JOURNAL OF APPLIED TOXICOLOGY
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2025
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IF 2.8
Kai Wang,Aneela Perveen,Jiakun Shen,Niaz Ali Kaka,Yansen Li,Dan Shen,Chunmei Li
T-2 mycotoxin is a highly toxic type A trichothecene mycotoxin that widely contaminates livestock feed, posing a serious threat to animal and human health. Long-term exposure can lead to immunosuppression, growth retardation, and liver damage, causing significant economic losses to the livestock industry. Offspring are particularly susceptible to maternal dietary influences during pregnancy and lactation. This research aimed to evaluate the impact of T-2 mycotoxin exposure on both dams and their pups. Thirty pregnant mice were randomly allocated into three groups ( n = 10). From gestational day 14 to lactational day 21, the dams received gavage doses of T-2 mycotoxin at concentrations of 0, 0.005, and 0.05 mg/kg/day. Randomly selected one male pup and one female pup from each dam were sacrificed on LD 1, 7, and 21; dams were dosed until the day they were sacrificed. T-2 mycotoxin decreased the relative body/organ weights of the dams and offspring ( p < 0.05). Moreover, T-2 mycotoxin-induced oxidative stress in dams and offspring increased the malondialdehyde content, which led to reduced activities of antioxidant enzymes, including catalase, superoxide dismutase, and glutathione peroxidase, and total antioxidant capacity in the serum and liver ( p < 0.05). T-2 mycotoxin induced histomorphological changes in the liver and early involution of the mammary gland acini in dams. The concentrations of liver-metabolizing enzymes such as glutamic oxaloacetic transaminase and glutamic pyruvic transaminase increased in offspring ( p < 0.05). The serum insulin-like growth factor-1 level in offspring was decreased, which may impair the development of vital organs such as the liver, kidneys, and spleen in offspring. Consequently, the body weight and length of the offspring of exposed dams decreased. This study revealed that T-2 mycotoxin exposure during late gestation and entire lactation harms dams, damages mammary gland acini, alters liver biochemistry, induces oxidative stress, and delays offspring growth while also impairing maternal weight gain during lactation.
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高影响因子
BIOCHEMICAL PHARMACOLOGY
·
2025
·
IF 5.6
Jia Liu,Senlin Li,Hong Zhou,Mengheng Wang,Chengliang Zhang,Cheng Tian,Yue Xu,Mengxuan Wang,Xin Li,Qing Li,Ming Xiang
Gemcitabine is a widely employed first-line chemotherapeutic drug for pancreatic cancer (PCa). However, the rapid emergence of gemcitabine resistance poses a major clinical hurdle. Here, we identified REG3A as a crucial determinant of poor prognosis in PCa. Notably, REG3A was upregulated in tumor tissues from clinical gemcitabine-resistant PCa patients. Through comprehensive in vitro cellular assays and in vivo studies using Reg3g (the murine homolog of REG3A) knockout mice, we demonstrated that REG3A deficiency sensitized PCa to gemcitabine treatment. Mechanistically, RNA sequencing (RNA-Seq) combined with Protein-Protein Interaction (PPI) analysis revealed that REG3A functioned as an exocytosis protein binds to the novel membrane receptor GPR54. The interaction increased membrane localization of GPR54, which subsequently engaged ARRB2 as a scaffolding molecule, leading to activation of the ERK1/2 pathway and suppression of gemcitabine-induced apoptosis. Moreover, the GPR54 agonist KP10 synergistically enhanced gemcitabine resistance in conjunction with REG3A, while interference with GPR54 or its antagonist KP234 attenuated REG3A-induced gemcitabine resistance. Targeting REG3A or pharmacologically inhibiting its downstream signaling molecules may represent a promising strategy to overcome gemcitabine resistance. Overall, REG3A could serve as a potential biomarker for gemcitabine resistance in PCa, offering a new avenue for therapeutic intervention and patient stratification.
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ACS Applied Energy Materials
·
2025
·
IF 5.5
Liru Yan,Shishuai Sun,Shuangting Ruan,Xiaocheng Liu,Huanqi Cao,Shougen Yin
Design of the photosensitive electrode material provides an effective strategy to improve the capacity and stability of supercapacitors. In this study, the photothermal-driven cobalt–zinc-doped Ni(OH)2/g-C3N4@NF nanoflower electrode materials were prepared base on the in situ chemical etching strategy. The electrochemical performance indicated that the optimized CZNC2.18 (cobalt–zinc codoped β-Ni(OH)2@g-C3N4) electrode material with exceptional stability (103.74% capacitance retention after 5000 cycles at 20 mA/cm2) exhibited an ultrahigh capacitance of 19.10 F/cm2 at a current density of 10 mA/cm2 under illumination, compared to 12.8 F/cm2 under dark conditions, achieving a light gain of 149%. The assembled asymmetric photothermal-assisted supercapacitor device delivers energy densities of 3.55 mWh/cm2 (1.23 mWh/cm2) at corresponding power densities of 8.39 mW/cm2 (37.03 mW/cm2) under illumination, surpassing performance metrics observed under dark conditions. The synergistic effects of photogenerated carriers (holes oxidizing Ni(OH)2 to NiOOH and electrons enhancing conductivity), Zn/Co codoping-induced conductivity improvement, and photothermal-assisted ion transport collectively enable CZNC2.18 exceptional photoelectrochemical performance, establishing a paradigm for light-responsive energy storage material design.
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JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
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2025
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IF 4.9
Dadaso D. Mohite,Sachin S. Chavan,P.E. Lokhande,Syed Khasim,Taymour A. Hamdalla,Vishal Kadam,Chaitali Jagtap,Udayabhaskar Rednam
Supercapacitors (SCs) are essential components in next-generation energy storage systems due to their excellent power density and fast charge-discharge capability. However, their limited energy density continues to impede broader adoption. This study explores the electrochemical properties of electrospun polyacrylonitrile (PAN) nanofiber composites doped with nickel and cobalt hydroxide (NiCo(OH) 2 ) nanoparticles to address this challenge. The fabrication process involves electrospinning PAN solutions with NiCo(OH) 2 precursors, followed by heat treatment to enhance the structural and electrochemical properties. The crystallographic structure and morphology of the composite fibers were examined using standard characterization techniques. XPS analysis confirmed the presence of Ni 2+ , Ni 3+ , Co 2+ , and Co 3+ states, while BET analysis revealed a high surface area of 99 m 2 g -1 and mesoporous structure; TEM images confirmed uniform nanofiber morphology with embedded nanoparticles. Electrochemical testing showed that the synergistic effect of NiCo 2 O 4 /PAN carbon nanofibers improved specific capacitance, rate performance, and cycling stability, signifying progress toward advanced SCs. The highest specific capacitance achieved was 440 F g -1 at a current density of 1 A g -1 . A supercapacitor device, composed of NiCo 2 O 4 /PAN-carbon NFs//AC electrodes and a PVA/KOH gel electrolyte, demonstrated an energy density of 6 Wh kg -1 at a power density of 2000 Wk g -1 . Furthermore, it exhibited exceptional cycling stability, retaining 98% of its capacitance after 5000 cycles, highlighting its solid electrochemical reversibility, which is crucial for practical SC applications.
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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
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2025
·Vol. 29
·期 15
·e70778
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IF 4.2
Hong Tang,Qi Dai,Ziyan Zhao,Weiye Ge,Danlei Li,Zelin Chang,Penglai Pi,Jia Li,Zheng Sun
Glioblastoma (GBM) is an aggressive and highly malignant primary brain tumour, accounting for a significant proportion of adult brain tumours. It is associated with a poor prognosis and high recurrence rates. Although temozolomide (TMZ) remains the standard first-line chemotherapy for GBM, its clinical efficacy is often limited by the development of drug resistance and toxic effects on normal tissues. Melatonin (Mel), a natural indoleamine synthesised by the pineal gland, has demonstrated synergistic anti-tumour effects when combined with various chemotherapy agents in multiple studies. This study investigates the synergistic potential of Mel to enhance TMZ's therapeutic efficacy against GBM. The results demonstrate that the combination of Mel and TMZ significantly inhibits glioblastoma cell proliferation, migration, and invasion. Mechanistically, this synergistic effect is mediated through the NF-κB/COX-2 signalling pathway. Mel enhances TMZ's anti-tumour activity by inhibiting IκBα phosphorylation, suppressing NF-κB activation, and downregulating COX-2 expression. Additionally, the combination treatment induced apoptosis via activation of the Caspase-3 pathway. These results suggest that Mel can potentiate the therapeutic efficacy of TMZ in glioblastoma treatment, offering a promising strategy to overcome TMZ resistance while reducing its associated toxicity.
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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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2025
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IF 3.1
Liqing Wang,Menghan Chen,Hanxue Wang,Qihui Sun,Sujuan Zheng,Xiaoyun Liu,Yong Yang,Rong Rong
Clinical studies have demonstrated that many traditional Chinese medicines (TCM) exhibit not only antiviral effects but also efficacy in alleviating clinical symptoms of Coronavirus Disease 2019 (COVID-19). However, the pharmacologically active constituents responsible for their anti-COVID-19 efficacy remain unclear. This study aimed to establish a novel strategy for identifying active ingredients from herbs clinically used for COVID-19. An integrated approach combining data mining with Affinity Ultrafiltration (AUF) was developed. Initially, using a data mining strategy, high-frequency herbs were selected from the herbs clinically used in COVID-19. Furthermore, AUF technology was used to screen for potential bioactive components from the high-frequency herbs. The anti-COVID-19 potential of active compounds was assessed through enzyme activity assays and molecular docking, followed by validation in cellular and animal models. Data mining revealed that Glycyrrhiza uralensis Fisch., Lonicera japonica Thunb. and Forsythia suspensa (Thunb.) Vahl were the high-frequency herbs used in COVID-19. Five potential 3-Chymotrypsin-like protease (3CL pro ) inhibitors were screened from three herbs via AUF and identified using high-resolution mass spectrometry. Further enzymatic and cellular assays demonstrated that Licochalcone C (LCC) and Forsythiaside A (FTA) inhibited Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) replication at micromolar concentrations. Notably, FTA treatment significantly suppressed the elevation of pulmonary parameters and inflammatory mediators induced by SARS-CoV-2 nucleocapsid protein in mice. In summary, this study proposes a novel strategy integrating data mining with AUF to discover active compounds from TCM. Two components, LCC and FTA, were identified as dose-dependent inhibitors of SARS-CoV-2 Omicron strain replication in vitro.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2025
·
IF 2.1
He Ma,Houchun Yan,Menghao Du,Yingmin Yu,Qingsong Li
To separate methyl 2-hydroxyisobutyrate from an aqueous solution, alkyl alcohols were selected as extractants. The liquid–liquid equilibrium data for the system {water + methyl 2-hydroxyisobutyrate + extractants (1-hexanol, 1-heptanol, 1-octanol, and 1-nonanol)} were determined at a temperature of 303.2 K. The partition coefficients and separation factors were calculated to assess the effectiveness of the extraction process. Additionally, the data were correlated using the NRTL and UNIQUAC models, with parameter regression conducted accordingly. The GMcal_TieLinesLL tool was utilized to evaluate the regression model parameters, and the results conformed to the Gibbs stability criterion. The present study further investigates the separation mechanism through analyses of σ-profile, deformation charge density, interaction energies, and Reduced Density Gradient (RDG) analysis. Ultimately, it was concluded that 1-nonanol exhibited the most effective extraction performance.
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INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Bao Jiang,Hongheng Chen,Xianmeng He,Lei Wu,Xueyin Fu,Yi Huang,Qun Jing,Zhaohui Chen
Rare-earth ions have garnered significant attention due to their large ionic radii and unique electronic configurations. In this study, two scandium-based pyrophosphates, ASc2(P2O7)2 (A = Ba, Pb), were successfully synthesized by using a high-temperature melting method. They are the first reported examples of divalent cations binding to scandium-based pyrophosphates. The anionic backbones in their structures are all based on Sc–P–O frameworks, and two distinct cluster configurations are observed: cyclic [ScP2O10] and linear [ScP2O11] clusters. A comprehensive comparison of Sc/Y-based pyrophosphates reveals a strong correlation between the Sc–P–O configurations and the A-site cationic coordination environments. This work also investigated the influence of cations on the P–O configuration of existing Sc/Y-based pyrophosphates, which also offers useful reference for the synthesis of novel scandium-based phosphates.
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高影响因子
Advanced Science
·
2024
·
IF 14.3
Jin Li,Qiuling Jiang,Xiujing Xing,Cuilian Sun,Ying Wang,Zhijian Wu,Wei Xiong,Hao Li
Electrochemical conversion of nitrate (NO 3 − ) to ammonia (NH 3 ) is a potential way to produce green NH 3 and remediate the nitrogen cycle. In this paper, an efficient catalyst of spherical CuO made by stacking small particles with oxygen-rich vacancies is reported. The NH 3 yield and Faraday efficiency are 15.53 mg h −1 mg cat −1 and 90.69%, respectively, in a neutral electrolyte at a voltage of -0.80 V (vs. reversible hydrogen electrode). The high activity of the electrodes results from changes in the phase and structure during electrochemical reduction. Structurally, there is a shift from a spherical structure with dense accumulation of small particles to a layered network structure with uniform distribution of small particles stacked on top of each other, thus exposing more active sites. Furthermore, in terms of phase, the electrode transitions from CuO to Cu/Cu(OH) 2 . Density functional theory calculations showed that Cu(OH) 2 formation enhances NO 3 - adsorption. Meanwhile, the Cu(OH) 2 can inhibit the competing hydrogen evolution reaction, while the formation of Cu (111) crystal surfaces facilitates the hydrogenation reaction. The synergistic effect between the two promotes the NO 3 - to NH 3 . Therefore, this study provides a new idea and direction for Cu-based oxides in electrocatalytic NH 3 production.
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Reaction Chemistry & Engineering
·
2024
·
IF 3.4
Qifeng Yang,Liping Liang,Ning Xu,Yang Li,Zhihui Wang,Dadong Shen,Yiming Mo
Electroorganic synthesis has received significant attention due to its environmentally friendly nature, offering the potential to replace traditional hazardous chemical production routes. However, an in-depth technoeconomic analysis (TEA) of electrosynthesis technology is still necessary to objectively assess the economic viability of this technology as an alternative to the traditional chemical synthesis. In this study, we used the cerium-mediated electrosynthesis of 2-methyl-1,4-naphthoquinone (2-MNQ, also known as vitamin K3) as a case study. The process development was conducted in both small-scale and large-scale electrochemical flow cells with 6.25 cm2 and 208 cm2 electrode sizes, respectively, to investigate the process scalability. Under the optimal conditions, a 66% yield was achieved for 2-MNQ with 90% Faradaic efficiency at 50 mA/cm2 current density. We performed a comprehensive TEA on the key factors influencing electroorganic synthesis, including current density, electrode cost and lifespan, membranes, and electricity price. Furthermore, considering ongoing technological advancements in electrodes, membranes, and renewable electricity generation, we analyzed the trend of future projected cost reductions for electrosynthesis processes.
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Lin Jia,Ruichun Luo,Xiaoyu Zheng,Xiaotao Zhang,Ping Wang,Lu Lv,Longyi Fu,Weikang Dong,Chunyu Zhao,Dian Li,Tong Zhu,Yingjie Wang,Minghui Li,Jing Li,Yang Yang,Denan Kong,Jijian Liu,Qingmei Hu,Yang Zhao,Yan Xiong,Wu Zhou,Jiadong Zhou,Yao Zhou
Mixing entropy engineering is a promising strategy to tune the physical and chemical properties of materials. Although high-entropy in van der Waals bulk solids have been reported, entropy engineering in 2D monolayers remains unconquered. In this work, the epitaxial growth of a 2-inch 1T″ hexanary medium-entropy alloy monolayer (Re a W b Mo c In d S x Se y ) is reported via the chemical vapor deposition method. The atomic structure and chemical composition are confirmed by X-ray photoelectron spectroscopy, scanning transmission electron microscopy, energy dispersive X-ray spectroscopy and electron energy loss spectroscopy, illustrating the uniform distribution of the six elements. The hexanary medium-entropy alloy photodetectors show an ultrawide photo-response from visible to near-infrared wavelengths with a responsivity of 100.2 A W −1 under 520 nm laser illumination. Meanwhile, the hexanary medium-entropy alloy monolayer exhibits excellent electrocatalytic hydrogen production with an overpotential of 176.6 mV in dark. Importantly, an overpotential of 43.7 mV at 10 mA cm −2 with a lowered Tafel slope of 51.9 mV dec −1 under 520 nm laser irradiation is obtained due to the excellent conductivity. The work opens a new way to design mixing = entropy alloys and enables the application of transition metal dichalcogenides in photo-enhanced electrocatalytic hydrogen production.
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IONICS
·
2025
·
IF 2.6
Wang Zhaomin,Zhao Chaoyue,Niu Xiaodong,Cheng Yong,Wang Limin,Huang Pai
With high theoretical discharge specific capacity, excellent reversibility of electrochemical reaction, and suitable oxygen evolution overpotential, α -Ni(OH) 2 is an auspicious cathode material for alkaline batteries, which supports the development of high-capacity nickel-based batteries. Nevertheless, α -Ni(OH) 2 exhibits substandard structural stability and is susceptible to crystalline transformation, leading to capacity degradation, affecting the battery charge/discharge performance and cycle life. In this study, the TiO 2 -nickel hydroxide (TiO 2 - α -Ni(OH) 2 ) is prepared by high-energy ball milling. Among them, TiO 2 can be uniformly dispersed on the surface of α -Ni(OH) 2 , which can effectively prevent the collapse of the α -phase structure. Benefiting from the unique elemental doping technology, the TiO 2 - α -Ni(OH) 2 composites as a nickel-metal hydride (Ni-MH) battery cathode can release a reversible specific capacity of 390 mAh g −1 at a 2 C rate for 200 cycles. A reversible specific capacity of 210 mAh g −1 is still released after 200 cycles at a 5 C rate. Consequently, TiO 2 - α -Ni(OH) 2 is a promising candidate for high-power Ni-MH batteries.
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