JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2025
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IF 4.9
Yuzhen Kang,Dongyu Wu,Tiantian Zhang,Yue Zhang,Yan Zhong,Shiqi Chen,Xiaoyu Wang,Xuyu Chai
In this study, we investigated the feasibility of using poly(N-acryloyl 6-aminocaproic acid) (PA6ACA) as a pH-responsive polymer for oral enteric drug delivery. PA6ACA, characterized by its acylamino group, carboxyl group, and flexible 5-carbon chain, demonstrates pH sensitivity due to the presence of ionizable carboxyl groups and hydrogen bonding interactions between the carboxyl and amino moieties. Our research focused primarily on the preparation, characterization, and evaluation of enteric drugs delivered via PA6ACA. We evaluated the morphology, structure, thermal properties, and crystallinity of PA6ACA. Cytotoxicity experiments conducted in Caco-2 cells and the oral administration studies in mice provided preliminary safety evidence for PA6ACA. Three model drugs (budesonide, sulfasalazine, and diclofenac sodium) were employed to fabricate drug-polymer coprecipitates, and PA6ACA exhibited high loading capacities for these drugs. Furthermore, the drug release profiles revealed that the drug-loaded polymers were resistant to acid at pH 1.0 and nearly completely dissolved within the next 8 h at pH 6.8. The kinetic model fitting results indicated that the release of drugs from the coprecipitates were more consistent with the Higuchi model, suggesting minimal polymer swelling in the media and a primary drug release mechanism via diffusion. Based on these findings, we conclude that PA6ACA holds promise for the development of innovative and efficient intestine-specific drug delivery systems.
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Materials
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2024
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IF 3.1
Jing Zhan,Liangchen Mao,Rongshui Qin,Jing Qian,Xiaowei Mu
Biomass has been widely used due to its environmental friendliness, sustainability, and low toxicity. In this study, aminophosphorylated cellulose (PNC), a biomass flame retardant containing phosphorus and nitrogen, was synthesized by esterification from cellulose and introduced into polyurethane to prepare flame-retardant rigid polyurethane foam. The combustion properties of the PU and PU/PNC composites were studied using the limiting oxygen index (LOI), UL-94, and cone calorimeter (CCT) methods. The thermal degradation behavior of the PU and PU/PNC composites was analyzed by thermogravimetric analysis (TGA) and thermogravimetric infrared spectroscopy (TG-IR). The char layer after combustion was characterized using SEM, Raman, and XPS. The experimental results showed that the introduction of PNC significantly improved the flame-retardant effect and safety of PU/PNC composites. Adding 15 wt% PNC to PU resulted in a vertical burning grade of V-0 and a limiting oxygen index of 23.5%. Compared to the pure sample, the residual char content of PU/PNC15 in a nitrogen atmosphere increased by 181%, and the total heat release (THR) decreased by 56.3%. A Raman analysis of the char layer after CCT combustion revealed that the ID/IG ratio of PU/PNC15 decreased from 4.11 to 3.61, indicating that the flame retardant could increase the stability of the char layer. The TG-IR results showed that PNC diluted the concentration of O 2 and combustible gases by releasing inert gases such as CO 2 . These findings suggest that the developed PU/PNC composites have significant potential for real-world applications, particularly in industries requiring enhanced fire safety, such as construction, transportation, and electronics. The use of PNC provides an eco-friendly alternative to traditional flame retardants. This research paves the way for the development of safer, more sustainable, and environmentally friendly fire-resistant materials for a wide range of applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Aili Niyazi,Chaoqun Mu,Ting Wang,Wangsheng Ye,Lvling Zhong,Zhixian He,Haoyang Xu,Zhiqiang Zhang,Liang Zhang
In this work, temperature-responsive poly(N-isopropylacrylamide) (PNIPAM) and the guanylthiourea (GLA) were used to modify chitosan (CS) to prepare a novel PNIPAM/GLA/CS adsorbent for Ag(I) ions. Temperature variations near the lower critical solution temperature (LCST) facilitate the adjustment of functional group distribution within the composite material, thereby influencing its adsorption performance for silver ions. The characteristics of this composite material were confirmed using a variety of techniques, including scanning electron microscopy (SEM), variable-temperature ultraviolet-visible near-infrared spectroscopy, Fourier-transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). Studies on the adsorption of Ag(I) ions by the PNIPAM/GLA/CS adsorbent indicated that the optimal pH for adsorption is 6.0. The adsorption kinetics were best described by the pseudo-second order kinetic model, while the equilibrium adsorption data aligned more closely with the Langmuir adsorption isotherm model, achieving a maximum adsorption capacity of 336.33 mg/g at 40°C. Experimental results demonstrated that higher adsorption amounts were observed above the LCST, while desorption of target ions was more favorable below the LCST. This research provides valuable insights for the design of new structural adsorbents.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Yukang Fan,Fangbao Fu,Dongjie Yang,Weifeng Liu,Xueqing Qiu
Constructing heteroatom-doped porous carbons with distinct charge storage properties is significant for high-energy–density supercapacitors, yet it remains a formidable challenge. Herein, we employed a thiocyanogen-modulated alkali activation strategy to synthesize N and S co-doped lignin hierarchical porous carbon (NSLHPC). In this process, thiocyanogen serves as a surface modulation mediator to substitute oxygen with nitrogen and sulfur species, while the combination of KOH activation and MgO template generates numerous nanopores within the carbon structure. The three-dimensional interconnected nanosheet architecture facilitates rapid ion transfer and enhances accessibility to active sites. Density functional theory (DFT) calculations demonstrate that introducing N and S heteroatoms through oxygen substitution reduces the adsorption energy barrier of Zn 2+ . Consequently, the optimized NSLHPC exhibits a remarkable specific capacitance of 438F/g at 0.5 A/g in 6 M KOH, delivering an energy density of 10.4 Wh/kg in the symmetric supercapacitor and an impressive energy density of 104.9 Wh/kg in the zinc-ion hybrid capacitor. The NSLHPC cathode also shows an excellent lifespan with capacitance retention of 99.0 % and Columbic efficiency of 100 % over 10,000 cycles. This study presents innovative strategies for engineering high-performance porous carbon electrode materials by emphasizing pore structure modulation and N, S co-doping as crucial approaches.
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CLINICAL RHEUMATOLOGY
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2025
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IF 2.8
Yin Jia,Yin Xuan,Tao Lei,Peng Yuanzhi,Zhao Shuhan,Hou Haifeng,Yin Xinyue,Ran Zhangshen,Zhou Aihong,Ding Guoyong
Background Alterations in immunoglobulin G (IgG) N -glycosylation have been implicated in various diseases, potentially including ankylosing spondylitis (AS). However, empirical evidence regarding the associations IgG N -glycosylation, inflammatory factors, and AS is sparse. We aimed to investigate these associations and evaluate the diagnostic performance of IgG glycosylation traits as a biomarker for AS. Methods This case–control study recruited 142 AS patients and 142 controls. We used hydrophilic interaction liquid chromatography with ultra-performance liquid chromatography to detect the profiles of plasma IgG N -glycans. An enzyme-linked immunosorbent assay kit was used to measure the levels of serum inflammatory factors. We used multivariate logistic regression, canonical correlation analysis (CCA), and Lasso regression to analyze the data. Results Multivariate logistic analysis identified 14 IgG N -glycan-derived traits significantly associated with AS. The changes were primarily characterized by decreased galactosylation, sialylation, bisgalactosylated fucosylation and sialated fucosylation, alongside increased core fucosylation, agalactosylated fucosylation, neutral fucosylation and sialated bisecting N -acetylglucosamine. Significant differences were observed between cases and controls in levels of C-reactive protein (CRP), IL-17, IL-22, IL-6, and TNF-α. CCA demonstrated a moderate correlation between IgG N -glycan-derived traits and inflammatory factors ( r = 0.476). The combined diagnostic performance of derived traits and inflammatory factors yielded a higher area under the curve (AUC = 0.90) than either alone (AUC derived traits = 0.88, AUC inflammatory factors = 0.78). Conclusion The findings indicate that abnormal IgG N -glycosylation may play an important role in the development of AS through promoting the pro-inflammatory function. The derived traits combined with inflammatory factors may serve as potential biomarkers to distinguish AS.
Key Points • We comprehensively analyzed IgG N-glycan-derived traits in AS by an HILIC-UPLC-based high-throughput method. • Abnormal IgG N-glycosylation plays a role in the development of AS through promoting the proinflammatory. • IgG N-glycosylation combined with inflammatory factors demonstrated strong diagnostic performance for AS.
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ADVANCED MATERIALS
·
2024
·Vol. 36
·期 18
·2309844
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IF 27.4
Rundong Fan,Wei Sun,Congmeng Li,Yihua Chen,Haipeng Xie,Yongli Gao,Yue Ma,Zongyang Peng,Zijian Huang,Ruiyang Yin,Fengtao Pei,Wentao Zhou,Yuetong Wu,Huifen Liu,Kailin Li,Tinglu Song,Dechun Zou,Huachao Zai,Hui Li,Qi Chen,Qian Wang,Huanping Zhou
Metal halide perovskite solar cells (PSCs) have garnered much attention in recent years. Despite the remarkable advancements in PSCs utilizing traditional metal electrodes, challenges such as stability concerns and elevated costs have necessitated the exploration of innovative electrode designs to facilitate industrial commercialization. Herein, a physically and chemically stable molybdenum (Mo) electrode is developed to fundamentally tackle the instability factors introduced by electrodes. The combined spatially resolved element analyses and theoretical study demonstrate the high diffusion barrier of Mo ions within the device. Structural and morphology characterization also reveals the negligible plastic deformation and halide-metal reaction during aging when Mo is in contact with perovskite (PVSK). The electrode/underlayer junction is further stabilized by a thin seed layer of titanium (Ti) to improve Mo film's uniformity and adhesion. Based on a corresponding p–i–n PSCs (ITO/PTAA/PVSK/C 60 /SnO 2 /ITO/Ti/Mo), the champion sample could deliver an efficiency of 22.25%, which is among the highest value for PSCs based on Mo electrodes. Meanwhile, the device shows negligible performance decay after 2000 h operation, and retains 91% of the initial value after 1300 h at 50–60 °C. In summary, the multilayer Mo electrode opens an effective avenue to all-round stable electrode design in high-performance PSCs.
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Advanced Energy Materials
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2025
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IF 26
Yao Wang,Jianrui Wang,Xiao Xu,Yan Wang,Baohai Jia,Shangyang Li,Kornelius Nielsch,Jiaqing He
The excellent performance of skutterudites is related to the interrelated filling fraction and doping limitation of the intricate matrix. Especially for the investigation of n-type electronegatively filling samples, the exceptionally low doping capacity at Sb sites leads to severely compromised thermoelectric performance. Here, a breakthrough is achieved in surpassing conventional doping limits by developing a novel “electrical compensation-bonding modulation” method, contributing to the reconfiguration of the unique X 4 ring structure (Consists of Sb 4 units) in S 0.2 Se 0.05 Co 4 Sb 12-x Te x skutterudites. The modulated bond hierarchy and disorder enable a concurrent regulation of phonon and carrier transport, resulting in a significant improvement of the transport properties. Building upon this foundation, a revolutionary off-center state has been introduced to the matrix via continuous doping of Se at Sb sites, aimed at suppressing the lattice thermal conductivity. Ultimately, a peak zT of 1.8 at 800 K is achieved, with an average zT of 1.1 across the 300–800 K temperature range. This work provides a universal approach to overcome doping limits in Co 4 Sb 12 -based thermoelectrics.
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Advanced Energy Materials
·
2019
·Vol. 9
·期 22
·1900149
·
IF 24.884
Jiabin Wu,He Zhou,Qun Li,Ming Chen,Jun Wan,Nian Zhang,Liukang Xiong,Song Li,Bao Yu Xia,Guang Feng,Meilin Liu,Liang Huang
Atomically dispersed transition metals confined with nitrogen on a carbon support has demonstrated great electrocatalytic performance, but an extremely low concentration of metal atoms (usually below 1.5%) is necessary to avoid aggregation through sintering which limits mass activity. Here, a salt-template method to fabricate densely populated, monodispersed cobalt atoms on a nitrogen-doped graphene-like carbon support is reported, and achieving a dramatically higher site fraction of Co atoms (≈15.3%) in the catalyst and demonstrating excellent electrocatalytic activity for both the oxygen reduction reaction and oxygen evolution reaction. The atomic dispersion and high site fraction of Co provide a large electrochemically active surface area of ≈105.6 m 2 g −1 , leading to very high mass activity for ORR (≈12.164 A mg Co −1 at 0.8 V vs reversible hydrogen electrode), almost 10.5 times higher than that of the state-of-the-art benchmark Pt/C catalyst (1.156 A mg Pt −1 under similar conditions). It also demonstrates an outstanding mass activity for OER (0.278 A mg Co −1 ). The Zn-air battery based on this bifunctional catalyst exhibits high energy density of 945 Wh kg Zn −1 as well as remarkable stability. In addition, both density functional theory based simulations and experimental measurements suggest that the Co N 4 sites on the carbon matrix are the most active sites for the bifunctional oxygen electrocatalytic activity.
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Reaction Chemistry & Engineering
·
2025
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IF 3.1
Xiangyu Wen,Qiusheng Yang,Ming Li,Xiaoshu Ding,Peng Zhai,Yao Lu,Xinqiang Zhao,Yanji Wang,Dongsheng Zhang
Amino-methyl-N-phenylcarbamate (TMC) is an important organic intermediate. In this study, a new two-step route, i.e., methoxycarbonylation and direct amination reaction, was designed for synthesis of TMC. During this process, p-Toluidine first reacted with dimethyl carbonate to form metholylcarbamate (MTCM), and then MTCM further converted to TMC via direct amination reaction. It was found that in methoxycarbonylation process, Zn(OAc)2 catalyst was a better choice and p-Toluidine was almost completely converted into MTCM, corresponding to 99% p-Toluidine conversion and 95.4% MTCM yield. As for direct amination reaction, Fe-V/ZSM-5 bimetallic catalyst was selected and high yield of total TMC was obtained at 69.6%. The catalyst characterization results showed that the synthesized bimetallic catalysts retained the structural features of ZSM-5, while the abundance of metal ions on the surface promoted the reaction
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ADVANCED MATERIALS
·
2025
·
IF 26.8
Lingxiao Xue,Jiahao Cui,Ruiying Li,Wenhe Xie,Keyu Chen,Hongxiu Yu,Limin Wu,Tianjun Ni,Qin Yue,Yonghui Deng
Cells have greatly inspired advancements in chemical processes, including leveraging the idea of cascade catalysis to drive thermodynamically unfavorable reactions and mimicking the compartmentalized architecture to design novel nanostructures. Here, a single-particle cascade catalysis promoted gas sensing platform is inspired to be designed (denoted as CoSnO 3 @mCeO 2 ) by positionally assembling n-type mesoporous CeO 2 catalytic shell on p-type CoSnO 3 gas sensitive core. Uniform CoSn(OH) 6 @mCe(OH) x core–shell particles with tailored mesostructures, tunable large mesopores, and adjustable shell thicknesses are first constructed. After thermal treatment, CoSnO 3 @mCeO 2 particles are obtained, which serve as cascade catalysis enhanced sensitive layer for fabricating gas sensors with independent catalytic and sensing control. As a proof-of-concept, the CoSnO 3 @mCeO 2 gas sensors exhibit nearly three times higher acetone sensitivity ( R g /R a = 26.81–50 ppm) than individual CoSnO 3 sensors with an ultralow limit of detection of 5.22 ppb. The enhanced sensitivity is achieved through a tandem catalytic reforming-oxidation sensing procedure, which begins with the primary catalytic reforming of acetone to acetic acid in the mCeO 2 shell, followed by the secondary sensing reaction of acetic acid in the CoSnO 3 core. The design concept of cascade catalysis promotes gas sensor can serve as a paradigm for developing single-particle functional nanodevices for various applications.
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Matter
·
2025
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IF 17.5
Xinghe Xu,Fu-Lin Gao,Lin Tian,Zhi-Yue Yang,Zhong-Zhen Yu,Jie Shang,Run-Wei Li,Xiaofeng Li
Flexible, self-powered thermoelectric temperature sensors with high reliability are increasingly recognized as essential components in tactile perception, wearable technologies, and medical monitoring. To fulfill the performance requirements of these applications—specifically, achieving high Seebeck coefficients and superior resolution—traditional fabrication strategies typically rely on intricate molecular engineering, microscale structural optimization, or macroscale topological design. However, these approaches often involve complex manufacturing processes and elevated production costs, constraining large-scale deployment. Here, we propose a simple multilayer assembly approach that harnesses a self-permeation effect to enable the facile and cost-effective fabrication of flexible thermoelectric sensors with significantly improved sensitivity and resolution. By inducing intensive p-n heterojunctions through self-permeation and leveraging phonon scattering at multilayer-structured interfaces, the obtained sensor exhibits an unprecedented sensitivity of 1,203.6 μV K −1 and an ultimate temperature difference detection capability of 0.001 K, showcasing great potential for applications in three-dimensional environmental monitoring and bionic robotic tactile sensing.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 1
·1-10
·
IF 5.3
Yang Dou,Shao Tong,Wang Xiaoshuang,Hong Min,Li Rui,Li Chenzhong,Yue Qiaoli
New portable hydrogel sensors for Al 3+ and Fe 3+ detection were designed based on the aggregation-induced emission (AIE) and color change of N-doped carbon dots (N-CDs). N-CDs with yellow fluorescence were prepared by a one-pot hydrothermal method from 2,5-dihydroxyterephthalic acid and acrylamide. The fluorescence of N-CDs was enhanced by Al 3+ about 20 times and quenched by Fe 3+ . It was interesting that although Fe 3+ showed obvious quenching on the fluorescence of N-CDs it did not cause a noticeable change in the fluorescence of N-CDs + Al 3+ . The colorless solution of N-CDs appeared blue in the presence of Fe 3+ without the influence of Al 3+ . Therefore, the turn-on fluorometry and colorimetry systems based on N-CDs were constructed for the simultaneous detection of Al 3+ and Fe 3+ . Furthermore, the portable sensing of Al 3+ and Fe 3+ was realized with the assistance of hydrogel, filter paper, cellulose acetate, and cellulose nitrate film. The proposed approach was successfully applied to the detection of Al 3+ and Fe 3+ in food samples and cell imaging. Graphical Abstract
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危险品化学品经营许可证（带存储）