INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Mengting Jiang,Hanyu Bao,Ying Pan,Xingang Li,Amjad Farooq,Lirong Yao,Can Gao,Gangwei Pan
PDA-assisted dip-coating fabricated dual-functional PGCL sutures. • Optimized CS/IBU coating achieved ≥99.99% antibacterial activity. • Functionalized fibers showed rapid initial and sustained IBU release. • The coating preserved PGCL's hydrolytic degradation and mechanics. • Modified sutures demonstrated excellent L929 cytocompatibility. Traditional sutures often lack functional bioactivity and could act as substrates for bacterial colonization, leading to surgical site infections, postoperative inflammation, and impaired wound healing. In this study, to develop a multifunctional suture with synergistic antibacterial and anti-inflammatory properties, a dip-coating strategy was employed. Taking advantage of the universal adhesive properties of polydopamine (PDA), chitosan (CS) and ibuprofen (IBU) were immobilized onto poly(gly co lide-co-caprolactone) fibers. Systematic characterization revealed that PDA loading enhanced the surface activity of the fibers and significantly improved their adhesive capacity. At an optimized CS/IBU ratio (2 wt%:2 wt%) and dual-coating cycle, the fibers exhibited excellent mechanical performance and achieved antibacterial rates of ≥99.99% against Escherichia coli and Staphylococcus aureus . Notably, the sutures exhibited sustained drug release and excellent cytocompatibility. This research provides a promising strategy for the development of absorbable, multifunctional sutures with integrated antibacterial, anti-inflammatory, and controlled drug release capabilities. Download: Download high-res image (244KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Bioscience
·
2026
·
IF 6.2
Haoduo Yang,Yiheng Wu,Yu Zhang,Bo Li,Yong-Jiang Xu
Sea buckthorn polyphenols (SBPs) have been reported to alleviate insulin resistance (IR), but their key bioactive compounds and underlying mechanisms remain unclear. In this study, 48 phenolics were annotated from four sea buckthorn varieties. SBPs improved glucose consumption and glycogen synthesis in IR-HepG2 cells, with MON showing the most pronounced effect. Correlation analysis suggested positive associations between several phenolics, including isorhamnetin, kaempferol, quercetin, eriodictyol, and catechin, and cellular glucose metabolism-related indicators. Network pharmacology identified these compounds as representative candidates associated with IR-related targets, including JNK, IRS-1, PI3K, and AKT. Molecular docking further suggested favorable predicted binding affinities between candidate phenolics and selected targets, with isorhamnetin showing relatively strong predicted affinity and cellular activity. Therefore, isorhamnetin was selected as a representative key candidate for mechanistic validation. Mechanistically, isorhamnetin reduced inflammatory and oxidative stress responses, modulated the JNK/IRS-1/PI3K/AKT signaling pathway, promoted glycogen synthesis, suppressed gluconeogenesis, and improved glucose utilization in IR-HepG2 cells. These findings provide preliminary in vitro evidence that isorhamnetin-rich SBPs may serve as promising dietary candidates for improving IR-related glucose metabolic dysfunction.
✓ 已验证
产品关联
DOI
高影响因子
Nature Synthesis
·
2026
·
IF 22.6
Wang Shuai,Yang Liu,Li Zhixuan,Ye Hui,Teng Fei,Yang Jun,Ye Chunting,Fan Dexun,Han Shuangyan
Methanol is a promising C1 feedstock for bioproduction but its cytotoxicity limits applications. Here we enhanced Komagataella phaffii GS115 methanol tolerance to 10–13% (v/v) by overexpressing four genes (phosphatidylethanolamine methyltransferase ( PET2 ), phosphatidylserine synthase ( PSA ), PAS_chr1-4_017 8 ( 0178 ) and PAS_chr2-2_0267 ( 0267 )) (S33 strain). Our results show that, under high methanol stress, S33 undergoes membrane lipid remodelling-driven metabolic reprogramming, with central carbon flux being redistributed from the pentose phosphate pathway and citric acid cycle towards glycolysis. Within this framework, 0178 encodes a vacuolar transporter of sulfur-containing amino acids, which we propose supports phospholipid methylation and redox balance. Meanwhile, 0267 encodes a peroxisomal thiolase-degrading long‑chain fatty acyl‑CoAs, limiting toxic long-chain sphingolipid accumulation, maintaining membrane stability. These genes enable S33 to achieve lipid titre of approximately 40 g l −1 under non-sterile fed‑batch fermentation conditions. This work positions S33 as a methanol-tolerant K. phaffii chassis for further strain and process development.
✓ 已验证
产品关联
DOI
高影响因子
ACS Catalysis
·
2026
·
IF 13.6
Peiyun Zhou,Shihao Feng,Xi Wang,Xiang Liu,Xingjian Xu,Xiubing Huang,Haohong Duan
Despite the practical advantages of conducting 5-hydroxymethylfurfural (HMF) electrooxidation to 2,5-furandicarboxylic acid (FDCA) in acidic media, such as facilitated product separation and improved reactant stability over alkaline environments, the lack of efficient electrocatalysts has hindered the development of efficient acidic processes. Herein, we reveal that HMF oxidation reaction (HMFOR) shares key oxygen-containing intermediates ([O], e.g., *OH and *OOH) with oxygen evolution reaction. By incorporating Ir into manganese oxide (MnOx), the kinetic constraints of acidic HMFOR were successfully broken. Specifically, in the designed Ir-MnOx, the presence of Ir sites not only accelerates the generation of [O] species to provide abundant oxidative active species but also modulates the electronic structure of Mn sites to activate their reactivity and enhance HMF adsorption. Synergistic cooperation between Ir and Mn sites endows Ir-MnOx with a record-high HMFOR current density (56.2 mA cm−2@1.40 VRHE), along with high FDCA selectivity (94%) and yield (92%) in an acidic electrolyte (pH 1.89). This work provides mechanistic insights and a design strategy for efficient HMFOR electrocatalysts in acidic environments.
✓ 已验证
产品关联
DOI
高影响因子
Animals
·
2026
·Vol. 16
·期 7
·1027
·
IF 3.2
Zhenghan Chen,Rui Zhang,Liwa Zhang,Zhenfei Xu,Xuejiao An,Chune Niu,Zhiguang Geng,Haina Shi,Jinxia Zhang,Lei Qu,Shuwei Dong,Yaojing Yue
Simple SummaryImproving the eating quality and nutritional value of lamb is a priority for the meat industry to meet consumer demands. This study investigated the meat characteristics of offspring produced by crossing two distinct breeds: the Suffolk sheep (known for good muscle growth) and the Hu sheep (recognized for high reproductive rates). We compared the meat quality, nutrient composition, and flavor profiles of these crossbred sheep against their parent breeds. The results showed that the crossbred sheep produced meat with excellent tenderness and water-holding capacity, making it juicy and pleasant to eat. Nutritionally, the meat was rich in healthy fats and specific amino acids that provide a sweet taste. Furthermore, the analysis of aroma compounds revealed that the crossbred meat had a unique flavor profile that reduced the strong, sometimes unpleasant, odor often associated with lamb while boosting pleasant roasted and fruity aromas. In conclusion, crossing Suffolk and Hu sheep successfully combines the beneficial traits of both parent breeds, resulting in superior meat quality. This finding is valuable as it provides a scientific basis for breeding better sheep.With the increasing consumer demand for high-quality lamb, crossbreeding has become a key technology for improving the production performance and meat quality of sheep. To evaluate the meat quality advantages and characteristics of Suffolk (SFK) and Hu sheep (HH) and their F1crossbreds (SH), thirty-six 3-month-old male lambs of SFK (n= 12), HH (n= 12), and SH (n= 12) were selected and raised in individual pens under the same nutritional and management conditions. After standardized feeding until 6 months of age, theLongissimus dorsimuscle was collected to determine meat quality traits, amino acid and fatty acid profiles, and volatile flavor compounds. The results indicated that the L*, a* and b* values of the SH group were significantly lower than those of the parental breeds (p< 0.05), with tenderness being intermediate between the two parent breeds. Notably, drip loss and cooking loss were significantly lower in the SH group (p< 0.05), indicating superior water-holding capacity. In terms of amino acid profiles, the contents of non-essential amino acids (NEAAs) and sweet-tasting amino acids in the SH group were significantly higher than those of the parent breeds (p< 0.05), with the overall profile meeting the FAO/WHO ideal protein pattern. Analysis of fatty acid profiles revealed that the SH group had significantly lower total saturated fatty acids (SFAs) (p< 0.05) and significantly higher levels of functional fatty acids (such as CLA), resulting in a significantly higher UFAs (unsaturated fatty acids)/SFAs (saturated fatty acids) ratio (p< 0.05) and superior nutritional value of fat. Furthermore, 32 volatile flavor compounds were detected in the SH group; among them, key aroma-active compounds such as isoamyl formate, 3-methyl-1-butanol, and acetoin were significantly higher than in the parental breeds (p< 0.05), contributing to a unique flavor profile. Consequently, this study systematically reveals the advantages of Suffolk × Hu F1crossbreds in terms of meat quality, nutritional value, and flavor characteristics, providing fundamental data for the optimization of crossbreeding systems, breeding selection, and the quality improvement of sheep meat products.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF FOOD SCIENCE
·
2026
·Vol. 91
·期 4
·e71025
·
IF 4.1
Yuxi Liu,Xiaolei Tang,Xitong Yuan,Yaling Yang,Yingqian Li,Xiaoyu Li,Bo Liu,Siming Wang,Hongmei Nan,Di Zou,Bin Qi,Li Liu
Panax quinquefolius L. (PQ) is used extensively in healthcare and daily diets, requiring post-harvest drying for preservation and distribution. The effects of hot air drying (AD), vacuum drying (VD), microwave drying (MD), freeze drying (FD), sun drying (SUD), and shade drying (SHD) on the physicochemical properties of PQ were examined, and the volatile organic compounds (VOCs) were analyzed using electronic nose (E-nose), gas chromatography-ion mobility spectroscopy (GC-IMS), and headspace-solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS). MD had the lowest unit energy consumption, and FD preserved the color and structure of fresh PQ. VOCs analysis showed terpenes, aldehydes, alcohols, acids, and esters as major volatiles. The GC-IMS results showed that MD had the highest VOC content, while the GC-MS results suggested that SUD and SHD had the highest VOC content. Both sets of results indicated that FD had the lowest VOC content. Furthermore, 27 differential VOCs were screened, and five key flavor VOCs and two flavor-contributing VOCs were selected by calculating the relative odor activity value (ROAV). Aldehyde compounds (3-methylbutanal, hexanal, and (E)-2-octenal) exhibit higher concentrations and ROAV among all flavor compounds, potentially indicating their greater contribution to flavor formation. This study provides a basis for selecting drying methods for PQ based on product quality and flavor. Practical Applications This study discusses the effect of different drying treatments on the physicochemical properties, volatile components, and flavor. The finding provides an important basis for selecting a suitable drying method for PQ and confirms that combining GC-IMS with GC-MS is a suitable approach for comprehensive flavor analysis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2026
·
IF 29.1
Ruotong Zhang,Yiu Leung James Poon,Huanqing Cui,Chang Li,Yang Cao,Christina C. K. Au Yeung,Gillian Season Eveline,Haisong Lin,Ho Cheung Shum
As one of the remote sensing abilities, electrolocation allows organisms to hunt, navigate, and interact with the environment by sensing electric fields. Mimicking this capability in artificial systems will provide a powerful strategy for remote object detection and inspection. However, current artificial approaches are restricted to conductive medium or charged targets, while electrolocation of uncharged targets in the non-conductive medium has not been achieved yet. In this work, an electrostatic interfacial enhancement-based electrolocation system (EIEEs) that fundamentally expands the scope of artificial electrolocation is proposed. Inspired by the electric organs of elasmobranch fish and the mechanosensory setae of insects, EIEEs employs electret materials as the electrostatic source and high-permittivity droplets as mechanosensory structures, locating objects with permittivities different from the medium. The proposed EIEEs can effectively detect uncharged solid/liquid objects without electrical connection, signal processing, or external power supply. Importantly, EIEEs also demonstrates the capability to detect multiple buried defects in objects, including gas in liquids, solid in liquids, liquid in liquids, and gas in solids, which has been largely unexplored in previous electrolocation systems. As a general-purpose remote sensing system for both surface and subsurface inspection, EIEEs can potentially provide a complementary modality for diverse scientific and technological domains.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2026
·Vol. 38
·期 20
·e19832
·
IF 29.1
Dechao Gan,Xiaoyu Xie,Fei Long,Haoran Chen,Qiqing Li,Zexuan Sui,Wang Wang,Dabing Li,Yulei Chang
The second near-infrared window (NIR-II, 1000–2000 nm) provides an ideal window for multichannel photoluminescence lifetime imaging (mPLI) because of its exceptional tissue penetration depth and minimal scattering. However, the inevitable spectral crosstalk that is caused by the broad and overlapping emissions of traditional luminescent materials (e.g., organic dyes and quantum dots) has restricted the scalability of mPLI channels. Herein, we developed a series of Ln 3+ -doped (Ln = Nd, Er, Tm, or Ho) stratified nanoparticles (Ln-SNPs) that enable highly efficient multiwavelength NIR-II luminescence. These nanoparticles can be further engineered into concentration-mediated Yb 3+ energy relay nanoparticles to enable the precise tuning of the luminescence lifetime across the 1060–2050 nm range, thereby expanding the NIR-II imaging channels in mPLI. Notably, the engineered Tm-SNPs exhibit optimized downshifting emission at ∼1850 nm (NIR-IIc subwindow) with distinguishable luminescence lifetimes that span three orders of magnitude at similar emission intensities. This advancement establishes a powerful toolkit for multidimensional information encryption and multiplexed bioimaging applications.
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Lin Li,Xinyu Xu,Xiaoxia Li,Hui Zhang,Ying Hu
Mimicking the structures and behaviors of natural organisms is of great significance for scientists to develop novel smart devices for practical applications. However, the design and fabrication of bionic actuators with outstanding actuation performance and complex functionality remain challenging. Herein, we draw inspiration from natural leaves to design a stripe-structured multifunctional actuator composed of Nafion, crystal violet (CV), and MXene@Fe 3 O 4 , which exhibits synergistic shape morphing and color transition in response to moisture stimulation. The programmable structural change capability of the actuator is uniquely achieved by constructing the vein-like stripe patterns through a facile magnetic field-assisted alignment method. The resultant moisture-responsive actuator demonstrates exceptional performance, including a rapid response speed of 205.7°/s, and a large bending angle of 288°. This actuator also responds to changes in relative humidity by reversible protonation of CV with distinct color shifts. As a proof-of-concept, the actuators are used to create versatile smart devices and robots, such as biomimetic grippers, weightlifting robots, self-sustained oscillation devices, soft crawling robots, smart mask, bionic hand, blooming flowers, artificial mimosa, and fluttering dragonfly. This study provides an elegant strategy for the design and fabrication of multi-functional moisture-responsive actuators for future bio-inspired intelligent soft robotics.
✓ 已验证
产品关联
DOI
高影响因子
Advanced Optical Materials
·
2026
·Vol. 14
·期 13
·e71145
·
IF 7.2
Binbin Su,Chenning Sun,Jiahui Wei,Zhichao Chang,Yayun Zhou,Guojun Zhou,Huidong Xie,Zhiguo Xia
The development of high-performance scintillators is crucial for advancing radiation detection and X-ray imaging technologies. Herein, we report the rational design and synthesis of a 0D hybrid copper iodide scintillator (CyclamH 4 )Cu 2 I 6 , which exhibits intense radioluminescence centered at 450 nm. This blue emission demonstrates excellent spectral match with the peak photon detection efficiency of modern silicon photomultipliers, thereby facilitating efficient photodetection. The (CyclamH 4 )Cu 2 I 6 scintillator achieves a high light yield of 42 720 photons/MeV, a detection limit of 83.5 nGy air s −1 , and notable radiation resistance stability. Accordingly, the inch-size flexible (CyclamH 4 )Cu 2 I 6 @PDMS scintillator film achieves superior performance in X-ray imaging, as evidenced by a high spatial resolution of 13.6 lp/mm. This work validates copper halides as a tunable platform for the design of scintillators, thereby opening new avenues for the innovation of X-ray imaging technology.
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Jianqi Ye,Jinhua Lu,Lanqing Li,Xinhao Wan,Jialu Wang,Haoxin Fan,Fangyuan Ma,Shan Chen,Dan Wen
Developing flexible, self-sufficient power generators is of significance for burgeoning wearable electronics. Biofuel cells (BFC) that harness perspiration metabolites can potentially offer a promising route toward simultaneous energy generation and self-powered sensing. However, insufficient power supply and susceptible enzyme-induced instability hinder widespread adoption. Herein, an enzyme-free hybrid glucose BFC is designed employing nitrogen-phosphorus doped carbon (NPC) flexible film derived from self-assembly graphene/polymer hydrogels, incorporating platinum nanoparticles for glucose oxidation and manganese dioxide-based O 2 -independent capacitive cathode. The O 2 -independent design eliminates potential interference to the anodic reaction, enabling a markedly enhanced maximum power density of 680 µW cm −2 and an open circuit voltage of 0.92 V, alongside operational stability exceeding 30 days. When functioning as the self-powered glucose sensor, it offers a wide range of 0.05–20 mM. Integrated into a conformal wearable system, the device enables bioenergy harvesting from human sweat and real-time glucose monitoring via compact signal processing electronics. This work underscores the potential of flexible hybrid BFC systems and paves the way for powering next-generation wearable bioelectronics in personalized healthcare.
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2026
·
IF 11
Hong Jiang,Qin-Xie Xie,Tianzhao Tian,Qingqing Yang,Peipei Qian,Jia-Yi Liu,Wending Yan,Shengfeng Huang,Cui Shao,Wei Yi,Yifa Chen,Xu-Jia Hong
The complex tumor microenvironment (TME), characterized by coexisting normoxic and hypoxic regions, demands oxygen-adaptive nanomedicines for multimodal therapy. Herein, GTPZ is presented, an oxygen-adaptive covalent organic framework (COF)-based nanoplatform that can achieve quadruple-modal synergistic therapy through the integration of chemodynamic therapy (CDT), photothermal therapy (PTT), Type I/II photodynamic therapy (PDT), and hypoxia-activated chemotherapy. Remarkably, GTPZ exhibits a record-high photothermal conversion efficiency of 72% among COF-based nanomedicines, enabling spatiotemporal control over hypoxia-activated tirapazamine (TPZ) release to generate cytotoxic radicals. Besides, GTPZ dynamically adapts to oxygen gradients by activating Type II PDT in normoxia and switching to Type I PDT in hypoxia, with phototherapy-induced oxygen depletion amplifying TPZ activation, exhibiting high oxygen-adaptive ability. In MCF-7 models, GTPZ achieves high tumor suppression through synergistic lipid peroxidation, cell cycle arrest, and ferroptosis. This work provides a paradigm for designing intelligent nanomedicines capable of dynamically adapting to TME.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）