JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2014
·
IF 2.045
Xiaofang Cao,Xiaomei Qin,Xi Wu,Yongsheng Guo,Li Xu,Wenjun Fang
Measurements on densities (ρ), viscosities (η), and refractive indices (nD) from (293.15 to 333.15) K and at 0.1 MPa along with the surface tensions (γ) at 298.15 K and 0.1 MPa for binary mixtures of 1,3-dimethyladamantane (1,3-DMA), 1-ethyladamantane (1-EA), and 1,3,5-trimethyladamantane (1,3,5-TMA) with 1-heptanol or cyclohexylmethanol have been carried out over the entire composition range. The experimental data are used to calculate the excess molar volumes (VmE), viscosity deviations (Δη), molar refraction deviations (ΔΦR), and surface tension deviations (Δγ). The VmE, Δη, ΔΦR, and Δγ values have been fitted to the Redlich–Kister polynomial equation. From these excess or deviation functions, the molecular interactions and nonideality of the binary systems are discussed. The results are expected to provide fundamental data for understanding the properties of adamantane derivatives as potential components and the composition optimization of new high energy-density hydrocarbon fuels.
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FLUID PHASE EQUILIBRIA
·
2014
·
IF 2.241
Rongrong Li,Guobo Huang,Huanan Hu,Chenghong Li,Wenping Jia
In this work, solid–liquid equilibria (SLE) data for ternary sodium 1-naphthalenesulfonate + sodium 2-naphthalenesulfonate + water system was measured at (283.15, 303.15 and 323.15) K respectively. The diagrams for solid liquid phase of the ternary system were well-established by the measured solubility data. The solid phases formed in the studied system were determined by the method of Schreinemaker’s wet residue. Moreover, the density of equilibrium liquid phase was gained in the process. At each temperature, there are two pure solids forming. They are sodium 1-naphthalenesulfonate and sodium 2-naphthalenesulfonate in the ternary system. The solubility data for the ternary system were calculated and regressed by NRTL model, giving acceptable results for the investigated systems.
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CHEMICAL PHYSICS
·
2025
·
IF 2.4
Mengyu Lin,Jiumei Chu,Dianjun Dong,Xue Yang,Dianquan Dong
Spinel-type titanium-based lithium-ion sieve H 4 Ti 5 O 12 has excellent theoretical adsorption capacity and selectivity. Still, spinel-type lithium adsorbents prepared in existing studies have poor adsorption, poor recyclability, and difficulty in recovery. To solve the above problems, composite mesoporous ion sieves, Polyvinyl Butyral-H 4 Ti 5 O 12 –1 (PVB-HTO-1) modified with dual surfactants, were synthesized for the first time in this paper. Hydrophilic lithium-ion sieve HTO-1 with a mesoporous structure was synthesized by adding two surfactants, CTAB and F127. Then the modified ion sieve was composited with PVB to make a fine rod-like composite material, PVB-HTO-1, with a diameter of no more than 0.5 mm, to solve the limitation of the industrial application that the recycling of powdered ion sieve is difficult. The bi-component surfactant-derived ion sieve, PVB-HTO-1, exhibits superior hydrophilicity and possesses a porous mesoporous framework that facilitates ion exchange processes, achieving adsorption equilibrium within a timeframe of three hours. It demonstrates a remarkable maximum adsorption capacity of 53.25 mg/g. Even after undergoing five cycles of adsorption and desorption, the material's adsorption capacity remains at over 90 % of its initial value, indicative of its robust cyclic stability. The uptake of Li + ions by PVB-HTO-1 aligns with the pseudo-second-order kinetic model and conforms to the Langmuir isothermal adsorption model.
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Science of Advanced Materials
·
2016
·Vol. 8
·期 5
·1145-1153
·
IF 1.812
Ma Wang,Yi Shengen,Lin Liangwu,Huang He,Peng Tao,Liu Zhongtao,Liu Zhipeng,Pei Dongni,Miao Xiongying,Wen Yu,Chen Wei,Xiong Li
To synthesize a novel photosensitizer loaded into hollow titanium dioxide nanoparticles (HTNP) and evaluate the efficacy of its anticancer effects on Panc-1 pancreatic cancer cells in vitro. DLS measurements showed that the size of the particles ranged from 80 to 1,000 nm, with
an average diameter of 120 nm. The PDI of the Photosan-loaded HTNP was 0.112 ± 0.01, indicating that the samples have excellent quality with a narrow size distribution in monomodal systems. The photodynamic effects were positively related to the photosensitizer concentration, the light
dose, and the incubation duration. Using the same parameters, photodynamic therapy induced with Photosan-loaded HTNP had a more severe inhibition effect on cancer cell growth than that induced using free Photosan. Moreover, the nano-Photosan groups produced effects within a shorter duration
than free Photosan. Neither the Photosan-loaded nanoparticles nor free Photosan affected H6C7 cells cultured from a normal pancreas. The flow cytometry results demonstrated that laser-induced cell death with Photosan-loaded HTNP was substantially more severe than that induced with free Photosan.
Photosan-loaded HTNP are safe and stable and exhibit faster and more effective tumoricidal effects than free Photosan in the inhibition of Panc-1 cell growth.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2020
·
IF 4.389
Jin-Hua Xue,Ke-Ping Xiao,Yong-Sheng Wang,Ling Liu,Jia-Qian Li,Mei Li,Yue-Ning Qu,Xi-Lin Xiao
In this study, we confirmed that protamine-templated gold nanoclusters (PRT-AuNCs) exhibit aggregation-induced emission properties (AIE-PRT-AuNCs). 1-Hydroxypyrene (1−OHPy) further induced the aggregation of AIE-PRT-AuNCs via hydrogen bonding and electrostatic and hydrophobic interactions, resulting in the aggregation-induced photoluminescence enhancement of AIE-PRT-AuNCs. 9-Hydroxyphenanthrene was able to decrease the background signal, thus increasing the sensitivity of the method. Based on these findings, a cost-effective, highly sensitive and selective strategy was proposed for the quantitative detection of 1−OHPy. This method displayed a wide linear range of 0.924 – 74.1 nmol/L with a low detection limit of 0.277 nmol/L, showing great potential for the monitoring of 1−OHPy in human urine. This strategy may provide a theoretical basis for future studies of the AIE properties of metal nanoclusters and their applications in the field of chemical and biological sensing.
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RSC Advances
·
2018
·Vol. 8
·期 56
·32325-32332
·
IF 2.936
Yuhan Zhu,Yu Pan,Wenjun Wang,Haibing Xu,Liqun Zhou,Xiaoguang Liu,Ling Li
The local crystal sites occupied by Eu3+ in Ca5(BO3)3F:1% Eu3+ phosphor were investigated experimentally and theoretically. Ca5(BO3)3F:1% Eu3+ was synthesized by high-temperature solid-state method in air. The crystal structure and optical properties of the phosphor were studied by X-ray powder diffraction and photoluminescence, respectively. Two different O2− → Eu3+ CT broad bands with the peaks at 266 and 283 nm in Ca5(BO3)3F:1% Eu3+ were detected, indicating the Eu3+ sites occupied Ca2 and Ca1, respectively. The different sharp f–f emission spectra under the excitation of 283 and 266 nm proved that there are two different local lattice environments around Eu3+ existing in Ca5(BO3)3F:1% Eu3+. Environmental factor he, the standard deviation of environmental factor (EFSD) and the bond energy were used to illustrate and explain the site occupancy mechanism of Eu3+ into the host lattice. By comparing the intensity ratios of 5D0 → 7F2 transition to the 5D0 → 7F1 transition, I(5D0/7F2)/I(5D0/7F1) of Eu3+ at Ca2 (7.381) was found to be 2.5 times stronger than that of Eu3+ at Ca1 site (2.933). was calculated to analyze the I(5D0/7F2)/I(5D0/7F1) value. On the basis of the bond valence model, a bond-energy method was used to study the occupancy of the Eu ion, which indicated that the preferential sites of Eu ion occupancy in the Ca5(BO3)3F are the Ca2 and Ca1 sites. All three theoretical calculation results are consistent with each other.
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BIOORGANIC CHEMISTRY
·
2024
·
IF 4.5
Ting Wang,Xiufeng Liao,Xiaodi Zhao,Kai Chen,Yangzhonghui Chen,Hui Wen,Dali Yin,Yuchen Wang,Bin Lin,Sen Zhang,Huaqing Cui
Mimicking the transition state of tryptophan (Trp) and O 2 in the enzymatic reaction is an effective approach to design indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors. In this study, we firstly assembled a small library of 2-substituted benzo-fused five membered heterocycles and found 2-sulfinyl-benzoxazoles with interesting IDO1 inhibitory activities. Next the inhibitory activity toward IDO1 was gradually improved. Several benzoxazoles showed potent IDO1 inhibitory activity with IC 50 of 82–91 nM, and exhibited selectivity between IDO1 and tryptophan 2, 3-dioxygenase (TDO2). Enzyme binding studies showed that benzoxazoles are reversible type II IDO1 inhibitors, and modeling studies suggested that the oxygen atom of the sulfoxide in benzoxazoles interacts with the iron atom of the heme group, which mimics the transition state of Fe-O-O-Trp complex. Especially, 10b can effectively inhibit the NO production in lipopolysaccharides (LPS) stimulated RAW264.7 cells, and it also shows good anti-inflammation effect on mice acute inflammation model of croton oil induced ear edema.
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ACS Synthetic Biology
·
2024
·
IF 3.7
Jialing Wang,Jie Chen,Kemin Lv,Zhen Gao,Jiahuang Li,Bin Wu,Bingfang He,Gerhard Schenk
Processive endoglucanases have generated significant interest due to their bifunctionality in the degradation of cellulose and low product inhibition. However, enhancing their catalytic efficiency through engineering remains a formidable challenge. To address this bottleneck, our engineering efforts targeted loop regions located in the substrate channel of processive endoglucanase EG5C-1. Guided by a comparative analysis of characteristic structural features of the substrate channels in cellobiohydrolase, endoglucanase, and processive endoglucanase, a highly active triple mutant CM6 (N105H/T205S/D233L) was generated that had a 5.1- and 4.7-fold increase in catalytic efficiency toward soluble substrate carboxymethyl cellulose-Na and insoluble substrate phosphoric acid-swollen cellulose (PASC), compared with wild-type EG5C-1. Furthermore, this mutant exhibited greater processivity compared to EG5C-1. Molecular dynamics simulations unveiled that the mutations in the loop regions reshaped the substrate channel, leading to a deeper cleft, resembling the closed channel configuration of cellobiohydrolases. The increased compactness of the substrate channel induced changes in the substrate binding mode and substrate deformation, thereby enhancing both binding affinity and catalytic efficiency. Moreover, metadynamics simulations demonstrated that the processive velocity of cellulose chain through the binding channel in mutant CM6 surpassed that observed in EG5C-1.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Rui Feng,Zhou Fang,Wei Wang,Tianbo Li,Xiaoyan Hu,Xinlong Yan,Zhongdong Zhang
Direct hydroxylation of benzene to phenol is an environmentally friendly strategy to produce phenol compared with the conventional process. In this work, vanadium-modified titanium silicate-1 (TS-1) with enhanced Lewis acid and charge density were prepared as catalysts for efficient hydroxylation of benzene to phenol in the presence of hydrogen peroxide as an oxidant under mild conditions. The hierarchical TS-1 zeolites with a high framework Ti content were synthesized in the presence of NH4HCO3, and then vanadium doping was used to change the acidity and charge density. It was found that NH4HCO3 favored the titanium substitution of framework sites and nanocrystal stacking of TS-1. Vanadium doping increased the amount of Lewis acid sites and the charge density associated with the framework Ti. The enhancement in acid and electron characteristics boosted the intrinsic catalytic reactivity of Ti-OOH species, which further improved the performances toward benzene hydroxylation. The presented strategy and mechanistic results clarified the relationship between the structure and acidity in TS-1 zeolite. It was also verified that hydroxyl radicals (•OH) rather than superoxide radicals (•O2–) were the reactive agents responsible for the consecutive selective oxidation of benzene.
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PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2024
·
IF 6.9
Qing Shao,Yiyi Yi,Yuxiang Xie,Jingyi Guo,Haike Yang,Yiqun Chen,Jian Shi,Zizheng Liu
Three zirconium-loaded zeolite (Zr-Z) composites—namely, Zr 4+ -Z, ZrO 2 -Z, and ZrMo 2 O 8 -Z—were prepared by co-precipitation of Zr 4+ , ZrO 2 , and ZrMo 2 O 8 , respectively, with artificial zeolite, and these composites were used for the efficient removal of a representative phosphonate, i.e., 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP). The adsorption efficiency of the three composites for HEDP at an initial concentration of 2 mg/L was more than double that of artificial zeolite. Pseudo-second-order kinetics could fit the adsorption process of the three composites well. The heterogeneous adsorption by Zr 4+ -Z, ZrO 2 -Z, and ZrMo 2 O 8 -Z was determined by using the Sips model. And the theoretical maximum HEDP-adsorption capacities of Zr 4+ -Z, ZrO 2 -Z and ZrMo 2 O 8 -Z were 3.52 mg P/g, 3.38 mg P/g and 3.77 mg P/g, respectively, at 308 K. At pH 4–9, the three Zr-Z composites could achieve efficient and stable HEDP adsorption. Among Co-existing ions (Cl − , HCO 3 − , NO 3 − , SO 4 2− , Ca 2+ , Mg 2+ ), 50 mM HCO 3 − hindered adsorption due to its competition with HEDP. The characterization results show that the adsorption mechanism involved hydrogen bonds, electrostatic attraction, and ligand exchange. In addition, the reusability and column adsorption performance of the Zr-Z composites were explored for the efficient removal of the organic phosphonate HEDP from wastewater in practical applications.
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
·
2024
·
IF 4.2
Bin Wang,Wei Wang,Jingyu Li,Jianjun Li
The molecular mechanism underlying the promotion of fracture healing by mechanical stimuli remains unclear. The present study aimed to investigate the role of zinc finger protein 36 like 2 (ZFP36L2)-histone deacetylase 1 (HDAC1) axis on the osteogenic responses to moderate mechanical stimulation. Appropriate stimulation of fluid shear stress (FSS) was performed on MC3T3-E1 cells transduced with ZFP36L2 and HDAC1 recombinant adenoviruses, aiming to validate the influence of mechanical stress on the expression of ZFP36L2-HDAC1 and the osteogenic differentiation and mineralization. The results showed that moderate FSS stimulation significantly upregulated the expression of ZFP36L2 in MC3T3-E1 cells ( p < 0.01). The overexpression of ZFP36L1 markedly enhanced the levels of osteogenic differentiation markers, including bone morphogenetic protein 2 (BMP2), runt-related transcription factor 2 (RUNX2), alkaline phosphatase (ALP), Osterix, and collagen type I alpha 1 (COL1A1) ( p < 0.01). ZFP36L2 accelerated the degradation of HDAC1 by specifically binding to its 3’ UTR region, thereby fulfilling its function at the post-transcriptional regulatory gene level and promoting the osteogenic differentiation and mineralization fate of cells. Mechanical unloading notably diminished/elevated the expression of ZFP36L2/HDAC1, decreased bone mineral density and bone volume fraction, hindered the release of osteogenic-related factors and vascular endothelial growth factor in callus tissue ( p < 0.01), and was detrimental to fracture healing. Collectively, proper stress stimulation plays a crucial role in facilitating osteogenesis through the promotion of ZFP36L2 and subsequent degradation of HDAC1. Targeting ZFP36L2-HDAC1 axis may provide promising insights to enhance bone defect healing.
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BMC Nephrology
·
2025
·Vol. 26
·期 1
·1-14
·
IF 2.4
Lou Yunpeng,Shi Hongguang,Sha Ning,Li Feifei,Gu Xiaofeng,Lin Huiyan
Background Ursodeoxycholic acid (UDCA), traditionally recognized for its hepatoprotective effects, has also shown potential in protecting kidney injury. This study aimed to evaluate the protective effects of UDCA against sepsis-induced acute kidney injury (AKI) and to elucidate the underlying mechanisms.Methods Sixty male C57BL/6 N mice were utilized to establish a sepsis-induced AKI model through intravenous injection of lipopolysaccharides (LPS, 10 mg/kg). UDCA (15, 30, and 60 mg/kg) was administered intraperitoneally once daily for 7 days before LPS injection. Kidney injury was evaluated by HE staining and biochemical markers, including serum creatinine (Cr), blood urea nitrogen (BUN), urinary protein, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), N-acetyl-β-D-glucosaminidase (NAG), and retinol binding protein (RBP). Oxidative stress parameters and nuclear factor erythroid 2-related factor 2 (Nrf2)/ heme oxygenase-1 (HO-1) pathway, pro-inflammatory cytokines and nuclear factor-kappa B (NF-κB) pathway were also evaluated. Additionally, HK-2 cells were treated with LPS in vitro, and cell viability and apoptosis were detected using CCK-8 kit and flow cytometer, respectively.Results UDCA significantly attenuated LPS-induced renal histopathological damage and improved renal function, as evidenced by reduction in serum Cr, BUN, and urinary protein levels. UDCA also up-regulated the protein expression of zonula occludens-1 (ZO-1) and Ezrin in the kidney, and reduced the urinary levels of NGAL, KIM-1, NAG, and RBP. Moreover, UDCA inhibited NF-κB p65 phosphorylation and reduced pro-inflammatory cytokines levels (TNF-α, IL-1β, and IL-6) in both serum and kidney. UDCA alleviated oxidative stress by activating the Nrf2/HO-1 pathway in the kidney. In vitro, UDCA reduced LPS-induced cell injury and apoptosis in HK-2 cells, with these protective effects being blocked by the Nrf2 inhibitor ML385.Conclusion sOur present study demonstrated that UDCA exerts protective effects against sepsis-induced AKI by attenuating oxidative stress and inflammation, primarily through the activation of the Nrf2/HO-1 pathway and inhibition of the NF-κB pathway. These findings highlight the therapeutic potential of UDCA in preventing sepsis-induced AKI.
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