ACS Applied Bio Materials
·
2018
·
IF 0
Xiaojuan Wei,Jian Shen,Zheng Gu,Yazhi Zhu,Feng Chen,Mingqiang Zhong,Li Yin,Yao Xie,Zhenjie Liu,Wei Jin,Mehdi Nouri,Lingqian Chang
Polydimethylsiloxane (PDMS) is a common biomaterial with excellent properties. However, its inherent hydrophobicity impedes cell growth and differentiation. PDMS is an intrinsically inert material, which limits its applications to specific scenarios where responsive materials are needed. Dopamine can easily adhere to various substrate surfaces through noncovalent and covalent interactions. In this work, a bioinert PDMS surface was modified into a bioactive surface by biocompatible and pH-sensitive polydopamine (PDA). The binding of PDA and PDMS in different forms was verified by the typical scanning electron microscopy (SEM) and atomic force microscope (AFM). By PDA film modification, the contact angle of PDMS was significantly reduced. Hydrophobicity was achieved by PDA nanosphere (PDA NS) modification. PDA-modified PDMS was also found to be pH-sensitive, as validated by contact angle measurement, macroscopic friction test, and protein adsorption. Compared to an unmodified surface, the PDA significantly improved cell adhesion, proliferation and spreading. We came to a conclusion that the surface roughness of PDA-modified PDMS had little effect on cell growth and the cytocompatibility of the materials was mainly determined by the surface chemical properties. Our results further validated that PDA/PDMS is pH-sensitive and can effectively promote cell growth and proliferation.
研究领域:
生物材料
·
生物医学工程
·
表面化学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Xuanjun Li,Xiaojing Su,Junping Liao,Pingping Deng,Zeyuan Lu,Shengye Chen,Kunquan Li,Hongqiang Li,Wenjian Wu
pH-Responsive superwetting materials have found increasingly extensive applications in oil-water separation. To broaden the response range of such materials, researchers have proposed dual pH-responsive materials for this application. While these materials exhibit wettability transitions under both acidic and alkaline conditions, they are still limited by poor recovery of superhydrophobicity. To address this limitation, a conductive superhydrophobic fabric with alkaline-responsive properties was fabricated by introducing silver nanowires onto the textile substrate followed by grafting hydrophobic and pH-responsive functional chemicals. The CG/Ag-S fabric exhibited excellent superhydrophobicity (water contact angle at 153.7°), and presented dual-induced pH response to both alkaline conditions and electric field. Notably, the fabric maintained its superhydrophobicity and stable responsiveness after 13 response cycles, with alkaline droplets (pH at 13) fully permeating through it within 30 s. Additionally, electrolysis-induced surface alkalization enabled water to wet and permeate through the fabric within 60 s for effective light oil-water separation. In oil-water separation tests, the CG/Ag-S fabric achieved a separation efficiency of 95.4 % for heavy oil-water mixtures with a flux of 1.68 × 10 4 L·m −2 ·h −1 before pH response, and a separation efficiency of 97.8 % for light oil-water mixtures with a flux of 1.72 × 10 4 L·m −2 ·h −1 after pH response. The design of dual-induced pH-mono-responsiveness solves the superwettability recovery challenge of pH-dual-responsiveness materials, and the dual-induced response capability also broadens the response range of pH-responsive materials.
研究领域:
材料科学
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化学工程
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环境科学
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表面工程
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智能材料
✓ 已验证
产品关联
DOI
高影响因子
Biotechnology for Biofuels and Bioproducts
·
2022
·Vol. 15
·期 1
·1-10
·
IF 0
Hua Xia,Zhang ChenHui,Han Jian,Xu Yong
Background Hydroxyl acid is an important platform chemical that covers many industrial applications due to its dual functional modules. At present, the traditional technology for hydroxyl acid production mainly adopts the petroleum route with benzene, cyclohexane, butadiene and other non-renewable resources as raw materials which violates the development law of green chemistry. Conversely, it is well-known that biotechnology and bioengineering techniques possess several advantages over chemical methods, such as moderate reaction conditions, high chemical selectivity, and environmental-friendly. However, compared with chemical engineering, there are still some major obstacles in the industrial application of biotechnology. The critical issue of the competitiveness between bioengineering and chemical engineering is products titer and volume productivity. Therefore, based on the importance of hydroxyl acids in many fields, exploring a clean, practical and environmental-friendly preparation process of the hydroxyl acids is the core purpose of this study. Results To obtain high-purity hydroxyl acid, a microbiological regulation for its bioproduction by Gluconobacter oxydans was constructed. In the study, we found a critical point of chain length determine the end-products. Gluconobacter oxydans catalyzed diols with chain length ≤ 4, forming hydroxyl acids, and converting 1,5-pentylene glycol and 1,6-hexylene glycol to diacids. Based on this principle, we successfully synthesized 75.3 g/L glycolic acid, 83.2 g/L 3-hydroxypropionic acid, and 94.3 g/L 4-hydroxybutyric acid within 48 h. Furthermore, we directionally controlled the products of C5/C6 diols by adjusting pH, resulting in 102.3 g/L 5‑hydroxyvaleric acid and 48.8 g/L 6-hydroxycaproic acid instead of diacids. Combining pH regulation and cell-recycling technology in sealed-oxygen supply bioreactor, we prepared 271.4 g 5‑hydroxyvaleric acid and 129.4 g 6-hydroxycaproic acid in 6 rounds. Conclusions In this study, a green scheme of employing G. oxydans as biocatalyst for superior-quality hydroxyl acids (C2–C6) production is raised up. The proposed strategy commendably demonstrated a novel technology with simple pH regulation for high-value production of hydroxyl acids via green bioprocess developments.
研究领域:
生物化学
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绿色化学
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生物工程
✓ 已验证
DOI
PubMed
COLLOID AND POLYMER SCIENCE
·
2016
·Vol. 295
·期 1
·1-12
·
IF 1.89
Qi Peilan,Bu Yongqiang,Xu Jing,Qin Benkai,Luan Shujuan,Song Shiyong
Many tumor cells have acidic microenvironment that can be exploited for the design of pH-responsive drug delivery systems. In this work, well-defined pH-sensitive and biodegradable polymeric micelles were prepared and evaluate as carrier of paclitaxel (PTX). A diblock copolymer constituting of a poly(ethylene glycol) (PEG) and a polycaprolactone (PCL) segment linked by a pH-sensitive hydrazone bond (Hyd), which was denoted as mPEG-Hyd-PCL, was synthesized. The copolymer was assembled to micelles with mean diameters about 100 nm. The mean diameters and size distribution of the hydrazone-containing micelles increased obviously in mildly acidic environments while kept unchanged in the neutral. No significant change in size was found on polymeric micelles without hydrazone (mPEG-PCL). PTX was loaded into micelles, and the anticancer drug released from mPEG-Hyd-PCL micelles was promoted by the increased acidity. In vitro cytotoxicity study showed that the PTX-loaded mPEG-Hyd-PCL micelles exhibited significantly enhanced cytotoxicity against HepG2 cells compared to the non-sensitive mPEG-PCL micelles. These results suggest that hydrazone-containing copolymer micelles with pH sensitivity and biodegradability show excellent potential as carriers of anticancer drugs.
研究领域:
药剂学
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肿瘤学
·
生物材料学
✓ 已验证
DOI
高影响因子
MATERIALS SCIENCE FORUM
·
2020
·
IF 0
Shu Guo Dong,Gui Hua Cui,Qian Duan
A novel end-functionalized glycopolymer poly (3-O-methacryloyl-D-glucofuranose) -b-poly (2-Diethylaminoethyl Methacrylate) (PMAGlc-b-PDEA-ZnTAPc) with zinc (II) teraamaninophthalocyanine was synthesized. First, a pH-responsive copolymer PMAIpG-b-PDEA was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Then PMAIpG-b-PDEA reacted with ZnTAPc and deprotected to form a water-soluble and pH-responsive photosensitizer. The structure of the PMAGlc-b-PDEA-ZnTAPc was characterized by 1H NMR and GPC. The photophysical properties were evaluated by UV-Vis and fluorescence spectra. The PMAGlc-b-PDEA-ZnTAPc can generate singlet oxygen species with good singlet oxygen quantum yields (Φ△=0.38), which is believed to be the major cytotoxic reactive oxygen species (ROS) for photodynamic therapy. The ZnPc functionalized glycopolymer will be used as a potential photosensitizer in the fields of photodynamic therapy.
研究领域:
材料科学
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生物医学工程
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药物化学
✓ 已验证
DOI
COLLOIDS AND SURFACES B-BIOINTERFACES
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2017
·
IF 3.887
Zili Gu,Minglu Chang,Yang Fan,Yanbin Shi,Guimei Lin
As current tumor chemotherapy faces many challenges, it is important to develop drug delivery systems with increased tumor-targeting ability, enhanced therapeutic effects and reduced side effects. In this study, a pH-sensitive liposome was constructed containing CHEMS-anchored PEG2000 for extended circulation and NGR peptide as the targeting moiety. The NGR-modified docetaxel-loaded pH-sensitive extended-circulation liposomes (DTX/NGR-PLL) prepared possess suitable physiochemical properties, including particle size of approximately 200 nm, drug encapsulation efficiency of approximately 70%, and pH-sensitive drug release properties. Experiments performed in vitro and in vivo on human fibrosarcoma cells (HT-1080) and human breast adenocarcinoma cells (MCF-7) verified the specific targeting ability and enhanced antitumor activity to HT-1080 cells. The results of intravenous administration demonstrated that NGR-modified liposomes can significantly and safely accumulate in tumor tissue in xenografted nude mice. In conclusion, the liposomes constructed hold promise as a safe and efficient drug delivery system for specific tumor treatment.
研究领域:
药学
·
肿瘤学
·
药物递送系统
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Jing Wang,Cheng Yang,Jianzhong Jiang
Plant-based proteins have garnered increased attention in recent years due to their unique interfacial properties and biocompatibility. However, their low solubility under neutral pH conditions has always limited their applications. In this paper, oat globulin (OG) (0.01 wt% - 0.05 wt%) could solely stabilize Pickering emulsions with controllable rheological properties at different pH without any modifications. Low viscosity Pickering emulsions (V oil :V water = 1:1) with stability exceeding six months were formed at pH= 2 (221 Pa s) and 12 (109 Pa s), owing to the formation of small OG aggregates (100 nm) with high interfacial activity. Conversely, at pH= 5–10, Pickering emulsions with high viscosity were obtained, where larger-size OG particles aggregated at the oil-water interface. Therefore, the stability, droplet size, and viscosity of the Pickering emulsions stabilized by OG particles could be regulated by pH variation. The strategy harnesses the OG aggregation state at diverse pH levels to engineer emulsions with distinct properties, avoiding the need for chemical grafting modifications, heat, or high-intensity ultrasound treatments, which holds promise for potential applications in functional materials.
研究领域:
食品科学
·
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
CELLULOSE
·
2025
·
IF 4.8
Li Xuanjun,Su Xiaojing,Deng Pingping,Chen Shengye,Chen Zhuohan,Li Kunquan,Wu Wenjian
In recent years, intelligent response membrane materials have aroused considerable interest in controllable oil–water separation. However, challenges such as unstable response repeatability and easy bacterial contamination continue to hinder their effective use. Herein, a superhydrophobic fabric with pH responsiveness and antibacterial property were synthesized by combing (3-mercaptopropyl)trimethoxysilane with AgNPs and pH-responsive polymer on a fabric substrate. The fabric persisted superhydrophobicity with a WCA of 156° under natural conditions, while underwent a controlled transition of surface wettability in acidic environments. Heavy oil–water mixtures and light oil–water mixtures achieved controllable separation both before and after pH response. The fabric exhibited outstanding oil–water separation capability, achieving a separation efficiency of 98.0% and a separation flux of up to 11,025.0 L·m −2 ·h −1 . The pH response and oil–water separation demonstrated excellent repeatability. Specially, the pH responsiveness was maintained for up to 10 cycles, and the oil–water separation remained repeatable for up to 15 cycles. Even when tested under various environmental conditions, the superhydrophobicity was retained. Additionally, the fabric possessed remarkable antibacterial property with an efficiency reaching 90.4%. The preparation of the superhydrophobic fabric serves as a valuable reference for developing multifunctional and stable intelligent materials for oil–water separation. Graphical abstract
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Xin Zhang,Ke Jiang,Huajun He,Dan Yue,Dian Zhao,Yuanjing Cui,Yu Yang,Guodong Qian
A fluorescent pH sensor based on post-synthetically modified nanoscale UiO-67-bpydc by encapsulating Eu 3+ cations in the pores was fabricated. The Eu 3+ incorporated sample (Eu 3+ @UiO-67-bpydc) shows excellent luminescence due to the sensitization and protection provided by the parented framework. Subsequently, Eu 3+ @UiO-67-bpydc was developed as a pH sensor. Eu 3+ @UiO-67-bpydc shows good chemical resistance to both acidity and alkalinity solutions with pH ranging from 1.06 to 10.99, which makes it potentially useful for wide-range pH sensor. In addition, cycling experiments have demonstrated the utilizability of the sensor. The MTT analysis shows that Eu 3+ @UiO-67-bpydc possesses favourable biocompatibility. Furthermore, fluorescence imaging of Eu 3+ @UiO-67-bpydc in PC12 cells was also performed to test its feasibility in vivo. Given its exceptional stability and pH-dependent fluorescent intensity, the fluorescent probe should be a promising candidate for application in fluorescent pH sensing in vitro and in vivo.
研究领域:
材料科学
·
生物医学工程
·
分析化学
✓ 已验证
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2018
·
IF 2.975
Lei Lei,Hengchang Ma,Jiawei Lv,Tao Wang,Yuan Yang,Pei Yin,Ziqiang Lei,Yanfang Qin,Yucheng Ma,Wenhuan Yao
Materials hybrided by organic and inorganic partners via chemical bonds formation are able to display stable and multi-functional behaviors. Then, the versatile sensing platform could be established depending on their specific chemical and physical properties. In this research paper, we prepared the fluorescence materials (POSS-PDB and POSS-NTB) by a simple method. Among of them, POSS-NTB was verified as a mesoporous material with a narrowed pore diameter around 17 nm and the large Brunauer-Emmett-Teller (BET) surface area of 227 m 2 /g. Then, the solid powder of POSS-NTB was selected and evidenced as effective gas sensor toward CO 2 , N 2 and O 2 at 273 K under 1 atm pressure. Additionally, these fluorescence materials could be successfully applied as a pH sensor in the solution phase. Through combining biocompatible POSS and fluorescent molecules, POSS-NTB could enter into the cells and aggregate in the cytoplasm successfully.
研究领域:
材料科学
·
生物医学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2018
·
IF 4.513
Bincheng Xu,Huaili Zheng,Hui Zhou,Yongjuan Wang,Kun Luo,Chun Zhao,Yu Peng,Xinyu Zheng
In this work, a novel chitosan-based magnetic adsorbent [poly(2-(dimethylamino)ethyl methacrylate) grafted magnetic chitosan microspheres , GMCMs] was synthesized by graft polymerization of (2-(dimethylamino)ethyl methacrylate on the surface of magnetic chitosan microspheres (MCMs). The as-prepared GMCMs exhibited significantly enhanced adsorption capacity towards anionic dyes (e.g., Acid Green 25 and Reactive Blue 19) compared with MCMs. It is due to the fact that the abundant tertiary amine groups of the grafted polymer protonated at low pH and the polymer chains stretched as a result of electrostatic repulsions and chain-solvent interactions. The stretched polymer chains provided a variety of adsorption sites, which efficiently adsorbed dyes through electrostatic interactions and hydrogen bonding . While, in alkaline conditions, the tertiary amine groups were deprotonated and the polymer chains collapsed due to hydrophobic interactions, which facilitated the regeneration of the dye-loaded GMCMs at high pH. The regenerated GMCMs showed excellent adsorption performance even after five adsorption–desorption cycles. Besides, the GMCMs could be rapidly separated from aqueous solutions under an external magnetic field. Therefore, the GMCMs materials bear great application potentials in water treatment owing to its high adsorption capacity, pH-responsiveness, facile regeneration and good reusability.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Polymer Chemistry
·
2015
·Vol. 6
·期 11
·2069-2075
·
IF 5.52
Fan Jia,Yin Wang,Haibo Wang,Qiao Jin,Tongjiang Cai,Yangjun Chen,Jian Ji
Ideal drug delivery systems are required to be stable in circulation, while instable at targeted sites to induce rapid drug release. To address this dilemma, novel light cross-linkable and pH de-cross-linkable micelles were developed as drug nanocarriers. Poly(ethylene glycol)-poly-(hydrazone umbelliferone)-aspartamide (mPEG-OMC) with light responsive coumarin moieties and pH responsive hydrazone groups in the side chains was synthesized. The polymers can self-assemble into micelles, which can be conveniently stabilized via UV-light induced cross-linking based on the dimerization of coumarin moieties. While under slight acidic conditions, the cross-linked micelles can also be de-cross-linked by the cleavage of hydrozone bonds in the cross-linking segments, accelerating the release of encapsulated drugs. Thus the benefits of pH and light stimuli-responsiveness can be combined and their disadvantages are avoided. The doxorubicin-loaded micelles showed high mortality towards HepG2 cells. We have demonstrated the UV light cross-linkable micelles with pH-triggered de-cross-linking properties as a new approach for designing smart drug delivery systems.
研究领域:
药剂学
·
生物材料学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）