POLYMER COMPOSITES
·
2025
·
IF 4.7
Hao Liu,Chunhong Zhang,Yue Yang,Junbo Zang,Youqing Liu,Lu Wang,Lei Shang,Yuhui Ao
Synthesizing waterborne polyurethane sizing agents via an isocyanate-free route to enhance the interfacial adhesion of carbon fiber composites remains challenging. Herein, a novel aqueous non-isocyanate polyurethane (CNIPU) was prepared via amineolysis of a CO 2 -derived resveratrol-based five-membered cyclic carbonate. The CNIPU with repeating hydroxyl and carbamate segments was used as a sizing agent due to its strong chemical compatibility with epoxy resin, significantly improving the interfacial bonding strength of CF/EP composites. Results demonstrated that the sizing agent with 1.5% wt. CNIPU concentration achieved the most substantial interfacial enhancement in the composites. The interfacial shear strength was 134.14 MPa and the interlayer shear strength was 78.33 MPa, which were 147.35% and 46.25% higher than those of the unprimed CF/EP composites, respectively. The synthesis of CNIPU enables potential replacement of traditional polyurethanes with eco-friendly non-isocyanate polyurethane sizing agents.
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高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Hui Yang,Guoming Yuan,Enxiang Jiao,Kunxin Wang,WenJie Diao,Zhao Li,ZhiJun Liu,Kun Wu,Jun Shi
The application of ordinary epoxy resins is severely limited by their poor dielectric properties and toughness, and the increasing focus on sustainability calls for raw materials to be renewable. Thus, a resveratrol-based compound (AE-Res) with three active ester structures was prepared and used to cure glycidyl ethers of bisphenol A (DGEBA) and a liquid crystal epoxy monomer (BPDGE). Test results showed that the combination (AE-Res/BPDGE) of resveratrol derivatives with liquid crystal epoxy monomers exhibited an excellent comprehensive performance. The mechanical strength and toughness of AE-Res/BPDGE were improved. Specifically, the tensile strength, elongation at break, flexural strength, and impact strength of AE-Res/BPDGE were 108.45 MPa, 12.31%, 159.92 MPa, and 39.51 kJ/m2, which were 48.14, 164.16, 92.51, and 143.74% higher than that of BPDGE cured by commercial methylhexahydrophthalic anhydride (MHHPA), respectively. This can be attributed to the introduction of a rigid structure and flexible ether bonds generated after curing. Meanwhile, the dielectric constant (Dk) of AE-Res/BPDGE decreased from 3.81 to 3.00 (10 MHz) compared to MHHPA/BPDGE, mainly owing to the enhanced d-spacing (4.69 vs 4.45 Å) and the absence of highly polar hydroxyl groups. In addition, AE-Res/BPDGE also exhibited good thermal stability and hydrophobicity with a T5% of 383.22 °C, a water contact angle of 110°, and a water absorption of 0.15% because of the presence of a rigid conjugated stilbene and biphenyl structure. Due to its ease of synthesis and environmental friendliness, AE-Res could be a satisfactory alternative to commercial epoxy curing agents.
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高影响因子
PHYTOTHERAPY RESEARCH
·
2024
·Vol. 38
·期 6
·3218-3239
·
IF 6.1
MinFeng Zhou,HuiFang Niu,DanDan Cui,GuoQuan Huang,JinXiao Li,HaoRan Tian,XiaoJuan Xu,FengXia Liang,Rui Chen
Colorectal cancer (CRC) is a significant health problem with elevated mortality rates, prompting intense exploration of its complex molecular mechanisms and innovative therapeutic avenues. Resveratrol (RSV), recognised for its anticancer effects through SIRT1 activation, is a promising candidate for CRC treatment. This study focuses on elucidating RSV's role in CRC progression, particularly its effect on autophagy-related apoptosis. Using bioinformatics, protein imprinting and immunohistochemistry, we established a direct correlation between FOXQ1 and adverse CRC prognosis. Comprehensive in vitro experiments confirmed RSV's ability to promote autophagy-related apoptosis in CRC cells. Plasmids for SIRT1 modulation were used to investigate underlying mechanisms. Molecular docking, glutathione-S-transferase pull-down experiments and immunoprecipitation highlighted RSV's direct activation of SIRT1, resulting in the inhibition of FOXQ1 expression. Downstream interventions identified ATG16L as a crucial autophagic target. In vivo and in vitro studies validated RSV's potential for CRC therapy through the SIRT1/FOXQ1/ATG16L pathway. This study establishes RSV's capacity to enhance autophagy-related cell apoptosis in CRC, positioning RSV as a prospective therapeutic agent for CRC within the SIRT1/FOXQ1/ATG16L pathway.
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PubMed
高影响因子
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
·
2018
·Vol. 35
·期 4
·1700447
·
IF 4.384
Lin Dai,Weiyan Zhu,Rui Liu,Chuanling Si
Self-nanoemulsifying drug delivery system (SNEDDS) is recently studied for enhancing the bioavailability of hydrophobic drugs, such as resveratrol (RSV). However, the functional design of SNEDDS for the drug structural protection is not studied yet. Here, this paper presents an efficient approach by adding lignin (a kind of abundant biomass resource) to enhance the stability of trans -RSV and meantime improve its oral bioavailability. Higher stability of trans -RSV (just decreased 2% to cis -RSV after 1 h under direct sunlight) is observed after loaded by lignin-containing SNEDDS (RSV/SLS SNEDDS). Low toxicity, high transfer efficiency (apparent permeability coefficient >1 × 10 −7 cm s −1 ), and bioavailability (1.371%) of RSV/SLS SNEDDS is successfully demonstrated in Caco-2 cells and rat model, respectively. This study serves to illustrate a simple, versatile, environmental, and economic sustainability approach to the development of nanodelivery systems for light instability drugs.
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BIOLOGICAL & PHARMACEUTICAL BULLETIN
·
2015
·Vol. 38
·期 10
·1658-1662
·
IF 1.828
Lu-yang Lu,Yuan Liu,Zhi-feng Zhang,Xiao-jun Gou,Jun-hao Jiang,Ji-zhong Zhang,Qian Yao
Pomegranate seed oil (PSO) has diverse bioactivities. It was hyphothesized that if PSO were employed to construct a trans-resveratrol-loaded self-nanoemulsifying drug delivery system (RES SNEDDS-PSO), not only could PSO serve as an oil phase but also exert synergistic effects with resveratrol to yield better therapeutic outcomes. In this study, we prepared RES SNEDDS-PSO for the first time to validate that hypothesis. The anti-inflammatory and anticancer activities of RES SNEDDS-PSO were compared with another SNEDDS composed of oil phase isopropyl palmitate (RES SNEDDS-IP). The results showed that upon exposure to a 10-fold amount of water, RES SNEDDS-PSO was converted into nanoemulsions with a mean size of 44 nm. Nanoemulsions enhanced the water solubility of resveratrol by 20-fold, significantly improved resveratrol stability in intestinal fluid, and slowed the decomposition of resveratrol in water by 1-fold. An in vivo anti-infection test showed that the degree of inflammatory swelling in mice given RES SNEDDS-PSO was only 60 and 76% that of the group fed with RES SNEDDS-IP at doses of 10 and 20 mg/kg, respectively. An in vitro anticancer study showed that the inhibitory rate of RES SNEDDS-PSO against MCF-7 breast cancer cells was 2.03- and 1.24-fold that of RES SNEDDS-IP at a concentration of 12.5 and 25 µg/mL, respectively. This study demonstrated that the newly developed SNEDDS may be a prospective formulation in the functional food and clinical fields.
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高影响因子
FOOD CHEMISTRY
·
2019
·
IF 5.399
Can-Peng Li,Shuang Tan,Hanzhang Ye,Jun Cao,Hui Zhao
A label-free fluorescence assay for resveratrol determination is presented for the first time. The approach was based on fluorescence resonance energy transfer (FRET), via competitive supramolecular recognition, between p-sulfonated calix[6]arene (CX6)-modified reduced graphene oxide (CX6@RGO) and a probe-resveratrol complex. The probe molecule (Rhodamine B or rhodamine 123) had a strong fluorescence signal, and its fluorescence was quenched by CX6@RGO, based on FRET. When the target molecule was added to CX6@RGO, the probe molecule was displaced by resveratrol, and a host-guest complex, CX6@RGO-resveratrol formed, turning-on the fluorescence signal. Fluorescence intensity of the CX6@RGO-probe complex increased linearly with increased resveratrol concentrations (2.0–40.0 μM). The proposed approach was used to determine resveratrol in red wine with satisfactory detection limits and recoveries. Compared with traditional determination methods, our procedure is advantageous because it saves time, is easy to operate, and does not require sample pretreatment.
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Artificial Cells Nanomedicine and Biotechnology
·
2019
·
IF 4.462
Bolin Lian,Mingfang Wu,Ziqi Feng,Yiping Deng,Chen Zhong,Xiuhua Zhao
This work investigated the preparation of specific targeted drug delivery systems in cancer chemotherapy by folate conjugated human serum albumin nanoparticles encapsulated resveratrol (RES) nanoparticles (FA-HSA-RESNPs). FA was coupled to HSA, and RES was encapsulated in FA-conjugated HSA by high pressure fluid nano-homogeneous emulsification. The average particle size and polydispersity index of NPs prepared under optimal conditions were 102.1 ± 4.9 nm and 0.001. The drug capsulation efficiency and drug loading efficiency were 98.36 and 14.66%, respectively. The analysis of the results of the physical characterization showed that the RES was present in the FA-HSA-RESNPs in an amorphous state. In vitro drug-release study showed that the NPs can release the drug persistently and slowly. The inhibition rate of FA-HSA-RESNPs and RES was detected using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide method to be 110.8 and 157.2 μM, respectively. The targeting ability of the FA-HSA-RESNPs for the HepG2 cell was measured by fluorescein isothiocyanate-modified albumin techniques. The uptake rate of FA-HSA-RESNPs was higher than that of the original RES. By using near-infrared imaging, in vivo activity was labeled with Cy5 fluorescent FA-HSA-RESNP confirmed FA-HSA-RESNP tumor-targeting ability. The intravenous administration bioavailability of FA-HSA-RESNPs was about 5.95-fold higher than that of the original RES.
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高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Chen-Chen Wang,Ran Feng,Fan Wang,Yan Liu,Bao Zhang
Resveratrol (RES) is a promising anti-inflammatory polyphenol for treating ulcerative colitis (UC), but its efficacy is constrained by poor solubility and colon-targeting efficiency. Biotin, as an active ligand, has been widely used to functionalize nanocarriers to enhance intestinal cell permeability, thereby increasing the absorption of bioactive components. Biotin modification enlarged the helical cavity of starch into a V7-type structure, creating a more favorable hydrophobic microenvironment for the encapsulation of guest molecules. The mass ratio of resveratrol to starch was 1:10 to 1:2, resveratrol acted as a nucleator, forming ordered B+V crystals with minimal size (312.4 nm), uniform distribution, and high encapsulation (20.02 %). Excess resveratrol distorted helices, causing aggregation and reduced efficiency. Biotin modification facilitating nanoparticles uptake by Caco-2 via receptor-mediated endocytosis. Furthermore, the colon length of colitis mice treated with resveratrol-loaded BSNP increased by 25 % ( P < 0.001) compared to that of untreated colitis mice. RES@BSNP can increase the relative abundance of beneficial gut microbiota such as Christensenellales and Lactobacillus and suppressing pro-inflammatory factor secretion, ultimately alleviating UC. This work elucidates the role of guest-molecule concentration and biotin functionalization in starch-based nanoparticle design, offering a promising strategy for targeted polyphenol delivery in colitis treatment.
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高影响因子
Chemistry-An Asian Journal
·
2022
·Vol. 17
·期 23
·e202200453
·
IF 4.839
Huan Lu,Jiangxue An,Yan Huang,Hanyue Cui,Jing Yang,Li Li,Yaping Ding
Graphical A novel molecularly imprinted electrochemical sensor based on nitrogen-doped molybdenum carbide nanosphere was fabricated for trace analysis of resveratrol. Molecularly imprinted polymer film was prepared by using resveratrol as the template molecule and o -phenylenediamine as the functional monomer. The sensor shows great analytical performance in the concentration range of 10 −9 mol L −1 to 10 −4 mol L −1 and the detection limit is as low as 4.37×10 −10 mol L −1 . A novel molecularly imprinted electrochemical sensor based on nitrogen-doped molybdenum carbide(N−Mo 2 C) nanosphere was fabricated for trace analysis of resveratrol in this work. N−Mo 2 C with large specific surface area and good electrical conductivity was introduced to construct a sensitive imprinting platform. Molecularly imprinted polymer film was prepared through a simple electropolymerization method using resveratrol as the template molecule and o -phenylenediamine as the functional monomer. The sensor shows great analytical performance in the concentration range of 10 −9 mol L −1 to 10 −4 mol L −1 and the detection limit is as low as 4.37×10 −10 mol L −1 . The sensor also has the advantages of good selectivity, reproducibility and stability, which opens a new way for the application of molecularly imprinted electrochemical sensors in the field ofbiomedicine detection.
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高影响因子
PHYTOCHEMICAL ANALYSIS
·
2022
·Vol. 33
·期 4
·590-598
·
IF 3.024
Xuemei Xue,Fei Deng,Zhenkai Ge,Jingwen Meng,Xiya Liu,Yongheng Zhao,Yanggen Hu,Xu Ling
Introduction The quantitative analysis of trace resveratrol and polydatin in plant tissues is suitable for elucidation of the compounds' mechanisms of action. Objectives The main objective of this work was to develop a feasible and effective sample pretreatment method to measure the concentrations of resveratrol and polydatin in complex samples. Methodology A polymer sorbent, poly(2-mercaptobenzimidazole), was electrochemically prepared and utilized for selective extraction, while resveratrol and polydatin were used as target analytes. The sorbent was characterized by cyclic voltammetry, scanning electron microscopy and Fourier transform infrared spectroscopy. After extraction and elution, the analytes were analyzed by a Thermo U3000 HPLC system. Several affecting parameters, including the volume of elution solution, sample pH value, sample flow rate and sample volume, were evaluated and optimized. Results The proposed method showed good linearity with low limits of detection (from 0.5 to 0.8 ng·mL −1 ) and ideal accuracy with spiked recoveries from 81.30% to 99.16%. A good enrichment factor (more than 200-fold) together with good sensitivity was obtained with this method. Analysis of resveratrol and polydatin in Polygonum cuspidatum samples by this method is efficient. Conclusion The method developed in this work exhibits several significant merits, including easy operation and high extraction efficiency, indicating that electrochemically prepared polymer sorbent is useful for sample pretreatment and analysis of traditional Chinese medicine samples.
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高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Yao Lu,Lan Zhang,Bin Yang,Hansheng Hu,Hao Sun,Dan Guo
The repair of large bone defects remains a significant challenge in the field of orthopedics, as traditional bone substitutes face issues such as limited supply and structural incompatibility. Therefore, the development of novel biomaterials to promote bone repair is of great significance. This study proposes a composite material based on a gelatin/alginate dual-network hydrogel scaffold (Gel/AlgMA), which regulates oxidative stress in the local microenvironment of bone defects by loading cerium metal–organic frameworks (Ce-UiO-66) and resveratrol (Res). The cerium ions in Ce-UiO-66 exhibit excellent antioxidant properties in their multivalent states, capable of scavenging excess reactive oxygen species (ROS), improving mitochondrial function, and enhancing stability through a polydopamine (PDA) coating. The Gel/Alg@Ce-Res/PDA composite scaffold was prepared via photopolymerization and its in vitro biocompatibility, antioxidant properties, and osteogenic potential were evaluated. The results indicated that the composite scaffold effectively scavenged ROS, alleviated oxidative stress, and promoted the proliferation and differentiation of osteoblasts. Moreover, in vivo experiments further confirmed the favorable effects of the Gel/Alg@Ce-Res/PDA scaffold in bone defect repair. This study provides an innovative biomaterial design for bone defect treatment, with promising clinical application prospects.
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Food Bioscience
·
2024
·
IF 4.8
Jianan Liu,Hongshun Hao,Jingran Bi,Hongman Hou,Gongliang Zhang
The aim of this study was to investigate the synergistic effect of benzyl isothiocyanate (BITC) and resveratrol (RES) on Staphylococcus aureus ( S. aureus ), the controlled release of the corresponding nanoparticles, and their application in beef preservation. The synergistic antibacterial effect of BITC and RES on S. aureus was determined using a checkerboard assay and time-to-kill kinetic analysis. The particle size, polydispersity index, zeta potential, Fourier transform infrared spectroscopy and X-ray diffraction results showed that BITC and RES were successfully encapsulated by the soybean protein isolate (SPI). The results of the first-order kinetic model indicated that the regression coefficient (R 2 ) values were 0.92–0.98. In addition, the molecular docking results showed that the docking scores of BITC, RES and BITC-RES with SPI ranged from −6.3 to −9.7 kcal/mol, indicating the stability of these nanoparticles. At 36 h, BITC-RES inhibited S. aureus 2.7–3.6 times more than the treatment group alone. SPI-BITC-RES inhibited S. aureus 2.5 times more than did BITC-RES at 48 h. Compared to those in the control group, the numbers of S. aureus in the SPI-BITC and SPI-RES groups decreased by 0.78 CFU/mL and 0.77 CFU/mL, respectively, while the number of S. aureus in the SPI-BITC-RES group decreased by 1.54 CFU/mL. The Gompertz model was used to predict the growth of S. aureus in beef treated with BITC, RES, BITC-RES and the corresponding nanoparticles, with R 2 values greater than 0.90. Therefore, these results suggested that BITC-RES nanoparticles are expected to be useful for food preservation.
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危险品化学品经营许可证（带存储）