ADVANCED MATERIALS
·
2022
·Vol. 34
·期 40
·2201838
·
IF 32.086
Guiru Sun,Rui Gao,Hailiang Jiao,Dan Luo,Yan Wang,Zexu Zhang,Wei Lu,Ming Feng,Zhongwei Chen
The major challenges for Li-O 2 batteries are sluggish reaction kinetics and large overpotentials due to the cathode passivation resulting from insulative and insoluble Li 2 O 2 . Here, a novel nanodot (ND)-modified electrolyte is designed by employing cobalt bis(trifluoromethylsulfonyl)imide (Co(TFSI) 2 ) as an electrolyte additive. The Co(TFSI) 2 additive can react with discharge intermediate LiO 2 and product Li 2 O 2 to form CoO NDs. The generated CoO NDs are well dispersed in electrolyte, which integrates both the high catalytic activity of solid catalyst and the good wettability of soluble catalyst. Under the catalytis of CoO NDs, Li 2 O 2 is produced and deposits on the cathode together with them. At the recharge process, these well dispersed CoO NDs help to decompose solid Li 2 O 2 at a lower overpotential. The Li-O 2 cells with Co(TFSI) 2 exhibit a long cycle life of 200 cycles at a current density of 200 mA g −1 under a cutoff capacity of 1000 mAh g −1 , as well as a superior reversibility associated with the Li 2 O 2 formation and decomposition. The study is expected to broaden the range of electrolyte additives and provide a new view to developing highly dispersed NDs-based catalysts for Li-O 2 batteries.
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Light-Science & Applications
·
2024
·Vol. 13
·期 1
·1-11
·
IF 20.6
Zhao Ming,Ge Yeping,Li Yurong,Song Xiaoyan,Xia Zhiguo,Zhang Xinping
Highly efficient inorganic phosphors are desirable for lighting-emitting diode light sources, and increasing the doping concentration of activators is a common approach for enhancing the photoluminescence quantum yield (PLQY). However, the constraint of concentration quenching poses a great challenge for improving the PLQY. Herein, we propose a fundamental design principle by separating activators and prolonging their distance in Eu 2+ -activated Rb 3 Y(PO 4 ) 2 phosphors to inhibit concentration quenching, in which different quenching rates are controlled by the Eu distribution at various crystallographic sites. The blue-violet-emitting Rb 3 Y(PO 4 ) 2 : x Eu ( x = 0.1%–15%) phosphors, with the occupation of Rb1, Rb2 and Y sites by Eu 2+ , exhibit rapid luminescence quenching with optimum external PLQY of 10% due to multi-channel energy migration. Interestingly, as the Eu concentration increases above 20%, Eu 2+ prefer to occupy the Rb1 and Y sites with separated polyhedra and large interionic distances, resulting in green emission with suppressed concentration quenching, achieving an improved external PLQY of 41%. Our study provides a unique design perspective for elevating the efficiency of Eu 2+ -activated phosphors toward high-performance inorganic luminescent materials for full-spectrum lighting.
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Lanlan Yu,Jincheng Mu,Huiling Liu,Gang Liao,Boyi Li,Yufen Xia,Zhimin Wang,Jili Yuan,Jiachao Shen,Chengbin Liu
Electrocatalytic nitrate reduction into ammonia (NitRR) over Co-based catalysts is attractive but still constrained by the competition with H* coupling to produce H 2 . Additionally, the fundamental mechanism underlying the interfacial engineering associated with electronic state transformation for strengthening oriented NitRR remains elusive. Herein, a Co(OH) 2 /Bi 12 O 17 Br 2 heterostructure is fabricated using a one-step wet chemistry method, performing remarkable reactivity for NH 3 production own to the formation of electron-deficiency Co sites induced by Bi 12 O 17 Br 2 . Unexpectedly, the NitRR activity of Co(OH) 2 /Bi 12 O 17 Br 2 increases gradually in the initial stage and then keeps at a high level, which is uncovered as the reconstruction of Bi 12 O 17 Br 2 into Bi 0 . Theoretical calculations suggest that the in situ reconstruction guides the electron-deficiency of Co and the shift of d -band center of Co toward the Fermi level, thus promoting the adsorption and conversion of intermediates. The synergistic effect of the hydrolysis dissociation over Co(OH) 2 and the inhibition of H* coupling over Bi 0 contributes to high selectivity and activity for NitRR. The reconstructed catalyst shows a high ammonia yield rate of 7343.3 µg h −1 mg −1 at −0.6 V versus RHE and nearly 100% Faradaic efficiency at −0.4 V versus RHE. This study provides insight into the strengthening mechanism of Co-based catalysts for NitRR.
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ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 31
·期 21
·2010367
·
IF 18.808
Fengning Yang,Yuting Luo,Qiangmin Yu,Zhiyuan Zhang,Shuo Zhang,Zhibo Liu,Wencai Ren,Hui-Ming Cheng,Jiong Li,Bilu Liu
Water electrolysis is promising for industrial hydrogen production to achieve a sustainable and green hydrogen economy, but the high cost of the technology limits its market share. Developing efficient yet economic electrocatalysts is crucial to decrease the cost of electricity and electrolytic cell. Meanwhile, electrolysis in seawater electrolyte can further reduce feedstock cost. Here, a type of electrocatalyst is synthesized, where trace precious metals are strongly anchored on a corrosion-resistive matrix. As an example, the produced Pt/Ni-Mo electrocatalyst only needs an overpotential of 113 mV to reach an ultrahigh current density of 2000 mA cm −2 in the saline-alkaline electrolyte, demonstrating the best performance reported thus far. It shows high activity and long durability in various electrolytes and under harsh conditions, including strong alkaline and simulated seawater electrolytes, and under elevated temperatures up to 80 ° C. This electrocatalyst is produced on a large scale at a low cost and shows good performance in a commercial membrane electrode assembly stack, demonstrating its feasibility for practical water electrolysis.
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ENERGY & FUELS
·
2024
·
IF 5.2
Guangjie Chen,Guangying Chen,Miao Fa,Yuxian Yang,Yu Wang,Fei Li,Li Sze Lai,Swee Pin Yeap
In order to reduce the regeneration energy consumption of CO2 capture in the postcombustion capture process and explore the regulatory characteristics of phase separation, a series of 1-amino-2-propanol (MIPA)/sulfolane biphasic solutions were proposed to capture CO2. The effects of the molar ratio on the phase separation behavior, CO2 equilibrium absorption, and desorption performances of MIPA/solfolane biphasic absorbents as well as three ternary solutions with the extra addition of ethanolamine (MEA) were investigated comprehensively in experiments. The results showed that the 4M/5M MIPA/sulfolane biphasic solution exhibited excellent performance with higher CO2 loadings in the phase separation point for a CO2-rich liquid (0.4530 mol/mol), better desorption efficiency (85.53%), and relatively low regeneration energy consumption (32% lower than 30 wt % MEA). Besides, MEA has a positive effect on promoting the phase separation of the MIPA/sulfolane solution and reducing the desorption energy consumption. Furthermore, 1H and 13C nuclear magnetic resonance (NMR) spectroscopy was used to explore the reaction and phase separation mechanisms. The results indicated that generated carbamate salts can increase the ionic strength of the aqueous solution, leading to the accumulation of reacted MIPA or MEA in the water phase and the exclusion of sulfolane from water to form a new liquid phase. The results of this work can provide theoretical support for the future industrial application of MIPA/sulfolane biphasic absorbents and offer some guidance for the mechanism exploration of other biphasic solvent systems.
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CHEMICAL PAPERS
·
2024
·
IF 2.1
Lin Yan,Ren Yu,Lin Xiaoyun
Reduced graphene oxide (RGO) loaded with sodium anthraquinone-2-sulfonate (AQS) was prepared using one-pot hydrothermal synthesis. The phase, composition and structure of the prepared materials were characterized by transmission electron microscope (TEM), energy-dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS) and powder X-ray diffraction (XRD). The AQS, RGO and AQS/RGO on functionalized carbon cloth (FCC) electrodes were established. The performance of AQS/FCC, RGO/FCC and AQS/RGO/FCC were tested by galvanostatic charge–discharge (GCD), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The specific capacitance ( C s ) of AQS/FCC, RGO/FCC and AQS/RGO/FCC is 9.29, 194.8 and 402.5 F g −1 at the current density ( C d ) of 0.5 A g −1 , respectively. After 1000 cycles of charging and discharging, the capacity retention of AQS/RGO/FCC remained at 92.6%. Therefore, the AQS/RGO/FCC electrode exhibits excellent rate performance, excellent charging and discharging performance and cycling stability in supercapacitors (SCs).
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RENAL FAILURE
·
2024
·
IF 3
Yushi Peng,Yingchun Zheng,Fu Xiong,Mingming Zhang,Yuchen Wang,Jia Luo,Wenli Zeng,Jialiang Hui,Wenfeng Deng,Jian Xu,Yun Miao,Renfei Xia,Yiling Fang
Background Primary hyperoxaluria type 2 (PH2) is a rare disorder caused by GRHPR mutations. Research on the mutation spectrum and pedigree of PH2 helps in comprehending its pathogenesis and clinical outcomes, guiding clinical diagnosis and treatment.Methods We report a case of PH2 with a three-generational pedigree. The GRHPR genotypes of the family members were confirmed by Sanger sequencing. Urine and blood samples were collected for biochemical analysis. Computational analysis was performed to assess the pathogenicity of the mutations. Cellular experiments based on site-directed mutagenesis were conducted to confirm the effect of mutations on GRHPR expression, activity, and subcellular localization.Results The proband underwent her first kidney transplantation in 2015, and experienced recurrent urinary tract infections and urolithiasis postoperatively. Graft failure occurred in 2018. Whole exome sequencing identified compound heterozygous GRHPR mutations p.G160E/p.P203Rfs*7. The patient underwent a second kidney transplantation in 2019 and maintained good graft function with urine dilution measures. Notably, her brother and sister carried the same mutations; however, only the proband progressed to renal failure. Computational analysis suggested that p.G160E reduced the affinity of GRHPR for coenzymes. Cellular experiments indicated that p.G160E reduced GRHPR activity (p < 0.001), whereas p.P203Rfs*7 not only suppressed expression (p < 0.001) and reduced activity (p < 0.001), but also facilitated protein aggregation. Based on our results, the variant p.G160E was classified as ‘pathogenic’ according to ACMG guidelines.Conclusions Our findings suggest that treatment strategies for the long-term prevention of oxalate nephropathy should be developed for patients with PH2 receiving isolated kidney transplantation. Moreover, the pathogenicity of the compound heterozygous GRHPR mutations p.G160E/p.P203Rfs*7 was also validated.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yue Lu,Jiahui Lei,Haoran Dong,Linrui Zhong,Qiqi Fu,Qingqing Xie,Long Li,Fangyi Liang
Chlorophenols (CPs) pose potential threat to the environment and public health due to their persistence and high toxicity. Zero-valent iron coupled with microorganisms have been applied for the degradation of halogenated organic matter, which is considered as a remediation technology of increasing interest. However, few studies have attempted to investigate the effects of this coupled system on CPs degradation and to comprehensively unveil the governing mechanisms. In this study, we systematically compared the effects of the composite system of microscale zero-valent iron (mZVI) with different particle sizes and Desulfitobacterium hafniense DCB-2 (i.e. 3 μm mZVI + DCB-2, 5 μm mZVI + DCB-2, and 10 μm mZVI + DCB-2) on the process of bioreductive dechlorination of 2,3-dichlorophenol (2,3-DCP). Interestingly, the lower particle sizes of mZVI (3 μm and 5 μm) were more favorable for rapid 2,3-DCP bio-dechlorination due to the fact that mZVI with smaller particle size were less likely to agglomerate with strain DCB-2, which facilitated the transfer of electrons from strain DCB-2 to 2,3-DCP. Besides, the optimal particle size of mZVI (3 μm) was selected from the above experimental results to further explore the percentage generation of reduction products and the dechlorination pathway of 2,3-DCP in composite system. The results showed that the low toxicity product 2-chlorophenol (2-CP) accounted for 31.76 % of the composite system, while in the pure bacteria treatment this value was only 20.42 %. The mZVI and DCB-2 coupling strategy might provide a new idea and feasible solution for the green reduction of chlorinated phenols.
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TALANTA
·
2024
·
IF 5.6
Meixiang Xue,Shuangxi Cai,Ye Deng,Fang Luo,Jianhui Huang,Zhenyu Lin
T-2 toxin, a hazardous mycotoxin often present in cereals and products based on cereals, poses a substantial risk to humans and animals due to its high toxicity. The development of uncomplicated, quick and highly sensitive methods for detecting T-2 toxin is imperative. In this work, a portable sensing system was constructed using water column height as a readout device in combination with a controlled release system, which allows for an accurate quantitative analysis of T-2 toxin without the need for expensive instrumentation or skilled technicians. Hyaluronic acid (HA) hydrogel was constructed by double cross-linked DNA/aptamer hybrids with polyethyleneimine (PEI) and embedded with platinum nanoparticles (Pt NPs). The aptamer specifically bound to T-2 toxin in its presence, resulting in the disruption of the hydrogel and subsequent release of the Pt NPs. These Pt NPs were later mixed with a solution of H 2 O 2 in a confined reaction flask, leading to the decomposition of H 2 O 2 into O 2 . A glass capillary tube containing a column of red water had been inserted into the cap of the reaction flask, and the low solubility of O 2 led to an increase in pressure within the reaction unit, causing the red water column to rise. There is a good linear correlation between the height of the capillary liquid level and the T-2 toxin concentration in the range of 20 ng/mL to 6 μg/mL. The system has been successfully used to detect T-2 toxin in samples of barley tea and corn.
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高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2025
·
IF 3.5
Yan-Xia Li,He Ma,Le Shi,Zhong-Fei Zhang,Yu-Meng Wu,Chao Yan,Yan Chen,Yong-Ming Lu
BACKGROUND Polysaccharides from Pleurotus citrinopileatus exhibit diverse bioactivities, yet their efficacy against ultraviolet B (UVB)-induced photoaging remains unexplored. This study aimed to purify and characterize a specific PCP and assess its protective effects using a UVB-induced zebrafish model. RESULTS A polysaccharide, designated as PCP-2, was isolated from P. citrinopileatus through hot-water extraction, ultrafiltration and chromatography. PCP-2 is a galactoglucan with a molecular weight of 1.52 × 10 6 Da, predominantly composed of 1,4-linked glucopyranosyl and 1,4,6-linked galactopyranosyl residues. In UVB-exposed zebrafish, PCP-2 administration resulted in a significant reduction of reactive oxygen species and malondialdehyde levels, alongside enhanced activities of antioxidant enzymes, including superoxide dismutase, catalase and glutathione peroxidase. Additionally, PCP-2 inhibited apoptosis by upregulating Bcl-2 expression and downregulating caspase-3. It also attenuated cellular senescence, as indicated by decreased β -galactosidase activity and increased telomerase activity. Moreover, PCP-2 promoted the synthesis of type I and III collagen by suppressing matrix metalloproteinases MMP-1 and MMP-3 and reduced melanin production through the downregulation of tyrosinase expression. Mechanistic studies suggested that these protective effects are mediated via activation of the Nrf2/HO-1 signaling pathway. CONCLUSION PCP-2 from P. citrinopileatus effectively mitigates UVB-induced photoaging, primarily by activating the Nrf2/HO-1 pathway. These findings suggest PCP-2's potential as an anti-photoaging agent in both food and pharmaceutical industries. © 2025 Society of Chemical Industry.
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高影响因子
BIOSENSORS & BIOELECTRONICS
·
2011
·
IF 5.361
Xi Juan Zhao,Cheng Zhi Huang
Pyrophosphate (PPi) is involved in lots of anabolism and bioenergetic processes in organisms and possesses important biological functions so that its detection is very significant. Here, we developed a selective fluorometric detection method for PPi with a copper(II) complex of 2,6-bis(2-benzimidazolyl)pyridine (bbimp), and then applied it to the detection of bacterial alarmone ppGpp. bbimp has the fluorescence emission at 395 nm, but the bbimp–Cu 2+ complex is hardly fluorescent because the intrinsic fluorescence of bbimp is effectively quenched by Cu 2+ . With the addition of PPi, however, the fluorescence emission of bbimp turns on with a 2 nm red-shift, and has a linear relationship with PPi in the range of 3–90 μmol/L. This method has good selectivity for PPi over other anions especially those phosphate-containing anions such as ATP, UTP, CTP, GTP, GDP, and PO 4 3− .
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高影响因子
Biomolecules
·
2020
·Vol. 10
·期 1
·123
·
IF 4.082
Li-Xin Sheng,Jiang-Yu Zhang,Li Li,Xiao Xie,Xiao-An Wen,Ke-Guang Cheng
In order to discover novel derivatives in the anti-tumor field, reported anti-tumor pharmacophores (uridine, uracil, and thymine) were combined with 2-methoxyestradiol, which has been characterized as having excellent biological properties in terms of anti-tumor activity. Thus, 20 hybrids were synthesized through etherification at the 17β-OH or 3-phenolic hydroxyl group of 2-methoxyestradiol, and evaluated for their biological activities against the human breast adenocarcinoma MCF-7 cell lines, human breast cancer MDA-MB-231 cell lines, and the normal human liver L-O2 cell lines. As a result, all the uridine derivatives and single-access derivatives of uracil/thymine possessed good anti-proliferative activity against tested tumor cells (half maximal inhibitory concentration values from 3.89 to 19.32 µM), while only one dual-access derivative (21b) of thymine possessed good anti-proliferative activity (half maximal inhibitory concentration ≈ 25 µM). Among them, the uridine derivative11and the single-access derivative of uracil12apossessed good anti-proliferative selectivity against tested tumor cells. Furthermore, basic mechanism studies revealed that hybrids11and12acould induce apoptosis in MCF-7 cells through mitochondrial pathway. These hybrids induced morphological changes in MCF-7 cells, causing mitochondrial depolarization. These two hybrids also had the following effects: arrest of the cell cycle at the G2 phase; up regulation of Apaf-1, Bax, and cytochrome c; down regulation of Bcl-2 and Bcl-xL for both mRNA and protein; and increase of the expression for caspase-8 and -9. Finally, apoptotic effector caspase-3 was increased, which eventually caused nuclear apoptosis at least through an intrinsic pathway in the mitochondria. Additionally, hybrids11and12acould specifically bind to estradiol receptor alpha in a dose-dependent manner.Keywords:2-methoxyestradiol;anti-tumor activity;intrinsic apoptosis pathway
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