Journal of Materials Chemistry A
·
2014
·Vol. 2
·期 33
·13471-13478
·
IF 0
Yunfeng Qiu,Zhuo Ma,PingAn Hu
We report the facile synthesis of environmentally benign Au NPs/chitosan composites and magnetic Au NPs/chitosan/Fe3O4 composites without employing any toxic reductants or capping agents. Renewable natural chitosan not only functioned as supporting matrix, but also served as a reductant and stabilizer for the formation and dispersions of Au NPs. Fe3O4 nanospheres were easily embedded into the chitosan matrix due to the strong complexation ability of chitosan with Fe3O4, which originated from the sharing of the lone electron pairs from the nitrogen atom in amine with FeII or FeIII on the surface of Fe3O4. The as-prepared magnetic composites exhibited much higher activities, as well as more convenient magnetic recyclability than other supported Au NPs towards the reduction of 4-nitrophenol. From the practical point of view, apart from good performance of the reduction of nitro compounds, the biocompatibility and biodegradability of present Au NPs/chitosan/Fe3O4 composites promote the potential applications in the biochemical catalysis or therapy.
✓ 已验证
产品关联
DOI
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Chen Wang,Yilin Wu,Jian Lu,Juan Zhao,Jiuyun Cui,Xiuling Wu,Yongsheng Yan,Pengwei Huo
A bioinspired photocatalytic nanocomposite membrane was successfully prepared via polydopamine (pDA)-coated poly(vinylidene fluoride) (PVDF) membrane, as a secondary platform for vacuum-filtrated Au-TiO2 nanocomposites, with enhanced photocatalytic activity. The degradation efficiency of Au-TiO2/pDA/PVDF membranes reached 92% when exposed to visible light for 120 min, and the degradation efficiency of Au-TiO2/pDA/PVDF membranes increased by 26% compared to that of Au-TiO2 powder and increased by 51% compared to that of TiO2/pDA/PVDF nanocomposite membranes. The degradation efficiency remained about 90% after five cycle experiments, and the Au-TiO2/pDA/PVDF nanocomposite membranes showed good stability, regeneration performance, and easy recycling. The pDA coating not only served as a bioadhesion interface to improve the bonding force between the catalyst and the membrane substrate but also acted as a photosensitizer to broaden the wavelength response range of TiO2, and the structure of Au-TiO2/pDA/PVDF also improves the transfer rate of photogenerated electrons; the surface plasmon resonance effect of Au also played a positive role in improving the activity of the catalyst. Therefore, we believe that this study opens up a new strategy in preparing the bioinspired photocatalytic nanocomposite membrane for potential wastewater purification, catalysis, and as a membrane separation field.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2016
·Vol. 4
·期 11
·2117-2122
·
IF 5.066
Dandan Men,Fei Zhou,Lifeng Hang,Xinyang Li,Guotao Duan,Weiping Cai,Yue Li
Free-standing 2D Au nanosphere array/hydrogel composite sensing films were prepared by attaching a 2D Au nanosphere array onto a polyacrylic acid (PAAc) hydrogel film, which could be used as visualized sensors. These 2D Au nanosphere array/hydrogel composite films displayed visually diffraction color and much stronger diffraction intensity due to their periodic structures and large scattering cross-section of the Au nanospheres. Their diffraction intensity was increased by more than one order of magnitude (88 times) compared to that of 2D PS sphere array/hydrogel composite films to external stimuli, which is useful for visual observation by the naked eye and further optical characterization. Such 2D Au nanosphere array/hydrogel composite films exhibit ultrahigh diffraction intensity for them to be used for the visual determination of an analyte. The presented strategy could be extended to develop different visualized sensors based on various functional hydrogel films.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2016
·
IF 2.822
Meirong Cui,Ruizhen Yu,Xiaomeng Wang,Hong Zhou,Jing Liu,Shusheng Zhang
Recent studies show that ECL resonance energy transfer (ECL-RET) coupled with H 2 O 2 -related enzymatic reactions is an efficient strategy for designing excellent ECL biosensors with high sensitivity. Here we find that a ternary composite named graphene/Au-CdS:Eu QDs demonstrated ECL-RET effect with Au nanorods (Au NRs) and horseradish peroxidase (HRP) on the Au NRs could catalyze hydrogen peroxide reduction in the presence of hydroquinone (HQ). Therefore, we developed an efficient dual-quenching ECL immunosensor based on the novel ternary composite with high ECL intensity coupled with H 2 O 2 -related enzymatic reactions and ECL-RET strategy from Au NRs. This ultrasensitive ECL sensing strategy combined the advantages of the excellent ECL sensing properties of graphene/Au-CdS:Eu QDs, and dual-quenching effect and achieve sensitive detection of alpha fetoprotein (AFP).
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale Research Letters
·
2016
·Vol. 11
·期 1
·1-13
·
IF 2.584
Yang Yao,Zhang Jingjing,Xia Fangfang,Zhang Chunlei,Qian Qirong,Zhi Xiao,Yue Caixia,Sun Rongjin,Cheng Shangli,Fang Shan,Jin Weilin,Yang Yuming,Cui Daxiang
How to realize targeted photoacoustic imaging, enhanced immunotherapy, and photothermal therapy of gastric cancer has become a great challenge. Herein, we reported for the first time that human cytokine-induced killer cells (CIK) loaded with gold nanorods were used for targeted photoacoustic imaging, enhanced immunotherapy, and photothermal therapy of gastric cancer. Silica-modified gold nanorods were prepared; then incubated with human cytokine-induced killer cells (CIK), resultant human CIK cells loaded with Au nanorods were evaluated for their cytotoxicity, targeted ability of gastric cancer in vitro and in vivo, immunotherapy, and photothermal therapy efficacy. In vitro cell experiment shows that human CIK cells labeled with gold nanorods actively target gastric cancer MGC803 cells, inhibit growth of MGC803 cells by inducing cell apoptosis, and kill MGC803 cells under low power density near-infrared (NIR) laser treatment (808-nm continuous wave laser, 1.5 W/cm2, 3 min). In vivo experiment results showed that human CIK cells labeled with gold nanorods could target actively and image subcutaneous gastric cancer vessels via photoacoustic imaging at 4 h post-injection, could enhance immunotherapy efficacy by up-regulating cytokines such as IL-1, IL-12, IL-2, IL-4, IL-17, and IFN-γ, and kill gastric cancer tissues by photothermal therapy via direct injection into tumor site under near-infrared (NIR) laser irradiation. High-performance human CIK cells labeled with Au nanorods are a good novel theranostic platform to exhibit great potential in applications such as tumor-targeted photoacoustic imaging, enhanced immunotherapy, and photothermal therapy in the near future.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2017
·Vol. 123
·期 9
·1-9
·
IF 1.455
Leng Yumin,He Junbao,Li Bo,Xing Xiaojing,Guo Yongming,Ye Liqun,Lu Zhiwen
The different sized and shaped Au NPs have intrigued considerable attention, because they possess different surface plasma resonance (SPR) absorption bands and thus result in many colorimetric Au NP-based detection applications. In this article, four different sized and shaped Au NPs of nanodots/rods were prepared and characterized. The as-prepared Au NPs were modified by the negatively charged anions of [SCH 2 CO 2 ] 2− to investigate both the size and shape effects of modified Au NPs on colorimetric detection of Co 2+ and the corresponding SPR absorption properties. The different-shaped Au NPs possess different SPR absorption properties. The Au nanorods appeared to be colorimetric sensitive for Co 2+ sensing.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2017
·Vol. 53
·期 3
·1945-1961
·
IF 2.599
Xu Jing-Wen,Cui Zhuo-Miao,Xu Feng,Luo Yan-Ling
Multi-component block copolymer nanohybrids consisting of Fe 3 O 4 nanoparticles and poly(acryloyloxyethyloxyl 1-mercaptohemisuccinate) and poly(methacrylic acid) (PMAA) blocks were synthesized via the surface-initiated atom transfer radical polymerization, followed by the esterification with d,l-mercaptosuccinic acid. The block copolymer nanohybrids were coordinated with Au nanoparticles (Au NPs) through pendent thiol groups to form Au NPs coordinated Fe 3 O 4 graft block copolymer nanohybrids. Fluorescent spectrometry, TEM and SEM findings indicated that these block copolymer nanohybrids could self-assembled and form globular core–shell nanomicelles, and their critical micelle concentrations decreased with the decrease in the length of PMAA chains and the incorporation of Au NPs. Zeta potential measurements signified that the copolymer nanohybrids possessed significantly high stability. DLS results indicated that hydrodynamic diameters of the copolymer nanohybrids distributed within the scope of 85–155 nm, hinging on the length of the graft chains and the complexation of Au NPs. The hybrid block copolymer nanomicelles exhibited pH, electrochemical and magnetic responsiveness, with pH transition points at 5.3–5.9. The incorporation and the loading percentage of Au NPs improved the reversibility of the electrochemical response and plasmon resonance. The block copolymer nanohybrids were superparamagnetic and were expected to broaden their applications by virtue of the multi-component combination and the resulting multifunctionality.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2017
·
IF 3.012
Fangming Lou,Zhisong Lu,Fangxin Hu,Chang Ming Li
In this paper, a high-performance three dimensional (3D) bio-platform of glucose oxidase (GOD) adsorbed on Au nanoparticles (AuNPs) assembled polyaniline (PANi) nanowires network (GOD/AuNPs/PANi) was constructed to sensitively detect glucose by electrochemiluminescent (ECL) technology for the first time. Due to the unique structure of porous network, excellent conductivity and good biocompatibility for enzyme, the bio-platform enable highly strong the ECL emission, which make the proposed biosensor achieves a wide linear range of 0.1–100 μM (R 2 = 0.992), extremely low detection limit of 0.05 μM (S/N = 3), excellent selectivity and good stability in glucose detection. When the proposed biosensor was used in serum samples determination, a satisfactory result also obtained.
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2017
·
IF 2.714
Yi Shang,Zhihai Cao,Hangnan Chen,Yangyi Sun,Jia Yao,Lin Yang,Dongming Qi,Ulrich Ziener
In our previous paper, we reported the synthesis of easily recyclable and highly active rice roll-like (RR-like) Au/SiO 2 nanocatalysts (NCs) in inverse miniemulsions [Colloids Surf. A 517, 2017, 52–62]. In the present contribution, the influences of three key synthesis parameters, including the 3-aminopropyltriethoxysilane (APTES) content, reaction temperature, and urea amount, on the particle properties of the Au/SiO 2 NCs were systematically investigated. The role of these synthesis parameters in the formation of SiO 2 nanosupports and Au nanoparticles (NPs) was discovered. The RR-like SiO 2 nanosupports could only be formed in the systems within the range of 20–80 mol% of APTES content, at reaction temperatures above 60 °C, and with more than 0.72 mg of urea. The AuCl 4 − ions could be immobilized onto the aminopropyl-functionalized SiO 2 nanosupports through a coordination interaction. The immobilized ions were reduced by the aminopropyl groups at elevated temperatures. The APTES content and reaction temperature play an important role in controlling the particle size and its distribution of Au NPs. The catalytic activity of Au/SiO 2 NCs depends significantly on the APTES content. The RR-like Au/SiO 2 NCs with smaller immobilized Au NPs and higher specific surface area display higher catalytic activity towards hydrogenation of p -nitrophenol.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2016
·
IF 3.782
Jiasheng Fang,Yiwei Zhang,Yuming Zhou,Shuo Zhao,Chao Zhang,Hongxing Zhang,Xiaoli Sheng
A novel strategy was described to construct Au-based yolk-shell SCVmS-Au nanocomposites (NCs), which combined the sol-gel template-assisted process for the assembly of hierarchical SCVmS NCs with modified CeO 2 /mSiO 2 as yolks/shells, and the unique deposition-precipitation (DP) process mediated with Au(en) 2 Cl 3 compounds for the synthesis of extremely stable supported Au nanoparticles (NPs). Characterization results indicated that the obtained SCVmS-Au NCs featured mesoporous silica shells, tunable interlayer voids, movable CeO 2 -modified cores and numerous sub-5 nm Au NPs. Notably, the Au(en) 2 Cl 3 was employed as gold precursors to chemically modify into the modulated yolk-shell structure through the DP process and the subsequent low-temperature hydrogen reduction induced the in-situ formation of abundant supported Au NPs, bestowing these metal NPs with ultrafine grain size and outstanding sinter-resistant properties that endured harsh thermal conditions up to 750 °C. Benefiting from the structural advantages and enhanced synergy of CeO 2 -Au/mSiO 2 -Au yolks/shells, the SCVmS-Au was demonstrated as markedly efficient catalysts with superior activity and reusability in catalyzing the reduction of 4-nitrophenol to 4-aminophenol, and its pristine morphology still maintained after eight recycling tests.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2016
·
IF 8.387
Zhenzhen Wang,Kai Dong,Zhen Liu,Yan Zhang,Zhaowei Chen,Hanjun Sun,Jinsong Ren,Xiaogang Qu
As common reactive oxygen species, H 2 O 2 is widely used for bacterial inactivation and wound disinfection . However, the concentrations used are always higher than physiological levels , which frequently result in potential toxicity to healthy tissue and even delay wound healing. Here we report highly efficient nanozyme hybrids that are capable of activating biologically relevant concentrations of H 2 O 2 for defending bacterial infections. The integration of AuNPs with ultrathin graphitic carbon nitride (g-C 3 N 4 ) provides excellent peroxidase-activity, which can catalyze the decomposition of H 2 O 2 to OH radicals much more efficiently, allowing the use of bio-safety levels of H 2 O 2 for the first time. Furthermore, our system not only exhibits striking bactericidal performance against both DR Gram-negative and DR Gram-positive bacteria, but also shows high efficiency in breaking down the existing DR-biofilms and prevented formation of new biofilms in vitro. More importantly, in vivo experiments indicate that our system could significantly prevent bacterial infections and accelerate the healing rate of wounds.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2016
·
IF 7.476
Hong-Lei Shuai,Ke-Jing Huang,Ying-Xu Chen,Lin-Xia Fang,Meng-Pei Jia
An ultrasensitive electrochemical biosensor for detecting microRNAs is fabricated based on hollow molybdenum disulfide (MoS 2 ) microcubes. Duplex-specific nuclease , enzyme and electrochemical–chemical–chemical redox cycling are used for signal amplification . Hollow MoS 2 microcubes constructed by ultrathin nanosheets are synthesized by a facile template-assisted strategy and used as supporting substrate. For biosensor assembling, biotinylated ssDNA capture probes are first immobilized on Au nanoparticles (AuNPs)/MoS 2 modified electrode in order to combine with streptavidin-conjugated alkaline phosphatase (SA-ALP). When capture probes hybridize with miRNAs, duplex-specific nuclease cleaves the formative duplexes. At the moment, the biotin group strips from the electrode surface and SA-ALP is incapacitated to attach onto electrode. Then, ascorbic acids induce the electrochemical–chemical–chemical redox cycling to produce electrochemical response in the presence of ferrocene methanol and tris (2-carboxyethyl) phosphine. Under optimum conditions, the proposed biosensor shows a good linear relationship between the current variation and logarithm of the microRNAs concentration ranging from 0.1 fM to 0.1 pM with a detection limit of 0.086 fM (S/N=3). Furthermore, the biosensor is successfully applied to detect target miRNA-21 in human serum samples.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）