查找使用阿拉丁产品的科研文献

Tuning the heterostructure improves the catalytic activity of recyclable nanozymes for efficient absorption and degradation of norfloxacin-contaminated water

Yanning Zheng,Dankui Liao,Bimei Xie,Jinlei Sun,Jianhua Sun,Zhangfa Tong,Guangzhi Zhou

Effective removal of antibiotic residues from water is crucial for maintaining balance and cleanliness in the ecological environment. To achieve this, we conducted a study on the development of a highly efficient catalyst from the in-situ growth of Fe 3 O 4 nanoparticles on nitrogen-doped hollow porous carbon spheres (Fe 3 O 4 @N-HollCS). We controlled the in-situ growth time to optimize its performance. Material characterization and theoretical calculations revealed that the improved catalytic performance of Fe 3 O 4 @N-HollCS is due to electron transfer from the graphitic-N in N-HollCS to the catalytic interface of Fe 3 O 4 nanoparticles. Fe 3 O 4 @N-HollCS, with an ordered mesoporous structure and high specific surface area, had remarkable adsorption capacity for NOR antibiotics, with an enrichment efficiency exceeding 60% within 10 min. Moreover, the Fe 3 O 4 @N-HollCS degraded more than 90% of fluoroquinolone antibiotics, especially norfloxacin (NOR), which was eliminated within 60 min. The Fe 3 O 4 @N-HollCS also exhibited stable catalytic recycling ability within 10 magnetic separations. Fukui function predicted the sensitive sites of NOR, and we proposed potential degradation pathways. Ecological structure activity relationship model evaluation showed that the intermediate produced by Fe 3 O 4 @N-HollCS degradation of NOR has low levels of ecotoxicity. Overall, Fe 3 O 4 @N-HollCS catalysts have great potential for antibiotic wastewater treatment.

Thermosensitive drug-loaded liposomes for photothermal and chemotherapeutic treatment of colon cancer

Haihua Zhou,Hongyan Pan,Faisal Raza,Hajra Zafar,Yu Ge,Nan Wang,Ronglei Zheng,Degeng Zhang,Yanmin Yang

Cancer is a grave threat to human life and well-being today. Photothermal therapy, a non-invasive method that converts light energy into heat energy to eliminate tumor cells, has emerged as a promising approach. In this study, bismuth nanosheets were utilized as photothermal agents, while 5-fluorouracil and metformin served as model drugs. By designing a temperature-sensitive liposome (BiNSs/Met/5-FU@TSL) that encapsulates bismuth nanosheets, a multifunctional drug delivery system was developed, combining photothermal therapy with synergistic chemotherapy for enhanced anti-tumor effects. Through transmission electron microscopy, it was confirmed that bismuthene nanosheets were successfully encapsulated in stable and uniformly spherical liposomes. Photothermal performance tests demonstrated the system's effectiveness and stability in generating heat. In vitro release experiments further confirmed the thermosensitive liposomes’ responsiveness to photothermal stimuli. Both in vitro and in vivo studies showcased the system's excellent anti-tumor effects and the safety of the blank carriers. This research presents a novel concept, providing insights into the combination of tumor photothermal therapy with chemotherapy, opening new avenues for effective cancer treatment.

Photodynamic antibacterial property of g-C3N4 formulated dental resin composite

Ming Liu,Hao Yang,Daixing Zhang,Yingjie Yu,Xiaoping Yang,Qing Cai

The occurrence of secondary caries associated with the polymerization shrinkage of dental resin composite repairing is mainly due to the resin lacking of bacteria-killing ability to counteract bacterial colonization at the tooth-resin interface. Photodynamic therapy against bacterial infections paves a new way for developing novel antibacterial dental resin composites. Herein, a yellowish graphitic carbon nitride (g-C 3 N 4 ) is synthesized via thermal polycondensation of melamine and functions as photoactive filler for resin composites in oral application. Upon exposed to visible light, the g-C 3 N 4 would generate reactive oxygen species (ROS) to kill bacteria, that Staphylococcus aureus ( S. aureus ) and Streptococcus mutans ( S. mutans ) almost completely die within 30 min. As the g-C 3 N 4 mixed into photocurable bisphenol A glycidyl methacrylate/triethylene glycol dimethacrylate (Bis-GMA/TEGDMA) at 5 wt%, the resulted composite remains high S. aureus and S. mutans killing rates (> 99 %), even supplemented with extra 65 wt% Schott® dental glass powders. The mechanical properties and biocompatibility of the resin composite are not influenced with the addition of g-C 3 N 4 . Overall, this resin composite with excellent photodynamic antibacterial capacity displays significant potential for dental restoration application.

Study of endocrine-disrupting effects of disposable biodegradable tableware and key migrants based on in vitro assays, mass spectrometry analysis, and in silico predictions

Qian Li,Guowei Ma,Yiling Cui,Yuting Chen,Peixue Guo,Di Feng,Tingting Zhao

Colorimetric sensor modified with MXenes@MnCoZDH@Au composite nanomaterials for visualization of circulating tumor cells in lung cancer

Yuting Zhang,Ze Zhang,Hehua Zhang,Xin Xu,Tong Shen,Xiaohui An,Hongzhi Pan,Dong Chang

Circulating tumor cells (CTCs), as a critical biomarker for early diagnosis and real-time monitoring of tumor progression, play a significant role in early cancer diagnosis, treatment monitoring, and prognosis evaluation. However, existing CTCs detection methods are limited by low purity, long processing time, high cost, and insufficient specificity, making them inadequate for clinical needs. This study developed an ultrasensitive and visually detectable CTCs sensing platform. The platform integrates nucleic acid aptamer-functionalized dopamine-coated magnetic nanoparticles as capture probes for the specific isolation and enrichment of CTCs, and MXenes@MnCoZDH@Au NPs as signal-amplifying nanoprobes with exceptional peroxidase-like activity. The colorimetric sensing mechanism relies on the linear increase in absorbance with CTCs concentration, enabling quantitative detection. Under optimized experimental conditions, the sensor demonstrated a broad detection range of 10 to 10 6 cells/mL and an ultra-low 2 cells/mL detection limit. Compared to traditional methods, this detection approach exhibited high specificity, sensitivity, and reproducibility, highlighting its potential for clinical translation. This innovative method provides a reliable and practical tool for liquid biopsy-based cancer diagnostics, offering significant advancements in precision medicine.

Ultrasensitive Hydrogen Peroxide Detection in Leafy Vegetables Using a Dual Chelate Metal Synergistic MOFzymes Biosensor

Jin Xu,Zhaoyang Ding,Anqi Ji,Zuyao Fu,Jing Xie

Although various MOFzymes have been used for H2O2 detection, their application in leafy vegetables remains limited. This was primarily due to the interference of complex matrices in leafy vegetables, which affected the detection process. Additionally, the free catalytic metal in MOFzymes could lead to color fading, resulting in unstable and time-consuming reactions. In this study, inspired by the multiactive sites and high selectivity of iron porphyrin-based MOFzymes, along with enhanced stability by chelated iron, we developed a highly sensitive and selective MOFzymes PCN222(Fe)-Gly(Fe)2. This enzyme used zirconium as the metal center, iron porphyrin chelated iron as the organic ligand, and ferrous glycine as a modifier. While the advantages of MOFzymes were retained, the synergistic impact and internal Fenton-like reaction improved the reaction rate, leading to a remarkable 310.2% increase in catalytic velocity. In field testing environments, the H2O2 content in Pakchoi seedling leaves could be determined within 100 s. In addition, the sensor demonstrated practical utility in predicting the shelf life and freshness of Pakchoi seedlings.

Efficient Peroxymonosulfate Activation over Cobalt-Encapsulated Nitrogen-Doped Carbon Hollow Nanospheres toward Tetracycline Degradation: Performance and Catalytic Mechanism

Jin Qian,Sai Bai,Guoping Xiang,Dandan Zhang,Junmei Zhou,Minxian Cheng,Xiaohong Zhao,Xinying Chen,Yichu Zhang,Yueping Bao,Xiangning Xu

In this study, cobalt-encapsulated nitrogen-doped carbon hollow nanospheres (Co@NCs) were synthesized for peroxymonosulfate (PMS) activation and tetracycline (TC) degradation. Co@NCs synthesized at a high pyrolysis temperature exhibited relatively higher graphitic N and C═C contents, which effectively regulated the electron density of Co sites, enhancing the PMS activation efficiency. In the Co@NCs-900/PMS system, remarkable TC removal efficiency (97.14%, kobs = 0.179 min–1) and TOC removal (63.62%) were achieved within 60 min. Based on the quenching tests, EPR technology, and electrochemical measurements, a synergistic radical and nonradical pathway was unveiled, with SO4•–, 1O2, and ETP dominated. Co@NCs-900/PMS showed efficient catalytic performance and practical application potentials without interference from organic and inorganic compounds under the experimental background. Additionally, over 80% TC removal could be achieved after the seven-cycle catalytic reaction and showed negligible Co2+ leaching, indicating superior recyclability. Chemical analysis and DFT calculation revealed that PMS adsorption and activation could be strengthened by modulating the electron density with Co and N serving as the active sites. Overall, this study provides valuable insights into the incorporation of metal sites on N-doped carbonaceous catalysts for Fenton-like reactions in water purification applications.

Glucose-assisted grapevine-based ultrahigh microporosity activated hydrochar materials for supercapacitor electrodes

Zhixin Shang,Dongyin Ren,Yajie Tian,Zhen Shang

The doping of heteroatoms during the preparation of hydrothermal carbon represents an effective technology for the improvement of doped carbon materials for supercapacitors (SCs). In this study, N/S-doped hydrothermal carbon was prepared via a glucose-assisted glucose self-doping process during the hydrothermal carbonization stage. In addition, heteroatom-doped carbon materials for supercapacitors were prepared by KOH activation treatment, and their high specific surface area and microporous structure rate can be attributed to the stable structure of glucose and the large amount of heteroatoms in grapevines. It exhibited an amazing specific capacitance of 521.0 F/g at a current density of 0.5 A/g, an energy density of 49.6 W h/kg for symmetric devices, and a power density of 0.5 kW/kg. After 25,000 charge and discharge cycles under constant current conditions, the capacitance retention rate can still reach 86.99 %. This study proposes a new method for preparing heteroatom-doped carbon materials for supercapacitors using waste biomass.

Sorption behavior of diclofenac sodium and venlafaxine on microplastics: a mechanistic study based on spectroscopy and density functional theory

Duo Xu,Bowen Du,Xuan Jiang,Jiaxin Ling,Shengwei Xiao,Huimin Sun,Xianqiang Yin

Diclofenac sodium (DCF) and venlafaxine (VLF), as widely used and environmentally persistent pharmaceutical pollutants, are frequently detected in water bodies and exhibit bioaccumulation and ecotoxicity, which may threaten the stability of ecosystems by disrupting the endocrine systems of aquatic organisms and neural signaling. The combination of these pollutants with microplastics (MPs) not only enhances the migration of the pollutants, but also amplifies the risk of exposure to high trophic level organisms via the food chain, which is an important warning significance for the study of the safety of the aquatic environment and the mechanism of pollutant coupling in the global “plastic circle”. This study delved into the sorption behavior and mechanisms of DCF and VLF on two different MPs ( i.e. , polystyrene (PSMPs) and polylactic acid (PLAMPs)). Batch sorption experiments were used to quantify sorption capacity under controlled solution chemistry conditions, examining sorption kinetics, isotherms, and thermodynamics. The maximum sorption capacity of PLAMPs and PSMPs for DCF was 2.994 and 3.296 mg g −1 , respectively, while that of PLAMPs and PSMPs for VLF was 5.864 and 6.234 mg g −1 , respectively. The sorption of DCF and VLF on both MPs mainly depended on physical interactions, with the kinetic model in agreement with the pseudo-first-order model, the isotherms were consistent with the Langmuir model. Fourier infrared spectroscopy and X-ray photoelectron spectroscopy demonstrated variations regarding surface functional groups upon MPs before and after sorption. Both MPs showed a significant increase in oxygen and nitrogen-based functional groups after sorption of DCF and VLF, with the most obvious variations being the increase in C-O and C=O. Density-functional theory was used to detect the main sorption mechanisms and the binding energies between PhACs and MPs. In summary, our study found the sorption of DCF and VLF on MPs is controlled by electrostatic interactions, followed by some weaker interactions ( i.e. , van der Waals forces, hydrogen bonding, and hydrophobic interactions). This study provides new insights into the mechanisms of effective separation and interaction between complex pollutants.

Network pharmacology-based study in polymetformin’s new function of blocking ages/rage pathway curing diabetic complications

Kong Linghong,Wang Hui,Jiang Weiwei,Chen Yun,Du Zhuoling,Zhang Qiong,Dong Jianyue,Zeng Changchun,Liu Hanping

Advanced Glycation End Products (AGEs) are the molecular mediators that contribute to the progression of diabetic complications. However, there is a paucity of research on effective AGEs inhibitors and strategies for blocking the AGEs-RAGE pathway. To solve the problem, we synthesized polymetformin (PL), which for the first time proved the ability to inhibit AGEs formation and block the AGEs-RAGE pathway to protect the vascular from being damaged. Based on gene ontology (GO) analysis and Kegg enrichment, we found that PL could antagonize AGEs. Molecular docking and dynamics analyses showed that PL formed stable structures with AGEs through electrostatic interactions and hydrogen bonding. PL treatment altered AGEs structures have been proven in FT-IR results. The study discovered that PL interacted with AGEs via both non-covalent and covalent modifications, altering AGEs’ binding sites and antagonizing the AGEs-RAGE pathway. Immunofluorescence assays indicated lower levels of RAGE, IL-1β, and TNFα, while ROS assays demonstrated lower ROS levels, highlighting PL’s inhibitory effects and biocompatibility. Our work underscores PL’s potential to treat diabetic complications by elucidating its mechanism of action against the AGEs-RAGE pathway and inflammatory factors for the first time. This research provides insights for managing chronic illnesses linked to the AGEs-RAGE pathway beyond diabetes complications.

Self-utilization of indigenous materials in plateau areas: Peroxymonosulfate activation by manganese modified barley straw biochar for efficient degradation of enrofloxacin

Da Wang,Miao Zhang,Qingjie Xie,Song Han,Sisi Xiao,Huijuan Wang

In this study the indigenous materials in plateau areas were used to cope with the challenge of increasing antibiotics pollution in Qinghai-Xizang Plateau. The barely straw was chosen as the raw material to prepare the manganese modified biochar (XBSMBC) and then combined with peroxymonosulfate (PMS) to set up the PMS/XBSMBC system to treat the enrofloxacin (ENR) in water. The study showed that there was a higher PMS activation and thus ENR degradation of the manganese modified biochar prepared from the barley straw than those from Xizang wheat straw and Henan wheat straw. The preparation parameters of the XBSMBC, including the mass ratio of barley straw to manganese and the pyrolysis temperature, for the PMS activation as well as the ENR degradation were reviewed and found that the 1:1 and 900°C were the optimal preparing conditions (XBSMBC-900 (1:1)). The influence of the XBSMBC-900 (1:1) additive amount, PMS dosage and solution initial pH on the ENR degradation was also ascertained. Results of quenching experimental studies and electron paramagnetic resonance demonstrated that ENR degradation in the PMS/XBSMBC system was achieved by a combined effect of SO 4 ·- , ·OH, ·O 2 - and 1 O 2 . Four possible pathways of ENR degradation were provided, and the toxicity analysis predictions were applied to infer the validity of the PMS/XBSMBC process for the ENR solution treatment.

Tumor-Specific Activatable Nanopaltform Achieves Oxidative Stress Amplification and Reversal of Cisplatin Resistance to Provoke Enhanced Ferroptosis–Apoptosis Cancer Therapy

Jieming Zhang,Fangfang Zhou,Xin Du,Meiru Zhang,Suxiao Li,Songtao Niu,Qungang Chang,Yongju He

Cisplatin-based chemotherapy is widely used to combat cancers through an apoptosis pathway. However, drug resistance induced by upregulated glutathione (GSH) in tumor cells and systemic side effects significantly compromise its therapeutic efficacy. The application of nanocarriers with a GSH-scavenging ability is a promising strategy to overcome these obstacles. In addition, ferroptosis has shown great potential in eliminating the limitation of apoptosis-mediated chemotherapeutics. Herein, a multifunctional nanoplatform (S4MON-Cis@TA-Fe3+), loaded with cisplatin in tetrasulfide bonds-bridged mesoporous organosilica nanoparticles (S4MON) and then coated with tannic acid (TA)-Fe3+ metal-phenolic network, is developed for apoptosis–ferroptosis synergistic therapy. In the acidic tumor cells, the outer TA-Fe3+ network is disassembled into Fe3+ and TA, and the internal S4MON-Cis network is exposed. The released TA and endogenous GSH reduce Fe3+ to Fe2+, which significantly increases cellular oxidative stress through the Fenton reaction and GSH consumption. Moreover, S4MON-Cis decreases the intracellular GSH content through redox reaction between tetrasulfide bonds and GSH, which further augments cellular oxidative stress and triggers nanoparticle degradation to release cisplatin. Subsequently, cisplatin induces apoptosis and elevates the cellular hydrogen peroxide level to improve the Fenton reaction efficiency. The multiple oxidative stress amplification greatly promotes lipid peroxidation and glutathione peroxidase 4 downregulation, boosting tumor ferroptosis. Meanwhile, the dual GSH elimination significantly improves the antitumor effect of cisplatin. As a result, S4MON-Cis@TA-Fe3+ exhibits effective tumor growth inhibition through self-enhanced apoptosis–ferroptosis synergistic therapy, which holds great promise for cancer therapy.