ACS Applied Electronic Materials
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2020
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IF 0
Tianshu Zhai,Rongbin Wang,Takayoshi Katase,Frances Quigley,Hiromichi Ohta,Patrick Amsalem,Norbert Koch,Steffen Duhm
Tailor-made electrode work functions are indispensable to control energy-level offsets at the interfaces of (opto-)electronic devices. We show by means of photoelectron spectroscopy that several nanometer thick layers of the organic semiconductor 1,4,5,8,9,12-hexaazatriphenylene-2,3,6,7,10,11-hexacarbonitrile (HAT-CN) on virtually all substrates provide hole-injecting electrodes with work functions of around 5.60 eV. This substrate-independent energy-level alignment is due to a relatively large density of gap states in HAT-CN thin films, which is clearly visible in the photoemission data. Furthermore, this additional density of occupied states makes the wide-gap semiconductor thin films sufficiently conductive for electrode applications. Moreover, our study highlights a quite intriguing energy-level alignment scenario as the Fermi-level in HAT-CN thin films is located far from the midgap position, this is rather uncommon for undoped organic semiconductor thin films.
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ACS Nano
·
2020
·
IF 14.588
Jiani Zhu,Lei Wang,Jin Wang,Fudi Wang,Mengtao Tian,Shuchang Zheng,Ning Shao,Lele Wang,Miaolu He
Two-dimensional (2D) membranes exhibit exceptional properties in molecular separation and transport, which reveals their potential use in various applications. However, ion sieving with 2D membranes is severely restrained due to intercalation-induced swelling. Here, we describe how to efficiently stabilize the lamellar architecture using Keggin Al13 polycations as pillars in a Ti3C2Tx membrane. More importantly, interlayer spacing can be easily adjusted with angstrom precision over a wide range (2.7–11.2 Å) to achieve selective and tunable ion sieving. A membrane with narrow d-spacing demonstrated enhanced selectivity for monovalent ions. When applied in a forward osmosis desalination process, this membrane exhibited high NaCl exclusion (99%) with a fast water flux (0.30 L m–2 h–1 bar–1). A membrane with wide d-spacing showed notable selectivity, which was dependent on the cation valence. When it was applied to acid recovery from iron-based industrial wastewater, the membrane showed good H+/Fe2+ selectivity, which makes it a promising substitute for traditional polymeric membranes. Thus, we introduce a possible route to construct 2D membranes with appropriate structures to satisfy different ion-sieving requirements in diverse environment-, resource-, and energy-related applications.
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高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2020
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IF 3.004
Chen Sun,Mingyu Zhang,Yanhong Zhao,Jianxin Pang,Ying Peng,Jiang Zheng
Urate anion exchanger 1 (URAT1) expressed in the proximal renal tubules is responsible for about 90% of the reabsorption of uric acid. URAT1 is identified as an important target of uricosuric drugs. Here we present an LC-MS/MS-based approach, combined with URAT1-transgenic MDCK cells, for the assessment of uric acid. Cell lysis was executed with 50 mM NaOH to release uric acid. 1,3- 15 N 2 uric acid was employed as the internal standard. The harvested uric acid, along with the stable isotope-labeled uric acid, was analyzed by LC-MS/MS in multiple reactions monitoring and negative modes. Validation, i.e. determination of selectivity, precision, accuracy, extraction recovery, and matrix effect, and feasibility was evaluated by use of the approach developed. The linearity was observed in the range of 1.0–250 μM (r = 0.9960) with limit of detection of 50 nM and limit of quantitation of 200 nM. The precision and accuracy were found to be RSD ≤ 20% and 80–120% of the nominal value, respectively. Uric acid uptake showed concentration and time dependency in URAT1-transgenic cells. The observed inhibitory effects of three URAT1-targeted uricosuric drugs were consistent with those reported in literature. The stable isotope dilution-based approach was proven to be selective, sensitive, and convenient, which is a good in vitro model for URAT1-targeted drug candidate screening.
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高影响因子
Journal of Materials Chemistry C
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2020
·Vol. 8
·期 37
·12865-12875
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IF 7.059
Pan Shu,Xiaofei Cao,Yongqiang Du,Jiankui Zhou,Jianjun Zhou,Shengang Xu,Yingliang Liu,Shaokui Cao
The fiber-shaped resistive random access memory (RRAM) is an important subject for flexible wearable electronic textiles. The investigation of the resistive switching (RS) performance of the materials in the basic storage unit (crosspoint) of a flexible fibrous crossbar is very significant for realizing flexible wearable memories. In this work, fibrous crosspoint RRAM devices, abbreviated as FCPe-RRAMs, have been fabricated on the basis of organic–inorganic halide perovskite MAPbI3. Herein, a functional Al@MAPbI3 fiber is first prepared via a simple dip-coating method, in which the low-temperature solution processing method and cheap raw materials are conducive to the future large-scale and low-cost production. By optimizing the preparation conditions for MAPbI3, a pinhole-free, compact and uniform perovskite film is deposited on the bare Al fiber. Then, the FCPe-RRAM devices with a configuration of Al@MAPbI3/Al are assembled on a homemade holder by perpendicularly crossing the bare Al fiber and the functional Al@MAPbI3 fiber at a certain bending angle. The FCPe-RRAM devices exhibit a bipolar RS behaviour. The highest ON/OFF ratio reaches up to approximately 106 in the FCPe-RRAM devices, together with a low SET/RESET voltage (+1.66 V/−0.47 V) and a long retention time (>104 s). The FCPe-RRAM devices also exhibit excellent reproducibility and operational uniformity, which are important for practical applications in mass production. The investigation of the RS mechanism suggested that the FCPe-RRAM devices follow the mechanism of conductive metallic filament formation by the generated electrons with the help of thermionic emission. This work reveals the potential promising applications of FCPe-RRAM devices in flexible wearable memories with high storage density.
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高影响因子
Nature Protocols
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2020
·Vol. 16
·期 1
·431-457
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IF 10.419
Jin Shuai,Gao Qiang,Gao Caixia
Base editors can achieve targeted genomic base conversion. However, the off-target issue is one of the major concerns in their application. Whole-genome sequencing (WGS) at the individual level can provide direct information on genome-wide specificity, but it is difficult to distinguish true off-target single-nucleotide variants (SNVs) induced by base editors from background variation. Here we describe an unbiased WGS method for evaluating the specificity of base editors in rice. In this protocol, we describe the experimental design and provide details of vector construction, rice transformation and tissue culture, as well as a comprehensive WGS data analysis pipeline for overcoming two related core problems in various plant species: high background mutation rates and the heterogeneity of examined populations. Using this protocol, researchers can straightforwardly and accurately assess the genome-wide specificity of base editors and other genome editing tools in 12–15 weeks.
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高影响因子
REACTIVE & FUNCTIONAL POLYMERS
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2020
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IF 3.333
Naveed Athir,Sayyed Asim Ali Shah,Farooq Khurum Shehzad,Jue Cheng,Junying Zhang,Ling Shi
Zwitterion polyurethanes (ZPU) are used for non-fouling and antimicrobial surfaces but their sensitive nature under ultra-violet (UV) radiations limits the requirements of engineering materials . Herein, ZPU is successfully synthesized and then prepared different TiO 2 /ZPU composites, aiming to increase the service life of ZPU and to form active film for food packaging applications. The thermo-mechanical results revealed that the 4% TiO 2 /ZPU sample exhibits better performance, as evidenced through tensile testing and surface morphology analysis. The UV–Vis spectra results indicated that the rutile TiO 2 nanoparticles can enhance the UV absorption and visible light reflectance, decreasing photoaging properties of composites thereby prolonging its shelf life. Moreover, scanning electron microscopy ( SEM) observation after 5 h irradiation of UV light confirmed the photostability of TiO 2 /ZPU composite film . Further, the antioxidant ability of ZPU is increased from 51% to 71% with TiO 2 . The results of antimicrobial activity of TiO 2 /ZPU demonstrate strong bacterial growth inhibition against E. coli that regards its suitability for food and other packaging applications. Besides, the food preservation ability is monitored by visual changes of tomato fruit. In essence, we anticipate that the TiO 2 /ZPU composite films possessed all expected features to be considered as photostable material for food packaging.
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高影响因子
CATALYSIS TODAY
·
2020
·
IF 5.825
Linhao Yu,Hong Chen,Zhe Wen,Mengmeng Jin,Zewei Ma,Xueli Ma,Yushuai Sang,Mengmeng Chen,Yongdan Li
Selective oxidation of 5-hydroxymethylfurfural (HMF) to 2, 5-diformylfuran (DFF) with molecular oxygen is realized with an α-MnO 2 catalyst under mild conditions. In this work, α-MnO 2 exhibited the best performance among the samples examined. Meanwhile, solvent shows a significant effect on the product selectivity and isopropanol is found good for improving the selectivity of DFF. 93.2 % conversion of HMF was achieved at 140 °C for 4 h with 84.3 % selectivity of DFF. Moreover, α-MnO 2 catalyst keeps good reusability in recycling for five times. The reaction pathway indicated that the lattice oxygen species on α-MnO 2 is involved in the selective oxidation of hydroxyl group in HMF molecule.
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高影响因子
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
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2020
·
IF 2.366
Wei-Ming Chai,Zi-Yi Yu,Mei-Zhen Lin,Qi-Ming Wei,Shuang Song
In this study, 5-methoxy-2-mercaptobenzimidazole (5-M-2-MB) was confirmed as an efficient tyrosinase inhibitor by methods of enzyme kinetic, fluorescence quenching , ANS-binding, thermodynamics, energy transfer, and molecular docking in combination. The results proved that 5-M-2-MB significantly inhibited the tyrosinase (IC 50 = 60 ± 2 nM) in a reversible and competitive way with the K i value of 80 ± 1 nM. It quenched the intrinsic fluorescence of tyrosinase through a static mechanism, and caused conformational change of the enzyme by increasing the hydrophobic region. Moreover, this compound could bind to tyrosinase and form 5-M-2-MB-tyrosinase complex by hydrogen bond and hydrophobic interaction. The interactions were generated between 5-M-2-MB and specific amino acid residues (Trp-358, Thr-308, Glu-356, and Asp-357) located on the A chain of tyrosinase. Therefore, this study would offer a theoretical foundation for developing the new tyrosinase inhibitor.
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高影响因子
CORROSION SCIENCE
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2020
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IF 6.479
Yang Du,Mingyin Kou,Jiguo Tu,Mingyong Wang,Shuqiang Jiao
The electrochemical behavior of TiB 2 anode is investigated in the present work in order to obtain the anodic behavior in molten CaCl 2 -CaO. The work reveals that the passivation film is generated on the surface of TiB 2 anode during the anodic polarization process, leading to a higher pitting potential than that of the Pt electrode. After 100 h potentiostatic electrolysis, the TiB 2 anode shows a corrosion rate as low as 1.38 × 10 -3 g cm -2 h -1 . The formation mechanism of the TiB 2 anode passivation film after electrolysis is determined as TiB 2 + O 2- → Ti(BO 3 ) + O 2- → TiO 2 + CaO → CaTiO 3 .
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Journal of Functional Foods
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2020
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IF 3.701
Peixin Wang,Hongliang Zeng,Shaoling Lin,Zhigang Zhang,Yi Zhang,Jiamiao Hu
Hairtail ( Trichiurus lepturus ) is a nutritious marine product that has attracted increasing attention due to its bioactive compounds. In this study, the anti-fatigue properties of hairtail hydrolysate were evaluated by exhaustive swimming experiments. Results indicate hairtail peptide supplementation increased the exhaustive weight-loaded swimming time. Furthermore, decreases in blood lactic acid (BLA), blood urea nitrogen (BUN), creatine kinase (CK), and malondialdehyde (MDA) content; and increases in glycogen content and antioxidant enzymes activities were observed in mice receiving hairtail peptides treatment after a 30 min swimming test. Pearson correlation analysis suggests fatigue indexes, including energy sources (hepatic glycogen and muscle glycogen content), metabolites (BLA and BUN content), and CK content significantly correlated with antioxidant levels (glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) activities and MDA content) and fecal SCFA content (propionic acid and butyrate acid content). In conclusion, long-term supplementation with hairtail peptides may improve exercise performance by relieving fatigue.
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高影响因子
MACROMOLECULAR BIOSCIENCE
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2020
·Vol. 21
·期 1
·2000194
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IF 3.416
Yunfei Zhang,Kuan Hu,Xuan Xing,Jingshuang Zhang,Ming-Rong Zhang,Xiaohui Ma,Rui Shi,Liqun Zhang
Antibacterial coating is rapidly emerging as a pivotal strategy for mitigating spread of bacterial pathogens. However, many challenges still need to be overcome in order to develop a smart coating that can achieve on-demand antibacterial effects. In this study, a Staphylococcus aureus ( S. aureus ) sensitive peptide sequence is designed, and an antibiotic is then conjugated with this tailor-made peptide. The antibiotic-peptide conjugate is then linked to the surface of a titanium implant, where the peptide can be recognized and cleaved by an enzyme secreted by S. aureus . This allows for the release of antibiotics in the presence of S. aureus , thus achieving delivery of an antibacterial specifically when an infection occurs.
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高影响因子
Advanced Photonics Research
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2020
·Vol. 1
·期 1
·2000007
·
IF 0
Xuan Zhao,Yong Chen,XianYin Dai,WeiLei Zhou,JingJing Li,Yu Liu
Nitroaromatic compounds (NACs) are the components of explosives that pose a serious hazard to the environment and human health, especially 2,4,6-trinitrophenol (TNP), which has strong explosibility and good water solubility. An effective supramolecular fluorescent probe for nitroaromatic detection is prepared based on the sulfato-β-cyclodextrin (SCD)-induced molecular aggregation of 9,10-bis{4-[2-( N , N , N -trimethylammonium)hexyloxy]styrene} anthracene dibromide (AnEA) and subsequent aggregation-induced emission, which presents high sensitivity particularly toward TNP with a detection limit of 586 ppb in water and 23 ppb on the test paper. Herein, a convenient and effective supramolecular means for nitro-detection in water is provided.
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危险品化学品经营许可证（带存储）