INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.5
Sen Cao,Guoliang Dong,Taomei Yang,Jiaying Jin,Liangjie Ba,Donglan Luo,Zhibing Zhao
In this study, chitosan (CS) and xanthan gum (XG) were used as the base materials to prepare edible films containing cornmint oil (CO). The physical properties and structural characteristics of the films were thoroughly analyzed, along with an investigation into their preservation effect on blueberries. Scanning electron microscopy (SEM) showed that cornmint oil was successfully integrated into the edible film; however, aggregation was observed at higher concentrations. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) confirmed successful incorporation of the components. Notably, the CXG-1.5 film exhibited excellent thermal stability, barrier properties, significant antibacterial and antioxidant activities, compared to other formulations. During a storage period of 8 d for blueberries, compared with the control group, the CXG-1.5 group reduced the decay rate by 44.02%, reduced the weight loss rate by 75.85%, and reduced the malondialdehyde increase by 44.39%. At the same time, it maintained a high hardness and minimized the loss of 48.8% of total soluble solids and 56.34% of anthocyanins. Consequently, this novel cornmint oil-containing edible film effectively prolongs the shelf life of blueberries. These results suggest that the edible film developed in this study holds substantial potential for application in post-harvest preservation of fruits and vegetables.
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POLYMER DEGRADATION AND STABILITY
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2026
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IF 7.4
Lu Bai,Wei Tan,Yin Tian,Lei Tan,Ying Chang,Guixiang Song,Ping Li,Yuanlin Ren,Xiaohui Liu
To improve the flame retardancy of lyocell fabrics, in this paper, an eco-friendly flame retardant and antibacterial lyocell fabric (FR@Si-lyocell) was fabricated by surface grafting modification. The surface morphology, combustion properties and antibacterial rate of FR@Si-lyocell were investigated. FR@Si-lyocell exhibited excellent char-forming ability with residual char of up to 40.24 wt% and 11.78 wt% at 800 °C in N 2 and air, respectively. Its limiting oxygen index (LOI) value increased from 17.6% to 32.3%, and the peak heat release rate (PHRR) and total heat release (THR) decreased significantly by 94.4% and 74.5% compared to the control sample. The synergistic flame retardant mechanism of gas and condensed phases was proposed by analyzing the volatile pyrolysis products and char residue generated during the combustion process. In addition, FR@Si-lyocell showed excellent antibacterial properties, with inhibition efficiencies as high as 99.9% and 99.7% against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). This work provided an efficient and eco-friendly method to prepare multifunctional lyocell fabrics with potential application fields.
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Materials Today Communications
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2026
·
IF 4.5
Shu-Dong Wang,Ke Wang,Jin Yan,Chen Ding,Youzhu Zhang
This study reports the fabrication of a silk fibroin (SF)/chitosan (CS) nanofibrous scaffold via electrospinning for advanced skin tissue regeneration. Ethanol treatment induced a marked β-sheet transition in SF, as confirmed by FTIR and Raman spectroscopy, thereby enhancing thermal stability, mechanical strength, and dimensional stability. The optimized SF/CS scaffold achieved 100 % antibacterial activity against Staphylococcus aureus and Escherichia coli within 24 h, supported adhesion, proliferation, and differentiation of L929 fibroblasts and MC3T3-E1 osteoblasts, and exhibited excellent hemocompatibility (hemolysis rate: 3.29 ± 1.13 %). Molecular docking revealed stable SF–CS interactions through hydrogen bonding (e.g., GLU28, ASP29) and hydrophobic contacts (binding energy: –5.7 kcal/mol). Compared with clinical-grade polyurethane (hemolysis rate: 3.05 ± 0.45 %), the SF/CS scaffold demonstrated equivalent blood safety while offering superior biodegradation control and bioactivity. Collectively, these results establish ethanol-treated SF/CS nanofibrous scaffolds as multifunctional biomaterials with strong potential for chronic wound healing and full-thickness skin repair.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Yan Sun,Xiujuan Wang,Guihong Yao,Yaxin Hao,Mingqian Tan,Xiuli Xu
Aflatoxin contamination poses a serious threat to infant health, yet selective enrichment and separation of trace aflatoxins from complex food matrices remains challenging. Herein, we report a polydopamine surface-imprinted chitosan-polyethyleneimine-scaffolded COF aerogel (Fe₃O₄@COF@MIP-AG) featuring large pores, specific binding sites, and a unique medium-blocking effect that enhances resistance to matrix macromolecules and competing molecules. Adsorption follows pseudo-second-order kinetics and Freundlich isotherms, indicating chemisorption-dominated, heterogeneous multilayer adsorption. Notably, the material combines robust mechanical stability with ultrafast kinetics, making it highly suitable for solid-phase extraction (SPE). Density functional theory (DFT) confirmed the thermodynamic stability of the aflatoxin-adsorbent complex and directly links the gel's adsorption configuration to its high selectivity for target analytes. This work establishes a generalizable design strategy for adjustable-performance aerogels and offers mechanistic insights that support the development of highly specific aflatoxin enrichment technologies.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Yanfei Liu,Juan Li,Shaowen Huang,Dingbo Shu,Yanru Shan,Zhuohao Qiao,Xiaogang Yin
To address the heavy metal water pollution caused by industrial wastewater discharge, a novel hydrogel adsorbent was prepared using organic matter derived from distiller's grains (DGS), a by-product of the brewing industry, as the main raw material and carboxymethyl chitosan (CMCS) as the modifier. Characterization results revealed that CMCS converted the adsorbent into a three-dimensional macroporous structure while enhancing its highly selective adsorption performance for Pb(II) and Cd(II), with adsorption capacities reaching as high as 825.3 mg·g −1 and 644.3 mg·g −1 , respectively, and removal efficiencies up to 99.4% and 95.2% within 10 min. The adsorption process fitted well with the pseudo-second-order adsorption kinetic model (R 2 > 0.996) and the Langmuir isotherm model, indicating that the adsorption was dominated by chemical adsorption. Mechanistic analysis revealed that the hydrogel formed complexation and coordination with Pb(II) and Cd(II) via the lone pair electrons of O and N atoms, and combined with hydrogen bonding and electrostatic attraction to achieve synergistic adsorption. Furthermore, adsorption experiments on industrial wastewater using this adsorbent demonstrated that it maintained excellent adsorption performance even after six adsorption-desorption cycles, and achieved a degradation rate of 51.3% after 28 days. The synthesis of this highly efficient adsorbent not only realizes the functional modification and high-value utilization of DGS but also provides a green solution for wastewater remediation, exhibiting great application potential.
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Sustainable Materials and Technologies
·
2026
·
IF 9.7
Yanen Wang,Pei Wang,Qi Cai,Xinyuan Zhang,Jiaxuan Guo,Shige Wang,Zhen Tang,Tielou Chen
Temporomandibular joint osteoarthritis (TMJ-OA) is a degenerative disease marked by oxidative stress, cartilage loss, and inflammation. Current therapies are largely palliative and fail to restore joint structure or function. Here, we developed an injectable multifunctional hydroxybutyl-chitosan hydrogel (HBC@ZIrK) with thermo-responsive sol-gel transition property that integrates iridium nanozymes (Ir NPs), zeolitic imidazolate framework-8 (ZIF-8), and the chondrogenic molecule kartogenin (KGN) for synergistic therapy. ZIF-8 stabilized ultra-small Ir NPs, preserved their multi-enzyme activity, and enabled efficient KGN loading with sustained release in the inflamed microenvironment. The hydroxybutyl-chitosan matrix ensured injectability in sol state at room temperature, and underwent rapid gelation at body temperature to form a localized depot, achieving prolonged intra-articular retention of therapeutic components. In vitro studies proved that HBC@ZIrK showed excellent cytocompatibility, potent reactive oxygen species scavenging, apoptosis inhibition, and sustained KGN release. In a rat TMJ-OA model, micro-CT and histological analyses confirmed that the HBC@ZIrK hydrogel preserved subchondral bone, reduced osteophytes, suppressed inflammatory cytokines, and enhanced cartilage matrix synthesis. Remarkably, the joint morphology in the HBC@ZIrK group was statistically indistinguishable from that of healthy controls, which highlights the synergy between KGN and nanozyme-mediated antioxidation. Collectively, these results demonstrate that HBC@ZIrK is a minimally invasive and effective therapeutic platform, offering a dual-action strategy for microenvironmental modulation and structural regeneration in TMJ-OA.
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Materials Today Bio
·
2026
·
IF 11
Fangying Zheng,Yanyun Su,Xianbin Sun,Ding Tan,Ya Wang,Xiumei Li,Yu Gao
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are primary treatments for EGFR-mutated non-small cell lung cancer (NSCLC), but acquired resistance limits efficacy. To address this challenge, we developed CsO/IGA, a multifunctional nanoplatform combining osimertinib (AZD9291) with an indocyanine green-gadolinium (ICG-Gd) probe via oleanolic acid (OA)-modified chitosan encapsulation, integrating fluorescence/magnetic resonance imaging (FLI/MRI) with chemo-phototherapy and tumor microenvironment (TME) modulation. CsO/IGA (∼100 nm) demonstrated excellent stability and generated both singlet oxygen and hyperthermia under 808 nm irradiation. The nanoplatform exerted efficient anti-cancer effects to overcome resistance through reactive oxygen species induction, mitochondrial membrane potential reduction, and EGFR/phosphorylated EGFR downregulation in sensitive and resistant NSCLC cells. Notably, the OA component suppressed cancer-associated fibroblasts and α-smooth muscle actin expression, remodeling the TME to enhance tumor penetration. In vivo studies confirmed tumor-specific accumulation and deep penetration, FLI/MRI capability, and superior antitumor efficacy through chemo-phototherapy synergy. This work presents a promising OA-integrated theranostic strategy integrating targeted therapy, phototherapy, TME modulation, and diagnostic imaging for overcoming EGFR-TKI resistance in NSCLC.
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Biomedical Materials
·
2026
·Vol. 21
·期 3
·035031
·
IF 3.9
Changle Lu,Bailei Li,Jiali Liu,Xinyu Gao,Zhen Zhang,Yu Zhou,Qilong Cao,Xiaojun Liu,Rongqing Zhang
Diabetic wound healing remains a clinical challenge due to impaired repair, often leading to complications such as infection and tissue necrosis. Here, we present a novel dual-drug-loaded hydrogel formulated using oxidized hyaluronic acid (OHA) and catechol-modified chitosan (CS-pC). This system is engineered to enhance the local bioavailability of polydatin (PD) and delay the release of tetramethylpyrazine (TMP), achieving superior release performance and synergistic effects compared to single-drug formulations; thus, this system enables synergistic modulation of the target inflammatory microenvironment and promotes angiogenesis, thereby facilitating effective diabetic wound healing. The hydrogel exhibited a porous structure (100–200 μm) and moderate swelling (119.67% ± 6.66% at 24 h). Approximately 80% of TMP and PD were sustainably released within 48–52 h, aligning with clinical dressing intervals. In diabetic mice, it accelerated wound closure to 98.01% within 14 d—20.63% higher than controls. Most notably, the hydrogel significantly promoted wound healing, as evidenced by: (1) upregulation of vascular endothelial growth factor (VEGF) and α-SMA expression (RT-qPCR: 3.2-fold for VEGF and 3.7-fold for α-SMA vs control); (2) enhanced cell migration (3.1-fold vs control) and angiogenesis (1.3-fold vs control); and (3) increased expression of CD31, TGF-β1 and collagen types I and III (IHC). These results demonstrate the therapeutic potential of the OHA/CS-pC/TMP/PD hydrogel for diabetic wound healing.
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DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
·
2026
·Vol. 116
·期 3
·117523
·
IF 1.8
Huifeng Yang,Xiaoyi Li,Yimin Su,Jianxin Guo,Tengfei Wang,Zhigang Wang,Hai Fu,Zhi Chen,Zhongjian Xie,Defa Li
Purpose Acute respiratory infections caused by bacterial and viral pathogens pose a major global health burden. The recombinase polymerase amplification (RPA)-CRISPR-Cas12a system offers a promising point-of-care testing (POCT) platform, but its field deployment is limited by the instability of lyophilized reagents. This study aims to develop a composite lyoprotectant to enhance the stability of the RPA-CRISPR-Cas12a system for respiratory pathogen detection. Materials and methods A composite lyoprotectant composed of trehalose and carboxymethyl chitosan (Tre-CMC) was formulated at various mass ratios. The optimal ratio was identified by evaluating matrix microstructure, enzyme activity retention, and primer-dimer suppression. The lyophilized system was tested for sensitivity, specificity, and long-term stability against six respiratory pathogens (H1N1, IBV, Neisseria meningitidis , SARS-CoV-2, Streptococcus pneumoniae , and human adenovirus) using real-time fluorescence and gel electrophoresis. Results This study establishes a promising proof-of-concept framework for an integrated, lyophilized RPA-CRISPR–Cas12a diagnostic system. The optimal Tre: CMC ratio (2:1) produced a porous, non‑hygroscopic matrix that preserved reagent integrity. The lyophilized system achieved a detection limit of 10 copies/reaction within 30 min for all six pathogens, with 100% specificity. After six months of storage at 4°C, RPA enzyme activity remained above 89%, and Cas12a-crRNA complex functionality was fully retained. Tre-CMC significantly reduced primer-dimer formation and nonspecific background fluorescence. While clinical evaluation using 21 nasopharyngeal swab samples demonstrated 100% concordance with RT-qPCR—preliminarily supporting the system's potential diagnostic accuracy—we acknowledge that this initial methodological framework requires broader and more rigorous downstream validation with larger clinical cohorts to formally establish its robust diagnostic performance. Conclusion The Tre-CMC composite lyoprotectant effectively stabilizes the RPA-CRISPR-Cas12a system, enabling cold-chain-independent storage and reliable POCT for respiratory pathogens in resource-limited settings.
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REACTIVE & FUNCTIONAL POLYMERS
·
2026
·
IF 5.4
Huidong Fang,Shiai Xu,Siyu Han,Bin Zhao,Chao Zhang,Wanji Zhou
T-shaped droplet microfluidic device was used for preparing 5-Fu-loaded chitosan microspheres. • 5-Fu-loaded chitosan microspheres exhibit pH-responsive release patterns and sustainable release characteristics for up to 60 days. • The average particle size of the microspheres is 3.90 ± 0.57 μm, and the particle size distribution is narrow. • Drug-loaded microspheres of different particle sizes have different drug release rates and cycles. Microsphere formulations are a promising drug delivery system for targeted response and prolonged sustained release. However, conventional emulsification crosslinking methods for microsphere preparation usually result in a broad particle size distribution, large particle size, poor uniformity, and consequently erratic drug release kinetics. In this investigation, chitosan microspheres encapsulating 5-Fluorouracil (5-Fu CS-MS) were fabricated using a T-type droplet microfluidic device, and the formulation was optimized by single-factor experiments. The resulting microspheres had a consistent drug release profile, a smooth surface, high monodispersity, and a uniform particle size distribution with an average particle size of 3.90 ± 0.57 μm. The polymer-drug interaction in 5-Fu CS-MS was analyzed using FTIR and XRD. The XPS and EDS results confirmed the occurrence of a Schiff base reaction between glutaraldehyde (GA) and chitosan (CS), indicating successful encapsulation. TGA results revealed that the cross-linking reaction enhanced the thermal stability of the microspheres. Biocompatibility assessments using Human umbilical vein endothelial cells (HUVEC) line demonstrated the safety and compatibility of the fabricated microspheres. More importantly, the in vitro release results illustrated a pH-responsive drug release profile and sustained release of 5-Fu CS-MS for a period up to 60 days. In summary, the CS sustained-release microspheres produced using the microfluidic technique have the potential for intelligent response, precise drug delivery, and prolonged sustained release of small-molecule drugs. Download: Download high-res image (197KB) Download: Download full-size image
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Xiaoyun Zheng,Yixuan Liu,Yingqi Li,Weilin Zhou,Xianying Chen,HaiYu Feng,Xiaorong Lin,Yong Hu,Yun Chen,Chao Huang,Xiguang Ye
Chitosan-carbon quantum dots-tellurium nanoparticles (CS-CQDs-TeNPs) was a multifunctional nanozyme integrating high stability, photoluminescence, and enzyme-like catalytic activity. • Hg 2+ specifically triggered the oxidase-like activity of CS-CQDs-TeNPs through a ping-pong mechanism. • The mechanism proceeded via in-situ formation of HgTe, which catalyzed ROS (O 2 - /·OH) generation to oxidize the substrate for colorimetric detection. • The CS-CQDs-TeNPs-based colorimetric sensor demonstrated high selectivity and strong anti-interference capability, enabling reliable detection of Hg 2+ in environmental water samples. • The sensor performed on-site detection and simultaneous detoxification of Hg 2 (via conversion to HgTe), presenting a dual-function platform for mercury pollution control. Herein, a CS-CQDs-TeNPs-based colorimetric sensor was developed for the highly sensitive detection and simultaneous harmless conversion of Hg 2+ . In the presence of Hg 2+ , the oxidase-like activity of CS-CQDs-TeNPs was specifically triggered, and its catalytic kinetics followed the ping-pong mechanism. Under conditions of pH 4.0 and 30 °C, the colorimetric sensor constructed from 38.6 μg/mL CS-CQDs-TeNPs and 1.040 mmol/L TMB exhibited optimal activity, demonstrating a V max of 83 (10 −8 ·M·s −1 ) and a K m of 13 mmol/L. Mechanistic studies indicated that Hg 2+ reacted with CS-CQDs-TeNPs to form HgTe in situ. The generated HgTe catalyzed the generation of reactive oxygen species from O 2 . These reactive oxygen species, in combination with the surface oxygen vacancies of the CS-CQDs-TeNPs, synergistically oxidized TMB, thus resulting in a colorimetric response. The CS-CQDs-TeNPs-based colorimetric sensor exhibited excellent selectivity, anti-interference capability, and considerable detection potential, while converting Hg 2+ into low-toxicity HgTe during detection, thus realizing the integration of detection and remediation. This study provides a novel strategy for designing environmentally responsive nanozymes and remediating Hg 2+ pollution.
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JOURNAL OF FOOD SCIENCE
·
2026
·Vol. 91
·期 5
·e71088
·
IF 4.1
Hui Yuan,Tai Feng Lin,Xue Mei Liu,Zi Qi Xie,Xin Yang,Yun Jing Luo
Human consumption of food contaminated with oxytetracycline (OTC) residues can lead to its accumulation in the body and cause harm. In this study, due to the trace residues of OTC in food, surface imprinting technology was employed to prepare oxytetracycline magnetic molecularly imprinted polymers (OTC-MMIPs). This was achieved using Fe 3 O 4 @SiO 2 as the core, modified with chitosan, and with OTC as the template molecule. OTC-MMIPs were used to adsorb OTC. After combining with AuNPs, the OTC-MMIPs@AuNPs composite was used to adsorb OTC, and then SERS was employed for detection. According to the kinetic adsorption experiment, the maximum adsorption capacity of OTC-MMIPs was 44.58 mg g −1 , with a 7% decrease in adsorption capacity observed after four cycles of reuse. Following the adsorption of OTC onto OTC-MMIPs@AuNPs, detection was performed using SERS. A linear relationship was established between the intensity of the characteristic peak at 1329 cm − 1 and the OTC concentration, achieving a detection limit of 6.67 × 10 −12 M. Furthermore, the method was validated in pure milk samples, the recovery rate ranges from 91.73% to 96.22%. These results demonstrate the feasibility of the proposed method for detecting OTC in pure milk.
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