SENSORS AND ACTUATORS B-CHEMICAL
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2025
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IF 7.7
Zhenjie Zheng,Jingxuan Wang,Mengqi Ma,Yunpeng Xu,Da Huang,Jian Wang,Cuiying Lin,Zhenyu Lin,Fang Luo
Sensitive and selective detection of N -nitrosodimethylamine (NDMA), a highly carcinogenic environmental contaminant, is essential for public health and safety. In this study, we have developed a homogeneous electrochemiluminescence (ECL) biosensor for ultrasensitive NDMA detection by integrating Nafion-functionalized covalent organic framework (COF) with aptamer recognition and magnetic separation. The imine-linked COF (COF-LZU1) scaffold not only enables stable encapsulation of Ru(bpy) 3 2 + , but also creates a confined microporous environment that locally concentrates c (TPrA) and enhances the generation and survival of TPrA radicals, thereby amplifying the ECL signal. Nafion further improves Ru loading and ionic conductivity. Biotinylated aptamers were initially immobilized on streptavidin-coated magnetic beads (MBs) and hybridized with complementary DNA-modified Ru@COF-LZU1 to form Ru@COF-LZU1-MBs complex. Upon NDMA binding, a conformational switch releases Ru@COF-LZU1 into the solution. After magnetic separation, the ECL signal of the supernatant is measured in the presence of TPrA. This homogeneous format avoids electrode surface modification, which is commonly required in conventional Ru@COF-LZU1-based ECL sensors, offering improved reproducibility and simplified operation. The biosensor exhibits a wide linear range (100 fg/mL - 100 ng/mL) with a low detection limit of 9.11 fg/mL. This platform offers a sensitive, reproducible, and facile strategy for monitoring NDMA and similar small-molecule contaminants in complex matrices.
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CONSTRUCTION AND BUILDING MATERIALS
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2025
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IF 8
Shuo Wu,Tian Xia,Jianhui Xu,Shuchi Liu,Naike Wang,Shutong Tang,Xiaolin Liu
Humidity-induced self-healing offers a practical and environmentally sustainable strategy to improve material durability, yet its application in bituminous materials remains underexplored. This study presents a novel polyurethane (PU) synthesized with polytetrahydrofuran (PTMEG) as soft segments and isophorone diisocyanate (IPDI) as hard segments, combined with polar poly(N-isopropylacrylamide) (PNIPAM) to create a PU-PNIPAM copolymer featuring multiple hydrogen-bonding interactions. The PU-PNIPAM was incorporated into styrene-butadiene-styrene (SBS) modified bitumen, and rheological tests demonstrated that increasing PU-PNIPAM content enhances rutting resistance by improving creep recovery and reducing non-recoverable deformation. Optical microscopy observations under humid conditions revealed that PU-PNIPAM-modified bitumen exhibits humidity-responsive self-healing capabilities, with healing efficiency dependent on additive concentration. The humidity-induced self-healing mechanism of PU-PNIPAM was characterized by Fourier Transform Infrared Spectroscopy (FTIR), which monitored temporal evolution of the hydrogen bond index (HBI) under controlled humidity. A monotonic HBI increase confirmed aqueous hydrogen-bonding formation between PU and PNIPAM, driving autonomous repair. Water absorption and contact angle measurements revealed that despite PNIPAM-enhanced hydrophilicity of PU, incorporation of PU-PNIPAM into SBS-modified bitumen maintained bulk hydrophobicity, exhibiting water absorptivity below 1 wt% (deionized water) and 0.4 wt% (rainwater) after 4-day immersion. This strategy circumvents energy-intensive thermal healing, establishing an energy-efficient humidity-activated repair mechanism for bituminous composites. Crucially, the technology enables autonomous road maintenance in humid environments through continuous micro-crack sealing, extending service life while reducing resource consumption, maintenance frequency, and environmental footprint.
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INDUSTRIAL CROPS AND PRODUCTS
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2025
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IF 6.2
Qiaoguang Li,Wei Wei,Wenqing Xiao,Yunliang Li,Zekun Chen,Guijun Xie,Yigang Wang
We have successfully developed a molecular design strategy to synthesize a hydrogenated rosin-modified isocyanatopropyltriethoxysilane crosslinking agent (HRIS) with organic and inorganic active groups. Then curing it, rosin-based silicone rubber chemically cross-linked modified pine (RSP) is formed. This process enables the organic integration of fire-retardant silicon, nitrogen elements, and the rigid hydrogenated phenanthrene ring structure of rosin with the internal and external surfaces of the pine’s porous structure through chemical bonding. In the channels, rosin-based silicone rubber with 48.81 % of carbon, 42.96 % of oxygen, and 8.23 % of silicon, respectively was observed. The degradation mechanism coupled with LOI (limiting oxygen index) testing revealed that the RSP exhibited enhanced flame retardancy, with its LOI significantly increasing from 24.68 % to 25.4 %. Additionally, it exhibited higher thermal stability up to 330℃ than pine, indicating that the fire-retardant performance of RSP was effectively enhanced through the crosslinking modification with HRIS and PDMS (hydroxyl-terminated polydimethylsiloxane). During the thermal degradation process, RSP will produce gaseous cyclic siloxane molecules such as D3 (hexamethylcyclotrisiloxane), D4 (octamethylcyclotetrasiloxane), D5 (decamethylcyclopentasiloxane), etc. This study demonstrated that a new type of adhesive has been synthesized, but the influence of byproducts on the entire system should be considered in application, which is of significance for indicating the direction.
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TRENDS IN BIOTECHNOLOGY
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2025
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IF 14.9
Guozhen Ma,Xiaolong Jiang,Bin Yang,Linxing Li,Ruiying Liu,Qing Meng,Jiawei Li,Lijie Xie,Han Guo,Sijia Liu,Yuxuan Wang,Yibo Wang,Xiaojing Zhao,Ziyu Li,Yujie Wang,Menglei Xia,Di Huang
The growing demand for N -acetylneuraminic acid (NeuAc) has driven the need for efficient and environmentally sustainable biomanufacturing processes. Microbial fermentation offers a promising route, yet optimizing cell factories with excellent phenotypes remains challenging. Here, we engineered Escherichia coli to enable high-efficiency co-utilization of glucose and glycerol. We refactored two synthetic pathways with the same start and end to enhance N -acetylmannosamine (ManNAc) precursor levels and optimized NeuAc synthase using artificial intelligence (AI) techniques and machine learning (ML) sequence mining. Subsequently, phosphoenolpyruvate (PEP) levels were boosted by capturing carbon flow from competing regeneration pathways, thus balancing the intracellular PEP:ManNAc ratio for improved NeuAc synthesis. Besides glucose, an additional carbon inlet from glycerol was opened, achieving a NeuAc titer of 70.4 g/l in fed-batch fermentation with a productivity of 1.17 g/l/h. This work demonstrates a highly efficient microbial cell factory for the biosynthesis of NeuAc and provides a versatile system engineering strategy applicable to other high-value compounds.
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PubMed
高影响因子
Journal of Environmental Chemical Engineering
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2025
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IF 7.2
Qiansheng Li,Yi Dai,Hong Lu,Xiaoman Li,Fanghao Cheng,Jiti Zhou
Microbial-driven Fenton reactions are essential sources of reactive oxygen species in the aqueous environment and important pathways for pollutant degradation. However, their rates are usually limited by microbial respiration. Herein, N and Fe co-doped CDs (N, Fe-CDs) were used to construct a biological Fenton system with marine community YEP-1 for ketoprofen (KTP) removal. The addition of N, Fe-CDs significantly increased the aerobic degradation rate of KTP by 60.8 % at 48 h. Further analysis showed that N, Fe-CDs enhanced the microbial electron transfer system activity of YEP-1 to produce more H 2 O 2 . Moreover, the regeneration of Fe(II) in extracellular N, Fe-CDs was achieved under aerobic conditions, which was beneficial to activate the extracellular H 2 O 2 for more ·OH generation. Based on the metagenome analysis, N, Fe-CDs significantly increased the populations of genera Exiguobacterium , Leucobacter and Microbacterium . The enriched genes related to electron transfer and Fe(III) reduction were found to be closely associated with Microbacterium . Furthermore, the relative abundances of genes related to the chemotaxis and degradation of aromatic compounds were also increased. These results indicated that biological enzyme-catalyzed processes and N, Fe-CD-mediated Fenton reaction were jointly involved in KTP degradation. This work further advances our understanding of N, Fe-CDs-mediated microbial Fenton reactions.
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Materials Today Chemistry
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2025
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IF 6.7
Xiaotong Song,Junyuan Zhang,Weiqi Li,Huanying Li,Zhiguo Li,Xiaolong Xu,Changyu Liu,Jianbo Jia
Metal-organic framework (MOF)-derived carbon nanocomposites have been widely applied in electrocatalytic fields due to their simple synthesis, excellent conductivity, and high catalytic activity. In this study, ZIF-67 and MIL-101(Fe) were synthesized via liquid-phase precipitation and solvent thermal methods, respectively. Then, the two kinds of MOFs were ground and calcined with melamine to prepare flower-like carbon nanocomposites. Under the optimal conditions, the oxygen reduction reaction (ORR) onset potential (E onset = 1.019 V vs. reversible hydrogen electrode, RHE) and half-wave potential (E 1/2 = 0.866 V) of this prepared composite are both higher than those of commercial Pt/C catalyst (E onset = 0.971 V, E 1/2 = 0.838 V). The prepared nanocomposite exhibits a lower oxygen evolution reaction (OER) overpotential (η = 338 mV at 10 mA cm −2 ) than RuO 2 (η = 372 mV), demonstrating superior catalytic performance. The prepared nanocomposite achieves simultaneous enhancement in both ORR and OER bifunctional catalytic performances. The power density of a zinc-air battery (ZAB) assembled with the optimal nanocomposite was 2.65 times higher than that of the Pt/C + RuO 2 system. This study establishes a fundamental framework for the rational design of high-performance ORR/OER bifunctional catalysts, while pioneering new avenues for ZAB technology commercialization.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2025
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IF 4.1
Yan Ma,Peng Zeng,Yan Ma,Xiaomei Yang
Supercapacitors have been extensively studied for their excellent power density and cycle life, but they are limited by low energy density. This study successfully prepared nitrogen/oxygen/boron (N/O/B) co-doped phenolic resin-based porous carbon materials (NBC) through a sol-gel method combined with high-temperature carbonization and activation processes, and systematically investigated their electrochemical performance in supercapacitors. By adjusting the amount of boric acid and the carbonization temperature, the pore structure and heteroatom doping levels of the materials were optimized. Experimental results demonstrate that when the carbonization temperature is 700 °C and the mass ratio of L-tyrosine to boric acid is 1:1, the obtained sample NBC-700-1 exhibits a high specific surface area (1721 m 2 g −1 ), an abundant micro/mesoporous hierarchical structure, and uniform N/O/B doping (N content: 8.31 at.%, O content: 14.11 at.%, B content: 0.55 at.%). In a three-electrode system, NBC-700-1 (377 F g −1 ) exhibits superior specific capacitance, high rate performance (73% capacitance retention at 20 A g −1 ), and long cycle stability at 0.5 A g −1 in 6 M KOH electrolyte compared to NBC-600-1 (300 F g −1 ), NBC-700-0.5 (290 F g −1 ), NBC-700-2 (268 F g −1 ), and NBC-800-1 (351 F g −1 ). Furthermore, a symmetric supercapacitor assembled with Na 2 SO 4 gel electrolyte achieves an energy density of 29.9 Wh kg −1 at a power density of 550 W kg −1 , along with broad temperature adaptability (−25 to 75 °C) and remarkable flexibility (no significant performance degradation after 180° bending). Additionally, the design of a PVA-based gel electrolyte with wide pH applicability provides new insights for the application of such devices in complex environments.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2025
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IF 2.8
Jie Mao,Huiyao Zhao,Runqi Yang,Yongzhi Meng,Mao Pi,Yuan Wu,Wei Yuan
Silicone rubber serves as a critical insulating material in electrical engineering due to its outstanding antifouling characteristics, mechanical robustness, and electrical performance. Nevertheless, its insulating properties require further enhancement to meet the demanding requirements of ultra-high voltage (UHV) applications, particularly for long-distance, high-capacity power transmission. In this work, we developed an improved insulating silicone rubber by grafting p–p conjugated N -vinyl carbazole (VK) groups—known for their space charge trapping capability—onto thiol-silicone oil, followed by cross-linking with end-methyl branched vinyl silicone oil. The modified material demonstrated optimal insulating performance at a VK group concentration of 0.5 wt%, achieving a 23.19% increase in breakdown field strength compared to unmodified silicone rubber films. This study provides a viable approach for enhancing the dielectric strength of polymer-based silicone rubber materials.
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ACS Applied Optical Materials
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2025
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IF 3.8
Xi Ran,Hang Xia,Jing Liu,Mohan Yuan,Xudong Hu,Ya Wang,Xinzheng Lan
Lead sulfide (PbS) colloidal quantum dot (CQD) photodetectors are promising devices for low-cost, high-performance, and large-area infrared imaging. For integration with readout integrated circuits (ROICs), top illumination is urgently required to ensure simultaneous light absorption and signal acquisition. However, the traditional best-performing p-on-n PbS CQD photodetectors rely on opaque top metal contacts, thus limiting the development of top-illuminated imagers. Herein, we addressed this issue by introducing a bifunctional ZnTe layer. The presence of the ZnTe layer─while allowing efficient hole collection─serves as a protective layer for the CQD layer during subsequent transparent electrode deposition. The resultant PbS CQD photodetectors based on the ZnTe layer show a specific detectivity of 2.09 × 1012 Jones at ≈1300 nm, representing approximately a 5-fold improvement over the control device (4.30 × 1011 Jones). This performance is comparable to that of the best PbS CQD photodetectors reported at similar wavelengths. The advantages of this architecture are further demonstrated by building a PbS CQD imager with a pixel array of 256 × 256, verifying the compatibility of photodetectors with ROICs.
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ACS Applied Bio Materials
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2025
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IF 4.7
Xiaobing Ma,Xiangbin Sun,Rongmin Wang,Xiaoyu Han,Yuanyuan Xie,Yufeng He,Pengfei Song
Bacterial infection of surface-damaged fruit is one of the troubling issues in daily life. To address this issue, the β-cyclodextrin (CD) grafting N+-borneol ester antibacterial polymer (CD-NBOx), containing borneol with active groups and quaternary ammonium compounds (QACs) positive charges, was successfully synthesized using RAFT and characterized by NMR, Fourier-transform infrared, and gel permeation chromatography. Its antibacterial activity and biofilm inhibition were evaluated against Escherichia coli and Staphylococcus aureus, and the adhesion resistance was measured by crystal violet (CV) staining experiments. It indicated that the antibacterial rate of CD-NBOx reached 99.9 and 87.3% and the biofilm inhibition rates were up to 97.5% against E. coli. Interesting, there was no spoilage of the fruit and only 20% weight loss in the 15-day fruit preservation experiment. CD-NBOx possesses excellent antibacterial and adhesion resistance due to the synergy between cyclodextrin for biocompatibility and N cation for antibacterial and borneol stereochemistry. In summary, CD-NBOx as a constructing “offensive and defensive integrated” is validated as a viable antibacterial material while also expanding potential life applications of N+-borneol ester polymers in fruit preservation in the future.
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PubMed
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2025
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IF 4.9
Qingfeng Luo,Yuyi Deng,Qiyuan Yang,Nanxin Zhao,Can Wang,Xingsheng Li
Osteopontin (OPN), highly expressed in foam cells, serves as a hallmark of atherosclerotic plaques and a potential target for site-specific drug delivery. In this study, we developed OPN-targeted liposomes (OPN LIP) co-loaded with curcumin and perfluoro-n-pentane (PFP) to enhance therapeutic efficacy against atherosclerosis. The liposomes exhibited uniform particle size, colloidal stability, favorable biocompatibility, and minimal cytotoxicity. In vitro experiments demonstrated efficient and time-dependent cellular uptake by ox-LDL–stimulated RAW264.7 foam cells. Upon exposure to low-intensity focused ultrasound (LIFU), the nanocarriers underwent acoustic cavitation-induced rupture, leading to rapid curcumin release and significant induction of apoptosis. OPN LIP treatment notably reduced IL-1α and TNF-α levels and aggravated apoptosis in foam cells. Transcriptomic analysis revealed modulation of inflammatory and apoptotic pathways, including TLR, NF-κB, and Mapk3 signaling. These findings highlight the potential of OPN LIP as an ultrasound-responsive, targeted nanoplatform capable of suppressing inflammation and foam cell viability, providing a promising approach for the treatment of atherosclerosis through combined physical and pharmacological strategies.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2024
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IF 5.8
Xinlei Jia,Donghui Guo,Zelong Wang,Ning Zhou,Runze Jin,Baosheng Xu
Regulating the composition and microstructure of nanomaterials is a major challenge in the development of high-performance materials for electromagnetic wave (EMW) absorption. This paper introduces a new lightweight EMW-absorbing material Co@N/C with a yolk–shell structure and compositions of ferromagnetic metal and carbon materials. The minimum reflection loss (RL min ) of the as-designed Co@N/C nanospheres with a filler loading of 25 wt% reaches −67.68 dB and the effective absorption bandwidth of a 1.9 mm thickness is 5.3 GHz. The exceptional absorption performance of the EMW absorption is primarily achieved through the synergistic effect between the Co–carbonaceous material and the yolk–shell structure, which optimizes the impedance matching. The polarization loss, conductivity loss, magnetic loss, and multiple scattering mainly contribute to the excellent EMW-absorption ability of the materials. The proposed method for regulating the structure and morphology of Co@N/C can efficiently construct high-performance EMW absorbers.
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危险品化学品经营许可证（带存储）