COLLOID AND POLYMER SCIENCE
·
2026
·
IF 2.9
Guo Qi,Zhao Jing,Xiao Ailing,Guo Menglu,Cui Lu,Zheng Li-Na,Liang Fei,Xie Na
Traditional hydrogels are limited by their loose three-dimensional network structure, inadequate mechanical strength, and insufficient synergistic antibacterial and antioxidant activities, which restrict their application as high-performance wound dressings. In this study, a graphene oxide (GO)-reinforced ternary composite hydrogel wound dressing (PVA/CS-GA/GO) based on polyphenol-modified chitosan and polyvinyl alcohol was successfully fabricated via a green repeated freeze–thaw process. The effects of GO incorporation on the microstructure, mechanical properties, antibacterial activity, and antioxidant performance of the composite hydrogels were systematically investigated. The results demonstrated that, at the optimal GO content, the composite hydrogel exhibited a tensile strength of 9.3 kPa and an elongation at break of 2163.7%, representing approximately 1.2-fold and 1.3-fold increases, respectively, compared with the PVA/CS-GA hydrogel. Moreover, GO incorporation further enhanced the antibacterial and antioxidant performances of the hydrogel, achieving a maximum antibacterial rate of 99.8% against Escherichia coli ( E.coli ) and increasing the DPPH radical scavenging activity to 94.8%, corresponding to an approximately 1.9-fold improvement over the PVA/CS-GA hydrogel. In addition, the composite hydrogel exhibited excellent structural stability and biocompatibility, simultaneously achieving mechanical reinforcement and multifunctional performance enhancement. These findings provide a theoretical basis for the design and development of high-performance multifunctional hydrogel wound dressings.
✓ 已验证
DOI
高影响因子
JOURNAL OF LIPOSOME RESEARCH
·
2025
·
IF 4.3
Xiaowen Wang,Xia Jiang,Jinjing Yang,Michael Adu-Frimpong,Mingjie Gong,Qinyang Hua,Tingyuan Li,Jiaying Li,Pengfei Pan,Elmurat Toreniyazov,Xia Cao,Jiangnan Yu,Qilong Wang,Ximing Xu
Moringa A (MA), the hepatoprotective components of Moringa oleifera Lam. seeds, are metabolized and eliminated quickly in the body. In this study, cholesterol-modified chitosan (CH-CS) was used as a polymer carrier to prepare chitosan-modified MA liposomes (MA-CLs) in order to slow down the release of MA, prolong its circulation time, and improve the oral bioavailability of MA in comparison with common MA liposomes (MA-Ls). The particle size (PS) of MA-CLs was 218.25 ± 1.07 nm, with a polydispersity index (PDI) of 0.143 ± 0.005 and a zeta potential (ZP) of 30.64 ± 0.29 mV. The encapsulation efficiency (EE) was 85.17 ± 1.70%, while the drug loading (DL) was 7.92 ± 0.16%. In contrast, the PS of MA-Ls was 232.06 ± 1.36 nm, with a PDI of 0.215 ± 0.009 and a ZP of −14.21 ± 0.33 mV. The EE and DL of MA-Ls were 71.34 ± 0.60% and 8.39 ± 0.07%, respectively. These results indicated that MA liposomes could effectively mitigate the burst release of MA, thereby enhancing its oral bioavailability. Furthermore, the performance of MA-CLs was superior to that of MA-Ls. ELISA kits demonstrated that, both MA and MA liposomes groups significantly reduced the levels of ach detection index in mice. Specifically, the therapeutic effect followed the order: MA-CLs > MA-Ls > MA, thus exhibiting a concentration-dependent manner. Histopathological analysis of liver sections revealed that MA and its formulations alleviated hepatocyte swelling and necrosis, thereby protecting the liver from alcohol-induced damage. This study found that MA has a protective effect on the liver, while MA-CLs hold promise as a therapeutic agent for prevention of acute alcoholic liver injury (ALI).
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Zelin Liao,Hui Yu,Gaohong He,Xuehua Ruan,Hailong Li,Jinhui Dou,Xiujuan Zhang
Blood-contacting membranes require hydrophobicity to prevent leakage but suffer from poor hemocompatibility. Hydrophilic modification represents a key strategy to address this limitation. Herein, hydrophilic carboxymethyl-chitosan (CMCS) modification onto polyethersulfone (PES) membrane (CMCS-PES) was achieved via thermal-crosslinking and amidation reaction, followed by characterization through SEM, AFM, FTIR, XPS, BET, as well as water contact angle measurements, and systematic evaluation for its performance in hemocompatibility, antibacterial activity, long-term stability, and gas permeation. Compared with unmodified PES membranes, CMCS-PES membrane showed excellent hydrophilicity with surface water contact angle reduced from 84.3° to 30.9°, displayed improved hemocompatibility with bovine serum albumin adsorption decreased from 57.76 to 31.32 μg/cm 2 , bovine γ-globulin from 47.26 to 27.45 μg/cm 2 , hemolysis rate reduced from 0.9 % to 0.3 %, prolonged activated partial thromboplastin time by 12.4 s, lower blood fibrinogen level by 20 %, and exhibited good antibacterial activity with inhibition on E. coli growth by 28.9 % and S. aureus by 42.76%. Moreover, the CMCS-PES membrane still presents competitive gas permeation in comparison to other membranes investigated under similar conditions, and demonstrated excellent long-term stability in preventing blood leakage and platelet adhesion. This research provides an effective modification strategy for hemocompatibility improvement on blood-contacting membranes.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Hao-Ze Li,Ru-Meng Liu,Jia-Si Zhang,Chen-Yan Zheng,Jin-E Wu,Chao Chang,Zhi-Yong Gong,Yong-Ning Wu,Kai Zhang,Xin Liu
The persistent environmental threat posed by diclofenac sodium (DCF), a low-biodegradability pharmaceutical contaminant in aquatic systems, necessitates advanced adsorbents capable of overcoming the capacity, kinetics, and recyclability limitations of conventional materials. To address this, we synthesized a novel cationic covalent organic framework/chitosan (iCOF/CS) aerogel. This was achieved first through the Schiff base condensation of 1,2,3-triaminoguanidinium chloride (TG Cl ) and 6-dihydroxynaphthalene-1,5-dicarbaldehyde (DHNDA) to form the iCOF. Subsequently, the iCOF was integrated into a chitosan matrix that was cross-linked with 1,3,5-triformylphloroglucinol (Tp), resulting in a hierarchical pore structure. The composite demonstrated exceptional DCF adsorption performance with ultrafast equilibrium within 10 min (98 % removal in 2 min) and a record capacity of 557.1 mg·g −1 , surpassing pure iCOF (473.1 mg·g −1 ) and CS aerogel (381.6 mg·g −1 ), attributed to synergistic ion exchange (Cl − /DCF − ), electrostatic attraction, π-π stacking, and hydrogen bonding, as validated by spectroscopy and theoretical calculation. The pioneering cationic COF/CS aerogel was engineered to overcome inherent recyclability limitations of powdered iCOF. The iCOF/CS aerogel gave above 97 % DCF removal in real aqueous matrices (tap, river and lake water) and over 91 % adsorption capacity after four regeneration cycles, thereby establishing a scalable remediation platform for pharmaceutical contaminants via engineered iCOF composites.
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Yuchun Ren,Dandan Zhao,Fei Zhou,Zhengjun Gong,Dongmei Wang,Yingwei Xi,Zhenglian Wu,Li Yang,Yongsheng Fu,Chen Fu
Lithium is a critical strategic resource in the transition to clean energy, and developing efficient, sustainable recycling technologies is essential to achieving carbon neutrality goals. The study addresses challenges such as low lithium-ion concentrations and the presence of competing cations in shale gas produced water (SGPW). An innovative composite adsorbent enhanced by a hydrogen bond network, consisting of H 1.33 Mn 1.67 O 4 (HMO), MXene, and chitosan (CTS), is introduced. Directional bonding among MXene, CTS, and HMO forms an interpenetrating structure that stabilizes the HMO lattice, with only 0.005 % Mn loss after ten cycles. Adsorption tests with actual SGPW demonstrated that the material adsorbs lithium-ion capacity at 11.80 mg/g, exhibiting higher lithium selectivity compared to other cations. A laboratory-scale experiment was conducted using a fixed-bed filtration system, the most effective adsorbent reached saturation close to 52 h under a near approach velocity of 0.13 cm/min (hydraulic loading) with a full bed volume of 7.7 cm 3 , containing around 4.92 g of adsorbent. A novel material design paradigm for lithium extraction from neutral to alkaline wastewater is presented, combining high selectivity with long cycle life.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Qing Peng,Qi Yang,Zheng Yan,Xiaofei Wang,Ying Zhang,Mao Ye,Shuqin Zhou,Genlong Jiao,Weijian Chen
The wound healing process was often accompanied by bacterial infection and inflammation. The combination of electrically conductive nanomaterials and wound dressings could accelerate cell proliferation through endogenous electrical signaling, effectively promoting wound healing. In this study, polypyrrole was modified with dopamine hydrochloride by an in situ polymerization to form dopamine-polypyrrole (DA-Ppy) conductive nanofibers which successfully enhanced the water dispersibility and biocompatibility of polypyrrole. The DA-Ppy nanofibers were dispersed in an aqueous solution for >48 h and still maintained good stability. In addition, the DA-Ppy nanofibers showed good photothermal properties, and the temperature could reach 59.7 °C by 1.5 W/cm 2 near-infrared light irradiation (NIR) for 10 min. DA-Ppy conductive nanofibres could be well dispersed in 3,4-dihydroxyphenylpropionic acid modified chitosan-carboxymethylated β-cyclodextrin modified gelatin (CG) hydrogel due to the presence of DA, which endowed CG/DA-Ppy hydrogel with good adhesion properties, and the hydrogel adhered to the pigskin would not be dislodged by washing with running water. Under NIR, the CG/DA-Ppy hydrogel showed significant antimicrobial properties. Moreover, the CG/DA-Ppy hydrogel had excellent biocompatibility. In addition, CG/DA-Ppy hydrogel was effective in scavenging ROS, inducing macrophage polarization towards the M2 phenotype, and modulating the level of wound inflammation in vitro. Finally, it was confirmed in rat-infected wounds that the tissue regeneration effect and collagen deposition in the CG/DA-Ppy + NIR group were significantly better than the other groups in the repair of infected wounds, indicating better repair of infected wounds. The results suggested that the photothermal, antioxidant DA-Ppy conductive nanofiber had great potential for application in infected wound healing.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food and Bioprocess Technology
·
2026
·Vol. 19
·期 3
·163
·
IF 5.6
Xia Shiqi,Gao Tongxin,Cui Congli,Bi Chong-hao,Li Dong,Wang Li-jun
Decolorization is critical in sugar refining, where reducing sugar alkaline degradation products (RSADPs) constitute major colorants. Conventional decolorants face limitations including non-renewability, high cost, and narrow applicability. This study developed quaternary ammonium-functionalized chitosan adsorbents (QA) as high-performance and cost-effective alternatives. QA was synthesized via (3-chloro-2-hydroxypropyl) trimethylammonium chloride modification, followed by chemical cross-linking with glutaraldehyde and freeze-drying. QA displayed a more intricate surface morphology with rougher pore walls, while increasing quaternary ammonium-functionalized chitosan (QACS) content contributed to the preservation of the porous framework. Additionally, QA exhibited a stable positive charge (pH 3–11) and industrial-grade thermal stability. Compared to the unmodified chitosan adsorbent, QA exhibited superior adsorption performance and maintained pH-independent functionality, with adsorption capacity increasing with rising QACS content. QA 5 (with 5 wt.% quaternary ammonium-functionalized chitosan) performed optimally, achieving 95.9% RSADPs removal with 172.6 mg/g equilibrium capacity (theoretical max of 287.7 mg/g) and > 15% higher efficiency than unmodified adsorbent. The adsorption kinetics followed the pseudo-second-order model (chemisorption-dominated), and the isotherms fitted the Freundlich model, indicating multilayer heterogeneous adsorption. The QA thus provides an efficient, eco-friendly solution with broad pH tolerance for industrial sugar decolorization.
✓ 已验证
产品关联
DOI
高影响因子
Foods
·
2026
·Vol. 15
·期 3
·594
·
IF 6
Dan Zhao,Nannan Chen,Beizhi Zhang,Fuzhi Xie,Qing Zhang,Bei Fan,Xiaona Liu,Ziguo Rong,Min Ju,Mengmeng Yu,Yongchang Dai,Fengzhong Wang,Liang Zhang
In this study, sodium alginate–chitosan composite microspheres (S-C Ms) were prepared by ionic gelation to encapsulateZiziphus jujubapulp from wild jujube pulp. The effects of sodium alginate (SA) concentration, chitosan (CS) concentration, and core-to-wall ratio on encapsulation efficiency (EE%) and loading capacity (LC%) were systematically investigated. The results showed that both EE% and LC% were maximized when the SA concentration was 2.0% (w/v) and the CS concentration was 1.5% (w/v). The FTIR and XRD analyses confirmed the successful encapsulation of a phenolic-rich extract fromZ. jujubapulp (PRE) and its transformation into an amorphous state, while the SEM observations revealed that the composite microspheres possessed a well-defined morphology and a dense internal structure. Particle size analysis further indicated a narrow and uniform size distribution. Thermogravimetric analysis (TGA) and in vitro simulated digestion demonstrated that S-C Ms exhibited a pH-responsive release profile, characterized by slow, limited release in the gastric phase and markedly enhanced release in the intestinal phase. The release mechanism in simulated gastric fluid was dominated by Fickian diffusion, whereas it shifted to an erosion-controlled process in simulated intestinal fluid. Consistently, the swelling ratio of the microspheres was low at pH 1.2 but increased sharply at pH 7.0, reflecting a “gastric protection–intestinal release” behavior. Antibacterial assays showed that P-loaded microspheres exerted significant inhibitory effects againstStaphylococcus aureusand other test strains, with the antibacterial activity possibly associated with the controlled release during the in vitro digestion of compounds with antimicrobial potential, such as phenolic compounds. Overall, SA-CS composite microspheres exhibited favorable encapsulation performance, structural stability, and controlled-release potential, making them a promising delivery and protection system forZiziphus jujubepulp bioactive compounds.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Innovative Food Science & Emerging Technologies
·
2026
·
IF 6.9
Minghui Zhao,Jinghong Li,Sibing Li,Xiaohan Zhang,Hanyu Li,Huajiang Zhang
To mitigate post-harvest losses in field-grown fruits and thus contribute to global efforts against malnutrition and hunger, this study presents an edible coating inspired by the phase separation of ovalbumin (OVA) and chitosan (CS) complexes, resulting in distinct inner and outer functional layers. We demonstrate that the phase behavior of the OVA-CS complexes is modulated by resveratrol (RES). Specifically, RES modifies protein conformation and intermolecular interactions by enhancing hydrophobic forces and reorganizing hydrogen bonds, driving the self-assembly of a Janus-type coating during drying. Optimized at pH 5.6, the OVA-CS-RES (OCR) coating exhibits superior barrier properties, achieving the lowest water vapor permeability and oxygen permeability. Anisotropic wettability was confirmed by contact angle measurements and atomic force microscopy, with the maximum contact angle difference between the inner and outer surfaces reaching 57.2°. Scanning electron microscopy and confocal laser scanning microscopy further verified uniform coverage and effective sealing of epidermal pores on fruit surfaces. Application experiments showed that the OCR coating significantly delayed fruit oxidation, reduced weight loss, preserved texture and ascorbic acid content, and maintained aroma integrity throughout 40 days of storage. Overall, this study introduces a scalable, single-step coating strategy leveraging self-assembled functional Janus coatings to significantly extend fruit shelf life.
✓ 已验证
产品关联
DOI
高影响因子
Sustainable Materials and Technologies
·
2026
·
IF 9.7
Miaojia Du,Yaopeng Zhang,Yuezhong Wen,Fang Li,Kai Yin,Wenliang Wu,Chensi Shen
Antimony (Sb) treatment presents a paradox: oxidizing toxic Sb(III) to Sb(V) for detoxification generates Sb(OH) 6 − species with a large hydration radius (7.36 Å) that hinders adsorption on conventional crystalline adsorbents due to limited accessible sites. We developed a Ce(III/IV)-chitosan semi-crystalline complex with mixed-valence coordination (Ce 3+ /Ce 4+ = 62.3:37.7) that addresses this challenge. Ce coordination constructs a semi-crystalline architecture where amorphous regions provide more accessible sites for large Sb(OH) 6 − while ordered domains maintain structural stability. The mixed-valence system sustained positive surface charge (+25 to +40 mV, pH 2–10) for electrostatic Sb(V) attraction, while Ce 3+ /Ce 4+ cycling catalyzed H 2 O 2 -mediated Sb(III) oxidation. At 2 mg/L Sb, a challenging concentration for industrial wastewater, the material achieved >98% removal within 90 min, reducing residual Sb to <0.04 mg/ L. maximum capacities reached 595.5 mg/g (Sb(V)) and 461.6 mg/g (Sb(III)), with excellent regenerability (>86% after five cycles). This work demonstrates how coordination-induced structural reorganization and mixed-valence chemistry overcome fundamental barriers in mixed-oxidation-state contaminant treatment.
✓ 已验证
DOI
高影响因子
POLYMER
·
2026
·
IF 5.1
Mengyun Shen,Changzhou Zhang,Yuanyuan Lu,Pengyu Yang,Guangli Chen,Zaosheng Lv,Yanfen Huang
Oily wastewater pollution poses a serious environmental challenge, driving the development of efficient, stable, and multifunctional purification materials for treating complex wastewater. In this study, a composite coating was constructed by integrating a metal-organic framework (MOF, CAU) for high surface area, polydopamine (PDA) for strong adhesion, and chitosan (CS) for hydrophilicity. The coating was deposited onto cotton fabric (CF) via a simple immersion method. The resulting polydopamine-chitosan-CAU@ cotton fabric exhibits superhydrophilic and underwater superoleophobic properties, with an underwater oil contact angle of up to 160°. It enables efficient oil-water separation across various oil phases and harsh conditions (acidic, alkaline, high-salinity). After 10 cycles, separation efficiency remains 98 % for petroleum ether-water mixtures. Furthermore, the coated fabric adsorbs cationic dyes (methylene blue) and shows antibacterial activity. These results highlight the significant potential of polydopamine-chitosan-CAU modified cotton fabric in the purification of complex oily wastewater.
✓ 已验证
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2026
·
IF 13.8
Qi Wei,Pei Wang
To elucidate the mechanism by which carboxymethyl chitosan (CMCh) regulates heat-induced aggregation of gluten proteins, CMCh derivatives with distinct substitution sites (amino, hydroxyl, and dual amino/hydroxyl substitution) were prepared and systematically compared. The results demonstrated that CMCh effectively modulated gluten aggregation during heating, and the regulatory effect strongly dependent on the substitution site. The degree of substitution (DS) of the derivatives ranged from 0.58 for O-CMCh to 1.26 for N-CMCh, while N,O-CMCh exhibited a DS of 1.18 and the highest water solubility (67.98 g L −1 ). The dual substituted CMCh (N,O-CMCh) exhibited the most pronounced effect, significantly enhancing gluten network elasticity and thermal stability. The onset and peak denaturation temperatures increased to 62.56 °C and 67.88 °C, respectively, with a denaturation enthalpy of 0.70 J/g at 95 °C, markedly higher than that of the control. Furthermore, N,O-CMCh promoted more ordered disulfide cross-linking during heating, increasing the SDS-insoluble protein content (SDS-I) to 80.40% at 95 °C. This was accompanied by a controlled decrease in free sulfhydryl groups and a corresponding increase in disulfide bond formation. In contrast, the single-site substituted derivatives exhibited weaker regulatory effects: N-CMCh increased SDS-I to 75.20%, whereas O-CMCh displayed thermal behavior most similar to the control. The superior functionality of N,O-CMCh is attributed to its unique molecular structure, which enables synergistic electrostatic interactions, hydrogen bonding, and synergistic disulfide cross-linking.This study clarifies the substitution site–dependent structure–function relationship of CMCh and provides a theoretical foundation for the rational design of high-performance CMCh improvers for cereal food.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）