ELECTROCHIMICA ACTA
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2026
·
IF 5.8
Zhen-Fu Lin,Yu-Qi Ge,Yu-Zhu Zhao,Mei-Na Chen,Hao Li,Nai-Cui Liu,Zhencheng Chen,Guo-Cheng Han,Xiao-Zhen Feng,Heinz-Bernhard Kraatz
Beta-2-Microglobulin (β2M) is a critical biomarker for diseases such as kidney disorders and cancer. However, electrochemical detection methods for β2M remain scarce. Therefore, a novel electrochemical immunosensor for the ultrasensitive detection of β2M was developed in this study. It is based on a ternary composite of polyaniline (PANI), poly- l -cysteine (PL-Cys), and molybdenum disulfide (MoS₂) functionalized onto screen-printed carbon electrodes (SPCE). Through the specific recognition between Beta2-microglobulin antibody (anti-β2M) and its target antigen, and utilizing bovine serum albumin (BSA) to block non-specific binding sites, a BSA/anti-β2M/PANI/PL-Cys/MoS₂/SPCE immunosensor was constructed. Experimental results demonstrate that the sensor exhibits excellent linearity within the 0.001–500 ng/mL (R²=0.9924), with a detection limit as low as 0.33 pg/mL. It shows outstanding selectivity (RSD=2.69%), repeatability (RSD=0.74%), and long-term stability (30-day RSD=2.64%). Recovery rates in serum samples range from 100.40% to 103.76%, confirming its reliability in complex biological matrices. The sensor combines the signal amplification effect of the conductive substrate (PANI/L-Cys/MoS₂) with the impedance effect of the insulating biological layer (antibody-antigen complex), utilizing the quantitative relationship between target analyte concentration and signal attenuation to achieve detection. This approach provides an efficient and low-cost new strategy for on-site rapid screening.
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APPLIED SURFACE SCIENCE
·
2026
·
IF 6.9
JinPu Li,Jiyuan Wen,Kuang Li,Meiling Chen,Shicun Jin,Huining Xiao
In recent years, smart cellulosic nonwovens have emerged as a research hotspot due to their multifunctional integration capabilities. In this study, a multifunctional composite material (CNs-CaCO 3 -MoS 2 @TA) was fabricated through a stepwise fabrication process. First, tannic acid (TA) was employed to mediate the effective exfoliation of molybdenum disulfide (MoS 2 ) into nanosheets (MoS 2 @TA). Subsequently, calcium carbonate (CaCO 3 ) and the functionalized MoS 2 @TA nanosheets were successively integrated onto a cellulose nonwoven (CNs) substrate. Mechanical characterization revealed a significant enhancement in material strength compared to pure CNs, attributed to the synergistic effects between the interlayer-slip toughening mechanism of MoS 2 @TA and the rigid reinforcement provided by CaCO 3 . For photothermal conversion, the composite exhibited rapid heating characteristics under simulated sunlight, maintaining a surface temperature of 90 °C with excellent stability. This result benefits from the efficient combination of MoS 2 broadband light absorption and CaCO 3 light scattering effects. In addition, the CNs-CaCO 3 -MoS 2 @TA demonstrated 99.9% bactericidal efficiency against both E. coli and S. aureus through combined mechanisms including CaCO 3 -induced alkaline disruption, MoS 2 @TA-mediated photocatalytic ROS generation, and sharp nanosheet edge-induced physical membrane damages. These findings not only provide novel strategies for developing high-performance cellulose-based composites, but also open new avenues for smart nonwovens applications in medical and energy fields
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Bin Wen,Fan Chen,Yi Ran,Dongyun Que,Zhihao Zhang,Youwei Zeng,Yuyuan Yao
Molybdenum disulfide (MoS₂) is a promising inorganic co-catalyst for Fenton processes due to its structural durability and avoidance of secondary organic pollution. However, the conventional 2H-phase MoS₂ suffers from intrinsically low conductivity, severely limiting Fe 3+ reduction in the Fenton reaction. Herein, L-cysteine served as a multifunctional precursor during the preparation of MoS₂, promoting a slow-release sulfur supply, carbon‑nitrogen co-doping, and the prevention of restacking. The carbon and nitrogen co-doped molybdenum disulfide (CN-MoS 2 ) architecture was fabricated via a single-step hydrothermal reaction mediated by sodium molybdate, thiourea, and L-cysteine. Remarkably, benefiting from the introduction of L-cysteine, the resulting CN-MoS 2 exhibited a high 1 T-phase content (68%), abundant sulfur vacancies, and a substantially reduced particle size. CN-MoS 2 accomplished near-complete elimination of carbamazepine (CBZ) within merely 3 min, yielding a prominent apparent rate constant of 0.7111 min −1 , which is a 19-fold kinetic acceleration over thiourea-derived MoS 2 . CN-MoS₂ also exhibited high TOC removal, broad-spectrum degradation, and robust CBZ removal under various water conditions. Additionally, electrochemical analyses further verified that CN-MoS₂ reduced charge-transfer resistance and enriched electron density, thereby facilitating rapid electron shuttling to Fe 3+ . Concurrently, quenching experiments and electron paramagnetic resonance (EPR) diagnostics unambiguously validated SO 4 •- , 1 O 2 and O 2 •- as the driving reactive forces. Moreover, a continuous-flow device incorporating a CN-MoS 2 -based membrane exhibited outstanding performance in wastewater purification. This work offers a new strategy for designing high-activity co-catalysts for advanced oxidation processes.
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Nanomaterials
·
2026
·Vol. 16
·期 5
·327
·
IF 4.8
Gaorui Mai,Xin Tian,Zining Mei,Qinglin Deng,Lingmin Yao
Developing free-standing electrodes without the need of metal current collectors, binders, and conductive additives are essential for promoting the development of sodium-ion batteries (SIBs) to attain higher energy density. In this study, we developed and effectively synthesized a novel three-dimensional free-standing sodium-ion battery anode material with the composition of Bi@MoS2@C carbon nanofibers by cleverly utilizing the energy storage advantages of each material. By growing MoS2nanospheres on Bi carbon nanofibers and coating them with a carbon layer, this free-standing system achieves both structural optimization and synergistic performance enhancement. Experimental results show that this composite electrode has a remarkably high initial specific capacity of 275.31 mA h g−1at a current density of 0.5 A g−1, significantly exceeding that of Bi carbon nanofibers (150.6 mA h g−1). Furthermore, it retains a capacity retention of 96.07% after 800 cycles, which significantly exceeds that of pristine MoS2(72.33 mA h g−1) as a sodium-ion battery anode. The significant performance improvement originates from the free-standing structural design and synergistic effects of Bi carbon nanofibers, MoS2nanospheres and carbon layer, which not only provide 3D electron transport pathways and improved conductivity but also effectively accommodate volume changes during the charging and discharging processes. This work offers a promising and practical strategy for designing high-performance free-standing energy storage electrodes through hybrid mechanisms and synergistic effects.
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Biomaterials Science
·
2022
·Vol. 10
·期 15
·4243-4256
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IF 7.59
Rames Kaewmanee,Fan Wang,Yongkang Pan,Shiqi Mei,Jirut Meesane,Fengqian Li,Zhaoying Wu,Jie Wei
Implanted materials with both osteogenic and antibacterial functions are promising for facilitating osteointegration and preventing infection for orthopedic applications. In this work, we synthesized flower-like molybdenum disulfide (fMD) submicro-spheres containing nanosheets, which were incorporated onto the microporous surface of polyimide (PI) via concentrated sulfuric acid, suspending fMD contents of 5 wt% (SPM1) and 10 wt% (SPM2). Compared with sulfonated polyimide (SPM0), both SPM1 and SPM2 with microporous surfaces containing fMD exhibited nano-submicro-microporous surfaces, which improved the surface roughness, wettability, and surface energy. Due to there being more fMD submicro-spheres on the microporous surface, SPM2 revealed a better antibacterial effect than SPM1. In addition, compared with SPM1 and SPM0, SPM2 with more fMD significantly promoted rat bone marrow-derived stromal cell response in vitro. Moreover, SPM2 remarkably enhanced new bone formation and osteointegration in vivo. In summary, the combination of fMD with the microporous surface of SPM2 resulted in a nano-submicro-microporous surface with optimized surface performance, which possessed not only osteogenic bioactivity but also an antibacterial effect. As a bone implant, SPM2 with osteogenic and antibacterial functions may have enormous potential as a bone tissue substitute.
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ACS Applied Energy Materials
·
2021
·
IF 6.024
Huilin Fan,Pengchang Mao,Gongxu Lan,Chang Liu,Jiayuan Chen,Zhiyuan Wang,Zhipeng Li,Runguo Zheng,Yanguo Liu,Hongyu Sun
Two-dimensional (2D) ultrathin MoS2 nanosheets, owing to their abundant active sites, tunable interlayer space, and favored ion and mass diffusion, show promise as anode materials for energy storage. However, the low electronic conductivity due to the intrinsic semiconductor structure (2H-MoS2), the spontaneous aggregation caused by the large van der Waals force between layers, and the huge volume alteration during the entire reaction hinder the practical applications of MoS2-based anodes. Here, by employing a facial solvothermal approach, we uniformly disperse metallic-phase MoS2 (1T-MoS2) nanosheets on the functionalized carbon nanotube (CNT) surface to form a 1D@2D hierarchical architecture. The obtained CNT@1T-MoS2 composites show strong covalent interface interaction and improved electronic conductivity. The distinct phase layout, morphology, and component impart the CNT@1T-MoS2 electrode with outstanding sodium-storage performance. The CNT@1T-MoS2 electrode retains a capacity of 542.3 mA h g–1 at 0.1 A g–1 after 50 cycles. Even at a large current density of 20 A g–1, the electrode still gives a high capacity of 153.4 mA h g–1. Moreover, when it is applied in lithium storage, the CNT@1T-MoS2 electrode also possesses good stability with a capacity up to 913.5 mA h g–1 experiencing 50 cycles at 0.1 A g–1 as well as satisfactory fast-charging capability (613.6 mA h g–1 at 5A g–1). This work shows that controlling the phase structure and interface interaction is effective to boost the application of transition-metal dichalcogenide-based composite electrodes in energy storage and conversion.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Jiameng Liu,Shuangrun Zhao,Changbao Wang,Yashen Ma,Linghao He,Baozhong Liu,Zhihong Zhang
In this work, a two-dimensional heterostructure of molybdenum disulfide (MoS 2 ) and nickel hydroxyl oxide (NiOOH) nanosheets supported on catkin-derived mesoporous carbon (C-MC) was constructed and exploited as an efficient electrocatalyst for overall water splitting. The C-MC nanostructure was prepared by pyrolyzing biomass material of catkin at 600 °C in N 2 atmosphere. The C-MC network exhibited hollow nanotube structure and had a large specific surface area, comprising trace nitrogen and a large amount of oxygen vacancies. It further served as the support for the growth of NiOOH nanosheets (NiOOH@C-MC), which was combined with MoS 2 nanosheets by in situ growth, yielding a multicomponent electrocatalyst (MoS 2 @NiOOH@C-MC). By integrating the superior hydrogen evolution reaction (HER) performance of MoS 2 , oxygen evolution reaction (OER) performance of NiOOH, and the fast electron transfer capability of C-MC, the prepared MoS 2 @NiOOH@C-MC illustrated a low potential of − 250 mV for HER and 1.51 V for OER at the current density of 10 mV cm −2 . Consequently, when applied as the working electrode for driving overall water splitting in a two-electrode system, the bifunctional MoS 2 @NiOOH@C-MC electrocatalyst displayed a low cell voltage of 1.62 V at the current density of 10 mA cm −2 . The present work provides a new strategy that uses biomass material for developing bifunctional electrocatalyst for overall water splitting.
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RSC Advances
·
2021
·Vol. 11
·期 27
·16490-16499
·
IF 3.361
Li Lei,Zhuo Peng,Ting Liang,Hai-Rong Yu,Chang-Jing Cheng
Herein we report solvothermal synthesis of poly(acrylic acid) (PAA) decorated magnetic molybdenum disulfide nanosheets (MMoS2/PAA) for highly efficient adsorption of three cationic dyes of basic fuchsin (BF), methylene blue (MB), and crystal violet (CV) from aqueous solutions. The synthesized MMoS2/PAA was characterized by several techniques including transmission electron microscopy (TEM), Fourier transform-infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), and dynamic light scattering (DLS). Due to the strong electrostatic interaction between cationic dyes and the anionic nanosheet surface, the obtained MMoS2/PAA showed ultrafast adsorption of BF, MB and CV within 2 min with high adsorption capacities of 886.1, 709.0, and 633.6 mg g−1, respectively, much higher than those materials reported recently. PAA molecules bound on the nanosheets played a crucial role in significantly enhancing the dye adsorption. The adsorption kinetics and isotherms of three dyes onto the MMoS2/PAA were well described by the pseudo-second-order kinetic and the Langmuir models. Moreover, the MMoS2/PAA also exhibited high removal efficiencies for various mixed-dye solutions. Besides, such a functional nanomaterial could be effectively recovered from dye solutions under an external magnetic field and reused for dye adsorption without compromising on its performance indicating it can serve as an excellent adsorbent for effective removal of a variety of cationic organic pollutants from industrial effluents.
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JOURNAL OF PHARMACY AND PHARMACOLOGY
·
2021
·Vol. 73
·期 8
·1128-1135
·
IF 3.765
Li Guo,Meng Fayan,Lu Taicheng,Wei Liying,Pan Xin,Nong Zhenzhen,Wei Mei,Liao Chuanan,Li Xuehua
ObjectiveMolybdenum disulfide (MoS2) has been developed for medical uses due to its excellent medically beneficial characteristics. This research was designed to develop a multifunctional nano-drug delivery system based on the nano-structure of MoS2 for combined chemo/gene/photothermal therapy targeting multidrug-resistant cancer.MethodsMoS2 nanosheets were prepared by a hydrothermal reaction and modified. Afterward, the nanocarrier was characterised. In vitro cytotoxicity of the drug delivery systems on human breast adenocarcinoma cell lines was assessed.Key findingsThe nanocarrier was a flake-like structure with a uniform hydrodynamic diameter and possessing good colloidal stability. The nanocarrier showed the capacity to be deployed for co-delivery of Doxorubicin (DOX) and siRNA. The release of DOX could be triggered and enhanced by pH and application of near-infrared (NIR) laser. The nanocarrier had a good photothermic response and stability. The nanocarrier had little effect on the cells and exhibited good biocompatibility. Measurement of the therapeutic efficacy showed that synergistic therapy combining chemo-, gene- and photothermal therapy deploying this drug delivery system will achieve a better anticancer effect on drug-resistant cancer cells than DOX alone.ConclusionsOur results suggest that this drug delivery system has potential application in the therapeutic strategy for drug-resistant cancer.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Jing Wang,Yuxing Liu,Shuo Wang,Xinle Liu,Yipeng Chen,Peiyao Qi,Xiaofei Liu
Existing conductive hydrogels suffer from poor mechanical performance required for flexible wearable sensors. Herein, molybdenum disulfide (MoS 2 ) nanosheet enhanced crosslinked polyacrylamide-acrylic-Fe 3+ (PAAM-Fe 3+ ) hydrogels as strain sensors were synthesized by MoS 2 catalyzing the autogelation at room temperature. The obtained hydrogels possessed high tensile strength (4.19 MPa), tensile elongation (594.6 %), elasticity (1.5 MPa), and high toughness (14 MJ/m 3 ). The prepared hydrogels also achieved high self-recovery ability; the recovery efficiency of the compression stress was 136 % within 1 min. Based on microstructure observation and mechanical behavior analysis, we demonstrated that the existence of MoS 2 and FeCl 3 provided reversible physical crosslinking points and that MoS 2 utilized adsorption to attract more Fe 3+ to enhance ionic coordination in the system, leading to significantly improved mechanical properties and fatigue resistance. The hydrogels were further demonstrated to be strain sensors with high sensitivity (with high gauge factors of 1.50 and 9.06 at subtle (<100 %) and large strains (400 %)). Moreover, the ionic sensors successfully supplied real-time feedback on the movements of the human body. Accordingly, hydrogels offer promising insights for flexible electronic devices, sensors, human health monitoring and soft robots.
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MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 4
·1-8
·
IF 6.232
Li Lin,Han Dandan,Wang Mingwei,Han Yehong,Yan Hongyuan
A composite was synthesized from two-dimensional molybdenum disulfide (MoS 2 ) nanosheets and hypercrosslinked polymers (HCP), and the composite was characterized by infrared spectroscopy, scanning electron microscopy, and specific surface area. The fluffy and porous structure and multiple adsorption sites (π-interaction, static electricity, hydrogen bonding) make it ideal for use as an adsorbent. A pipette tip solid-phase extraction with the composite as the adsorbent combined with HPLC–FLD was developed to determine trace amounts of polycyclic aromatic hydrocarbons (phenanthrene, anthracene, fluoranthene, pyrene, benzo(α)anthracene) in environmental water. Under optimal extraction conditions, the method has a wide linear range (0.5–100 ng mL −1 ) and low limit of detection (0.024–0.099 ng mL −1 ), and the recoveries of PAHs from spiked environmental water were 73.8% to 123.6% (relative standard deviation ≤ 6.7%, n = 3).
Schematic representation of a three-dimensional molybdenum disulfide–ethylenediamine–hypercrosslinked polymer composite (MoS 2 –EDA–HCP) using pipette tip solid-phase extraction adsorbent for extracting trace levels of polycyclic aromatic hydrocarbons (PAHs) prior to HPLC–FLD. HCP, hypercrosslinked polymer; MoS 2 , molybdenum disulfide; EDA, ethylenediamine
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BIOSENSORS & BIOELECTRONICS
·
2016
·
IF 7.476
Hong-Lei Shuai,Ke-Jing Huang,Ying-Xu Chen,Lin-Xia Fang,Meng-Pei Jia
An ultrasensitive electrochemical biosensor for detecting microRNAs is fabricated based on hollow molybdenum disulfide (MoS 2 ) microcubes. Duplex-specific nuclease , enzyme and electrochemical–chemical–chemical redox cycling are used for signal amplification . Hollow MoS 2 microcubes constructed by ultrathin nanosheets are synthesized by a facile template-assisted strategy and used as supporting substrate. For biosensor assembling, biotinylated ssDNA capture probes are first immobilized on Au nanoparticles (AuNPs)/MoS 2 modified electrode in order to combine with streptavidin-conjugated alkaline phosphatase (SA-ALP). When capture probes hybridize with miRNAs, duplex-specific nuclease cleaves the formative duplexes. At the moment, the biotin group strips from the electrode surface and SA-ALP is incapacitated to attach onto electrode. Then, ascorbic acids induce the electrochemical–chemical–chemical redox cycling to produce electrochemical response in the presence of ferrocene methanol and tris (2-carboxyethyl) phosphine. Under optimum conditions, the proposed biosensor shows a good linear relationship between the current variation and logarithm of the microRNAs concentration ranging from 0.1 fM to 0.1 pM with a detection limit of 0.086 fM (S/N=3). Furthermore, the biosensor is successfully applied to detect target miRNA-21 in human serum samples.
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危险品化学品经营许可证（带存储）