ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
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2025
·
IF 2.9
Du Jing,Zhong Zicheng,Ouyang Huang,Hussain Irshad,Tan Bien
The novel hypercross-linked porous ionic polymers combine the advantages of ionic liquids, hydrogen-bond donors and hypercross-linked polymers. In this regard, imidazolium-based ionic liquids with different hydrogen-bond donors (hydroxyl and carboxyl groups) were grafted on hypercross-linked polymers by taking advantage of the easier functionalization of ionic liquids. With the introduction of ionic liquids, the CO 2 adsorption capacity of HCP-CH 2 IL-COOH was increased to 13.86 wt % (273 K, 1 bar). The catalytic performance of HCP-CH 2 IL-OH and HCP-CH 2 IL-COOH with containing hydrogen-bond donors was found better than that of HCP-CH 2 IL-Et without hydrogen-bond donor. In addition, HCP-CH 2 IL-OH showed the highest CO 2 conversion efficiency after 48 h with a high yield (up to 94%) at room temperature and pressure due to high specific surface area, high CO 2 adsorption capacity and the catalytic activity of ionic liquid, which achieved efficient CO 2 conversion by metal-free catalytic system under mild conditions. The TON and TOF values were found to be up to 292 and 6 h −1 , and the efficiency was comparable to that of the current metal-free heterogeneous catalytic systems. In addition, the catalyst can efficiently convert different terminal epoxides and show good universality. More interestingly, the catalytic activity of this catalyst was retained after five cycles, which endorse its recycling stability.
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Nature Communications
·
2025
·
IF 15.7
Wei Weiqin,Wei Zhen,Luo Xiaoli,Yuan Hong,Zhou Qingqing,Ren Xiao,Ouyang Shuxin,Zhang Tierui,Ma Ding
Upgrading fatty acid derivatives is a promising route to sustainable diesel and jet fuels, but conventional processes require high temperature, pressure, and large H₂ input, while contaminants in waste oil deactivate catalysts, demanding costly purification. Here, we present an integrated electrochemical strategy combining anodic decarboxylation, cathodic proton reduction, and olefin hydrogenation in one reactor, upgrading fatty acid derivatives to long-chain alkanes under mild conditions (60 °C, 1 atm) without external hydrogen. A high alkane yield of 88.9% is achieved and the reported performance is competitive. Experiments and calculations reveal that fatty acid chain length governs product yield and distribution by influencing –H departure and C γ –C β –COOH bond cleavage barriers. This approach shows high activity and selectivity toward diverse feedstocks, including unsaturated fatty acids, esters, mixtures, crude acids, and waste oils. Powered by solar energy, approximately 40 g of long-chain alkanes are produced in a 1 L reactor, highlighting its scalability and potential for green fuel synthesis.
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Communications Biology
·
2025
·
IF 5.1
Bai Xianan,Cai Shanshan,Jiang Jie,Tian Maojin,Du Jianxin,Zhao Peiqing
Breast cancer remains a leading cause of cancer-related mortality worldwide, largely due to the persistence of an immunosuppressive tumor microenvironment that limits therapeutic efficacy. However, the molecular mechanisms underlying this immune suppression are not fully understood. Here, we identify Semaphorin 7 A (Sema7a) as a key regulator of antitumor immunity in breast cancer through its interaction with Lysine Demethylase 4 A (Kdm4a). Transcriptomic analyses of The Cancer Genome Atlas (TCGA) dataset revealed Sema7a as an immune-related hub gene using Weighted Gene Co-expression Network Analysis and Least Absolute Shrinkage and Selection Operator algorithms. Functional experiments in breast cancer cell lines demonstrated that loss of Sema7a reduced Kdm4a expression, induced DNA replication stress, and activated the cGAS-STING signaling pathway, thereby increasing IFN-β and CXCL10 secretion. These changes enhanced CD8⁺ T cell chemotaxis and cytotoxic activity, suppressing tumor growth and metastasis in vivo. Conversely, Kdm4a overexpression reversed the antitumor effects of Sema7a deficiency. Our findings establish the Sema7a - Kdm4a axis as a crucial mechanism shaping the immunosuppressive microenvironment in breast cancer and highlight its potential as a therapeutic target to enhance antitumor immunity.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
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IF 3.8
Tan Yijun,Meng Dan,Li Fang,Luo Mingming,Li Ying,Dong Panpan,Xu Longping,Liu Ruowei,Wu Zijian
Herein
, an electrochemical/photoelectrochemical (EC/PEC) dual-mode sensing platform based on carbon dots/liquid exfoliated graphene (CDs/LEG) nanocomposites was developed in this work. The CDs/LEG heterogeneous effectively exploited the excellent photoelectric activity of CDs and the high conductivity of LEG. Ferrocene-labelled aptamer (Fc-Apt) and methylene blue-labelled complementary DNA (MB-cDNA) were introduced as dual-signal probes. Upon aflatoxin B1 (AFB 1 ) binding, it competitively displaced MB-cDNA, restoring Fc-Apt hairpin conformation and causing MB to move away from the electrode surface while Fc approached it. This conformational change significantly increased the I Fc to I MB peak current ratio ( I Fc / I MB ), enhancing the EC signals; meanwhile, the aptamer complex immobilized on the electrode surface reduced the PEC signals through spatial site-blocking and light-shielding effects. The dual-mode responded synergistically to form a unique self-validation mechanism, which showed excellent linearity over the AFB 1 concentration range of 0.01-100 ng/mL, with detection limits (LOD) of 1.356 pg/mL (EC mode) and 0.087 pg/mL (PEC mode). Graphical
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JOURNAL OF FLUORESCENCE
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2025
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IF 3.1
Xue Jinxiong,Huang Jingping,Lin Xue,Pan Wuyuan,Ke Fang
MicroRNA-183-5p is a clinically relevant biomarker, yet its detection is hindered by short sequence length, high homology, and low abundance in complex biological fluids. We report a hydrothermally synthesized nickel chloride-decorated graphitic carbon nitride (NiCl 2 @g-C 3 N 4 ) with intrinsic peroxidase-like and fluorescence activities for label-free dual-mode detection. Characterized by multiple spectroscopic and microscopic techniques, the nanocomposite enables quantitative analysis via π-π stacking and van der Waals interactions between the probe and target, eliminating the need for enzymes or fluorescent labels. Under optimal conditions, using the formula LOD = 3Sb/b, the detection limit was calculated as 0.69. This material with broad linear ranges, excellent selectivity, month-long stability, and recovery rates of 97.7-101.6% in spiked serum. This facile and cost-effective platform offers a promising tool for sensitive miRNA quantification in clinical diagnostics.
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JOURNAL OF POLYMER RESEARCH
·
2025
·Vol. 32
·期 12
·458
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IF 2.8
Shehu Mustapha Sani,Saeed Alaaddin M. M.,Cao Gui-Ping,Yan Jun-Yang
A novel gradient copolymer, poly(norbornadiene-grad-cyclohexadiene), was synthesized via ring-opening metathesis polymerization (ROMP) of norbornadiene (NBD) and vinyl-addition of cyclohexadiene (CHD) mechanism using Grubbs’ third-generation catalyst (G3). To overcome the intrinsic brittleness and limited thermal performance of cyclic olefin copolymers, the material was further modified through catalytic hydrogenation using a palladium supported on porous nickel decorated with carbon nanotubes (Pd@PN-CNT). The post-polymerization (catalytic hydrogenation) significantly enhanced the thermomechanical properties: the glass transition temperature increased from 127 ℃ to 139 ℃, and the degradation temperature rose from 438 ℃ to 519 ℃. Mechanical testing revealed improvements in tensile strength (from 14.58 MPa to 28.93 MPa), elongation at break (from 16.44% to 32.34%), and elastic modulus (from 28.61 MPa to 39.87 MPa). These improvements are attributed to the saturation of unsaturated bonds, reduction in chain defects, and enhanced phase separation. The high hydrogenation efficiency of the Pd@PN-CNT catalyst also demonstrated excellent reusability. This work presents a viable route for tailoring the thermal and mechanical performance of gradient copolymers, positioning hydrogenated poly(NBD-grad-CHD) as a promising candidate for advanced applications in elastomers and high-performance engineering materials.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 12
·863
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IF 5.3
Wen Hao-Xiang,Li Yan-Jun,Xiao Fu-Lan,Deng Yu-Yu,Zhou Lian-Di D.,Mu Yang,Zhang Qi-Hui H.,Yuan Chun-Su
Azithromycin (AZM) is regarded as a potential risk to human immunity and ecosystems, which requires an effective method for rapid on-site detection. Herein, a bifunctional monomer molecularly imprinted polymer and boronic acid-functionalized carbon dots (B-CDs) have been applied to develop an innovative sensor for the determination of AZM. The synergistic effects of boronic esters formation by boronic acid groups and non-covalent interaction of imprinted cavities by pyrrole enhance the binding affinity for improved recognition. In addition, the electrode modification strategy of B-CDs and multiwalled carbon nanotube (MWCNTs) enhance the electron transportation. The constructed sensor exhibited a broad linear detection range (0.2–300 µM), low detection limit (0.12 µM) and significant specificity for AZM (IF = 3.01). Furthermore, it showed satisfactory stability, repeatability and resistance to interference, enabling accurate detection of AZM in milk, serum and urine. This work provides a new avenue for the development of tailored sensitive electrochemical sensors to achieve specific detection. Graphical
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HEREDITAS
·
2025
·Vol. 162
·期 1
·232
·
IF 2.5
Xiaohui Yu,Jie Li,Jiangqiao Zhou
Background Coptisine (COP) is a natural compound extracted from Rhizoma Coptidis , and it represses the malignant biological behaviors of bladder cancer cells. However, the underlying molecular mechanism has not been fully elucidated. The aim of this study was to clarify the downstream mechanism by which COP treats bladder cancer. Materials and methods SwissTargetPrediction, STITCH, SymMap, ETCM, TCMSP, CTD databases were used to collect the related targets of COP. GeneCards, DisGeNET, TTD and OMIM databases were used to obtain the related targets of bladder cancer. A Venn diagram was used to identify the potential targets of COP in bladder cancer treatment. The protein-protein interaction network was constructed using STRING database, and Cytoscape 3.9.0 software was used to screen the hub targets. The binding relationship between COP and the hub targets was verified by molecular docking and molecular dynamics simulation. After the bladder cell lines T24 and BIU-87 were treated with different doses of COP, the regulatory effects of COP on PI3K/AKT pathway were investigated with western blotting. Additionally, the tumor-suppressive properties of COP on bladder cancer cells were validated with tumorigenesis model and metastasis model in nude mice. Results RAC-alpha serine/threonine-protein kinase 1 (AKT1), glycogen synthase kinase 3 beta (GSK3B), caspase-3 (CASP3), tumor necrosis factor (TNF) and cyclin D1 (CCND1) were identified as the main hub targets of COP in bladder cancer treatment. PI3K/AKT pathway was predicted to be a crucial pathway regulated by COP. The binding affinities between COP and AKT1, GSK3B, CASP3, TNF and CCND1 were high. COP treatment markedly repressed the phosphorylation level of ERK1/2, AKT1, PI3K p85 and mTOR in T24 and BIU-87 cells, and repressed the tumorigenesis and lung/liver metastasis of T24 cells in vivo. Conclusion COP may be a natural inhibitor for AKT1, GSK3B, CASP3, TNF and CCND1. COP represses PI3K/AKT pathway to suppress the progression of bladder cancer.
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JOURNAL OF MATERIALS SCIENCE
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2025
·
IF 3.9
Gao Bingying,Sun Yunyun,Wang Guqi,Mao Linqiang
Hazardous formaldehyde and acetaldehyde removal remains a critical challenge in volatile organic compounds (VOCs) control technologies. Adsorption-based technologies offer distinct advantages for VOCs removal in practical applications due to their operational simplicity, energy efficiency, and adaptability to complex gas matrices. Although metal–organic frameworks (MOFs) exhibit superior adsorption capacity for VOCs compared to conventional adsorbents, their widespread industrial application has been hindered by high production costs and limited stability under humid conditions. This study prepared attapulgite (ATP)-functionalized MOF composites that synergistically enhanced both VOCs adsorption capacity at static (formaldehyde: 185 mg/g; acetaldehyde: 196 mg/g at RH = 80%) and dynamic (Breakthrough time for formaldehyde and acetaldehyde: 36 min and 30 min; penetrating adsorption capacity for formaldehyde and acetaldehyde: 2.126 mg/g and 5.258 mg/g), overcoming the intrinsic moisture sensitivity and scalability challenges of pristine MOFs for industrial VOCs abatement. Kinetic analysis confirms that VOCs adsorption on the ATP-MOF composites occurs primarily through spontaneous physical adsorption mechanisms. This study demonstrates an innovative strategy of hybridizing MOFs with natural ATP minerals, offering a viable pathway to enhance the practical deployment of MOF-based adsorbents in complex real-world environments.
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Nature Communications
·
2025
·
IF 15.7
Peng Xudong,Zhang Yang,Wang Qiyu,Chen Lu,Chen Nanshan,Jiang Yanxin,Yang Zhiqiang,Pan Hongji,Li Hongxu,Zhao Tianshou,Li Yiju
Emerging applications, such as electric aircraft and ships, demand rechargeable batteries with high specific energy. However, current lithium (Li) ion batteries fall significantly short in this regard. Even with Li metal batteries, achieving a high cell-level specific energy (e.g. ≥600 Wh kg −1 ) remains a significant challenge. In this study, a synergistic strategy integrating a precisely engineered carbonate-based gel-solid-state electrolyte with a surface-modified Li is proposed. Our in-situ gelation technique confines unstable free carbonate solvent molecules, thereby suppressing the electrolyte-induced parasitic reactions. Furthermore, a bicontinuous gradient polymer layer that regulates Li deposition and improves moisture/oxygen resistance is introduced, enabling damage-free Li processing and avoiding harsh production requirements. As a result, our 11 Ah-level Li metal battery achieves a high specific energy of 604.2 Wh kg −1 (626.4 Wh kg −1 excluding the packaging materials) and operates for over 100 cycles with an energy retention of 92.83% under lean electrolyte conditions (0.85 g Ah −1 ). This work offers a practical strategy for the scalable production of long-cycle Li metal batteries with high specific energy for broad future applications.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·
IF 12.6
Xuejun Chen,Shaoyue Li,Qing Lu,Yitong Li,Mingrui Zhu,Shen Zhang,Yan Fang,Congjian Wen,Daohui Yang,Peili Fan,Huixiong Xu,Haohao Yin
Immunogenic cell death (ICD) significantly boosts anti-tumor immunotherapy effectiveness; however, the recruitment of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), driven by factors such as adenosine accumulation and oxygen depletion during ICD, impairs the overall therapeutic outcome as well as facilitates tumor development and metastasis. Recent studies identify CD300ld as a key regulator of PMN-MDSCs recruitment, making it a promising immunotherapeutic target. Here, an innovative strategy is developed to eminently amplify ICD while alleviating PMN-MDSC infiltration upon ultrasound (US) stimulation. A modified generation 5 (G5) poly(amidoamine) dendrimer (G5PBA) was employed to encapsulate hematoporphyrin (GH)-a widely used organic sonosensitizer-and modified the complex with pardaxin peptides (Par) to achieve precise endoplasmic reticulum (ER) targeting, and adsorbed the negatively charged siCD300ld (PGH@siRNA). Under US irradiation, PGH@siRNA precisely accumulates at ER to induce localized reactive oxygen species (ROS) bursts, and effectively silence CD300ld, thereby amplifying endoplasmic reticulum stress (ERS)-mediated ICD and reducing PMN-MDSCs infiltration to reshape the tumor microenvironment. This systematic preclinical evaluations demonstrated enhanced immune activation, suppressed metastasis, and improved therapeutic outcomes. This study introduces a sono-responsive synergistic strategy integrating ER-targeted sonodynamic therapy with gene silencing, offering a novel paradigm for targeting PMN-MDSCs and enhancing triple-negative breast cancer (TNBC) immunotherapy.
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Future Journal of Pharmaceutical Sciences
·
2025
·Vol. 11
·期 1
·1-19
·
IF 3
Anwar Maira,Badshah Ismail,Altaf Reem,Masaud Syed Muzzammil,Kiyani Amber,Murtaza Babar
Background Migraine is a neurological disorder and major cause of disability globally, especially in women and young adults. This study aimed to investigate the beneficial effects of polydatin (PD), a natural compound, against nitroglycerin (NTG) induced migraine like headache in mice. Materials and methods Behavioural paradigms included Von Frey filament test, tail flick test, light aversion test and assessment of migraine-associated pain like behaviour. In addition, biochemical investigations were undertaken to determine the effect of PD on migraine associated markers including oxidative stress, nitric oxide (NO) and calcitonin gene related peptide (CGRP). Integrated in vivo, in silico, and network pharmacology approaches were employed to evaluate PD’s antimigraine effects. Statistical significance was set at p < 0.05. Results Treatment with PD attenuated NTG-induced migraine like headache and related behavioural changes. PD-subjected animals exhibited enhanced levels of catalase, glutathione-S-transferase, and glutathione, as well as reduced lipid peroxidation, compared to NTG-only treated animals. Reduction in CGRP and nitrite levels along with reduced expression of neuronal nitric oxide synthase (nNOS) and inducible nitric oxide synthase (iNOS) was also observed in mouse cortex and trigeminal nucleus caudalis (TNc) after treatment with PD compared with disease controls. Histological sections from PD treated animals from these regions resembled closely with those of controls with improved cell viability. Molecular docking studies suggested that PD docked in the similar binding pocket as that of CGRP, Rimegepant (a CGRP receptor blocker) and Sumatriptan. Network pharmacology revealed potential interaction of hub genes with PD, with proteins like NOS1 (nNOS), NOS2 (iNOS), NOS3, PDE5A, GATM, ARG1 and ARG2 having significant role in network functionality and the potential mediation of PD therapeutic effect. Conclusion PD ameliorated NTG-induced migraine like headache through modulation of NO, CGRP and oxidative stress dependant mechanisms.
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