SEPARATION AND PURIFICATION TECHNOLOGY
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2025
·
IF 9
Zishuai Hu,Mankun Li,Yidan Pang,Yongmei Liang,Baochen Han,Jian Qi,Fanchun Meng,Yaqiang Li,Guangqian Zhu,Lekbach Yassir,Jianhui Li,Dan Liu
Hydrogel coatings demonstrate potential for protecting against microbiologically influenced corrosion; however, they encounter limitations related to weak mechanical properties and toxicity from chemical crosslinkers. In this study, we prepared a photocatalytic antibacterial hydrogel coating using chitosan and sodium alginate loaded with 2D g-C 3 N 4 , which exhibited robust tensile properties, low swelling rates, and exceptional antibacterial efficacy against Escherichia coli and Staphylococcus aureus. The antibacterial activity is primarily attributed to the adsorption of bacteria by –NH 2 groups and the generation of reactive oxygen species by 2D g-C 3 N 4 . Furthermore, the electron-rich microenvironment created by –NH 2 and –OH groups attract the h + generated during 2D g-C 3 N 4 photocatalysis, thereby enhancing the efficiency of charge carrier separation. Density functional theory calculations further support this conclusion. The incorporation of 2D g-C 3 N 4 nanomaterials alters the hydrogel coating structure, disrupting hydrogen bonding and exposing additional –NH 2 groups that bind with H + to improve active adsorption. This innovative hydrogel coating offers a novel strategy for protecting against microbial corrosion in marine environments.
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高影响因子
ANALYTICAL SCIENCES
·
2025
·
IF 2
Xia Shaojie,Yang Zhenyuan,Sun Xiaohui,Huang Junjie,Peng Kuan,Wang Yonghong
Ochratoxin A (OTA), a highly toxic mycotoxin, extensively contaminates a wide range of food commodities. Given increasing demands for sensitive and user-friendly detection platforms, we developed a colorimetric OTA biosensor leveraging copper-silver nanoclusters (Cu/Ag NCs), whose peroxidase-like activity is augmented via G/C-rich DNA hybridization. The system employs two tailored DNA strands: a template strand featuring a cytosine-rich domain for NC synthesis flanked by terminal recognition segments and an enhancer strand containing a guanine-rich signal amplification domain and a complementary linker. Upon OTA binding with the aptamer, the apt-template complex dissociates, facilitating template-enhancer hybridization to form G/C-rich double-stranded DNA. This structural transition substantially enhances the peroxidase-like activity of DNA-Cu/Ag NCs, accelerating the oxidation of 3,3′,5,5′-tetramethylbenzidine by H 2 O 2 while simultaneously amplifying the colorimetric signal. Quantitative OTA detection is accomplished by monitoring this dynamic color response. The biosensor demonstrates a semi-log linear detection range from 5.0 nM to 1.0 μM with a detection limit of 5.0 nM. Furthermore, the specific test has high selectivity for other common mycotoxins, and its applicability has been validated through real sample analysis, suggesting that the DNA-Cu/Ag NCs biosensor used for OTA detection holds promising practical applications in food samples. Graphical abstract
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PubMed
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2014
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IF 2.291
Li-Na Wen,Meng-Xia Xie
s G-quadruplex DNA is an effective target for anticancer drug, and investigation of the G-quadruplex DNA with natural compounds plays a key role in the development of anticancer drugs. In this article, room temperature phosphorescence sensing system based on l -cysteine-capped Mn-doped ZnS QDs has been established. Sanguinarine can adsorb on the surface of Mn-doped QDs and quenched the phosphorescence emission of the sensor. When the G-quadruplex sequences combined with the sanguinarine of the QDs-sanguinarine system, the phosphorescence intensities of the QDs sensors would be restored, and the binding abilities of the G-quadruplex DNA with the sanguinarine can be evaluated by the phosphorescence recoveries of the sensor system. Based on the developed approach, the interaction of sanguinarine and six G-quadruplex DNA with various sequences (tel24-1, tel24-2, tel22, k-ras, HIF-1α and c-kit1) has been investigated. The results showed that the binding abilities of the G-quadruplex DNA with sanguinarine were related to their number of bases and conformations. The conformational changes of the six G-quadruplex DNA, after binding with sanguinarine, have also been probed by circular dichroism. Combining the changes of the phosphorescence lifetime, the binding mechanism of the G-quadruplex DNA and sanguinarine has been discussed. The developed method was simple, rapid and specific, and can avoid fluorescence interferences of the system, and it would be prospective to evaluate the interaction of the drug with different G-quadruplexes.
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NEW JOURNAL OF CHEMISTRY
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2025
·
IF 2.5
Qian Zhang,Qianrui Yang,Tianci Liu,Yuchen Yue,Jingran Zhang,Guifu Zuo
In this work, a novel Faraday cage-type electrochemiluminescence (ECL) biosensor was constructed for the ultrasensitive "turn on" detection of CEA. The capture unit was prepared by immobilizing the Carcinoembryonic antibody Ab 1 onto the functionalized magnetic Fe 3 O 4 nanoparticles, while the detection unit consisted of modified g-C 3 N 4 labeled with antibody Ab 2 . The recognition scaffold was assembled as follows: the capture unit was first fixed onto the magnetic electrode surface; the target CEA was then captured; followed by further hybridized with the detection unit; ultimately forming the Faradaycage biosensor structure. In this configuration, the signal unit became part of the electrode surface, enabling all electrochemiluminophores in the signal unit to participate in the electrode reaction, thereby significantly enhancing the detection sensitivity. Utilizing the proposed Faraday-cage cascade, the ECL intensity increased with the rising CEA concentration. The linear range was from 0.01 to 100 ng/mL, with a detection limit of 0.35 pg/mL. The sensor was validated for its selectivity, stability, reproducibility, precision, and application potential. This Faraday cage-type ECL biosensor shows promising prospects for clinical CEA detection.
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高影响因子
FUEL
·
2025
·
IF 7.5
Shiyu Wang,Shuai Wang,Mingmei Ge,Yang Zhao,Hua Song,Huan Wang
This work introduces a template-free strategy for preparing three-dimensional (3D) honeycomb-like graphitic carbon nitride (g-C 3 N 4 ) with high specific surface area through phosphoric acid-regulated supramolecular self-assembly. By systematically tuning phosphoric acid dosage, the self-assembly process of melamine-cyanuric acid aggregates is precisely controlled, resulting in a hierarchically porous architecture with interconnected channels and abundant porosity. The optimized phosphoric acid-mediated support (SSCN-0.89) enables uniform dispersion and stabilization of ultrafine Pt nanoparticles (∼1.7 nm) via enhanced metal-support interactions. Under mild conditions (120 ℃, 0.5 MPa H 2 ), the resultant Pt/SSCN-0.89 catalyst achieves 94.1 % phenol conversion within 80 min with exclusive cyclohexanol selectivity (100 %). Mechanistic studies reveal that the hierarchical porous structure facilitates rapid mass transfer, while the tailored surface nitrogen species lower the reaction energy barrier. The catalyst retains robust stability over five cycles, demonstrating the pivotal role of 3D morphological engineering in designing high-performance carbon nitride-based catalytic supports for biomass upgrading.
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高影响因子
PLOS BIOLOGY
·
2025
·Vol. 23
·期 12
·e3003480
·
IF 7.2
Fang Ye,Zhiyi Zhang,Binghao Zhang,Xinyu Li,Jiaxi Deng,Qian Miao,Peiruo Ning,Yunlin Chi,Geng Chen,Zhangsong Wu,Qian Wang,Lezhi Xu,Ningjie Gong,Bangning Cheng,Zhigang Ma,Chungen Qian,Lizhe Zhu,Xin Pan,Yang Du
The hydroxycarboxylic acid receptors (HCAR2 and HCAR3), also known as prototypical metabolite-sensing receptors, are key targets for treating dyslipidemia and metabolic disorders. While HCAR2 activation, but not HCAR3 activation, is associated with side effects of cutaneous flushing, the structural features and ligand preferences of HCAR3 remain less understood. Here, we used Sf9 cells to express HCAR3-Gi and HCAR2-Gi complexes, and present cryo-EM structures of HCAR3-Gi complexes with agonists compound 6O (3.31 Å), D-phenyllactic acid (3.05 Å), IBC293 (3.26 Å), and acifran (3.18Å), as well as HCAR2-Gi complex with agonist acifran (2.72 Å). Our findings reveal the mechanism behind 6O’s highest affinity to HCAR3, attributed to its full occupation of both R1 and R2 regions of the orthosteric binding pocket. Moreover, combined with cAMP assay in HEK-293 cells, we have elucidated that the ligand selectivity between HCAR3 and HCAR2 depended on π – π interaction with F107 3.32 (L107 3.32 in HCAR2) and ligand-binding pocket size difference, facilitated by key residues difference V/L83 2.60 , Y/N86 2.63 , and S/W91 23.48 . Collectively, these structural insights lay the groundwork for developing HCAR3-specific drugs, potentially avoiding HCAR2-induced adverse effects.
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PubMed
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 71
·41591-41602
·
IF 3.049
Yu Qiao,Qian Han,Dong Li,Hongji Li,Bing Wei,Guangbo Che,Wei Jiang,Weisheng Guan
A novel Ag/metal–organic framework/graphitic carbon nitride (Ag/HKUST-1/g-C3N4, AHC) photocatalyst was prepared via an in situ growth strategy and photo-deposition technique for environmental remediation. The as-obtained samples were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), N2 adsorption–desorption isotherm measurement, UV-vis diffuse reflection spectroscopy (UV-vis DRS), and photoluminescence (PL) spectroscopy. The results indicated that the hybrids have large surface area, mesoporous structure and enhanced visible-light absorption. The as-prepared hybrid samples exhibited considerable improvement in photocatalytic activity and stability for rhodamine B (RhB) degradation under visible light irradiation (λ > 420 nm). In addition, they also have good adsorption properties. Compared to the pure g-C3N4 and Ag/g-C3N4, the 5% AHC photocatalyst showed superior photocatalytic activity. Moreover, 5% AHC exhibits good photocatalytic activity even after four cycles. Additionally, the active species trapping and electron spin resonance (ESR) experiments indicated that h+ and ·OH were the main active species.
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高影响因子
Desalination and Water Treatment
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2024
·
IF 1
Jun Yin,Xinan Cai,Bingshan Wang
In order to reduce silica nanoparticles (SiO 2 NPs) agglomeration, improve the dispersity of SiO 2 NPs in the matrix of polyethersulfone (PES) composite membrane, the poly (acrylic acid) grafted SiO 2 NPs (SiO 2 -g-PAA NPs) are beforehand synthesized via surface-initiated activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP). PES/SiO 2 -g-PAA organic-inorganic composite membranes are convenient fabricated by blending PES matrix with the as-synthesized SiO 2 -g-PAA NPs via the non-solvent induced phase separation (NIPS) process. The attenuated total reflectance Fourier-transform infrared spectroscopy and surface scanning electron microscope (SEM) results confirm that the well dispersed SiO 2 -g-PAA NPs tend to migrate toward the membrane top surfaces. As a result, the composite membrane exhibited the highest pure water flux and oil flux around 233.72 and 97.29 L/m 2 h, which equal to 3.6 times and 8.8 times of unmodified PES membrane respectively. The flux recovery rate increased from 45.74% to 77.12%, suggesting the fouling-resistance of the composite membranes was greatly improved. Furthermore, the SiO 2 -g-PAA NPs exhibit excellent stability in the membrane matrix benefit from the interaction between PAA polymer chains and PES. In addition, the reactive PAA chains on the membrane surface provide a platform for further functionalization.
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高影响因子
GREEN CHEMISTRY
·
2026
·
IF 9.2
Lin-Yu Jiao,Ze-Long Sun,Wen-Yu Luo,Ying-Ying Xu,Fei Wen,Yanfei Xu,Zhuo Li,Wei Zhao,Shanshan Liu,Mingyue Ding
Sustainable green energy has emerged as critically important topics, with catalytic valorization and utilization of biomass receiving considerable attentions in recent years. This study investigates the photocatalytic selective oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-diformylfuran (DFF) using sonochemically synthesized g-C3N4/Bi2MoO6 heterostructured catalyst. A series of composites with varying mass ratios were fabricated, with the 1:1 (w/w) g-C3N4/Bi2MoO6 demonstrating the optimal catalytic performance. Systematic investigations were conducted to elucidate the effects of reaction conditions including irradiation wavelength, solvent polarity, reaction atmosphere, and substrate concentration on photocatalytic efficiency. The system achieved exceptional DFF selectivity of 90.8% with 92.2% HMF conversion under very mild conditions (air atmosphere and 10 W blue LED, 455 nm) with the generation of H2O2 as co-product, demonstrated the extremely high catalytic activity of the catalyst. The catalyst exhibited remarkable stability, as confirmed by recycling tests and post-reaction X-ray diffraction (XRD) characterization. Mechanistic studies through radical quenching experiments and electron paramagnetic resonance (EPR) spectroscopy identified superoxide radicals (·O2−) and photogenerated holes (h+) as the dominant reactive species, propose a dual-pathway oxidation mechanism. In this study, the S-scheme heterojunction charge transfer mechanism was comprehensively validated through systematic characterization and theoretical calculations, highlighting the pivotal role of S-scheme heterojunctions in selective oxidation reactions.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 7.7
Shikun Li,Qin Zhou,Junru An,Silong Qiang,Weihao Hu,Zhixiu Sun,Jianjun Liao,Shiwei Lin
Traditional electrochemical methods often face challenges in accurately detecting heavy metal ions in seawater due to high salinity and complex organic matrices. Herein, a porous, defect-rich graphitic carbon nitride/bismuth–bismuth oxide (pdr-g-C 3 N 4 /Bi@Bi 2 O 3 ) composite was fabricated via two-step calcination and hydrothermal assembly, and applied for simultaneous Cd(II) and Pb(II) detection by SWASV. The unique porous structure and abundant defect sites facilitate efficient ion preconcentration and electron transfer, leading to high sensitivity and selectivity. Under optimized conditions in sodium acetate–acetic acid buffer (pH 6.0), the sensor exhibits linear detection ranges of 5–200 ppb for both Cd(II) and Pb(II), with limits of detection (LOD) of 0.513 ppb and 0.313 ppb, respectively. Remarkably, the sensor demonstrates excellent stability and accuracy even in unprocessed seawater samples, achieving LODs of 0.32 ppb for Cd(II) and 10.13 ppb for Pb(II). These results confirm the feasibility of direct, on-site detection of trace heavy metals in complex marine environments, offering a practical strategy for rapid environmental monitoring.
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高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2019
·
IF 3.074
Xiaolin Wang,Zhengping Liu,Liyan Huang
A novel pH and thermo dual-responsive graft copolymer , starch- graft -poly( N , N -diethyl aminoethyl methacrylate- co -poly(ethylene gly co l) methyl ether methacrylate) [starch-g-P(DEAEMA-co-PEGMA)], was successfully synthesized through single-electron transfer living radical polymerization (SET-LRP). The structure and molecular weight of the grafted chains were confirmed by 1 H NMR. These graft copolymers can self-assemble into micelles with starch backbone and PDEAEMA as the core and PPEGMA as the corona in water at pH 7.4. The critical micelle concentration (CMC) of the graft copolymers varied between 0.0313 and 0.1364 mg/mL, decreasing with an increase in the molecular weight of the grafted chains and the ratio of PDEAEMA and PPEGMA segments. The pH and thermo dual-responsive behaviors of starch-g-P(DEAEMA-co-PEGMA) micelles were investigated by DLS and TEM . As the pH decreasd from 8.0 to 5.5, the micelle sizes continued to increase due to the protonation of the PDEAEMA segments, and as the pH decreased to below 5.5, the micelles began to disassemble, which was verified by TEM observations. Upon heating, the size of the micelles decreased because of the shrinkage of the PDEAEMA segments. The pH and thermo dual-responsive behaviors of the starch-g-P(DEAEMA-co-PEGMA) micelles are reversible. Doxorubicin (DOX), a hydrophobic drug, was encapsulated in the micelles, and in vitro release from the drug-loaded micelles displayed good pH-responsive behavior.
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高影响因子
Small
·
2026
·
IF 11.8
Kun Gao,Miao Ji,Xinya Chen,Qinghua Liu,Yaning Liu,Zhongyan Gong,Biao Xie,Chaoyang Li,Jiaxin Li,Furong Qiao,Zhihao Lu,Yingying Cai,Gongqiang Li,Gang Lu
Electroreduction of carbon dioxide (CO 2 ER) to carbon monoxide (CO) represents a promising pathway to the production of sustainable fuel and carbon neutrality. Molecular catalysts, such as cobalt phthalocyanine (CoPc), are known to be effective in converting carbon dioxide (CO 2 ) to CO. However, increasing the rate and selectivity of this reaction remains challenging and sometimes complicated. In this work, we report a simple molecule-coadsorption strategy to improve the efficiency of CoPc-catalyzed electrocatalytic conversion of CO 2 to CO on graphitic carbon nitride (g-C 3 N 4 ). By coadsorbing nitropyrene (NPy) molecules, together with CoPc, on the surface of graphitic g-C 3 N 4 via π–π conjugation, the catalytic activity of CoPc increased by 84%, and the Faradaic efficiency (FE) of CO increased up to 98.2% ± 1.6% in a H-type cell. This FE could further improve up to ∼100% in a flow cell. The improved catalysis performance could be attributed to the NPy-modulated change in electronic structure of the cobalt center in CoPc and the modulated reaction thermodynamics. Overall, this work paves a new way for fine modulation of the electronic structure of molecular catalysts for improvements in both activity and selectivity.
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