JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
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2024
·Vol. 113
·期 1
·e37847
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IF 3.9
Jianing Cheng,Liguo Hao,Xiaorong Zhu,Ruifan Ma,Silong Li,Qiangqiang Yin,Dongxu Wang,Haifeng Hu,Tianyu Zhang,Zheng Li,Houyi Cong,Xiaoyang Zheng,Jun He,Yuguang Wang
Triggered by the vulnerability to atherosclerotic plaques, cardiovascular diseases (CVDs) have become a main reason for high mortality worldwide. Thus, there is an urgent need to develop functional molecular imaging modalities to improve the detection rate of vulnerable plaques. In this study, polyethyleneimine (PEI) was coated on the surface of mesoporous silica nanoprobes (MSN) loaded with Gd 2 O 3 (MSN@Gd 2 O 3 ), followed by coupling the fluorescent dye carboxylated heptamethine cyanine (IR808), and then the dextran sulfate (DS) was modified on the surface of MSN@Gd 2 O 3 @IR808 by electrostatic adsorption, to construct a targeted and pH-responsive magnetic resonance (MR)/near-infrared fluorescence imaging (NIRF) dual-modal nanoprobe (MSN@Gd 2 O 3 @IR808@DS nanoparticles). The nanoprobe presented a more concentrated distribution of spherical shapes in transmission electron microscopy. In vitro simulated vulnerable plaque microenvironment (pH = 5.5) presented significant T 1 -weighted imaging (T 1 WI) signal and longitudinal relaxation in the nanoprobe. Immunofluorescence staining and cellular uptake assays showed that MSN@Gd 2 O 3 @IR808@DS nanoparticles have the ability to specially bind to scavenger receptors A (SR-A). In vascular endothelium from the high-fat diet (HFD) New Zealand White rabbits, MSN@Gd 2 O 3 @IR808@DS nanoparticles can exhibit specific contrast-enhanced signals by MR/NIRF dual-modal imaging. In addition, cytotoxicity assays and hematoxylin and eosin (H&E) staining results demonstrated that MSN@Gd 2 O 3 @IR808@DS nanoparticles have good biocompatibility. Hence, this multifunctional MR/NIRF bimodal nanoprobe provides new experimental and technological ideas for the accurate diagnosis of vulnerable plaques.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Jie Song,Lijun Chen,Yingnan Zhou,Zhiwen Yuan,Yuhua Niu,Zhiqiang Wei
With the rapid development of industrialization, the removal of heavy metal ions and small organic molecules from wastewater has triggered a hot debate. ZIF-8 was grown on a sodium alginate backbone using an in situ growth technique, the core-shell P-SMG@ZIF-8 was synthesized. It was also characterized by FTIR, XRD, SEM, UV–Vis and XPS, and the optimal conditions and mechanism of adsorption were explored. At pH 2.0, a contact time of 200 min, and 298 K, removal of Cu(II) and Ph up to 80.2 %, 65.6 % by P-SMG@ZIF-8, adsorption behavior consistent with Langmuir model for pseudo-secondary rates, the saturated adsorption of Cu(II) and Ph could reach up to 83.5812 mg/g and 78.1779 mg/g, respectively. And the adsorbed P-SMG@ZIF-8 is easy to separate and reusable, which is a cost-effective and efficient natural product-based adsorption material.
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TRANSACTIONS OF TIANJIN UNIVERSITY
·
2025
·
IF 8.5
Sun Siyu,Zhang Feifei,Liu Wanlin,Zhang Rui,Yin Pengfei,Yang Jing,Dong Cunku,Nie Xinming,Liu Hui,Du Xiwen
The development of highly active and cost-effective catalysts for the full pH range of the hydrogen evolution reaction (HER) to meet the industrial application demands is an urgent challenge. In this work, the performance and structure–activity relationships of CuIr alloys prepared by the pulsed laser ablation in liquid technique as full pH range HER catalysts were investigated. Results indicated that Ir is doped into the Cu matrix as single atoms in CuIr-0.1, and CuIr-0.1 single-atom alloys (SAAs) exhibit superior HER performance and stability across the full pH range, with overpotentials of 135, 203, and 172 mV at the current density of 10 mA/cm 2 in acidic, neutral, and alkaline electrolytes, respectively. The enhanced performance of CuIr-0.1 SAAs can be attributed to the abundant active sites and accelerated reaction kinetics brought about by the electronic effects. This work successfully alloyed two immiscible metals to improve the catalytic performance, providing an avenue for the development of highly efficient and versatile HER catalysts for industrial applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Wenjing Zhang,Shengfeng Ye,Zhaolan Zhai,Dan Wang,He Liu,Shibin Shang,Zhanqian Song
Nanocelluloses as a natural polysaccharide nanoparticle are widely used in preparing Pickering emulsions, but less involved in stimuli-responsive Pickering emulsions, due to complicated covalent modification. In this study, a novel pH-responsive emulsion system was prepared using nanocellulose hydrophobized in situ with a unique pH-responsive surfactant (MPAA) derived from rosin. The headgroup charge of MPAA could be reversibly switched between a cationic form (MPAAH) and an anionic form (MPAANa) via adjusting pH, both of which had excellent water solubility. In acidic condition (pH 4.0), the negatively charged nanocellulose could be hydrophobized in situ by absorbing the cationic MPAAH, and stable and high-viscosity Pickering emulsion gels were obtained. In alkaline condition (pH 10.0), the nanocellulose dispersed in aqueous phase and formed thick aqueous lamellae with negative charge, preventing the flocculation and coalescence of the negatively charged droplets, and oil-in-dispersion emulsions with smaller droplet size and low viscosity were formed. The corresponding properties, such as droplet size, stability, and viscosity could be easily controlled by changing pH. Importantly, MPAA and nanocellulose could be separated and reused multiple times. The work proposed an effective method to achieve multiple recycling and reuse of emulsifiers, showing good economic benefits and potential sustainable applications.
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Materials Horizons
·
2024
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IF 12.2
Jimin Huang,Jinzhou Huang,Xinxin Zhang,Qinyi Xie,Yi Zheng,Chaoqin Shu,Zhe Shi,Xiao Wang,Jiajie Chen,Bing Ma,Chengtie Wu,Yufang Zhu
Wound healing in diabetes is a complex physiological process with risks of ulceration and amputation. Real-time monitoring and treatment of diabetic wounds is an effective prevention of further deterioration. Herein, a multifunctional dressing is developed by encapsulating europium-containing bioactive glass (EuBG) and MoO3-x in biocompatible sodium alginate (SA) dressing (MoO3-x-EuBG-SA), aiming to simultaneously monitor the wound pH value and hydrogen peroxide (H2O2) concentration, establish anti-inflammatory microenvironment, and promote wound healing. pH-responsive fluorescence quenching effect of the EuBG contributes to visible pH values monitoring, and MoO3-x enables high responsiveness and accurate colorimetric indication of H2O2 variability to understand the dynamic wound status. Then, these fluorescent and colorimetric photographs can be captured by smartphones and transformed into signals for wound pH value and H2O2 concentration, enabling rapid and convenient real-time assessment of wound dynamic conditions. Furthermore, MoO3-x-EuBG-SA dressing can reduce inflammation and promote the proliferation, differentiation, and migration of fibroblasts and endothelial cells in vitro with the help of the released bioactive Si, Ca, and Mo ions. Notably, the MoO3-x-EuBG-SA dressing exhibits excellent abilities of monitoring wound microenvironment, immune regulation, and promoting diabetic wound healing in vivo. Overall, the multifunctional dressing has great potential for managing diabetic wounds and promoting wound healing.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Jifang Yuan,Meirong Li,Xiaofeng He,Qian Hou,Xiaobing Fu,Jianxiu Hao
Chitosan is an excellent carrier material for bioactive substances, and its binding ability is affected by the pH value of surrounding environments. Healthy skin is maintained in a slightly acidic environment, whereas the wound healing environment is normally neutral or slightly alkaline. In the present study, the authors proposed developing a thermally stable bioactive chitosan scaffold (T-CS) with pH-responsive exosome adsorption and release functions to promote wound healing. Our results revealed that T-CS could automatically capture exosomes from human umbilical cord mesenchymal stem cells in an acidic environment and release them in alkaline or neutral environments. The exosomes separated by T-CS and the traditional ultracentrifugation (UC) method exhibited similar size and protein markers. Furthermore, the exosomal biological activities of the T-CS (T-CS-E) and UC groups exhibited similar anti-inflammatory, proproliferation, promigration, and proendothelial cell-tube formation effects on human umbilical vein endothelial cells. Similar results were achieved in a mouse model by sustainably releasing exosomes. T-CS-E could facilitate wound healing by enhancing cell proliferation, inhibiting wound inflammation, and promoting vascularization. Therefore, this study developed a T-CS scaffold that integrates exosome isolation and application for wound healing, laying the foundation for future clinical use.
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Analytical Methods
·
2024
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IF 2.7
Changmao Yang,Yue Xiao,Yunjun Yan,Houjin Zhang
The development of straightforward and cost-efficient methods for bacterial identification is very important. In this study, we utilized xylenol orange, metal ions, and diverse bacterial carbon sources to construct a sensor array, achieving precise bacterial identification. Initially, we examined the absorbance variations of xylenol orange with five metal ions (Mn2+, Co2+, Ni2+, Cu2+, and Zn2+) at pH levels ranging from 4 to 7, observing significant changes at 570 nm or 580 nm. Given that bacteria can generate varying amounts of acid in different carbon sources, we employed a blend of xylenol orange and the five metal ions as pH-sensitive probes to characterize bacterial metabolism in three carbon sources, resulting in the development of a five-sensor array that effectively differentiated seven bacteria. Additionally, by utilizing xylenol orange with Co2+, we successfully identified six different bacterial mixtures and five types of probiotic drink products. These findings highlight the potential of our methods for broader practical application in bacterial identification in practical use.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
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IF 8.1
Zhihua Mo,Chengjian Li,Yu Zhang,Jingsai Ren,Zhantong Zhu,Jialin Liang,Maoyou Ye,Zhi Zhu,Suiyi Zhu,Weilu Yang,Zhimin Xu,Jonathan W.C. Wong
Advanced oxidation processes utilizing percarbonate (SPC) have garnered considerable interest in the realm of water purification, but the all-encompassing constraint on pH conditions largely hindered its environmental applications. Here, a combination process of ball-milled pyrite@biochar and SPC was constructed to accelerate the degradation of norfloxacin (NOR) at an inherent pH environment. Results showed that the ball-milled pyrite@biochar + SPC system accomplished almost complete removal of NOR within 60 min, demonstrated excellent pH resilience ranging from pH 3.0 to 10.0, and manifested over 90 % NOR removal in cycle operation. The main mechanism of NOR removal encompassed both adsorption and oxidation processes. The NOR initially adhered to the ball-milled pyrite@biochar interface. Then, the interaction of the ball-milled pyrite@biochar and SPC yielded a multitude of reactive oxygen species (ROS), such as •OH, O 2 •− , and 1 O 2 , along with electron complexes. The enhanced performance of SPC activated by the ball-milled pyrite@biochar could essentially be attributed to the greater Fe 3+ /Fe 2+ circulation and better electron utilization efficiency through the existence of sulfur species and oxygen-containing functional groups. Accordingly, the regenerated Fe 2+ was able to rapidly activate SPC for the production of ROS and electron complexes. Moreover, three possible NOR degradation pathways were put forward. It was illustrated that the application of the ball-milled pyrite@biochar + SPC could effectively reduce the ecotoxicity of NOR in wastewater. Overall, this study established a solid foundation for the implementation of ball-milled pyrite@biochar + SPC system in efficient water purification process.
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REACTIVE & FUNCTIONAL POLYMERS
·
2024
·
IF 4.5
Yan Liu,Wenji Kang,Libo Nie,Fen Xiao,Yilong Li,Qinbin Ma,Danqi Lin,Guiyin Zhou,Sihua Liu,Kehui Sun,Xiangqian Li
Oral colon-targeted drug formulations play a pivotal role in managing colon diseases, yet the effectiveness of most hydrophobic drug formulations in reaching the colon orally is hindered by challenges such as poor solubility, premature release in the stomach, and low bioavailability. In this study, we devised a pH-sensitive dual-network hydrogel utilizing sodium alginate and methacrylic acid for treating ulcerative colitis. The primary rigid network layer is activated thermally through free radicals, while the secondary flexible network layer is formed by the coordination of alginic acid and calcium ions. Sulfadiazine was loaded into the hydrogels using a solution displacement method. We conducted a comprehensive analysis of the morphology, mechanical properties, and drug release mechanisms of the hydrogels. The hydrogel demonstrated outstanding pH-responsive swelling properties. In acidic environments, protonation of carboxyl groups led to hydrogel network contraction, while in weakly alkaline environments, deprotonation induced electrostatic repulsion, facilitating swelling and controlled drug release. The alteration of pH from 1.2 to 7.4 increased the drug release rate from 33 % to 92 %, aligning with the first-order kinetic release model. The drug-loaded gel exhibited a compressive stress of 0.13 MPa at 50 % strain, and its superior mechanical properties ensured stability before drug release. Moreover, the hydrogel displayed excellent biocompatibility, hemocompatibility, and thermal stability. In summary, these findings underscore the substantial potential of drug-loaded gels in advancing controlled drug delivery systems.
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ACS Sustainable Chemistry & Engineering
·
2024
·
IF 7.1
Liheng Chen,Tang Li,Xueqing Qiu,Yanlin Qin
This study addresses the challenge of pH-triggered charge reversal nanoparticles (pH-CRNPs), focusing on enhancing their precision and scalability for widespread use. Leveraging the unique properties of lignin, a renewable aromatic macromolecule abundant in plants, we developed lignin nanoparticles (LNPs) through chemical modification with various amino acids followed by methylation in one pot. Methylation partially sealed negative charges, enhancing hydrophobicity, and enabled self-assembly into colloidal spheres with pH responsiveness under alkaline conditions. This innovative approach overcomes the limitations of weak positive charges in conventional LNPs, expanding their application beyond highly acidic tissues. Comprehensive studies explored the relationship between the molecular structure and colloidal sphere stability. Notably, the reagents used exhibited low toxicity, positioning these LNPs as promising candidates for drug delivery with simplified purification steps. This research contributes to the advancement of green synthesis strategies, making LNPs more accessible and efficient for diverse biomedical applications.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2024
·
IF 8.1
Xianda Sun,Jinxu Hao,Siyi Bao,Xin Ye,Bingye Song,Xuankai Zhang,Yuandong Yang
The huge energy consumption primarily resulting from the sluggish oxygen evolution reaction (OER) is the paramount hindrance in achieving the cost-effectiveness of hydrogen production via water electrolysis. In this work, alcohols are employed to assist the hydrogen production, and the feasibility of coproducing electricity and hydrogen in the cation-exchange membrane direct alcohol fuel cells is conceptually validated. After the performance optimization, the peak power density of 114 mW cm −2 is achieved at the hydrogen generation current density of 230 mA cm −2 . Impressively, the fairly flat 24-h constant current discharge and hydrogen production plots demonstrate the good durability of the proposed hydrogen production device. Moreover, the fuel flexibility of the cation-exchange membrane direct alcohol fuel cells on methanol, ethanol, propanol, iso-propanol and ethylene glycol furthering suggests its application potential. This work proposes an effective strategy for the energy-saving green hydrogen production.
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Food Packaging and Shelf Life
·
2024
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IF 8.5
Guangmei Xia,Yingying Ma,Qiance Ma,Xiaohui Yao,Zhen Xu,Xingxiang Ji,Fengshan Zhang
The pH-responsive color-changing indicator films are necessary for the intelligent packaging systems. However, casting and evaporation techniques are usually employed to prepare these indicator films, which are time-consuming and energy-wasting, limiting their large-scale production. Hence, a sol-gel transformation approach was proposed to fabricate cellulose/alizarin composite films by using low-cost waste paper cups as cellulose resource in this work. It was found that cellulose/alizarin composite films displayed homogeneous structures due to the extensive hydrogen bonding between cellulose and alizarin, and their properties varied obviously with the content of alizarin, Specially, the cellulose/alizarin composite films showed noticeable color transition with an increasing pH from 1.0 to 13.0, and cellulose/alizarin composite films with low content (＜7.5 %) of alizarin were much more sensitive to pH change. It was also proved that the as-prepared cellulose/alizarin films possessed good mechanical properties, high UV barrier capacity and impressive antioxidant activity. Particularly, the tensile strength of the cellulose/alizarin composite films can reach as high as 31 MPa, while UV-shielding performance and radical scavenging capacity were enhanced significantly with increasing the content of alizarin. Finally, the cellulose/alizarin films were successfully employed to monitor fish freshness as intelligent indicator films. Therefore, UV shielding, antioxidant and pH-responsive cellulose-based composite films incorporated with alizarin were manufactured successfully, which demonstrated great potentials to be used in intelligent packaging fields.
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