Science China-Chemistry
·
2024
·
IF 10.4
Kimaka P. Rinel R.,Wang Ping,He Miao,Meng Senyao,Yao Jiasai,Li Huawei,Yang Cheng,Li Zhenxing
Polymetallic layered double hydroxides are promising cost-effective catalysts for the oxygen evolution reaction (OER) due to their versatile anionic and cationic tunability. Nevertheless, several challenges persist, notably, issues related to low electrical conductivity, poor catalytic activity, and stability, especially at high current density. Herein, we report the design of Ce- and La-doped CoNiFe-layered double hydroxide (CeLaCoNiFe-LDH) nanosheets through a facile and scalable in situ self-assembly strategy that displays enhanced OER activity. Experimental and theoretical investigations provide insights into the impact of Ce-and La-doping by comparing CeCoNiFe-LDH, LaCoNiFe-LDH, and pristine CoNiFe-LDH, all synthesized using the same methodology. These results reveal that doping Ce 3+ and La 3+ into CoNiFe-LDH substantially improves its electronic structure, resulting in enhanced conductivity, more oxygen vacancies (Vo), electron interaction, and active site formation. Consequently, significantly reduced overpotentials of 175, 314, and 424 mV at 10, 100, and 500 mA cm −2 , respectively, and a highly stable current density of 120 h in 1 M KOH were achieved. Notably, these performance metrics surpass those of unmodified LDHs and are competitive with many lanthanide-doped transition metal-based LDH electrocatalysts, as well as noble metal catalysts like ruthenium catalysts. This work represents a pioneering effort in doping Ce 3+ and La 3+ ions into a functional CoNiFe-based electrocatalyst, offering inspiring OER performance and scalability potential.
✓ 已验证
DOI
高影响因子
Journal of Sustainable Metallurgy
·
2024
·
IF 2.5
Peng Miaomiao,Xi Chen,Shen Keyu,Tan Yangjing,Li Fei
A novel greenness and low-cost biosorbent was prepared by polyethylene polyamine-modified waste biomass of sugarcane bagasse in this study, which was used to remove molybdenum(VI) from aqueous solution. The structural properties and adsorption mechanism of this amine-functionalized sugarcane bagasse adsorbent (SCB-A) on Mo(VI) were investigated by SEM–EDS, BET, TG, FTIR, XPS, and batch adsorption experiments. The results show that the adsorption reaction between SCB-A and Mo(VI) was a spontaneous endothermic process, and its theoretical maximum adsorption capacity was about 231.48 mg/g. The adsorption capacity was 8.93-fold compared to that of pristine sugarcane bagasse. This adsorption process was more consistent with the Langmuir model and pseudo-second-order kinetics model, indicating that this process was monolayer adsorption on a homogeneous surface and the adsorption rate was controlled by the chemisorption process. SCB-A possessed great reusability, maintaining a stable adsorption capacity after five recycles. For the adsorption toward Mo(VI), SCB-A also exhibited superior selectivity in a multi-ion coexistence solution. Therefore, SCB-A has tremendous potential in the economically and feasible removal of Mo(VI) from wastewater. Graphical Abstract
✓ 已验证
DOI
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-18
·
IF 14.7
Zhang Yan,Shen Jiayi,Xie Famin,Liu Zhiwei,Yin Fangfang,Cheng Mingxiu,Wang Liang,Cai Meiting,Herzog Herbert,Wu Ping,Zhang Zhi,Zhan Cheng,Liu Tiemin
Resistance to stress is a key determinant for mammalian functioning. While many studies have revealed neural circuits and substrates responsible for initiating and mediating stress responses, little is known about how the brain resists to stress and prevents overreactions. Here, we identified a previously uncharacterized neuropeptide Y (NPY) neuronal population in the dorsal raphe nucleus and ventrolateral periaqueductal gray region (DRN/vlPAG) with anxiolytic effects in male mice. NPY DRN/vlPAG neurons are rapidly activated by various stressful stimuli. Inhibiting these neurons exacerbated hypophagic and anxiety responses during stress, while activation significantly ameliorates acute stress-induced hypophagia and anxiety levels and transmits positive valence. Furthermore, NPY DRN/vlPAG neurons exert differential but synergic anxiolytic effects via inhibitory projections to the paraventricular thalamic nucleus (PVT) and the lateral hypothalamic area (LH). Together, our findings reveal a feedforward inhibition neural mechanism underlying stress resistance and suggest NPY DRN/vlPAG neurons as a potential therapeutic target for stress-related disorders.
✓ 已验证
DOI
PubMed
高影响因子
MOLECULAR DIVERSITY
·
2024
·
IF 3.9
Ou Yuqin,Guo Xue,Zhang Qi,Zhang Wei,Gan Xiuhai
Plant-parasitic nematodes are seriously affecting agricultural production worldwide and there are few highly effective and low-risk nematicides to control nematode diseases. In order to discover new nematicides, a series of 1,2,4-oxadiazole derivatives containing amide fragments have been designed and synthesized with the principle of active substructure splicing. The nematicidal activity of the target compounds was evaluated in vitro and it indicated that compound C3 exhibited the most nematicidal activity against Bursaphelenchus xylophilus , Aphelenchoides bessey i, and Ditylenchus destructor with the LC 50 values of 37.2, 36.6, and 43.4 μg/mL, respectively, which were superior to positive agent tioxazafen. The preliminary mechanism results revealed that compound C3 not only inhibited the reproduction of B. xylophilus populations, but also affected the production of ROS and the accumulation of lipofuscin and lipids. Furthermore, compound C3 showed good inhibition of succinate dehydrogenase (SDH) with the IC 50 value of 45.5 µmol/L. Molecular docking indicated that compound C3 had excellent binding to amino acids around the SDH active pocket. This work indicated that 1,2,4-oxadiazole derivative containing amide fragment is a promising template for the discovery of new nematicides and compound C3 can be used as a potential nematicide candidate. Graphical abstract
✓ 已验证
DOI
PubMed
高影响因子
ACTA PHARMACOLOGICA SINICA
·
2024
·
IF 6.9
Yang Qin,He Wen-hao,Xie Li,Chen Tao,Liu Ruo-fan,Hu Jia-jia,Guo Jia-yin,Tan Guo-zhu,Wu Fu-ling,Gu Peng,Chen Peng,Chen Yu
Acetaminophen (APAP) overdose-induced acute liver injury (ALI) is characterized by extensive oxidative stress, and the clinical interventions for this adverse effect remain limited. Astilbin is an active compound found in the rhizome of Smilax glabra Roxb . with anti-inflammatory and antioxidant activities. Due to its low oral bioavailability, astilbin can accumulate in the intestine, which provides a basis for the interaction between astilbin and gut microbiota (GM). In the present study we investigated the protective effects of astilbin against APAP-induced ALI by focusing on the interaction between astilbin and GM. Mice were treated with astilbin (50 mg·kg −1 ·d −1 , i.g.) for 7 days. After the last administration of astilbin for 2 h, the mice received APAP (300 mg/kg, i.g.) to induce ALI. We showed that oral administration of astilbin significantly alleviated APAP-induced ALI by altering the composition of GM and enriching beneficial metabolites including hydroxytyrosol (HT). GM depletion using an “antibiotics cocktail” or paraoral administration of astilbin abolished the hepatoprotective effects of astilbin. On the other hand, administration of HT (10 mg/kg, i.g.) caused similar protective effects in APAP-induced ALI mice. Transcriptomic analysis of the liver tissue revealed that HT inhibited reactive oxygen species and inflammation-related signaling in APAP-induced ALI; HT promoted activation of the Nrf2 signaling pathway to combat oxidative stress following APAP challenge in a sirtuin-6-dependent manner. These results highlight that oral astilbin ameliorates APAP-induced ALI by manipulating the GM and metabolites towards a more favorable profile, and provide an alternative therapeutic strategy for alleviating APAP-induced ALI.
✓ 已验证
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2024
·Vol. 416
·期 27
·6001-6010
·
IF 3.8
Yang Qin-Qin,He Shao-Bin,Zhang Yi-Lin,Li Min,You Xiu-Hua,Xiao Bo-Wen,Yang Liu,Yang Zhi-Qiang,Deng Hao-Hua,Chen Wei
α-Glucosidase (α-Glu) is implicated in the progression and pathogenesis of type II diabetes (T2D). In this study, we developed a rapid colorimetric technique using platinum nanoparticles stabilized by chitosan (Ch-PtNPs) to detect α-Glu activity and its inhibitor. The Ch-PtNPs facilitate the conversion of 3,3′,5,5′-tetramethylbenzidine (TMB) into oxidized TMB (oxTMB) in the presence of dissolved O 2 . The catalytic hydrolysis of 2-O-α- d -glucopyranosyl- l -ascorbic acid (AA-2G) by α-Glu produces ascorbic acid (AA), which reduces oxTMB to TMB, leading to the fading of the blue color. However, the presence of α-Glu inhibitors (AGIs) hinders the generation of AA, allowing Ch-PtNPs to re-oxidize colorless TMB back to blue oxTMB. This unique phenomenon enables the colorimetric detection of α-Glu activity and AGIs. The linear range for α-Glu was found to be 0.1–1.0 U mL −1 and the detection limit was 0.026 U mL −1 . Additionally, the half-maximal inhibition value (IC 50 ) for acarbose, an α-Glu inhibitor, was calculated to be 0.4769 mM. Excitingly, this sensing platform successfully detected α-Glu activity in human serum samples and effectively screened AGIs. These promising findings highlight the potential application of the proposed strategy in clinical diabetes diagnosis and drug discovery. Graphical
✓ 已验证
DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2023
·
IF 2.7
Zhao Xiaoyu,Du Qian,Qiu Huiying,Zhao Yaqin,Wang Songbai,Li Junfen,Dong Chuan
In this work, bright yellow fluorescent and multifunctional carbon dots (N-CDs) were prepared by hydrothermal method from O-phenylenediamine and 4-aminobenzoic acid. The fluorescence characterization showed that the N-CDs possessed good optical properties (QY = 32%) and excitation dependent multi-color emission. By exciting with 390 nm, the strong selective interaction of VB 12 with N-CDs could result in a sharp decrease in the luminescence of N-CDs at 567 nm. An efficient fluorescence sensor in aqueous solution was constructed which could linearly respond VB 12 in wide concentration ranges of 0–90 μM and 140–250 μM. The linear correlation coefficients of N-CDs and VB 12 were 0.9950 and 0.9968, respectively, and the detection limit was 0.119 μM. N-CDs were performed for sensitive determination of VB 12 in real samples. Moreover, the N-CDs were exploited to image cell. This N-CDs was a sensitive fluorescence probe to monitor VB 12 and presented prospective potential in living cells imaging. Graphical abstract Schematic diagram of the synthesis process and application research of N-CDs
✓ 已验证
DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Gong Yafei,Fu Yan,Lou Dawei
Abnormal tryptophan (Trp) metabolism can be used as an important indicator of chronic hepatitis, paranoia, Parkinson’s disease and other diseases. Deficiency or excessive accumulation of Cu 2+ can cause diseases such as Wilson’s disease and Alzheimer’s disease. Eu-based metal-organic framework (Eu-MOF) was successfully prepared for fluorescence sensing of Trp and Cu 2+ in an aqueous solution (pH = 7.4). Eu-MOF showed high selectivity and sensitivity for Trp and Cu 2+ with detection limits of 0.22 µM and 0.09 µM and K sv of 6.17 × 103 M − 1 and 2.37 × 10 4 M − 1 respectively. Trp and Cu2+ had overlapped UV absorption spectra with that of Eu-MOF and competed for the excitation light source. Trp also attenuated the antennae effect of organic ligands on Eu-MOF, thus quenching the red fluorescence of Eu-MOF. This study provides insights into the application of MOFs in bioanalysis and diagnostics.
✓ 已验证
DOI
PubMed
高影响因子
CELLULOSE
·
2023
·Vol. 31
·期 1
·235-246
·
IF 5.7
Xiong Jie,Feng Shuang,Peng Rufang,Jin Bo
A series of aziridino[60]fullerenes was synthesized by the reaction of octabromo[60]fullerene with various anilines. Their ability to absorb free radicals and acid gases was studied, and their potential applications as stabilizers in nitrocellulose-containing propellants were discussed. The results of differential thermal analysis showed that aziridino[60]fullerene can increase the exothermic peak temperatures of nitrocellulose by 0.55–2.37 °C. The methyl violet test found that aziridino[60]fullerenes can extend the complete decomposition period by 31–71 min. The results of vacuum stability test and thermogravimetric test indicated that aziridino[60]fullerene can delay the decomposition of nitrocellulose. Furthermore, their stabilization mechanism was studied by electron spin resonance spectroscopy, and the free-radical scavenging rate of 3c reached 86.09%. The findings demonstrate that aziridino[60]fullerenes could effectively eliminate the nitrogen oxides released by nitrocellulose autocatalysis and might be used as a new stabilizer for nitrocellulose-containing propellants. Graphical abstract
✓ 已验证
DOI
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Xu Guangxian,Wang Hong,Zhang Jinyang,Gao Jiao,Guan Jiwen,Xu Qiang,Truhlar Donald G.,Wang Zhandong
Elucidating the formation mechanism of polycyclic aromatic hydrocarbons (PAHs) is crucial to understand processes in the contexts of combustion, environmental science, astrochemistry, and nanomaterials synthesis. An excited electronic-state pathway has been proposed to account for the formation of 14π aromatic anthracene in the benzyl ( b -C 7 H 7 ) self-reaction. Here, to improve our understanding of anthracene formation, we investigate C 7 H 7 bimolecular reactions in a tubular SiC microreactor through an isomer-resolved method that combines in situ synchrotron-radiation VUV photoionization mass spectrometry and ex-situ gas chromatography–mass spectrometry. We observe the formation of o -tolyl ( o -C 7 H 7 ) radical isomer, and identify several C 14 H 10 products (diphenylacetylene, phenanthrene and anthracene) and key C 14 H 14 and C 14 H 12 intermediates. These isomer-specific results support the occurrence of reactions on the electronic ground-state potential energy surface, with no evidence for key intermediates of the proposed excited-state pathway as the key pathway. Furthermore, theoretical calculations unveil new facile reaction pathways that may contribute to the enhanced production of anthracene, and these mechanistic findings are further substantiated by pyrolysis experiments. The results add insight into the molecular formation of PAHs in C 7 H 7 bimolecular reaction, and contribute to establishing accurate models to predict PAH chemistry in diverse laboratory, environmental, and extraterrestrial contexts.
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2023
·Vol. 30
·期 6
·1-13
·
IF 2.8
Zhang Haoran,Xu Shuyan
With the advent of the 5G era, various thermal conductivity nanocomposites are being investigated to solve the heat accumulation on the surface of electronic devices. In this study, magnetic nanofiller ferroferric oxide-polydopamine-boron nitride nanosheets (Fe-PDA-BNNSs) are fabricated by mussel-inspired and coprecipitation methods with polydopamine (PDA) and ferroferric oxide (Fe 3 O 4 ). The aligned Fe-PDA-BNNSs/poly(vinyl alcohol) (PVA) composites with higher in-plane thermal conductivity and decent mechanical properties are prepared by applying a horizontal magnetic field. The in-plane thermal conductivity of the aligned composite at 30 wt% filler loading reaches 5.237 W/(m·K), which is 1.1 times and 20.5 times that of the unaligned composites and neat PVA. Moreover, the aligned composite maintains mechanical strength and obtains commendable thermal stability and heat dissipation capability, which can be applied to the thermal management of flexible electronic devices.
✓ 已验证
DOI
高影响因子
CELLULOSE
·
2024
·Vol. 31
·期 6
·3747-3761
·
IF 4.9
Xia Nan Nan,Wu Qin,Bi Shi Lin
Cellulose-based adsorbents have attracted extensive attention owing to their ecofriendly characteristics. However, most cellulose-based adsorbents possess inadequate adsorption capabilities for typical pollutants such as heavy-metal ions and dyes. Herein, we developed a cost-effective and robust cellulose-based adsorbent with a three-dimensional network structure based on hydrogen bonds and electrostatic interactions via the simple supramolecular self-assembly of carboxymethyl cellulose (CMC), cationic polyacrylamide (CPAM), and tannic acid (TA) (referred to as CMC–CPAM–TA). Benefiting from the abundant catechol/carboxyl groups and mesoporous/macroporous channels, CMC–CPAM–TA could trap Cu(II) ions and rhodamine B (RhB) (representing a typical heavy-metal ion and dye, respectively) by rapidly forming Cu–O coordination bonds and inducing electrostatic interactions. CMC–CPAM–TA exhibited high adsorption capacities for Cu(II) ions and RhB, which were 669.8 and 202.2 mg/g, respectively. These values are 1.3–23.6 and 1.1–72.2 times higher than those of commonly reported cellulose-based adsorbents, respectively. Furthermore, CMC–CPAM–TA showed high regenerative ability for Cu(II) ions and RhB after five cycles owing to its robust structure.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）