Food Bioscience
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2024
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IF 4.8
Li Jin,Xinyu Zheng,Chenxi Yu,Ping Li,Guiran Xiao
Metastasis is one of the most important factors related to malignant tumor development and therapeutic failure. Phytic acid (PA), a poly-phosphorylated inositol derivative in plant seeds and grains, has been shown to have antitumoral activity. However, the effect of PA on tumor metastasis and the underlying mechanisms remain uncharacterized. In the current study, we aimed to identify the effect of PA on tumor metastasis by employing a Drosophila model of malignant tumor Raf GOF Scrib −/− . We observed that PA supplementation in food inhibited the invasion and migration of tumors. Further studies indicated that PA drives Yki phosphorylation and inactivation through Lats kinase, which subsequently results in decreased expression of the JAK/STAT pathway ligands unpaired cytokines (Upds). Moreover, the reduced JAK/STAT pathway inhibits the recruitment and proliferation of hemocytes. To summarize, these findings provide valuable pathological and mechanistic insights into the potential application of PA for functional food or natural medicine development.
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SCIENCE OF THE TOTAL ENVIRONMENT
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2025
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IF 8
Wenju Zhu,Shuang Xu,Xiaokang Yang,Kai Song,Shuixia Liu,Shuolong Wang,Wei Peng,Zhao Dai,Chunlei Jiang
Phytic acid's high-efficiency flame retardant and N-halamine antibacterial were synergistically applied to cotton fibers for durable antibacterial and flame retardancy. Antimicrobial flame retardant structures were characterized by H Nuclear Magnetic Resonance Spectra (NMR) and Fourier Transform Infrared Spectrometer (FT-IR). FT-IR, X-ray Photoelectron Spectroscopy (XPS), Scanning Electron Microscope (SEM), Thermogravimetric (TG), Vertical Flammability Test (VFT), and Limiting Oxygen Index (LOI) were utilized to test and characterize the prepared cotton fibers. The results showed that the antibacterial flame retardant could be durably grafted on the surface of cotton fibers for a long time, and it still maintained its self-extinguishing property after 50 washing cycles, with an LOI value of 32.2 % and a damaged length of 67 mm. The N Cl bond was formed by simple bleaching treatment, which exhibited excellent bacteriostatic effect, and had a significant inhibitory effect on Escherichia coli and Staphylococcus aureus , and chlorine oxide, as an antibacterial factor, could be reactivated after long-term storage and washing. Through the systematic analysis of cone calorimetry and carbon residue, it was concluded that the flame retardant mechanism of antibacterial flame retardant was mainly condensed phase. The results of the physical property analysis of cotton fibers showed that the whiteness, air permeability, flexibility, and other physical properties of cotton fibers had no obvious change, while the hydrophilicity of the finished fibers were enhanced.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Lei Song,Ashuang Liu,Sunjun Yang,Jingbo Yin,Rong Wang
Ionic conductive hydrogels have emerged as promising materials for constructing flexible wearable sensors due to their excellent flexibility, conductivity, and strain sensitivity. However, current hydrogel sensors face some important challenges, such as poor mechanical performance, high swelling ratios, and limited functionality, significantly hindering their applications. This study developed a poly(acrylic acid- co -acrylamide) (P(AA- co -AM)) hydrogel that was synergistically reinforced by phytic acid (PA) and carboxymethyl cellulose (CMC) (PAA/AM-PA-C ionic conductive hydrogel). The hydrogel demonstrated a tensile strength of 2.05 MPa and an elongation at break of 1081.93 %, along with good fatigue resistance. Additionally, it showed low swelling ratios in aqueous environments including in seawater, ensuring the hydrogel sensor exhibited exceptional strain-sensing capabilities in various conditions. As a flexible sensor, this hydrogel exhibited excellent sensitivity and stable sensing performance, providing precise and consistent responses to joint motion and speaking. Because of the addition of PA, the hydrogel also showed obvious anti-freezing properties, and can maintain good mechanical properties and sensing properties at −20 °C, broadening its applications in various conditions. In addition, the hydrogel showed remarkable antibacterial properties and biocompatibility, offering new avenues for the development of multifunctional hydrogel-based wearable sensors.
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Materials
·
2022
·Vol. 15
·期 7
·2537
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IF 3.748
Qingqing Zhou,Jiayi Chen,Zhenqian Lu,Qiang Tian,Jianzhong Shao
Fabrics were flame-retardant finished using phytic acid, a cost-effective, ecologically acceptable, and easily available flame-retardant finishing chemical. Then, on the surface of the completed fabric, silver nanoparticles (Ag NPs) were grown in situ to minimize Ag NPs aggregation and heterogeneous post-finishing and to increase washing durability. Thus, flame-retardant and antibacterial qualities were added to textiles. The as-prepared textiles were evaluated for their combustion performance, thermal performance, and antibacterial capabilities. At the same time, their microstructures were studied using X-ray diffractometry (XRD), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS). The findings indicated that flame-retardant textiles had an excellent launderability (limiting oxygen index = 31% after 20 washing cycles). Meanwhile, Ag NPs-loaded flame-retardant textiles demonstrated self-extinguishing properties, with a limiting oxygen index (LOI) of 27%. Bacteriostatic widths of flame-retardant antibacterial textiles againstEscherichia coliandStaphylococcus aureuswere 5.28 and 4.32 mm, respectively, indicating that Ag NPs-loaded flame-retardant fabrics have certain flame-retardant and antibacterial capabilities. SEM and TEM analysis indicated that nanoparticles were uniformly dispersed over Ag NPs-loaded flame-retardant textiles and were around 20 nm in size. When compared to flame-retardant textiles, Ag NPs-loaded flame-retardant fabrics showed varied binding energy of P and N on the surface and Ag ion emergence. Thermogravimetric analysis at various heating rates revealed that the main pyrolysis temperature range of flame-retardant fabrics decreased, while the main pyrolysis temperature range of Ag NPs-loaded flame-retardant fabrics increased; the heating rate influenced the pyrolysis range but not the fabric mass loss. In situ reduction synthesis of Ag NPs-loaded flame-retardant textiles may successfully reduce agglomeration and heterogeneous dispersion of nano-materials during post-finishing.Keywords:antibacterial treatment;phytic acid;flame-retardant cotton textiles;Ag NPs
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THERMOCHIMICA ACTA
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2018
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IF 2.189
Xian-Wei Cheng,Jin-Ping Guan,Xu-Hong Yang,Ren-Cheng Tang
A novel and durable organic-inorganic flame retardant (FR) system for wool fabric was fabricated using natural phytic acid (PA), titanium dioxide (TiO 2 ) nanoparticles and 1,2,3,4-butanetetracarboxylic acid (BTCA). In order to address the diffusion barrier action of wool fiber to the FR agents, an additional exhaustion process was employed ahead of the traditional pad-dry-cure procedure. The flame retardancy, smoke generation, thermal stability, and washing durability of the treated fabrics were discussed. The PA/TiO 2 /BTCA system endowed wool fabric with excellent flame retardancy and washing durability. The treated fabric was still able to self-extinguish after 30 washing cycles. Moreover, the FR system effectively reduced the smoke generation capacity. Thermogravimetry test shows that the FR system altered the thermal decomposition behavior of wool, and the formation of thermal protective intumescent char mainly contributed to the improved flame retardancy, revealing a significant condensed-phase FR mechanism of the treated wool.
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NEW JOURNAL OF CHEMISTRY
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2022
·Vol. 46
·期 39
·18952-18960
·
IF 3.925
Xuezhen Gao,Zhiyong Cao,Changzhen Li,Junshen Liu,Xunyong Liu,Lei Guo
As a supporting material in the high-tech field, the distribution of indium in the earth's crust is small and scattered. An efficient material is required to selectively adsorb indium from the leaching of other minerals and secondary resources. In this study, an adsorbent phytic acid–hyperbranched polyethyleneimine–oxidized carbon fiber (PA–HPEI–OACF) was prepared by modifying carbon fibers with hyperbranched polyethyleneimine (HPEI) and phytic acid (PA) for the efficient adsorption and separation of In(III) in hydrochloric acid media. The adsorption and separation of absorbents was investigated using static adsorption. The adsorption mechanism of absorbents for In(III) was determined by XPS. The maximum adsorption capacity of PA–HPEI–OACF for In(III) was 34.21 mg L−1 at 298 K and pH of 3.5. The adsorption process of PA–HPEI–OACF for In(III) conforms to the pseudo-second-order kinetic model and involves an endothermic reaction. The adsorption isotherm follows the Freundlich isotherm adsorption model. In the In(III), Fe(II), Cu(II), and Zn(II) mixed solution, PA–HPEI–OACF only adsorbed In(III) and Fe(II) at pH 3.5, and the selectivity coefficient of PA–HPEI–OACF for In(III) over Fe(II) was 798.81. The XPS analysis revealed that the adsorption of PA–HPEI–OACF for In(III) was the result of the combined action of amine groups and phosphate groups with In(III).
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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
·
2015
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IF 3.35
Qingxue Fu,Huizhen Wang,Mengxin Xia,Bing Deng,Hongyi Shen,Guang Ji,Guowen Li,Yan Xie
This study investigated the effect of phytic acid (IP6), a potential absorption enhancer of flavonoid components, on tight junction (TJ) integrity in Caco-2 cell monolayers and its possible mechanisms. Transepithelial electrical resistance (TEER) across the monolayers decreased rapidly, and the flux of fluorescein sodium (a paracellular marker) increased after treating with IP6 in a concentration-dependent manner. Confocal microscopy results showed that IP6 produced a concentration-dependent attenuation in the distribution of occludin , ZO-1, and claudin-1. Immunoblot analysis revealed that IP6 could down-regulate the expression level of these TJ proteins , which resulted in the opening of TJ. Additionally, the divalent cations Ca 2 + and Mg 2 + influenced the IP6-induced distribution of occludin, ZO-1, and claudin-1 in different directions, which enhanced barrier function. In conclusion, IP6 can decrease the integrity of Caco-2 cell monolayers by modulating the TJ proteins' localization and down-regulating the expression levels of TJ proteins including claudin-1, occludin, and ZO-1; the reduction effects of divalent cations such as Ca 2 + and Mg 2 + on the regulation of TJ induced by IP6 should be addressed. The present work will offer some useful guidance for the application of IP6 in drug delivery area.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Yong Lu,Huixia Feng
Phytic acid (PA) has a potential use as a coating on metal surface to retard corrosion. However, a loose structure and micro-cracks in the phytic acid coating layer damage the tightness of the coating, providing channels for the infiltration of corrosive media and seriously weakening the protective effect of the coating. Sodium alginate (SA) was added as an accelerating agent to improve the anti-corrosion protective effect and coating densification of the phytic acid coating on a Q235 steel surface. The micro-morphology, elemental composition and elemental chemical state of different samples were observed by the surface analysis technologies of scanning electron microscopy (SEM) equipped with X-ray energy dispersive spectrum (EDS) and X-ray photoelectron spectroscopy (XPS), all of which show a dense and homogenous phytic acid film with lower crack was precipitated on the sample treated by PA-SA conversion coating. Atomic force microscopy (AFM) and contact angle measurements were used to evaluate the adhesion properties of the prepared coating and the results showed that the PA-SA coated steel exhibited better wettability and adhesion to the top layers compared to the bare steel and phytic acid coating. The electrochemical measurements show that the corrosion resistance of the conversion coating was markedly improved on the steel substrate treated by phytic acid conversion bath containing SA.
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INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Yaohong Yang,Yuefeng Huang,Xinjie Yang,Li Liu,Peng Wang,Zhenqiang Kan,Wei Bi,Kaimeng Xu,Guanben Du,Lianpeng Zhang
Bio-based composites can mitigate the pollution issues linked to petroleum-based materials due to their eco-friendly properties. On the other hand, bio-based functionalized metal-organic frameworks have gained attention in the field of flame retardants due to their multi-pathway flame retardant mechanism and environmentally friendly synthesis process. However, its application in wood industry is less. In this work, a novel functional adhesive and coating (ACS-MACS/PA-UiO66-NH 2 ) was developed by using phosphorus-rich biomass phytate functionalized metal-organic framework (MOF) PA-UiO66-NH 2 as a flame retardant and mixed with modified chitosan. Furthermore, using ACS-MACS/PA-UiO66-NH 2 and three-layer wooden boards, a tight cross-linked network was formed through hot pressing dehydration and condensation reactions to prepare multifunctional wood composites. The experimental results indicated that the mechanical properties of the multifunctional wood composites are excellent. Additionally, these wood composites exhibit high levels of charring and graphitization, leading to excellent flame retardancy. The preparation process of these multifunctional wood composites is straightforward, and their excellent properties provide a foundation for the development of high-performance green composite materials.
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ACS Applied Materials & Interfaces
·
2026
·
IF 8.2
Liang Hao,Ruo Zhang,Youran Xu,Jiayao Lu,Hao Zhang,Xiao Kong,Yulin Xiang,Guang Yang,Yanjiao Chang
Hydrogels have emerged as one of the most promising platforms for next-generation solar-driven water evaporation (SDIWE), offering a sustainable route to freshwater production due to their tunable physicochemical properties. However, the rational design of hydrogel evaporators that simultaneously reduce vaporization enthalpy, regulate water content, and resist biofouling during long-term operation remains a significant challenge. Herein, we report a phytic acid (PA)-reinforced poly(vinyl alcohol) (PVA)/Chitosan-based hydrogel (PCH) engineered for high-performance solar-driven water evaporation. PA promotes the construction of a dual-network architecture within the PVA-Chitosan matrix, leading to markedly improved mechanical strength and finely tuned hydration behavior. Additionally, the strongly polar character of PVA, chitosan, and PA collectively contributes to a significant reduction in the vaporization enthalpy. These synergistic advantages result in an evaporation rate of 2.60 kg m–2 h–1 under 1 Sun illumination, accompanied by excellent salt rejection and effective purification of diverse wastewater streams. Finally, the hydrogel exhibits potent antibacterial activity mediated through chelation, electrostatic interactions, and localized acidification imparted by chitosan and PA. This study underscores the efficacy of rational double-network design using phytic acid as a multifunctional modifier for achieving low vaporization enthalpy, controlled hydration, and enhanced antimicrobial performance, which provide a versatile and efficient strategy toward combating global freshwater scarcity.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Junpeng Ren,Xiuheng Yang,Zhou Wang,Jinhao Xiao,Zonglin Chu,Yu Wang
Phytic acid-derived PAGMA enables a 3D crosslinked bio-based hybrid adhesive network. • Tunable rheology promotes wood interfacial adhesion and water resistance. • MD reveals curing-induced network stabilization and enhanced interfacial adhesion. • Phosphorus–nitrogen synergy enables V-0 rating and an LOI of 50.2%. • PCP exhibits strong antifungal performance without additional antifungal agents. To address the sustainability and multifunctionality limitations of conventional wood adhesives, a formaldehyde-free bio-based hybrid adhesive was developed. PAGMA, a reactive monomer derived from phytic acid, was combined with chitosan (CS) and polyvinyl alcohol (PVA) to construct a three-dimensional crosslinked network. The adhesive exhibits tunable viscosity and good processability, while providing strong bonding, water resistance, flame retardancy, and antifungal performance. Structural characterization and molecular dynamics simulations indicate that the system evolves from a network dominated by physical interactions into a thermally stabilized hybrid crosslinked structure during curing, characterized by P–N and C–O–P bonding features. This transformation promotes network densification and facilitates the formation of a compact char layer during combustion, thereby enhancing thermal stability and flame retardancy. The optimized adhesive achieved dry and wet lap-shear strengths of 11.78 and 6.49 MPa, respectively, and a char yield of 27.41% at 800 °C. In addition, the coated wood exhibited an LOI of 50.2% and achieved UL 94 V-0, while the peak heat release rate and total smoke release decreased by 29% and 18.1%, respectively. After 30 d, fungal coverage remained below 5%, demonstrating strong antifungal performance. This work provides a molecular design strategy for multifunctional bio-based hybrid wood adhesives with balanced bonding strength, water resistance, fire safety, and antifungal performance. Download: Download high-res image (524KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Chengdong Li,Lingfeng Li
PA/F127 co-assembly forms robust Si–O–P bonds and uniform microstructure in silica xerogels. • Xerogels integrate high strength, monolithicity, self-extinguishing ability, and thermal insulation. • PA's dual role enables rapid gelation, bypassing conventional slow acid-catalyzed growth. • Excellent fire resistance with minimal flame damage outperforms commercial silica aerogel sheets. • A green, additive-free strategy overcomes the flame-retardancy vs. mechanical-integrity trade-off. Conventional flame-retardant additives often raise environmental and health concerns due to their toxicity and persistence. Developing high-performance, inherently fire-resistant silica xerogel monoliths via scalable ambient pressure drying remains a significant challenge, as mechanical robustness, monolithic integrity, and flame retardancy are typically mutually exclusive. This study addresses this issue by introducing a green and synergistic strategy using bio-derived phytic acid (PA) and the amphiphilic block copolymer Pluronic F127 to direct the sol-gel co-assembly of a methyltrimethoxysilane/tetraethoxysilane (MTMS/TEOS) system. PA serves dual roles: as a potent biobased acid catalyst, it accelerates precursor hydrolysis, and as a non-toxic, multidentate cross-linker, it forms persistent Si–O–P bonds that chemically reinforce the silica network. F127 acts as a microstructure director, templating a homogeneous gel network with robust inter-particle connectivity. This cooperative action enables rapid gelation (within 1–20 min) and yields monolithic phosphorus-incorporated silica (P-silica) xerogels. The optimized material exhibits excellent mechanical performance (compression strength = 0.140 MPa, strain = 60.3%), outstanding thermal stability (90.3 wt% residual mass at 1000 °C), and superior fire resistance, showing immediate self-extinguishment and minimal damage upon direct flame impingement. It also provides effective thermal insulation, surpassing commercial silica aerogel sheets at a thickness of 3 mm. By replacing conventional hazardous flame retardants with benign, biobased PA and achieving a unique property synergy, this work presents a viable and environmentally sound design principle for advanced thermal insulation materials in fire-risk environments, contributing to safer and more sustainable material solutions. Download: Download high-res image (123KB) Download: Download full-size image
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