conscious kneading (0.25 ± 0.03 kg/cm²), allowing for patient-controlled, on-demand analgesia. This kneading-responsive hydrogel enables self-controlled, on-demand analgesia without the need for specialized equipment, providing a convenient strategy for precision pain management in OA. Statement of Significance Many pain-relief options rely on clinic devices or fixed depots that patients cannot control. We report an equipment-free, kneading-responsive hyaluronic-acid hydrogel that converts gentle finger pressure (0.25 kg·cm⁻², measured) into on-demand local anesthesia for osteoarthritis flares. The reservoir combines a pH-sensitive OHA/CMS network with pressure-sensitive multivesicular liposomes that release phosphoric acid, transiently lowering the pH to cleave imine (Schiff-base) bonds and accelerate benzocaine release. In OA rats, a single kneading produced ∼48 h of drug elevation, while the depot persisted for up to 14 days; once-daily kneading maintained effective analgesia for up to 6 days, improving pain, mobility, and cartilage preservation. Benchmarking versus NIR/ultrasound highlights the trade-off between remote triggering and simple, patient-directed use. This self-managed platform enables localized, repeat-dosing pain control.
研究领域:
生物医学工程
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药物递送
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疼痛管理
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生物材料
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骨关节炎治疗
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PubMed
高影响因子
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2025
·
IF 2.4
Taiping Xie,Shengli Xie,Yuxuan He,Kailin Xu,Jin Qian
BACKGROUND Antibiotic pollution in aquatic environments poses significant threats to human health and ecosystems by promoting the spread of antibiotic resistance. RESULTS This study investigates the use of MoSe 2 -based bimetallic composite selenides (MoSe 2 /CoSe 2 and MoSe 2 /MnSe) to activate peroxymonosulfate (PMS) for the oxidation of levofloxacin (LEF), a model fluoroquinolone antibiotic. The composites were synthesized via a solvothermal method and characterized using SEM, TEM, XRD, and XPS, confirming the formation of heterojunction interfaces and the presence of active metal sites. Catalytic performance tests demonstrated that MoSe 2 /CoSe 2 and MoSe 2 /MnSe significantly enhanced LEF degradation, achieving removal efficiencies of 92.98% and 89.4%, respectively, compared to 49.07% with MoSe 2 alone. Optimization of reaction parameters revealed that PMS dosage, catalyst dosage, and pH critically influence degradation efficiency. Reusability tests confirmed the catalysts' stability over multiple cycles with minimal loss in activity. Electron paramagnetic resonance (EPR) and radical quenching experiments identified sulfate radicals (SO 4 •- ) as the primary active species driving LEF degradation. CONCLUSION This work provides a robust theoretical foundation for the application of SR-AOPs in wastewater treatment, highlighting the potential of MoSe 2 -based composites in mitigating antibiotic contamination. © 2025 Society of Chemical Industry (SCI).
研究领域:
环境科学
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材料化学
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水处理
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催化
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高影响因子
Advanced Science
·
2025
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IF 14.1
Jinghui Wang,Xiaoyu Liu,Yujiao Du,Yepu Chen,Jieyi Guo,Linyuan Fan,Min Tang,Xiaofeng Qiao,Yuanjie Zhu,Zhiyang Zhang,Chaojie Dong,Lizhen Wang,Yubo Fan
The mechanism of human tactile perception offers inspiration for developing a high-performance artificial sensory system. Pacinian corpuscles (PCs) allowing high-frequency tangential sensitivity that endows humans with the ability to perceive multidimensional tactile stimuli. However, replicating similar high-frequency and tangential perception as that of PCs in artificial systems remains a significant challenge. Here, an artificial PC (APC) from ultralight aerogel with a multilayer-stacked and anisotropic structure analogous to that of PC via a multi-directional freeze-drying method is reported. The APC sensor with radial-axial anisotropy exhibits tangential sensitivity (1022 kPa −1 ), detects multidimensional tactile stimuli, and identifies stick-slip states with high precision. By mimicking PC clusters, the APC sensor system achieves spatiotemporal sensing capabilities for discriminating frictional patterns (static, sliding, or rolling) and tracking slip. A robot equipped with the APC sensory system possesses enhanced tactile perception for diverse tactile events in active (100% accuracy) and passive (98.18% accuracy) interaction with humans. It is found that high-frequency components are crucial for stick-slip detection, providing insights into the underlying tangential tactile sensing mechanisms of PCs. The work exemplifies a bidirectional enhancement of understanding between technological innovation and biological mechanisms.
研究领域:
机器人学
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感知系统
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仿生学
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触觉传感
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材料科学
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DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Qi Xu,Yuwen Gai,Shuang Wang,Xinmeng Li,Weixiao Ding,Jian Cui,Peng Zhou,Luyu Yang,Lei Zhang,Dongping Sun
In recent years, the development of flexible wearable materials and electromagnetic shielding materials has progressed rapidly. The demand for monitoring movement data and providing protection against electromagnetic waves has also increased significantly. However, there is currently a lack of materials suitable for applications in high-humidity and underwater environments, which limits their ability to meet the needs of users in special conditions. In this study, we designed an aerogel sensor based on MXene and bacterial cellulose (BC) capable of monitoring movement in both dry and wet states while also exhibiting good electromagnetic wave absorption properties.The sensor showed a sensitivity of −6.43 with excellent linearity (99.8%) and stability. The sensor exhibits a high compressive strength of up to 15 kPa in the dry state, with a resistance change rate reaching 50% under 8% strain, and can undergo 710 cycles, demonstrating high sensitivity and stability. Under water-induced conditions, the sensor demonstrates high flexibility, shape-memory performance, and a wide strain range (0–80%) as a wet-state sensor, maintaining good structural stability and sensing performance throughout the dry–wet transition process. The BCNF/MXene sensor also demonstrates good resistance to electromagnetic interference. The RLmin of the BCNF/MXene-30% sensor reaches −45.60 dB, with an electromagnetic wave absorption rate of 99.99% and a relatively broad effective absorption bandwidth (4 GHz). This resistive sensor can be applied in electronic skins, human–machine interactions, smart wearable devices, and personalized health monitoring. Our work successfully demonstrated the application of water-sensitive shape-memory materials in electronic skins, health monitoring components, and electromagnetic wave protection.
研究领域:
材料科学
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柔性电子学
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传感器
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电磁屏蔽
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可穿戴设备
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纳米复合材料
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高影响因子
Foods
·
2025
·Vol. 14
·期 12
·2145
·
IF 5.1
Chang’e Wang,Yi Guo,Lili Zhang,Junjian Miao,Ying Lu
The by-products that may contain tetrodotoxin (TTX) produced during the processing of farmed pufferfish have caused food safety risks and environmental pollution. Peptidoglycan (PG) of lactic acid bacteria could adsorb TTX; however, its complex structure and poor solubility limited adsorption efficiency. In this study, hydroxyl modifications of three PGs (A3α, A1γ and A4α) were realized via TEMPO-mediated selective oxidation of the primary hydroxyl group. Compared with PGs, it was found that the carboxyl density of hydroxyl-modified PGs (HM-PGs) increased from 1.66 mmol/g to 3.33 mmol/g and the surface electronegativity increased from −36 mV to −59 mV. The adsorption capacity of HM-PGs to TTX reached 1.48 μg/mg, which was comparable to the adsorption of the conventional adsorbent chitosan for aflatoxin B1 (1.39 μg/mg). Moreover, HM-PGs decreased the toxicity of TTX from strong toxic to nearly non-toxic, with the toxicity reduction rate reached 99.85%. After treatment with HM-PGs, the mouse hippocampus and neuronal cell model confirmed that lower neural injury and sodium channel blocking effects were observed in the residual TTX, whose neurotoxicity was lower. Molecular docking simulation and physicochemical analysis revealed that the adsorption of TTX by HM-PGs was a complex adsorption mode driven by the synergy of physicochemical interaction. There were both physical adsorptions based on electrostatic and hydrophobic interactions and chemical binding with strong hydrogen bonding (1.46 Å) and Mayer bond order (0.1229). This study not only developed a new, efficient and safe tool for TTX removal, but also provided a theoretical basis for the development of biological toxin removal material.
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PubMed
高影响因子
JOURNAL OF POLYMER SCIENCE
·
2025
·
IF 3.6
Chenghua Yu,Yujing Mo,Jie Zhou,Zikeng Qiu,Yating Wang
Lack of color diversity results in the limited application of most superhydrophobic materials. Nanocellulose, a renewable biomass material with wide sources and excellent properties, has garnered significant research interest in superhydrophobic areas. Its excellent colorability provides favorable conditions for constructing colorful superhydrophobic materials. In this study, we introduced a method for fabricating colorful nanocellulose-based superhydrophobic coatings. Nanocellulose was dyed and constructed into micron–nanometer composite structure particles, which were modified by silanization and finally obtained colorful nanocellulose particles with superhydrophobicity. Then, the modified particles were mixed with polydimethylsiloxane (PDMS) proportionally to formulate the coatings, which could be sprayed on filter papers to obtain the colorful superhydrophobic surface. This coating could draw a variety of colorful patterns and exhibit self-cleaning properties with water contact angle of 156.6°. Because of its special surface wettability, colorful superhydrophobic coatings could also be used to efficiently separate oil–water mixtures. In addition, the obtained coatings also had good durability. After 70 frictions by the weights, the contact angle was still maintained at 150.7°. This preparation method was simple and mild preserving the inherent advantages of nanocellulose and introducing a diversity of colors. It offered a novel approach to personalized and multifaceted applications of superhydrophobic materials. Graphical Schematic illustration of the fabrication process for nanocellulose-based colored superhydrophobic coatings.
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高影响因子
危险品化学品经营许可证（带存储）