JOURNAL OF APPLIED TOXICOLOGY
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2025
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IF 2.8
Kai Wang,Aneela Perveen,Jiakun Shen,Niaz Ali Kaka,Yansen Li,Dan Shen,Chunmei Li
T-2 mycotoxin is a highly toxic type A trichothecene mycotoxin that widely contaminates livestock feed, posing a serious threat to animal and human health. Long-term exposure can lead to immunosuppression, growth retardation, and liver damage, causing significant economic losses to the livestock industry. Offspring are particularly susceptible to maternal dietary influences during pregnancy and lactation. This research aimed to evaluate the impact of T-2 mycotoxin exposure on both dams and their pups. Thirty pregnant mice were randomly allocated into three groups ( n = 10). From gestational day 14 to lactational day 21, the dams received gavage doses of T-2 mycotoxin at concentrations of 0, 0.005, and 0.05 mg/kg/day. Randomly selected one male pup and one female pup from each dam were sacrificed on LD 1, 7, and 21; dams were dosed until the day they were sacrificed. T-2 mycotoxin decreased the relative body/organ weights of the dams and offspring ( p < 0.05). Moreover, T-2 mycotoxin-induced oxidative stress in dams and offspring increased the malondialdehyde content, which led to reduced activities of antioxidant enzymes, including catalase, superoxide dismutase, and glutathione peroxidase, and total antioxidant capacity in the serum and liver ( p < 0.05). T-2 mycotoxin induced histomorphological changes in the liver and early involution of the mammary gland acini in dams. The concentrations of liver-metabolizing enzymes such as glutamic oxaloacetic transaminase and glutamic pyruvic transaminase increased in offspring ( p < 0.05). The serum insulin-like growth factor-1 level in offspring was decreased, which may impair the development of vital organs such as the liver, kidneys, and spleen in offspring. Consequently, the body weight and length of the offspring of exposed dams decreased. This study revealed that T-2 mycotoxin exposure during late gestation and entire lactation harms dams, damages mammary gland acini, alters liver biochemistry, induces oxidative stress, and delays offspring growth while also impairing maternal weight gain during lactation.
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高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
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2025
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IF 5.4
Zhen-yan Song,Wen-jing Yu,Yi-jie Jin,Meng-fen Zhou,Chun-xiang He,Ze Li,Jia-wei He,Qi Chen,Ping Li,Yaqiao Yi,Shao-wu Cheng
Ethnopharmacological relevance Derived from the plant Scutellaria baicalensis Georgi, baicalin is a naturally occurring flavonoid, has demonstrated anti-inflammatory, neuroprotective, hypoglycemic, and lipid-lowering properties. While its effects on Alzheimer's disease (AD) or type 2 diabetes mellitus (T2DM) have been studied individually, its therapeutic role in AD comorbid with T2DM remains unclear. Aim of the study This study aims to explore the potential therapeutic mechanisms associated with baicalin through a rat model featuring AD combined with T2DM. Materials and methods A dual-pathology rat model was developed using a streptozotocin (STZ) and a high-fat dietary regimen injections to induce T2DM, followed by intracerebroventricular STZ to induce AD pathology. Behavioral tests, biochemical assays, histological analyses, qPCR, and Western blotting were used to evaluate baicalin's effects. Untargeted metabolomics was applied to profile metabolic alterations, while network pharmacology and molecular docking were integrated to predict key targets and pathways. Finally, cellular thermal shift assay (CETSA) was conducted to validate the direct binding of baicalin to core proteins. Results Baicalin significantly improved cognitive performance, ameliorated glucose and lipid metabolism, and suppressed neuroinflammation in AD-T2DM rats. Metabolomics identified disruptions in energy metabolism, amino acid metabolism, and purine metabolism pathways. Network pharmacology analysis revealed ALDH2, NOS2, GOT1, GPT, and XDH as key targets associated with these metabolic disturbances. Molecular docking demonstrated strong binding affinities between baicalin and the identified targets. qPCR confirmed the regulation of ALDH2 and NOS2 gene expression by baicalin, and CETSA experiments further validated the thermal stabilization of these proteins, supporting direct interactions in vivo. Conclusions Baicalin exerts therapeutic effects by targeting ALDH2 and NOS2 to modulate arginine and proline metabolism and regulate key metabolites such as GABA and L-arginine. This mechanism improves neuronal function and insulin sensitivity, highlighting baicalin as a promising multi-target treatment for AD with T2DM.
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JOURNAL OF MOLECULAR LIQUIDS
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2025
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IF 5.2
Yue Wang,Wenxiu Li,Tao Zhang
The separation of 2-methylfuran (2-MF) and methanol (MeOH) azeotropes presents a critical challenge in biofuel production due to the efficiency and sustainability limitations of conventional methods. In this study, three ionic liquids (ILs)—1-ethyl-3-methylimidazolium hydrogen sulfate ([EMIM][HSO 4 ]), 1-ethyl-3-methylimidazolium thiocyanate ([EMIM][SCN]), and 1-ethyl-3-methylimidazolium dicyanamide ([EMIM][DCA])—were selected as green extractants for 2-MF – MeOH azeotropic separation. Ternary liquid-liquid equilibrium (LLE) data for the system 2-MF (1) + MeOH (2) + IL (3) were experimentally determined at 303.15 K and 101.325 kPa. The order of both distribution coefficient and selectivity is [EMIM][HSO 4 ] > [EMIM][SCN] > [EMIM][DCA]. Then, the NRTL model was subsequently employed to regress the experimental data, and the accuracy of the NRTL binary parameters was verified through the “GMcal_TieLinesLL” tool. Further mechanistic investigation integrated theoretical approaches (ESP, IGMH, RDF, and MSD analysis) with experimental validation via FT-IR spectroscopy. This combined methodology conclusively elucidates the pivotal role of hydrogen bonding in the extraction and separation process.
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APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Kunfeng Zhang,Jinxia Liang,Sainan Yang,Fangfei Song,Hongxia Chen,Baozhong Zhang,Bo Peng,Hanyu Chen,Hongxing Dai
Constructing an S-scheme heterojunction presents an effective strategy to enhance photocatalytic efficiency via accelerating photoexcited charge separation while preserving strong redox potentials. Herein, amorphous Ni(OH) 2 (a-NH) was in-situ integrated with crystalline Bi 12 O 17 Br 2 (BOB) nanosheets to form an amorphous/crystalline a-NH/BOB S-scheme heterojunction. The as-synthesized a-NH/BOB-0.5 photocatalyst exhibited superior bisphenol A (BPA) degradation efficiency, achieving 48.7 and 3.7-fold enhancements compared to individual a-NH and BOB, respectively. Comprehensive investigations revealed that the improved photocatalytic activity originated from the synergistic effects of enhanced light-harvesting ability and the formation of strong interfacial electric field at the amorphous/crystalline interface. Moreover, the influences of solution pH, coexisting anions, and water matrices on BPA degradation efficiency were also investigated. Reaction mechanism and toxicity assessment demonstrated that BPA could be gradually transformed into small molecules with low toxicity. This work demonstrates an efficient approach for the design of high-performance photocatalysts for environmental remediation by constructing amorphous/crystalline interface and S-scheme charge transfer mechanism.
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DRUG AND CHEMICAL TOXICOLOGY
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2025
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IF 1.9
Yongxiao Huang,Caina Jiang,Fangyao Li,Xianli Ma
As a commonly used flame retardant in numerous products, it is inevitable that tris(2-chloroethyl)phosphate (TCEP) is released into the surrounding environment during its use. This process gives rise to potential environmental concerns that must be addressed. In recent years, there has been significant interest in the role of TCEP in the development of hyperuricemia (HUA). However, the specific mechanisms by which TCEP contributes to this condition remain to be fully elucidated. In this study, we have employed a combination of network toxicology and in vitro experiments to investigate the potential effects of TCEP on HUA and its mechanism of action. Through systematic analysis of GeneCards, OMIM, Swiss Target Prediction, and CHEMBL databases, a total of 242 TCEP-induced HUA targets were identified. Utilizing the STRING and DAVID databases further elucidated the core targets and associated signaling pathways of TCEP in relation to HUA. The molecular docking assay results demonstrated that TCEP exhibits binding activity with the selected targets. In vitro, our findings revealed that TCEP exacerbates HUA by amplifying the inflammatory response and upregulating the mRNA expression levels of GLUT9 and URAT1. The present study provides a new perspective and theoretical basis for the in-depth understanding of the molecular mechanism of TCEP affecting HUA, and helps to further understand the pathogenesis of HUA and the role of environmental factors.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2025
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IF 6.6
Mengchen Li,Bo Li,Binbin Long,Leibin Li,Yang Chen,Mingye Peng,Mengzhou Zhou
Lactobacillus plantarum R is the predominant bacterium widely used in food fermentation. However, it has a low tolerance to ethanol during fermentation, which restricts its broader application in the food industry. Although biofilm formation enhances bacterial resistance to various stresses, regulating biofilm formation in L. plantarum R remains challenging. In this study, we established a pathway for producing autoinducer 2 (AI-2), a quorum-sensing (QS) signaling molecule, by heterologously expressing pfs and LuxS in L. plantarum R. This approach aimed to modulate cell membrane structure and improve bacterial ethanol resistance. The findings showed that exogenous AI-2 significantly enhanced the growth of L. plantarum R under high-ethanol concentration and improved its biofilm formation at different ethanol concentrations. Furthermore, a multi-omics analysis revealed potential mechanisms by which AI-2 improved the tolerance of L. plantarum R to ethanol. Notably, the upregulation of the crr gene, a component of the phosphotransferase system (PTS), enhanced biofilm formation in response to ethanol stress. In addition, differential metabolites enriched in cysteine and methionine metabolic pathways further supported the role of QS in enhancing the tolerance of L. plantarum R to ethanol. These findings lay the groundwork for enhancing the fermentation performance of strains applied in the food fermentation industry, presenting a novel method for expanding the utilization of L. plantarum R in high-ethanol fermentation.
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JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
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2025
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IF 4.9
Dadaso D. Mohite,Sachin S. Chavan,P.E. Lokhande,Syed Khasim,Taymour A. Hamdalla,Vishal Kadam,Chaitali Jagtap,Udayabhaskar Rednam
Supercapacitors (SCs) are essential components in next-generation energy storage systems due to their excellent power density and fast charge-discharge capability. However, their limited energy density continues to impede broader adoption. This study explores the electrochemical properties of electrospun polyacrylonitrile (PAN) nanofiber composites doped with nickel and cobalt hydroxide (NiCo(OH) 2 ) nanoparticles to address this challenge. The fabrication process involves electrospinning PAN solutions with NiCo(OH) 2 precursors, followed by heat treatment to enhance the structural and electrochemical properties. The crystallographic structure and morphology of the composite fibers were examined using standard characterization techniques. XPS analysis confirmed the presence of Ni 2+ , Ni 3+ , Co 2+ , and Co 3+ states, while BET analysis revealed a high surface area of 99 m 2 g -1 and mesoporous structure; TEM images confirmed uniform nanofiber morphology with embedded nanoparticles. Electrochemical testing showed that the synergistic effect of NiCo 2 O 4 /PAN carbon nanofibers improved specific capacitance, rate performance, and cycling stability, signifying progress toward advanced SCs. The highest specific capacitance achieved was 440 F g -1 at a current density of 1 A g -1 . A supercapacitor device, composed of NiCo 2 O 4 /PAN-carbon NFs//AC electrodes and a PVA/KOH gel electrolyte, demonstrated an energy density of 6 Wh kg -1 at a power density of 2000 Wk g -1 . Furthermore, it exhibited exceptional cycling stability, retaining 98% of its capacitance after 5000 cycles, highlighting its solid electrochemical reversibility, which is crucial for practical SC applications.
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Pharmaceuticals
·
2024
·Vol. 17
·期 11
·1420
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IF 4.3
Xinlan Hu,Yan Wu,Hanyi Ouyang,Jiayan Wu,Mengmeng Yao,Zhuo Chen,Qianbin Li
Background/Objectives:Homeodomain-interacting protein kinase 2 (HIPK2) is critically involved in the progression of renal fibrosis. This study aims to identify and characterize a novel HIPK2 inhibitor, CHR-6494, and investigate its therapeutic potential.Methods:Using structure-based virtual screening and molecular dynamics simulations, we identified CHR-6494 as a potent HIPK2 inhibitor with an IC50of 0.97 μM. The effects of CHR-6494 on the phosphorylation of p53 in Normal Rattus norvegicus kidney cells (NRK-49F) induced by transforming growth factor-β (TGF-β) were assessed, along with its impact on TGF-β signaling and downstream profibrotic markers.Results:CHR-6494 significantly reduces p53 phosphorylation induced by TGF-β and enhances the interaction between HIPK2 and seven in absentia 2 (SIAH2), facilitating HIPK2 degradation via proteasomal pathways. Both CHR-6494 and Abemaciclib inhibit NRK-49F cell proliferation and migration induced by TGF-β, suppressing TGF-β/Smad3 signaling and decreasing profibrotic markers such as Fibronectin I (FN-I) Collagen I and α-smooth muscle actin (α-SMA). Additionally, these compounds inhibit nuclear factor kappa-B (NF-κB) signaling and reduce inflammatory cytokine expression.Conclusions:The study highlights the dual functionality of HIPK2 kinase inhibitors like CHR-6494 and Abemaciclib as promising therapeutic candidates for renal fibrosis and inflammation. The findings provide new insights into HIPK2 inhibition mechanisms and suggest pathways for the design of novel HIPK2 inhibitors in the future.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2025
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IF 2.1
He Ma,Houchun Yan,Menghao Du,Yingmin Yu,Qingsong Li
To separate methyl 2-hydroxyisobutyrate from an aqueous solution, alkyl alcohols were selected as extractants. The liquid–liquid equilibrium data for the system {water + methyl 2-hydroxyisobutyrate + extractants (1-hexanol, 1-heptanol, 1-octanol, and 1-nonanol)} were determined at a temperature of 303.2 K. The partition coefficients and separation factors were calculated to assess the effectiveness of the extraction process. Additionally, the data were correlated using the NRTL and UNIQUAC models, with parameter regression conducted accordingly. The GMcal_TieLinesLL tool was utilized to evaluate the regression model parameters, and the results conformed to the Gibbs stability criterion. The present study further investigates the separation mechanism through analyses of σ-profile, deformation charge density, interaction energies, and Reduced Density Gradient (RDG) analysis. Ultimately, it was concluded that 1-nonanol exhibited the most effective extraction performance.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2025
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IF 2.1
Guangjie Chen,Guangying Chen,Ge Gao,Li Sze Lai,Swee Pin Yeap,Wee Horng Tay,Helei Liu
The utilization of biphasic absorbents for CO2 capture can substantially reduce energy consumption. This study investigated the mass transfer kinetics and thermodynamics of the phase separation absorption process using 1-amino-2-propanol (MIPA)/sulfolane (TMS) biphasic solvents. 13C NMR spectroscopy was employed to analyze the species in different CO2-loaded solutions. The direction and extent of species transfer during the absorption process were elucidated and the phase separation mechanism was explored. CO2 absorption kinetics were studied in a wetted-wall column, and the physicochemical properties and the absorption reaction kinetics data under different experimental conditions were obtained. Results showed the overall mass transfer coefficient (KG) was 1.6 times higher than 30 wt % MEA and twice that of DETA/TMS solution. NMR and kinetic data analysis revealed that phase separation is mainly contributing to the deterioration of the mass transfer process in biphasic solution, reducing the liquid-film mass transfer coefficient (KL) by 63.2% during the phase separation stage. Furthermore, the desorption heats of different biphasic solvents with identical amine concentrations were measured using a microcalorimeter. Findings indicated that TMS did not alter the thermodynamic properties of the solution. Since only the CO2-rich phase is regenerated, the energy consumption is significantly reduced compared to that of MEA.
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JOURNAL OF MOLECULAR STRUCTURE
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2025
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IF 4.7
Wenzhi Su,Mengyu Zhang,Chuancheng Zhang,Yong Zou,Wenpeng Liu,Shoujun Ding
Upconversion (UC) fluorescence intensity ratio (FIR) technology has emerged as a promising approach for optical thermometry due to its ability to provide non-contact, high-precision temperature measurements. Unlike conventional UC phosphor-based systems, single-crystal UC materials offer enhanced responsiveness and sensitivity for thermal detection, thanks to their structural stability and superior thermal conductivity. In this study, we successfully synthesized an Yb 3+ , Ho 3 ⁺:NaBi(MoO 4 ) 2 (NBM) single crystal with exceptional optical quality using the Czochralski (Cz) growth technique. Comprehensive structural characterization was carried out using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM). The results confirmed that Yb 3+ , Ho 3+ :NBM crystallizes in a tetragonal structure with the space group I4 1 /a. The emission of different visible light colors under various excitation wavelengths was found to be due to the multiphonon relaxation process. Systematic analysis of power-dependent up-conversion emission spectra conclusively showed that the green and red up-conversion emissions arise from two-photon excitation processes. Moreover, temperature-dependent spectral evolution in the range of 300–500 K was quantitatively analyzed, allowing the calculation of both absolute sensitivity ( S ₐ) and relative sensitivity ( S ᵣ) parameters to evaluate the material's optical thermometric performance. These findings highlight the promising potential of Yb 3+ , Ho 3+ :NBM single crystal for developing high-performance optical thermometry devices.
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SOLAR ENERGY
·
2025
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IF 6.6
Jiachen Li,Biao Hu,Hui Wang,Jinxin Yang,Chunwang Li,Xin Du
A eutectic hydrate salt phase change material composed of NH 4 Al(SO 4 ) 2 ·12H 2 O-CH 3 COONa·3H 2 O was prepared. The eutectic composition, determined experimentally to consist of 92.5 wt% NH 4 Al(SO 4 ) 2 ·12H 2 O and 7.5 wt% CH 3 COONa·3H 2 O, deviated significantly from predictions made by the Scholar’s equation, highlighting the need for optimization of theoretical prediction methods. The eutectic material exhibited promising thermal storage properties, but a significant supercooling degree of 12.98 K was observed. To mitigate this issue, 14 different nucleating agents were evaluated and five nucleating agents were identified as effective in reducing the supercooling degree to below 1 °C. Furthermore, the thermophysical properties of the eutectic phase change materials with five preferred nucleating agents, including phase change temperature, latent heat, volume expansion ratio and thermal storage density, were characterized using differential scanning calorimetry, T-history, and solid–liquid density testing. Among the five preferred nucleating agents, Nano Cu demonstrated the best performance, achieving a high thermal storage density of 223.45 kJ/kg and a minimal volume expansion ratio of 4.92 %. Future studies will focus on optimizing heat transfer characterization and integrating this material into renewable energy-based heating systems such as heat pumps, solar heating systems, and valley electric heating systems to achieve sustainable and efficient heating solutions.
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